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糖尿病药物与抗骨质疏松药物在糖代谢和骨代谢中相互作用的研究进展

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药物生物技术 2024年第1期31卷 107-110页

作者：倪维欢李峰潍坊医学院临床医学院/潍坊市人民医院山东潍坊261042

糖尿病是一种因糖代谢紊乱导致的系统性疾病,其治疗面临复杂的挑战,糖尿病的治疗药物不仅会改变血糖水平,还会引起骨代谢的变化。一些糖尿病治疗药物,如二甲双胍和GLP-1受体激动剂,通过提高骨密度、降低骨折风险,对骨健康产生积极影响... 详细信息

糖尿病是一种因糖代谢紊乱导致的系统性疾病,其治疗面临复杂的挑战,糖尿病的治疗药物不仅会改变血糖水平,还会引起骨代谢的变化。一些糖尿病治疗药物,如二甲双胍和GLP-1受体激动剂,通过提高骨密度、降低骨折风险,对骨健康产生积极影响。相反,其他糖尿病药物如磺脲类、胰岛素和噻唑烷二酮类可能增加骨折的风险。在选择糖尿病治疗药物时要保持警惕,以防止骨代谢的紊乱,监测和了解糖尿病治疗药物与骨代谢之间的相互作用有助于预防骨质疏松症的发生。同时,抗骨质疏松药物包括抑制骨吸收药物和促进骨合成代谢药物,也会影响糖尿病患者的糖代谢。作为抑制骨吸收药物的双膦酸盐和地诺单抗,具有改善空腹血糖水平的潜力,从而积极调节糖代谢。相反,选择性雌激素受体调节剂可能降低胰岛素敏感性,对糖代谢产生不良影响。总之,通过糖尿病药物和抗骨质疏松药物对骨和糖代谢的影响进行全面综述后,二甲双胍对糖尿病患者的骨代谢是有益的;在新型糖尿病药物中,GLP-1类似物在骨代谢中发挥积极作用,降低骨折的风险;对于已有骨质疏松症的糖尿病患者来说,双磷酸盐类药物是推荐的一线药物;在肾功能受损或严重骨质疏松症的患者中,特立帕肽是更好的选择。这种复杂的关系强调了在管理糖尿病和骨质疏松症时采用细致和个性化的治疗方案的重要性和必要性。

关键词：糖尿病骨质疏松药物治疗葡萄糖代谢骨代谢相互作用

nickel sulfide-based energy storage materials for high-performance electrochemical capacitors

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Rare Metals 2021年第2期40卷 353-373页

作者： Ramyakrishna Pothu Ravi Bolagam Qing-Hong Wang wei ni Jin-Feng Cai Xiao-Xin Peng Yue-Zhan Feng Jian-Min Ma School of Physics and Electronics Hunan UniversityChangsha410082China School of Chemistry and Materials Science Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional MaterialsJiangsu Normal UniversityXuzhou221116China Institute for Advanced Study Chengdu UniversityChengdu610106China Faculty of Technology University of OuluOulu90014Finland Yiyang Wanjingyuan Electronics Co. Ltd.Yiyang413000China Key Laboratory of Materials Processing and Mold(Zhengzhou University) Ministry of EducationZhengzhou UniversityZhengzhou450002China

Supercapacitors are favorable energy storage devices in the field of emerging energy technologies with high power density,excellent cycle stability and environmental benignity.The performance of supercapacitors is definitively influenced by the electrode materials.nickel sulfides have attracted extensive interest in recent years due to their specific merits for supercapacitor application.However,the distribution of electrochemically active sites critically limits their electrochemical performance.Notable improvements have been achieved through various strategies such as building synergetic structures with conductive substrates,enhancing the active sites by nanocrystallization and constructing nanohybrid architecture with other electrode materials.This article overviews the progress in the reasonable design and preparation of nickel sulfides and their composite electrodes combined with various bifunctional electric double-layer capacitor(EDLC)-based substances(e.g.,graphene,hollow carbon)and pseudocapacitive materials(e.g.,transition-metal oxides,sulfides,nitrides).Moreover,the corresponding electrochemical performances,reaction mechanisms,emerging challenges and future perspectives are briefly discussed and summarized.

