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探讨师伟教授治疗子宫腺肌病的用药规律信息学研究

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中药药理与临床 2024年第8期40卷 103-107,35页

作者：刘洋师伟山东中医药大学第一临床医学院济南250014 山东中医药大学附属医院妇科济南250014

目的:基于数据挖掘探讨师伟教授治疗子宫腺肌病(Adenmyosis,AM)的用药规律。方法:收集2020年5月1日-2023年5月31日就诊于山东中医药大学附属医院师伟教授专家门诊的子宫腺肌病患者病案信息,用Excel软件建立处方数据库,采用SPSS Modeler1... 详细信息

目的:基于数据挖掘探讨师伟教授治疗子宫腺肌病(Adenmyosis,AM)的用药规律。方法:收集2020年5月1日-2023年5月31日就诊于山东中医药大学附属医院师伟教授专家门诊的子宫腺肌病患者病案信息,用Excel软件建立处方数据库,采用SPSS Modeler18.0、SPSS Statistics 25.0软件对中药处方中的药物分别进行药物的复杂网络分析、二项、三项关联分析、系统聚类。结果:纳入254例子宫腺肌病患者临床病案处方信息,收集有效处方768首,涉及药物174味,用药总频次15827次。统计分析得出,师伟教授在治疗子宫腺肌病的组方中使用频次最多的药物是甘草、黄芪、赤芍、茯苓、皂角刺、重楼、桂枝、桃仁、没药、牡丹皮;“四气”使用频次较多的是寒、温、平性,“五味”使用频次最多的是甘、苦、辛味,“归经”使用频次最多的是肝经、心经、脾经,中药功效使用频次最多的是补虚药、活血化瘀药。复杂网络核心处方主要由桂枝茯苓丸合黄芪建中汤合没竭散化裁组成,高频药物系统聚类分析得到5个药物聚类组合。结论:师伟教授认为AM病机是阳虚血瘀为本,病位在冲任、胞宫,变化在气血,表现为痛证与血证。在治疗AM时,师伟教授遵循“衰其大半而止”的原则,治法重在平心、调肝、健脾,燮理冲任气血,恢复脏腑功能;用药寒温平调,攻邪不忘扶正,以益气活血、祛瘀消癥为主;临证遣方擅于化裁经典方剂,方简效宏。治疗时谨守病机,审证求因,分期施治。

关键词：数据挖掘子宫腺肌病用药规律师伟教授

Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： HUANG Hao-yue LIN Yu-ping wei Hua FU Yu ZHOU Yue-hong FANG Zhao-hui QIU Xiao-tang WANG Mei LI Qing-bo LI Shan-shan WANG Shi-dong DAI Fang LIU Zhen-jie ZHAO Ling WEN Jian-xuan WU Li-yan ZENG Hui-yan ZHANG Jin-ming LU Qi-yun HE Liu SONG wei SUN Lu LUO Lu-lu HE Jia-li XIE Wen-wen LIANG Qing-shun HUANG Yuan ZHU Sheng-ling LONG Jie-er GAO Zhi-juan WEN Ze-huai LI Chun-ji OUYANG Wen-wei LI Geng WU Ming-hui LI An-xiang HUANG Jin-zhu Sanjoy K Paul TANG Xian-yu FAN Guan-jie Department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second clinical College of Guangzhou university of Chinese Medicine Guangzhou510120China Department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong Provincial Academy of Chinese medical Sciences Guangzhou510120China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China Department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China Department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China Department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(P0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction

Isodon Suzhouensis extract interferes with miRNA expression profile for prevention and treatment of Chronic Obstructive Pneumonia Disease

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Food Science and Human Wellness 2024年

作者： Hong Duan Han Li Jun Feng Jing Zhou Ying Shi Li Wang Zeng Dong Kefeng Zhai Lili Li Zhaojun wei School of Biological and Food Engineering， Engineering Research Center for Development and High Value Utilization of Genuine Medicinal Materials in North anhui Province， Suzhou university College of Biological and Food Engineering， anhui Polytechnic university College of Pharmacy， Xinjiang medical university General clinical Research Center， anhui Wanbei Coal-Electricity Group General Hospital School of Biological Science and Engineering， North Minzu university

