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Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan Cao Younghye Moon Chen Chen Nai-Kui Liu Xiao-Ming Xu wei wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing wu wei wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu wei wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

采用耗能装配节点的榫卯木构架抗震性能有限元分析

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地震工程学报 2025年第1期47卷 10-21页

作者：吴忠铁张轲解宁赵城吴为西北民族大学土木工程学院甘肃兰州730030

针对榫卯木构架常规梁柱榫卯节点的缺陷,提出一种榫卯木构架的梁柱耗能装配节点。为研究该耗能装配节点对木构架抗震性能的影响,利用有限元软件ABAQUS建立带有全钢耗能装配节点、橡胶柔性耗能装配节点、无加固的榫卯式节点三种不同类型... 详细信息

针对榫卯木构架常规梁柱榫卯节点的缺陷,提出一种榫卯木构架的梁柱耗能装配节点。为研究该耗能装配节点对木构架抗震性能的影响,利用有限元软件ABAQUS建立带有全钢耗能装配节点、橡胶柔性耗能装配节点、无加固的榫卯式节点三种不同类型榫卯木构架的有限元模型,并进行单调荷载加载分析和低周反复加载分析,主要研究这三类榫卯木构架模型的破坏特征、滞回曲线、骨架曲线、承载力及耗能能力等力学性能;同时,利用能力谱曲线和需求谱曲线,采用性能点探讨三类木构架的抗震性能。结果表明,与原榫卯木构架相比,该耗能装配节点能够有效地调整和控制木构架的破坏模式,增强梁柱节点的非线性力学性能,显著提高榫卯木构架的整体抗震性能。

关键词：榫卯木构架耗能装配节点力学性能性能点抗震性能

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与同胞同住对青少年学业表现的影响

深圳社会科学 2025年第1期8卷 124-135页

作者：吴炜南京理工大学公共事务学院江苏南京210094

已有的同胞结构与教育获得研究主要关注了由代际资源稀释所致的同胞竞争效应,很少考虑同胞组内的资源生产与传递及其后果,也较少探讨同胞的居住安排这一同胞结构维度对教育获得的影响。基于此,研究以同胞支持为理论视角,使用CEPS基线调... 详细信息

已有的同胞结构与教育获得研究主要关注了由代际资源稀释所致的同胞竞争效应,很少考虑同胞组内的资源生产与传递及其后果,也较少探讨同胞的居住安排这一同胞结构维度对教育获得的影响。基于此,研究以同胞支持为理论视角,使用CEPS基线调查数据,分析了与同胞同住对青少年学业表现的影响,并对其群体差异进行了实证分析。研究发现:在人口大流动的时代背景下,我国青少年与同胞不同住现象已经比较普遍,有同胞的青少年中近三成未与同胞共同居住在一起;固定效应模型的结果显示,与同胞同住能够显著地提升青少年的学业表现;利用替换变量法和匹配方法进行稳健性检验,结果显示与同胞同住对青少年学业表现的影响仍然存在;机制分析表明,文化资本和社会资本是这一影响的中介路径,与那些未能和同胞同住的青少年相比,与同胞同住的青少年拥有更高的家庭文化资本和社会资本,进而提高了他们的学业表现;进一步的调节效应分析表明,与同胞同住对青少年学业表现的影响不存在阶层差异,与优势阶层的青少年相比,劣势阶层的青少年与同胞同住的教育效应并不存在差异。研究表明,同胞之间的居住安排对青少年的教育成就乃至社会流动具有重要作用,这意味着国家可以通过积极的社会政策促进家庭做出整体性迁移的决策,达到促进青少年的教育发展的目标。

关键词：与同胞同住居住安排同胞结构阶层背景学业表现

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基于固相萃取-高效液相色谱-串联质谱测定孕妇尿液中8种邻苯二甲酸酯代谢物及新生儿出生结局评价

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色谱 2025年第1期43卷 60-67页

作者：王梓皓徐梦菲李贝妮吴萍吴微湖北中医药大学检验学院湖北武汉430065

邻苯二甲酸酯(PAEs)是一种环境内分泌干扰物,广泛存在于日常生活中,并可通过多种途径进入机体。孕妇作为一类特殊人群,若暴露于PAEs,将会对子代的生长发育造成不良影响。研究建立了固相萃取-高效液相色谱-串联质谱(SPE-HPLC-MS/MS)同时... 详细信息

