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血清Nrf2、Keap1水平变化与糖尿病视网膜病变分期间关系

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徐州医科大学学报 2024年第1期44卷 37-42页

作者：范存莉徐维诚陈玮翁月胜如皋市中医院眼科江苏如皋226500

目的探讨血清单核细胞核因子E2相关因子(Nrf2)、Kelch样ECH关联蛋白1(Keap1)水平变化与糖尿病视网膜病变(DR)分期间关系。方法选取2020年4月—2023年2月如皋市中医院DR患者147例作为观察组,并根据DR分期分为非增生型糖尿病视网膜病变(NP... 详细信息

目的探讨血清单核细胞核因子E2相关因子(Nrf2)、Kelch样ECH关联蛋白1(Keap1)水平变化与糖尿病视网膜病变(DR)分期间关系。方法选取2020年4月—2023年2月如皋市中医院DR患者147例作为观察组,并根据DR分期分为非增生型糖尿病视网膜病变(NPDR)、增生型糖尿病视网膜病变(PDR);另选取同期糖尿病无视网膜病变患者49例作为对照Ⅰ组,健康体检者49例作为对照Ⅱ组。对比3组及观察组不同DR分期患者血清Nrf2、Keap1水平,Spearman秩相关系数分析血清Nrf2、Keap1水平与DR分期间关系;多因素logistic回归分析血清Nrf2、Keap1水平对DR分期的影响;限制性立方样条图分析血清Nrf2、Keap1水平与DR分期的剂量-效应关系。结果观察组血清Nrf2水平低于对照Ⅰ组、对照Ⅱ组,Keap1水平高于对照Ⅰ组、对照Ⅱ组,对照Ⅰ组血清Nrf2水平低于对照Ⅱ组,Keap1水平高于对照Ⅱ组(P0.05),血清Nrf2水平是DR分期的独立保护因素,高脂血症、糖尿病病程、空腹血糖、糖化血红蛋白、血清Keap1水平是DR分期的独立危险因素(P3.00μg/L时,PDR风险显著增加。结论血清Nrf2、Keap1水平变化与DR分期关系密切,血清Nrf2水平3.00μg/L时提示DR进展至PDR的风险显著增加。

关键词：糖尿病视网膜病变单核细胞核因子E2相关因子 Kelch样ECH关联蛋白1 增生型糖尿病视网膜病变限制性立方样条图

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GC-MS分析大莪术根茎挥发油成分

化工管理 2024年第8期 59-61,65页

作者：张娜翁伟锋黄淳魏坤盛刘敬中山火炬职业技术学院广东中山528436

文章分析了大莪术根茎挥发性成分,并探究不同加工方法对其成分的影响,为大莪术的加工工艺筛选和进一步的研究开发提供实验依据。利用冷冻干燥和真空干燥处理新鲜的大莪术根茎样品,采用水蒸气蒸馏法提取大莪术挥发油,应用GC毛细管柱进行... 详细信息

文章分析了大莪术根茎挥发性成分,并探究不同加工方法对其成分的影响,为大莪术的加工工艺筛选和进一步的研究开发提供实验依据。利用冷冻干燥和真空干燥处理新鲜的大莪术根茎样品,采用水蒸气蒸馏法提取大莪术挥发油,应用GC毛细管柱进行分离、质谱检测、面积归一化法测定相对含量,分析其挥发性化学成分。由于不同干燥方法加工大莪术根茎挥发油的组分绝大部分相同,但是相对含量存在一定差异。实验证明,大莪术根茎主要含有表莪术呋喃烯酮、β-榄香烯、β-桉叶醇、吉马酮、莪术双环烯酮、蓬莪术环氧酮、莪术烯、β-石竹烯等挥发性成分,均具有一定的生理活性,具有广泛的开发前景。

关键词：大莪术根茎挥发性成分 GC-MS 中医药药理药效

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伸缩式自动化井口上卸扣装置的设计与分析

钻采工艺 2024年第1期47卷 138-143页

作者：陈淼郭登明付青威翁玮白晓弘杨建忠徐洪兵长江大学机械工程学院湖北省荆州市434023 中国石油长庆油田分公司油气工艺研究院中国石油集团渤海石油装备制造有限公司辽河热采机械制造分公司

随着修井作业朝着自动化方向发展,国内外均致力于研究自动化修井作业设备。文章结合自动化修井机特点,设计出一种伸缩式自动化井口上卸扣装置,分析了自动液压钳、扶正对中装置等主要结构,系统阐述了该装置的工作原理,计算得出液压钳钳... 详细信息

随着修井作业朝着自动化方向发展,国内外均致力于研究自动化修井作业设备。文章结合自动化修井机特点,设计出一种伸缩式自动化井口上卸扣装置,分析了自动液压钳、扶正对中装置等主要结构,系统阐述了该装置的工作原理,计算得出液压钳钳牙与油管之间的防打滑条件,对背钳夹紧液压缸进行选型计算,设计出合适的自动液压钳以及整个装置的液压回路,保证该装置在工作时的安全性与稳定性。现场试验结果表明,伸缩式自动化井口上卸扣装置能够实现精准对中,快速平稳完成上卸扣作业,大大减轻了工人的工作强度,节省井口操作平台空间,提升工作效率,并提高了工人的安全性。