Chronic obstructive pulmonary disease (COPD) is a respiratory condition characterized by several symptoms. The pathogenesis of COPD is complex and involves multiple factors. A fantastic drug from traditional Chinese medicine (TCM)， Isodon Suzhouensis (ISZ) is a perennial herb belonging to the labiaceae family. It has the functions of resolving phlegm， removing stasis， promoting blood circulation and eliminating qi stagnation. ISZ has been found to possess great potential against COPD. Present study is focused to identify microRNA (miRNA) biomarkers for COPD and to determine the role of ISZ leaves extract in regulating the disease through miRNA expression in serum exosomes. The sprague-dawley (SD) rats were randomly divided into control group， model group and drug groups. After the establishment of the model， the rats were sacrificed and the results were compared with control group. Then the total RNA， of rat serum was extracted and identified by nanoparticle tracker. Finally， high-throughput screening and sequencing were performed to screen miRNAs with significant differential expression. Then different databases were used to figure out the possible target genes and their functions were assessed by employing gene ontology (GO) as well as kyoto encyclopedia of genes and genomes (KEGG) analyses. The sequencing results were then further verified by qRT-PCR. The results pointed out that these 17 differentially expressed miRNAs may have the potential of diagnostic and prognostic biomarkers against COPD. Interestingly it was also found that ISZ leaves extract may regulate the occurrence of COPD by affecting the expression of miRNAs. This study identified the biomarkers of COPD and clarified the mechanism of the treatment of COPD by ISZ leaves extract， which is helpful to improve the level of early diagnosis and treatment of COPD.

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前列腺癌早期筛查风险预测模型的建立与验证研究

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中国全科医学 2024年第20期27卷 2483-2490页

作者：李宏基赵晓龙胡伟韩东晖王安辉秦卫军空军军医大学第一附属医院泌尿外科陕西省西安市710032 空军军医大学军事预防医学系流行病学教研室陕西省西安市710032

背景前列腺癌作为常见的恶性肿瘤,威胁中老年男性生命健康,其预后与初诊时肿瘤级别与分期密切相关。前列腺特异性抗原(PSA)是前列腺癌早期筛查的重要分子,但非肿瘤负荷的前列腺良性疾病或操作也会引起PSA升高,盲目穿刺常导致过度诊疗。... 详细信息

背景前列腺癌作为常见的恶性肿瘤,威胁中老年男性生命健康,其预后与初诊时肿瘤级别与分期密切相关。前列腺特异性抗原(PSA)是前列腺癌早期筛查的重要分子,但非肿瘤负荷的前列腺良性疾病或操作也会引起PSA升高,盲目穿刺常导致过度诊疗。依据患者穿刺活检前的临床指标构建前列腺癌风险预测模型,可以为早筛可疑患者是否进行穿刺活检提供重要参考。目的寻找前列腺穿刺活检阳性的独立危险因素,构建前列腺癌发生的风险预测模型,预测前列腺癌发生风险。方法选取2011年1月—2023年6月于空军军医大学第一附属医院泌尿外科住院并进行前列腺穿刺活检的患者1138例,排除351例临床数据不完整病例后,剩余787例病例通过R语言split函数随机分为训练集(n=548)与验证集(n=239)(划分比例为7∶3)。收集患者的基本信息以及穿刺活检前生化检查指标,依据患者穿刺活检病理结果判断是否发生前列腺癌。应用LASSO回归筛选前列腺癌发生的独立危险因素,对独立危险因素进行多因素Logistic回归分析,利用分析结果构建前列腺癌早期筛查的风险预测模型并绘制列线图。依据训练集与验证集数据对模型进行验证。结果使用LASSO回归分析筛选出6个预测变量,包括年龄、总PSA(tPSA)、碱性磷酸酶、总蛋白、钙、尿素。多因素Logistic回归分析结果显示,年龄≥60岁(OR=3.769,95%CI=2.393~5.937)、tPSA≥10μg/L(OR=2.259,95%CI=1.419~3.596)、碱性磷酸酶≥45 U/L[45~<125 U/L:OR=20.136,95%CI=4.419~91.752;≥125 U/L:OR=45.691,95%CI=9.199~226.951]是前列腺癌的危险因素(P<0.05),总蛋白≥65 g/L(OR=0.086,95%CI=0.031~0.236)、钙≥2.11 mmol/L(OR=0.148,95%CI=0.054~0.403)、尿素≥9.5mmol/L(OR=0.069,95%CI=0.019~0.252)是前列腺癌的保护因素(P<0.05)。依据有统计学差异的6个预测变量绘制列线图,建立预测模型。预测模型预测训练集前列腺癌发生的ROC曲线下面积(AUC)为0.778(95%CI=0.740~0.816),灵敏度为53.2%,特异度为85.5%,验证集前列腺癌发生的AUC为0.770(95%CI=0.708~0.832),灵敏度为61.2%,特异度为80.0%。拟合优度检验显示训练集P=0.543,验证集P=0.372,具有较好的拟合度。决策曲线分析(DCA)显示训练集高风险阈值<10%,验证集的高风险阈值约为15%,在临床实践中有一定的指导意义。结论本研究建立了包含年龄、tPSA、碱性磷酸酶、总蛋白、钙、尿素共6项穿刺前指标的前列腺癌列线图风险预测模型,可用于预测早期筛查可疑患者的前列腺癌发生风险。