邻苯二甲酸酯(PAEs)是一种环境内分泌干扰物,广泛存在于日常生活中,并可通过多种途径进入机体。孕妇作为一类特殊人群,若暴露于PAEs,将会对子代的生长发育造成不良影响。研究建立了固相萃取-高效液相色谱-串联质谱(SPE-HPLC-MS/MS)同时检测孕妇尿液中8种PAEs代谢物(mPAEs)的分析方法。尿液样品经β-葡萄糖苷酶酶解后,采用Bond Elut Plexa固相萃取柱净化,样品经洗脱、浓缩、复溶后,进行HPLC-MS/MS分析。采用Agilent Eclipse Plus C18色谱柱(100 mm×3 mm,3.5μm)进行分离,以0.1%乙酸水溶液和0.1%乙酸乙腈作为流动相进行梯度洗脱,在多反应监测(MRM)模式下检测,内标法定量。结果表明,8种mPAEs在0.1~200 ng/mL范围内线性关系良好,检出限为0.015~0.048 ng/mL,定量限为0.050~0.160 ng/mL。在低、中、高3个加标水平(1、10、50 ng/mL)下,8种mPAEs的加标回收率为80.2%~99.7%。采用此方法对鄂州市妇幼保健院497名孕妇尿液中的8种mPAEs水平进行检测,结果表明,497名孕妇广泛暴露于PAEs,其中邻苯二甲酸单丁酯(MBP)的含量最高,中位数水平为104.46 ng/mL;邻苯二甲酸单苄酯(MBzP)的含量最低,中位数水平为0.22 ng/mL。同时,研究还对新生儿的出生结局进行了评估,线性回归模型表明,孕妇尿液中的邻苯二甲酸单乙酯(MEP)每增加一个自然对数(ln)水平,孕周减少0.11周(95%置信区间(CI):-0.18~-0.03);孕妇尿液中的邻苯二甲酸(2-乙基-5-氧己基)酯(MEOHP)和邻苯二甲酸单(2-乙基己基)酯(MECPP)每增加一个ln水平,新生儿出生体重分别降低39.28 g(95%CI:-76.48~-2.09)和39.62 g(95%CI:-73.73~-5.52)。该方法操作简便,检出限低,具有较高的准确度和精密度,通过此方法测定了孕妇尿液中的8种mPAEs,并结合新生儿的出生结局发现,孕期PAEs暴露会影响新生儿的生长发育。

关键词：高效液相色谱-串联质谱邻苯二甲酸酯代谢物孕妇尿液出生结局

腹部超声在炎症性肠病患儿诊断及治疗后活动性评估中的应用

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中国医学创新 2025年第1期22卷 134-139页

作者：陈捷吴蔚郑巍江西省儿童医院超声科江西南昌330006 江西省儿童医院消化科江西南昌330006 江西省儿童医院影像科江西南昌330006

目的:探究腹部超声在炎症性肠病(IBD)患儿诊断及治疗后活动性评估中的应用价值。方法:选择2021年1月—2023年1月于江西省儿童医院就诊的82例疑似IBD患儿,以结肠镜检查及组织活检结果为金标准,最终77例确诊IBD(纳入IBD组),其中克罗恩病(C... 详细信息