关键词： Supercapacitors nickel sulfides Hybrid structures Energy storage materials Pseudocapacitance

Recognition of moyamoya disease and its hemorrhagic risk using deep learning algorithms:sourced from retrospective studies

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Neural Regeneration Research 2021年第5期16卷 830-835页

作者： Yu Lei Xin Zhang wei ni Heng Yang Jia-Bin Su Bin Xu Liang Chen Jin-Hua Yu Yu-Xiang Gu Ying Mao Department of Neurosurgery Huashan HospitalFudan UniversityShanghaiChina Department of Electronic Engineering Fudan UniversityShanghaiChina

Although intracranial hemorrhage in moyamoya disease can occur repeatedly,predicting the disease is difficult.Deep learning algorithms developed in recent years provide a new angle for identifying hidden risk factors,evaluating the weight of different factors,and quantitatively evaluating the risk of intracranial hemorrhage in moyamoya disease.To investigate whether convolutional neural network algorithms can be used to recognize moyamoya disease and predict hemorrhagic episodes,we retrospectively selected 460 adult unilateral hemispheres with moyamoya vasculopathy as positive samples for diagnosis modeling,including 418 hemispheres with moyamoya disease and 42 hemispheres with moyamoya syndromes.Another 500 hemispheres with normal vessel appearance were selected as negative samples.We used deep residual neural network(ResNet-152)algorithms to extract features from raw data obtained from digital subtraction angiography of the internal carotid artery,then trained and validated the model.The accuracy,sensitivity,and specificity of the model in identifying unilateral moyamoya vasculopathy were 97.64±0.87%,96.55±3.44%,and 98.29±0.98%,respectively.The area under the receiver operating characteristic curve was 0.990.We used a combined multi-view conventional neural network algorithm to integrate age,sex,and hemorrhagic factors with features of the digital subtraction angiography.The accuracy of the model in predicting unilateral hemorrhagic risk was 90.69±1.58%and the sensitivity and specificity were 94.12±2.75%and 89.86±3.64%,respectively.The deep learning algorithms we proposed were valuable and might assist in the automatic diagnosis of moyamoya disease and timely recognition of the risk for re-hemorrhage.This study was approved by the Institutional Review Board of Huashan Hospital,Fudan University,China(approved No.2014-278)on January 12,2015.

关键词： brain central nervous system deep learning diagnosis hemorrhage machine learning moyamoya disease moyamoya syndrome prediction rebleeding

Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination among COVID-19 convalescents

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Frontiers of Medicine 2023年第4期17卷 747-757页

作者： Hao Wang Yu Yuan Bihao Wu Mingzhong Xiao Zhen Wang Tingyue Diao Rui Zeng Li Chen Yanshou Lei Pinpin Long Yi Guo Xuefeng Lai Yuying Wen Wenhui Li Hao Cai Lulu Song wei ni Youyun Zhao Kani Ouyang Jingzhi Wang Qi Wang Li Liu Chaolong Wang An Pan Xiaodong Li Rui Gong Tangchun Wu Ministry of Education and State Key Laboratory of Environmental Health(Incubating) School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Affiliated Hospital of Hubei University of Chinese Medicine Wuhan 430061China Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan 430061China

Emerging SARS-CoV-2 variants have made COVID-19 convalescents susceptible to re-infection and have raised concern about the efficacy of inactivated vaccination in neutralization against emerging variants and antigen-specific B cell response.To this end,a study on a long-term cohort of 208 participants who have recovered from COVID-19 was conducted,and the participants were followed up at 3.3(Visit 1),9.2(Visit 2),and 18.5(Visit 3)months after SARS-CoV-2 infection.They were classified into three groups(no-vaccination(n=54),one-dose(n=62),and two-dose(n=92)groups)on the basis of the administration of inactivated vaccination.The neutralizing antibody(NAb)titers against the wild-type virus continued to decrease in the no-vaccination group,but they rose significantly in the one-dose and two-dose groups,with the highest NAb titers being observed in the two-dose group at Visit 3.The NAb titers against the Delta variant for the no-vaccination,one-dose,and two-dose groups decreased by 3.3,1.9,and 2.3 folds relative to the wild-type virus,respectively,and those against the Omicron variant decreased by 7.0,4.0,and 3.8 folds,respectively.Similarly,the responses of SARS-CoV-2 RBD-specific B cells and memory B cells were boosted by the second vaccine dose.Results showed that the convalescents benefited from the administration of the inactivated vaccine(one or two doses),which enhanced neutralization against highly mutated SARS-CoV-2 variants and memory B cell responses.Two doses of inactivated vaccine among COVID-19 convalescents are therefore recommended for the prevention of the COVID-19 pandemic,and vaccination guidelines and policies need to be updated.