关键词：前列腺肿瘤前列腺增生筛查危险因素列线图

Integrated data mining and network pharmacology to discover a novel traditional Chinese medicine prescription against diabetic retinopathy and reveal its mechanism

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TMR Modern Herbal Medicine 2024年第2期7卷 41-55页

作者： Kai-Lun Zhang Xu Wang Xiang-wei Chang Jun-Fei Gu Bo-Yang Zhu Shi-Bing wei Bo Wu Can Peng Jiu-Sheng Nie De-Ling Wu College of Pharmacy Anhui University of Chinese MedicineHefei 230012China School of Traditional Chinese Medicine and School of Integrated Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing 210023China MOE-anhui Joint Collaborative Innovation Center for Quality Improvement of anhui Genuine Chinese Medicinal Materials Anhui University of Chinese MedicineHefei 230012China institute of Pharmaceutics Anhui Academy of Chinese MedicineHefei 230012China anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application Anhui University of Chinese MedicineHefei 230012China Engineering Technology Research Center of Modernized Pharmaceutics Anhui Education Department(AUCM)Hefei 230012China The First clinical medical College Anhui University of Chinese MedicineHefei 230012China

Background:Diabetic retinopathy(DR)is currently the leading cause of blindness in elderly individuals with *** Chinese medicine(TCM)prescriptions have shown remarkable effectiveness for treating *** study aimed to screen a novel TCM prescription against DR from patents and elucidate its medication rule and molecular mechanism using data mining,network pharmacology,molecular docking and molecular dynamics(MD)***:TCM prescriptions for treating DR was collected from patents and a novel TCM prescription was identified using data ***,the mechanism of the novel TCM prescription against DR was explored by constructing a network of core TCMs-core active ingredients-core targets-core ***,molecular docking and MD simulation were employed to validate the findings from network ***:The TCMs of the collected prescriptions primarily possessed bitter and cold properties with heat-clearing and supplementing effects,attributed to the liver,lung and kidney ***,a novel TCM prescription for treating DR was identified,composed of Lycii Fructus,Chrysanthemi Flos,Astragali Radix and Angelicae Sinensis *** core active ingredients and ten core targets of the novel TCM prescription for treating DR were ***,the novel TCM prescription played a crucial role for treating DR by inhibiting inflammatory response,oxidative stress,retinal pigment epithelium cell apoptosis and retinal neovascularization through various pathways,such as the AGE-RAGE signaling pathway in diabetic complications and the MAPK signaling ***,molecular docking and MD simulation demonstrated that almost all core active ingredients exhibited satisfactory binding energies to core ***:This study identified a novel TCM prescription and unveiled its multi-component,multi-target and multi-pathway characteristics for treating *** findings provide a scientific basis and novel insights into

关键词： TCM prescriptions diabetic retinopathy medication rule molecular mechanism data mining network pharmacology molecular docking

Melatonin can prevents morphine and fentanynl induced hyperalgesia in rats

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Melatonin can prevents morphine and fentanynl induced hypera...