关键词：上卸扣装置自动化修井机液压油管钳液压系统自动化

Extremely low-energy collective modes in a quasi-one-dimensional topological system

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Science China(Physics,Mechanics & Astronomy) 2022年第5期65卷 90-96页

作者： Zhengxin wei Shuai Zhang Yulun Su Liang Cheng Haidong Zhou Zhigang Jiang Hongming weng Jingbo Qi State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengdu 610054China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Department of Physics and Astronomy University of TennesseeKnoxvilleTennessee 37996USA School of Physics Georgia Institute of TechnologyAtlantaGeorgia 30332USA

We have investigated the quasiparticle dynamics and collective excitations in the quasi-one-dimensional material ZrTe_(5) using ultrafast optical pump-probe spectroscopy.Our time-domain results reveal two coherent oscillations having extremely low energies of hω_(1)~0.33 me V(0.08 THz)and hω_(2)-1.9 me V(0.45 THz),which are softened as the temperature approaches two different critical temperatures(~54 K and~135 K).We attribute these two collective excitations to the amplitude mode of photoinduced dynamic charge density waves in ZrTe_(5) with tremendously small nesting wave vectors.Furthermore,a peculiar quasiparticle decay process associated with the hω_(2) mode with a timescale of~1-2 ps is found below the transition temperature T*(~135 K).Our findings provide pivotal information for studying the fluctuating order parameters and their associated quasiparticle dynamics in various low-dimensional topological systems and other materials.

关键词： charge density waves ultrafast quasiparticle dynamics amplitude mode

Occurrence,risk factors,and microbiology of surgical site infections after total knee arthroplasty:preliminary results of a retrospective study

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Chinese Medical Journal 2023年第14期136卷 1747-1749页

作者： Yiming Xu Yingjie Wang wei Zhu Bin Feng Zehui Lyu Yixin Bian Xisheng weng Department of Orthopedics State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

To the Editor:Total knee arthroplasty(TKA)has became an established treatment for end-stage joint disease.In China,there was a 5.9-fold increase in the number of TKA cases between 2011 and 2019.All kinds of infections are catastrophic complications of TKA.Recent reports have highlighted the underestimated prevalence of surgical site infections(SSIs)and projected an increase in complex SSIs following hip and knee arthroplasties by 14%between 2020 and 2030.^([1])However,there are few reports describing SSIs in Chinese population.This preliminary retrospective study aimed to gain some insights into the occurrence,risk factors,and microbiological patterns of SSIs in China.

关键词： infections knee arthroplasty

Intrapartum and early postpartum glycemic profiles in women with gestational diabetes mellitus:an observational study

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Chinese Medical Journal 2022年第21期135卷 2547-2553页

作者： Yu Ding Xueying Zheng Yujie Liu Tian wei Tong Yue Siqi Wang Suyu Chen Jianping weng Sihui Luo Department of Endocrinology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China Department of Obstetrics and Gynecology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China Institute of Endocrine and Metabolic Diseases The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China

Background: Data on the glycemic profile of pregnant women with gestational diabetes mellitus (GDM) during the perinatal period are sparse. This study described the intrapartum and early postpartum glucose profiles among pregnant women with GDM, and analyzed factors potentially affecting glycemic parameters during the period.Methods: This was a prospective observational study conducted from March 2020 to November 2021. Pregnant women with GDM receiving lifestyle interventions alone during pregnancy and matched women with non-diabetic pregnancies (NDPs) were enrolled from among patients admitted to the obstetrics department for childbirth. Glucose monitoring was performed via a flash glucose monitoring (FGM) system on admission, and glucose readings during labor and early postpartum were analyzed. The clinical characteristics and FGM-based parameters of participants in the two groups were compared.Results: A total of 124 participants (mean age: 29.5 ± 3.5 years, 92 [74.2%] primipara) were included in the final analysis. A total of 17,571 glucose readings were retrieved. There were no significant differences in clinical characteristics between the GDM (n = 60) and NDP (n = 64) groups. The average glucose level was 92.2 mg/dL, and the level was higher in the GDM group (95.5 ± 12.1 mg/dLvs. 89.1 ± 13.4 mg/dL,P = 0.008) during the intrapartum and early postpartum periods. The data were split into the intrapartum period (from the start of labor to delivery of the placenta) and the early postpartum period (within 24 h after placental delivery) for analysis. During intrapartum, women with GDM exhibited glycemic profiles and fluctuations similar to those in the NDP group. However, women with GDM had higher postpartum glucose levels (97.7 ± 13.4 mg/dLvs. 90.8 ± 15.3 mg/dL,P = 0.009), a longer time spent >140 mg/dL (8.7 ± 9.3%vs. 5.9 ± 10.3%,P = 0.011), and greater glycemic fluctuations than those with NDP. Postpartum hyperglycemia in GDM might be associated with high parity and postprandial glucose abnormalities in GDM scr