关键词： COVID-19 convalescent SARS-CoV-2 inactivated vaccination neutralizing antibody B cell response

Ypsiyunnosides A-E,Five New Cholestanol Glycosides from Ypsilandra yunnanensis

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Natural Products and Bioprospecting 2016年第3期6卷 173-182页

作者： Yu Chen Yong-Ai Si wei ni Huan Yan Xu-Jie Qin Chang-Xiang Chen Hai-Yang Liu State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100039China

Phytochemicalinvestigation onthe whole plants of Ypsilandra yunnanensiswas carried out forthe firsttime andledtothe isolation of five new cholestanol glycosides,ypsiyunnosides A–E(1–5),and one known analogue.Their structures were determined mainly by detailed spectroscopic analysis,including extensive 1D and 2D NMR,MS and UV,as well as chemical methods.Among them,compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon,which was identified as(23R,25R)-3β,16α,26-triol-16,23-cyclocholest-5,17(20)-dien-22-one.Their induced platelet aggregation activities and cytotoxicities were evaluated.Graphical Abstract Five new cholestanol glycosides,ypsiyunnosides A–E(1–5),were isolated from the whole plants of Ypsilandra yunnanensis.Compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon.Their structures were elucidated by a combination of 1D and 2D NMR,MS and chemical analysis.

关键词： Ypsilandra yunnanensis Liliaceae Cholestane glycoside Ypsiyunnosides A-E

Transformation of nanoscale inclusions in 316L stainless steel processed by laser beam powder bed fusion during isothermal heating

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Journal of Iron and Steel Research(International) 2023年第4期30卷 795-807页

作者： Cheng-song Liu wei Liu Hua Zhang Hong-wei ni The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan 430081HubeiChina

Transformation mechanisms and reaction kinetics for formation of nanoscale inclusions in as-built 316L stainless steel produced by laser beam powder bed fusion(LB-PBF)during subsequent isothermal heating process were investigated and clarified experimentally and theoretically.The resulting changes in morphologies,size distributions,number densities,and chemical compositions of the inclusions were measured and discussed,along with microstructure and texture of the steel.The results showed that with increasing isothermal heating time and temperature,the columnar grains in the as-built LB-PBF 316L stainless steel transformed into equiaxed grains,which grew gradually and exhibited a large number of twins in the FCC structure.During isothermal heating,the reaction of Si in the steel with MnO–Cr_(2)O_(3)in the nanoscale inclusion resulted in a transformation from the homogeneous oxide MnO–SiO_(2)–Cr_(2)O_(3)to an inclusion with an obvious core–shell structure,and the core part was eventually rich in Si and the shell part was predominantly rich in Mn and Si,depending on the heating temperature and time.An Ostwald ripening model used for predicting the growth of nanoscale inclusions during isothermal heating verified that the observed effects of isothermal heating time and temperature were predicted for Si diffusion control.

关键词： 316L stainless steel Laser beam powder bed fusion Nanoscale inclusion Isothermal heating Transformation

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从叶天士辛润通络法论治强直性脊柱炎

风湿病与关节炎 2024年第5期13卷 43-47页

作者：侯珺婷韦尼北京中医药大学东方医院北京100078

强直性脊柱炎属中医学“大偻”范畴,病因病机复杂,符合“久病入络”“久痛入络”的络病发展规律,因而可从络论治。辛润通络法为叶天士首创,是络病的治疗大法。目前,辛润通络法已经广泛运用于强直性脊柱炎的治疗中,主要通过辛味药与质润... 详细信息

强直性脊柱炎属中医学“大偻”范畴,病因病机复杂,符合“久病入络”“久痛入络”的络病发展规律,因而可从络论治。辛润通络法为叶天士首创,是络病的治疗大法。目前,辛润通络法已经广泛运用于强直性脊柱炎的治疗中,主要通过辛味药与质润之品的合理配伍形成了辛润通补通络、辛润祛邪通络、辛润行津通络、辛润化瘀通络等方法,丰富了强直性脊柱炎的辨证论治方法。但需要注意的是,辛润通络法治疗强直性脊柱炎也具有一定的局限性,如辛味药是辛润通络法中起主要治疗作用的药物,其多属温热之性,更适用于辨证属寒湿偏盛的强直性脊柱炎患者,而对于以湿热为主要证型的强直性脊柱炎患者则不适用,临证中需多加注意。

关键词：强直性脊柱炎大偻辛润通络法叶天士辛味药