Involvement of prostaglandin E receptor EP2 in paeoniflorin-induced human hepatoma cells apoptosis

中国药理学会第十次全国学术会议

作者： Xin wei,Ling Lin,Chun Wang,wei wei (institute of clinical pharmacology,anhui medical university.The Key Laboratory of Antiinflammatory and Immunopharmacology,Ministry of Education,P.R.China,Hefei 230032)

Objective Opioid drugs are widelv used for treating moderate to severe pain,but accumutalting evidence suggests that administration of opioids such as morphine,fentanynl and remifentanyl can leads not only to analgesia, but also to an enhancement in pain sensitivity induced by central *** phenomenon is re- ferred to as opioid induced hyperalgesia(OIH).The present study assessed the effect of melatonin on fentanyl and morphine induced hyperalgesia using a tail-flick *** In the first set of experiments,to induce hyperalgesia, fentanynl was injected four times resulting in a total dose of 60,180,240 ug/kg *** 1 *** with MT in various doses(25,50,100 mg/kg) 30 min before fentanynl and after *** second set experiment, morphine induced tolerance and hyperalgesia were induced in rats by repeated injection of morphine(10 mg/ kg,s.c.) twice daily ***(25,50,100 mg/kg) were used orally in combination with morphine. Results Moderate and high dose(180,240 ug/kg) but not low fentanynl could induce hyperalgesia after drug *** present observations suggest that melatonin(50,100 mg/kg) could prevent fentanynl and morphine induced hyperalgesia and partially reversed morphine *** Melatonin can combined used with opioids to prevent OIH.

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Involvement of prostaglandin E receptor EP2 in paeoniflorin-...

血红蛋白稳定的铂基聚吡咯纳米颗粒及其光热抗肿瘤研究

第十三次全国临床药理学学术大会

作者： Wuyi Sun,Shanshan Hu,Qingtong Wang,Jingyu Chen,Huaxun Wu,wei wei.institute of clinical pharmacology,anhui medical university,Key Laboratory of Anti-inflammatory and Immunopharmacology,Ministry of Education,Hefei,anhui Province,China 230032

Objective:Prostaglandin E(PGE) has been shown to play important roles in several aspects of tumor development and *** mediated its biological activity through binding to the four prostanoid receptors EP through *** present study was designed to investigate the role of EP receptor in the proliferation and apoptosis of human hepatocellular carcinoma cell lines HepG2,SMMC-7721 and the effect of paeoniflorin,a monoterpene glucoside. Methods:After treatment with butaprost,a selective EP receptor agonist,the proliferation of HepG2 and SMMC-7721 cells was determined by methyl thiazolyl tetrazolium(MTT) and the apoptosis of HepG2 and SMMC-7721 cells was measured by flow cytometry with annexin V-fluorescein isothiocyanate(FITC)/propidium iodide(PI) *** expression of Bcl-2 and Bax was detected by Western blotting and *** expression of EP receptor and the cysteine-aspartic acid protease(caspase)-3 was observed by Western blotting. Results:EP receptor agonist butaprost significantly stimulated HepG2 and SMMC-7721 cells proliferation. Paeoniflorin significantly inhibited HepG2 and SMMC-7721 cells proliferation stimulated by butaprost at different time(24h,48h,and 72h).Meanwhile,paeoniflorin induced HepG2 and SMMC-7721 cells to undergo apoptosis,which was demonstrated by annexin-V and PI ***,the results showed that the expression of EP receptor,Bcl-2 was significantly increased,Bax and caspase-3 was decreased in HepG2 and SMMC-7721 cells after stimulated by *** significantly decreased the EP receptor,Bcl-2 expression and increased Bax,caspase-3 levels in HepG2 and SMMC-7721 cells addition with butaprost. Conclusion:Our results suggested PGE receptor subtype EP may play a vital role in the HepG2 and SMMC-7721 cell ***,which may be a promising agent in the treatment of liver cancer,induced apoptosis in HCC cells through downregulating EP,increase Bax-to-Bcl-2 ratio and thus upregula

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药学学报 2024年第6期59卷 1812-1818页

作者：李静曾伟伟李晗玥梅林陈大全烟台大学药学院分子药理和药物评价教育部重点实验室(烟台大学)新型制剂与生物技术药物研究山东省高校协同创新中心山东烟台264005 中国医学科学院、北京协和医学院生物医学工程研究所先进医用材料与医疗器械全国重点实验室天津市生物医学材料重点实验室天津300192

光热治疗是利用近红外激光特异性激活蓄积在病灶部位的光热剂,从而达到热消融癌细胞的一种新型肿瘤治疗手段。然而,光热材料在体内代谢周期长、清除难,这成为阻碍其临床转化的主要障碍之一。本研究利用血红蛋白作为新型稳定剂、六氯铂... 详细信息

