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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li wei-qi Zhang Yu-Ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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Functional sample path properties of subsequence's C-R increments for a Wiener process in Hlder norm

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Applied Mathematics(A Journal of Chinese Universities) 2015年第2期30卷 217-226页

作者： wei qi-cai School of Mathematics & Computer Science Wuhan Polytechnic University

In this paper, with the aid of large deviation formulas established in strong topology of functional space generated by HSlder norm, we discuss the functional sample path properties of subsequence＇s C-R increments for a Wiener process in HSlder norm. The obtained results, generalize the corresponding results of Chen and the classic Strassen＇s law of iterated logarithm for a Wiener process.

关键词： Wiener process subsequence's C-R increments HSlder norm.

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Previous Articles Next Articles Spatial pattern and driving factors of migrants on the qinghai-Tibet Plateau:Insights from short-distance and long-distance population migrants

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Journal of Geographical Sciences 2021年第2期31卷 215-230页

作者： qi wei YI Jiawei Institute of Geographic Sciences and Natural Resources Research CASBeijing 100101China Key Laboratory of Regional Sustainable Development Modeling CASBeijing 100101China State Key Laboratory of Resources and Environmental Information System CASBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

As one of the most ecologically sensitive issues in the world,migration now plays an important role in population growth on the qinghai-Tibet *** promote sustainable development in the world’s third pole,it is necessary to investigate population migration on the *** 2010 census data,a spatial database of county-level migrants on the Plateau was constructed,and migrants were divided into short-distance and long-distance migrants according to the hukou-registered *** migration intensity allowed the spatial pattern of population migration on the Plateau to be *** driving factors were identified using spatial regression models,and the main conclusions are as follows:(1)In 2010,there were 1.23 million inter-county migrants on the qinghai-Tibet Plateau,and the overall migration intensity reached 10.50%.There existed significant spatial differences in population migration intensity on the Plateau at that time,and the provincial or prefectural capitals were attractive destinations for *** qinghai,which boasted mining industries,constituted a significant spatial cluster with a relatively high migration ***,most areas on the Plateau attracted relatively few migrants,especially in western and northern parts of Tibet,which were sparsely populated and uninhabitable.(2)There were 0.95 million short-distance migrants and 0.28 million long-distance *** short-distance migration intensity was 8.14%,while the long-distance migration intensity was only 2.36%.Short-distance migration was the main form of population migration,with a pattern similar to the layout of overall population migration *** a few county-level units strongly attracted long-distance migrants,which were mostly distributed in northwestern qinghai.(3)Economic factors were considered fundamental drivers for migrants to live on the *** with high levels of economic development and more opportunities in non-agric

关键词： migration migrants spatial pattern driving factors qinghai-Tibet Plateau

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Planar core based starburst triphenylamine molecules as hole transporting materials for high-performance perovskite solar cells

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Science China Chemistry 2019年第1期62卷 5-6页

作者： qi wei Zhijun Ning School of Physical Science and Technology Shanghai Tech University

Starburst triphenylamine molecules are generally used as hole transporting materials (HTMs)for optoelectronic devices like solar cells,light emitting diode and field effect transistors .The use of starburst triphenylamine molecules like spiro-OMeTAD HTM initiated the construction of solid state perovskite solar cells (PSCs).Currently,based on triphenylamine HTMs,the highest power conversion efficiency (PCE)of PSCs is up to 22.1%.

关键词： Starburst triphenylamine molecules

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Emerging highly emissive and stable white emitting “phosphores” based on lead-free inorganic halide perovskites

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Science China Chemistry 2019年第3期62卷 287-288页

作者： qi wei Zhijun Ning School of Physical Science and Technology ShanghaiTech University

Single materials generating high-efficiency white light emission are of particular interest for lighting. Recently, metal halide perovskite is emerging as a promising candidate for white light emission materials. However, lead halide perovskites showing broad spectrum light emission generally present low luminescence quantum yield and the emission spectrum deviates from the standard white light color coordinate.

关键词： Single materials generating high-efficiency lighting

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Primary amine coupling on nanocarbon catalysts: Reaction mechanism and kinetics via fluorescence probe analysis

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Green Energy & Environment 2020年第4期5卷 453-460页

作者： Fan Li Xueya Dai wei qi Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

Non-metallic nanocarbon materials catalyzed coupling reactions of primary amines to produce imine is an efficient,green and sustainable synthetic route,which has a wide application prospect in fine chemicals or pharmaceutical *** the present study,we show firstly the relatively high catalytic activity of graphene oxide in the reaction of oxidative coupling of benzylamine(OCB),which is even comparable with typical metal-based catalysts,indicating the great potential of nanocarbon materials in this reaction *** importantly,a novel twophoton fluorescence probe molecule(N-propyl-4-hydrazinyl-1,8-naphthalimide,NA)with special chemical structure of hydrazine functionality was *** probe NA could selectively react with aldehyde or ketone compounds,leading to the photoluminescence enhancement via inhibition of photo induced electron transfer(PET)*** synthesized NA was applied as probe in carbon catalyzed OCB system to predict the existence of reaction intermediate benzaldehyde(BA),indicating the reaction pathway of oxidation-deamination-condensation in nanocarbon catalyzed OCB *** proposed luminescence-probe strategy for revealing the kinetics and mechanism may also shed light in other reaction systems concerning the intermediates or products of ketones or aldehydes.