目的:探究腹部超声在炎症性肠病(IBD)患儿诊断及治疗后活动性评估中的应用价值。方法:选择2021年1月—2023年1月于江西省儿童医院就诊的82例疑似IBD患儿,以结肠镜检查及组织活检结果为金标准,最终77例确诊IBD(纳入IBD组),其中克罗恩病(CD)37例(纳入CD组)、溃疡性结肠炎40例(纳入UC组);另选择于本院体检的50例健康儿童纳入健康组。计算腹部超声诊断IBD的敏感度、特异度、准确率;比较IBD组、健康组的肠壁厚度、动脉阻力指数(RI)及血流状态;比较CD组和UC组的超声检查图像指标、病变定位符合率及活动期和缓解期的肠壁厚度、动脉RI及血流状态。结果:腹部超声诊断IBD的敏感度、特异度、准确率分别为92.21%、60.00%、90.24%;IBD组肠壁厚度高于健康组,动脉RI低于健康组,血流分级差于健康组(P<0.05);CD组正常结构消失、肠间淋巴结肿大、肠间积液、炎性包块发生率均高于UC组(P<0.05);CD组超声诊断病变定位符合率为94.59%,UC组超声诊断病变定位符合率为90.00%;活动期、缓解期,CD组肠壁厚度均高于UC组,差异均有统计学意义(P<0.05);活动期,两组肠壁厚度高于缓解期,动脉RI低于缓解期,差异均有统计学意义(P<0.05)。缓解期,两组肠壁血流分级情况优于活动期,差异有统计学意义(P<0.05);活动期、缓解期,两组肠壁血流分级情况比较,差异均有统计学意义(P<0.05)。肠壁厚度、动脉RI诊断CD活动期的AUC分别为0.790、0.741,诊断UC活动期的AUC分别0.668、0.714。结论:腹部超声对IBD具有较高诊断价值,能够相对准确地定位病变位置,减少误诊,且可预判患儿治疗后活动性。

关键词：超声炎症性肠病诊断

Identification method for helicopter flight dynamics modeling with rotor degrees of freedom

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Chinese Journal of Aeronautics 2014年第6期27卷 1363-1372页

作者： wu wei College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics

A comprehensive method based on system identification theory for helicopter flight dynamics modeling with rotor degrees of freedom is developed. A fully parameterized rotor flapping equation for identification purpose is derived without using any theoretical model, so the confidence of the identified model is increased, and then the 6 degrees of freedom rigid body model is extended to 9 degrees of freedom high-order model. Bode sensitivity function is derived to increase the accuracy of frequency spectra calculation which influences the accuracy of model parameter identification. Then a frequency domain identification algorithm is established. Acceleration technique is developed furthermore to increase calculation efficiency, and the total identification time is reduced by more than 50% using this technique. A comprehensive two-step method is established for helicopter high-order flight dynamics model identification which increases the numerical stability of model identification compared with single step algorithm. Application of the developed method to identify the flight dynamics model of BO 105 helicopter based on flight test data is implemented. A comparative study between the high-order model and rigid body model is performed at last. The results show that the developed method can be used for helicopter high-order flight dynamics model identification with high accuracy as well as efficiency, and the advantage of identified high-order model is very obvious compared with low-order model.

关键词： Flight dynamics Frequency domain Helicopters Identification Modeling Rotors

军民融合、产业协同集聚与区域创新绩效———基于交互作用与空间溢出效应的检验

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湖北科技学院学报 2025年第1期45卷 34-42页

作者：赵庆吴伟国务院国资委中国大连高级经理学院辽宁大连116086 大连交通大学机车学院辽宁大连116028

基于空间数据分析方法,分析军民融合、产业协同集聚和区域创新绩效在我国省际间分布格局,结果显示三者均存在显著的空间自相关性即空间溢出效应,并在局部地区形成了不同的集聚区域,存在高低集聚“俱乐部”现象。基于空间计量模型、实证... 详细信息

基于空间数据分析方法,分析军民融合、产业协同集聚和区域创新绩效在我国省际间分布格局,结果显示三者均存在显著的空间自相关性即空间溢出效应,并在局部地区形成了不同的集聚区域,存在高低集聚“俱乐部”现象。基于空间计量模型、实证检验军民融合、产业协同集聚对区域创新绩效的影响,得出主要结论:全国范围军民融合、产业协同集聚均对区域创新绩效具有显著的促进作用,但西部地区军民融合影响的效果最大,而东部地区则产业协同集聚影响的效果最大;同时,在全国范围内二者间具有较强的交互作用,并且在对有限的创新生产要素资源抢占作用下,二者呈现出替代效应,交互作用下对区域创新绩效产生抑制作用,东部、中部地区亦是如此,而在西部地区,二者呈现出互补效应,交互作用下对区域创新绩效产生促进作用;并对影响区域创新绩效的其他因素进行了分析。

关键词：军民融合产业协同集聚区域创新交互作用空间溢出效应