光热治疗是利用近红外激光特异性激活蓄积在病灶部位的光热剂,从而达到热消融癌细胞的一种新型肿瘤治疗手段。然而,光热材料在体内代谢周期长、清除难,这成为阻碍其临床转化的主要障碍之一。本研究利用血红蛋白作为新型稳定剂、六氯铂酸作为新型氧化剂、吡咯作为单体,通过氧化聚合一步法,制得血红蛋白稳定的铂基聚吡咯纳米颗粒(Hb@PtP)并对其形貌结构等理化性质进行详细考察。在聚乙二醇修饰后,获得的Hb@PtPP粒径为99.08±8.3 nm,zeta电位为−18.7±1.2 mV,透射电镜显示Hb@PtPP纳米颗粒为不规则球形且分散均匀。在不同功率密度的808 nm激光照射下,Hb@PtPP呈现出功率密度依赖性升温行为,CCK-8和死活染色实验证实其能有效地发挥光热效应杀伤肿瘤细胞。小动物活体成像结果表明Hb@PtPP具有较好的肿瘤靶向和滞留能力,在激光激发下,实现了小鼠肿瘤生长的抑制和消融。研究涉及的所有动物实验均按照中国医学科学院机构动物护理与使用委员会中国医学科学院、北京协和医学院放射医学研究所批准的方案执行[IRM/2-IACUC-2312-005]。

关键词：血红蛋白稳定剂纳米粒聚吡咯光热治疗

Effects of a periodic intermittent theta burst stimulation in Alzheimer's disease

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General Psychiatry 2024年第1期37卷 53-63页

作者： Xingqi Wu Yibing Yan Panpan Hu Lu Wang Yue Wu Pan Wu Zhi Geng Guixian Xiao Shanshan Zhou Gongjun Ji Bensheng Qiu Ling wei Yanghua Tian Hesheng Liu Kai Wang Department of Neurology First ffiliated Hospital of Anhui Medical UniversityHefeiAnhuiChina School of Mental Health and Psychological Sciences Anhui Medical UniversityHefeiAnhuiChina anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhuiChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhuiChina Department of Psychology and Sleep Medicine The Second Affliated Hospital of Anhui Medical UniversityHefeiAnhuiChina Center for Biomedical Imaging University of Science and Technology of ChinaHefeiAnhuiChina institute of Artificial Intlligence Hefei Comprehensive National Science CenterHefeiAnhuiChina Department of Neuroscience Medical University of South CarolinaCharlestonSouth CarolinaUSA

Background Previous studies havedemonstrated that excitatory repetitive transcranial magnetic stimulation(rTMS)can improve the cognitive function of patients with Alzheimer's disease(AD).Intermittent theta burst stimulation(iTBS)is a novel excitatory rTMS protocol for brain activity stimulation with the ability to induce long-term potentiation-like plasticity and represents a promising treatment for ***,the long-term effects of iTBS on cognitive decline and brain structure in patients with AD *** We aimed to explore whether repeating accelerated iTBS every three months could slow down the cognitive decline in patients with *** In this randomised,assessor-blinded,controlled trial,iTBS was administered to the left dorsolateral prefrontal cortex(DLPFC)of 42 patients with AD for 14days every *** included the Montreal Cognitive Assessment(MoCA),a comprehensive neuropsychological battery,and the grey matter volume(GMV)of the *** were evaluated at baseline and after *** longitudinal pipeline of the Computational Anatomy Toolbox for SPM was used to detect significant treatment-related changes over *** The iTBS group maintained MoCA scores relative to the control group(t=3.26,p=0.013)and reduced hippocampal atrophy,which was significantly correlated with global degeneration scale *** baseline Mini-Mental State Examination(MMSE)score,apolipoprotein E genotype and clinical Dementia Rating were indicative of MoCA scores at ***,the GMV of the left(t=0.08,p=0.996)and right(t=0.19,p=0.977)hippocampus were maintained in the active group but significantly declined in the control group(left:t=4.13,p<0.001;right:t=5.31,p<0.001).GMV change in the left(r=0.35,p=0.023)and right(r=0.36,p=0.021)hippocampus across the intervention positively correlated with MoCA changes;left hippocampal GMV change was negatively correlated with global degeneration scale(r=-0.32,p=0.041)*** D

关键词： stimulation Alzheimer maintained