关键词： Nanocarbon Benzylamine coupling reaction Fluorescence probe Reaction mechanism

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Wavelet-Based Boundary Element Method for Calculating the Band Structures of Two-Dimensional Phononic Crystals

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Acta Mechanica Solida Sinica 2021年第5期34卷 687-705页

作者： qi wei Xingfu Ma Jiawei Xiang College of Mechanical and Electrical Engineering Wenzhou UniversityWenzhou325035China

A wavelet-based boundary element method is employed to calculate the band structures of two-dimensional phononic crystals,which are composed of square or triangular lattices with scatterers of arbitrary cross *** the aid of structural periodicity,the boundary integral equations of both the scatterer and the matrix are discretized in a unit *** make the curve boundary compatible,the second-order scaling functions of the B-spline wavelet on the interval are used to approximate the geometric boundaries,while the boundary variables are interpolated by scaling functions of arbitrary *** any given angular frequency,an effective technique is given to yield matrix values related to the boundary ***,combining the periodic boundary conditions and interface conditions,linear eigenvalue equations related to the Bloch wave vector are *** numerical examples illustrate the superior performance of the proposed method by comparing with the conventional BEM.

关键词： Wavelet-based boundary element method B-spline wavelet on the interval Phononic crystal Band structure

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Two-Machine Hybrid Flow-Shop Problems in Shared Manufacturing

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Computer Modeling in Engineering & Sciences 2022年第5期131卷 1125-1146页

作者： qi wei Yong Wu Ningbo University of Finance&Economics Ningbo315175China

In the“shared manufacturing”environment,based on fairness,shared manufacturing platforms often require manufacturing service enterprises to arrange production according to the principle of“order first,finish first”which leads to a series of scheduling problems with fixed processing *** this paper,two two-machine hybrid flow-shop problems with fixed processing sequences are *** job has two *** first task is flexible,which can be processed on either of the two machines,and the second task must be processed on the second machine after the first task is *** consider two objective functions:to minimize the makespan and tominimize the total weighted completion ***,we show the problem for any one of the two objectives is ordinary NP-hard by polynomial-time Turing ***,using the Continuous ProcessingModule(CPM),we design a dynamic programming algorithm for each case and calculate the time complexity of each ***,numerical experiments are used to analyze the effect of dynamic programming algorithms in practical *** experiments show that these dynamic programming algorithms have comprehensive advantages over the branch and bound algorithm(a classical exact algorithm)and the discrete harmony search algorithm(a high-performance heuristic algorithm).

关键词： Hybrid flow-shop dynamic programming algorithm computational complexity numerical experiments shared manufacturing

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Space-time Relationship Between Urban Municipal District Adjustment and Built-up Area Expansion in China

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Chinese Geographical Science 2017年第2期27卷 165-175页

作者： WANG Kaiyong qi wei Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China Key Laboratory of Regional Sustainable Development Modeling Chinese Academy of SciencesBeijing 100101China

Municipal district adjustment and built-up area expansion are two main forms of urban spatial expansion. Using geometric methods, this study constructed a space-time path method to characterize the space-time relationship between municipal district adjustment and built-up area expansion, and drew the space-time path sets of major prefecture level cities from 2000 to 2010 by constructing a coordinate system of the standardized built-up areas and municipal district areas. This divided them into four quadrants, namely, H-H, L-H, L-L, and H-L, based on the relative mean value to evaluate overall and individual stability by three indexes of the trajectory vectors, namely, direction, length, and slope. Results provide the following conclusions. 1) Municipal district adjustment is an effective spatial expansion way for city-scale promotion in China. Since 2000, municipal district adjustments have been mainly distributed in the eastern coastal regions and mid-western capital cities along with their surrounding cities. 2) Municipal district adjustment affects the scale and status of a city in China. Many cities that have expanded municipal districts behave stably and cross quadrants. 3) Great majority second-tier cities have effectively promoted their scale and status through municipal district adjustment. The municipal district adjustment of medium and small cities in the mid-west area is relatively advanced compared with city development. 4) Municipal district adjustment with minimal magnitude is severely restricted from upgrading the scale and status of a city. The transformation from entirely incorporated counties or cities to municipal districts should be the mainstream in future municipal district adjustment.

关键词： municipal district adjustment built-up area space-time path administration division

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Long-time Asymptotics for the Reverse Space-time Nonlocal Hirota Equation with Decaying Initial Value Problem:without Solitons

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 708-727页

作者： wei-qi PENG Yong CHEN School of Mathematical Sciences East China Normal UniversityShanghai 200241China College of Mathematics and Systems Science Shandong University of Science and TechnologyQingdao 266590China

In this work,we mainly consider the Cauchy problem for the reverse space-time nonlocal Hirota equation with the initial data rapidly decaying in the solitonless *** from the Lax pair,we first construct the basis Riemann-Hilbert problem for the reverse space-time nonlocal Hirota ***,using the approach of Deift-Zhou nonlinear steepest descent,the explicit long-time asymptotics for the reverse space-time nonlocal Hirota is *** the reverse space-time nonlocal Hirota equation,since the symmetries of its scattering matrix are different with the local Hirota equation,the v(λ_(i))(i=0,1)would like to be imaginary,which results in theδ_(λi)^(0)contains an increasing t(±Imv(λ_(i)))/2,and then the asymptotic behavior for nonlocal Hirota equation becomes differently.

关键词： Riemann-Hilbert problem reverse space-time nonlocal Hirota equation long-time asymptotics nonlinear steepest descent method

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