关键词： Blood glucose Flash glucose monitoring Gestational diabetes mellitus Glycemic profiles

一种多地DFIG联动控制的多馈入受端系统连续换相失败抑制策略

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中国电机工程学报 2024年第9期44卷 3452-3462,I0009页

作者：江毅翁汉琍曹善康吴宇奇熊振钦梅瀚予林湘宁魏繁荣李正天李振兴新能源微电网湖北省协同创新中心(三峡大学) 湖北省宜昌市443002 强电磁工程与新技术国家重点实验室(华中科技大学) 湖北省武汉市430074 三峡大学电气与新能源学院湖北省宜昌市443002

我国沿海负荷中心呈现直流多馈入的结构特征,海上风电的大规模开发使得系统在非正常工况下容易诱发次同步振荡,电压的快速波动可能会造成连续换相。针对该现象进行机理分析,通过优化双馈风电机组(doubly fed induction generator,DFIG)... 详细信息

我国沿海负荷中心呈现直流多馈入的结构特征,海上风电的大规模开发使得系统在非正常工况下容易诱发次同步振荡,电压的快速波动可能会造成连续换相。针对该现象进行机理分析,通过优化双馈风电机组(doubly fed induction generator,DFIG)的控制方法,有效抑制了次同步振荡。同时,针对不同区域风电场调节能力差异,通过关联各直流落点的多馈入交互作用因子(multi-infeed interaction factor,MIIF),充分调动不同区域风电场的补偿能力抬升系统电压。该方法有效地抑制直流多馈入系统的异地连续换相失败。最后,通过PSCAD仿真对比验证所提策略的有效性。

关键词：双馈风电场(DFIG) 次同步振荡直流多馈入连续换相失败

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剪切试验下砂土接触面摩擦特性影响因素分析

建筑技术 2024年第9期55卷 1140-1142页

作者：吴彩虹翁锴亮茅嘉炜上海勘测设计研究院有限公司上海200434 同济大学地下建筑与工程系上海200092

针对目前缺少对于砂土接触面三维剪切试验研究的情况,以大型土工三轴仪为原型进行改造,自主研制了一套砂土三维剪切试验设备,并利用所研制的试验设备和方法开展了砂土剪切试验,讨论分析了砂土土体初始相对密实度和土体不均匀系数两个影... 详细信息

针对目前缺少对于砂土接触面三维剪切试验研究的情况,以大型土工三轴仪为原型进行改造,自主研制了一套砂土三维剪切试验设备,并利用所研制的试验设备和方法开展了砂土剪切试验,讨论分析了砂土土体初始相对密实度和土体不均匀系数两个影响因素。试验结果表明随着土样初始相对密实度的提高,砂土初始剪切刚度基本不受影响,但其峰值剪切应力和残余剪切应力均得到提高。而随着土体不均匀系数的提高,增大了土样的颗粒尺寸差异,土体具有良好的颗粒骨架,使得砂土剪切试验下峰值应力得到提高。试验表明,该试验设备和方法为后续开展的砂土摩擦特性影响因素探究提供了技术支持和研究基础。

关键词：砂土摩擦特性室内试验剪切位移

Aerophilic Triphase Interface Tuned by Carbon Dots Driving Durable and Flexible Rechargeable Zn‑Air Batteries

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Nano-Micro Letters 2023年第2期15卷 238-258页

作者： Kuixing Ding Yu Ye Jiugang Hu Liming Zhao wei Jin Jia Luo Shan Cai Baicheng weng Guoqiang Zou Hongshuai Hou Xiaobo Ji College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083People’s Republic of China College of Standardization China Jiliang UniversityHangzhou 310018People’s Republic of China School of Environmental Science and Engineering Suzhou University of Science and TechnologySuzhou 215009People’s Republic of China

Efficient bifunctional catalysts for oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)are vital for rechargeable Zn-air batteries(ZABs).Herein,an oxygen-respirable sponge-like Co@C–O–Cs catalyst with oxygen-rich active sites was designed and constructed for both ORR and OER by a facile carbon dot-assisted strategy.The aerophilic triphase interface of Co@C–O–Cs cathode efficiently boosts oxygen diffusion and transfer.The theoretical calculations and experimental studies revealed that the Co–C–COC active sites can redistribute the local charge density and lower the reaction energy barrier.The Co@C–O–Cs catalyst displays superior bifunctional catalytic activities with a half-wave potential of 0.82 V for ORR and an ultralow overpotential of 294 mV at 10 mA cm^(−2) for OER.Moreover,it can drive the liquid ZABs with high peak power density(106.4 mW cm^(−2)),specific capacity(720.7 mAh g^(−1)),outstanding long-term cycle stability(over 750 cycles at 10 mA cm^(−2)),and exhibits excellent feasibility in flexible all-solid-state ZABs.These findings provide new insights into the rational design of efficient bifunctional oxygen catalysts in rechargeable metal-air batteries.

关键词： Aerophilic triphase interface Oxygen-rich active sites O2 diffusion Bifunctional oxygen catalyst Flexible rechargeable Zn-air battery