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circT P63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway

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Science China Life Sciences 2025年

作者： Dan Wang Sicheng Zuo Junshang Ge Hongke Qu Jie Wu Na Yi Lei Shi Yumin Wang Yongzhen Mo Chunmei Fan Yi He Pan Chen ming Zhou Bo Xiang wei Xiong Wenjia Guo Zhaoyang Zeng Can Guo NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research Institute and School of Basic Medicine Sciences Central South University Furong Laboratory Cancer Research Institute Affiliated Cancer Hospital of Xinjiang Medical University Xinjiang Key Laboratory of Translational Biomedical Engineering

Circular RNAs(circRNAs) play pivotal roles in the development and progression of various diseases, including malignant tumors. However,the biological functions and the underlying mechanisms of many circRNAs remain elusive. In this study, we identified a novel circRNA,circTP63-N, generated through the splicing of exons 2–4 of the TP63 gene in nasopharyngeal carcinoma(NPC). circTP63-N was found to be downregulated in clinical samples of NPC. Both in vitro and in vivo experiments unequivocally demonstrated that circTP63-N inhibits the proliferation and metastasis of NPC cells. Further investigations revealed that circTP63-N interacted with the HSP90AB1 protein, leading to the recruitment of LATS/YAP1 proteins. This, in turn, induced phosphorylation and ubiquitination-dependent degradation of YAP1, resulting in reduced nuclear translocation of YAP1 and inhibition of the transcriptional activation of downstream oncogenic genes, including INHBA, MMP3, and CCNE2. Our findings highlight the identification of circTP63-N, a novel circRNA encoded by an important tumor-relevant gene TP63 and elucidate its molecular mechanism as a tumor suppressor in NPC. These insights offer novel potential molecular markers and therapeutic targets for the clinical diagnosis and treatment of NPC.

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EDA: an enhanced dual-active algorithm for location privacy preservation in mobile P2P networks

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第5期14卷 356-373页

作者： Yan-zhe CHE Kevin chiew Xiao-yan HONG Qiang YANG Qin-ming HE College of Computer Science and Technology Zhejiang University School of Engineering Tan Tao University Department of Computer Science University of Alabama College of Electrical Engineering Zhejiang University

Various solutions have been proposed to enable mobile users to access location-based services while preserving their location privacy. Some of these solutions are based on a centralized architecture with the participation of a trustworthy third party, whereas some other approaches are based on a mobile peer-to-peer (P2P) architecture. The former approaches suffer from the scalability problem when networks grow large, while the latter have to endure either low anonymization success rates or high communication overheads. To address these issues, this paper deals with an enhanced dual-active spatial cloaking algorithm (EDA) for preserving location privacy in mobile P2P networks. The proposed EDA allows mobile users to collect and actively disseminate their location information to other users. Moreover, to deal with the challenging characteristics of mobile P2P networks, e.g., constrained network resources and user mobility, EDA enables users (1) to perform a negotiation process to minimize the number of duplicate locations to be shared so as to significantly reduce the communication overhead among users, (2) to predict user locations based on the latest available information so as to eliminate the inaccuracy problem introduced by using some out-of-date locations, and (3) to use a latest-record-highest-priority (LRHP) strategy to reduce the probability of broadcasting fewer useful locations. Extensive simulations are conducted for a range of P2P network scenarios to evaluate the performance of EDA in comparison with the existing solutions. Experimental results demonstrate that the proposed EDA can improve the performance in terms of anonymity and service time with minimized communication overhead.

关键词： Location-based service Privacy preservation Spatial cloaking Mobile peer-to-peer networks

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不同来流条件下急弯段环流结构演化过程研究

乡村振兴背景下大学生返乡创业政策评估与优化策略

工程力学 2025年第1期42卷 259-272页

作者：胡呈维余明辉渠庚长江科学院河流研究所武汉430010 长江科学院水利部长江中下游河湖治理与防洪重点实验室武汉430010 武汉大学水资源与水电工程科学国家重点实验室武汉430072

弯道环流是弯道水流运动的典型特征之一，一直以来都是众多学者关注的重点。弯道环流主要分为两类：第一类由水流经过弯道时受到的径向压差力差而引起，流速较大;第二类主要由紊流各向异性引起，尽管流速很小，但其与弯道岸坡冲刷过程... 详细信息

弯道环流是弯道水流运动的典型特征之一，一直以来都是众多学者关注的重点。弯道环流主要分为两类：第一类由水流经过弯道时受到的径向压差力差而引起，流速较大;第二类主要由紊流各向异性引起，尽管流速很小，但其与弯道岸坡冲刷过程密切相关。然而当前成果较少关注第二类弯道环流发展演化过程。因此，该文采用弯道水槽试验与数值模拟方法得到的高精度三维流速数据，研究弯道环流结构的变化规律及其动力特性，特别是第二类弯道环流的发展变化。研究结果表明：对于高雷诺数的急弯水流，由于紊动各向异性特征明显，弯道水流常会出现多个环流;对于纵向流速，当水流流经弯顶断面后，纵向流速沿垂向的分布已经明显偏离对数流速分布;当水流经过弯顶断面后，纵向流速沿着垂线存在着显著的均匀化趋势;当弗劳德数较大时，大尺寸涡体在不断分解中，使得原来的各向异性影响越来越小，凹岸附近的小尺寸环流趋近于各向同性状态，造成凹岸小环流逐渐微弱并最后消失;急弯段中环流与纵向水流互馈作用十分显著，弯道环流将对断面内的动量进行重分配，携带某些高速流体到断面内的其他区域，因此，在出现弯道环流的区域其纵向流速也一般比较小。

关键词：弯曲型河流急弯河段弯道环流水槽试验数值模拟

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黑龙江高教研究 2025年第2期43卷 155-160页

作者：杨伟明栗麟李鑫深圳信息职业技术学院广东深圳518115 河南农业大学河南郑州450000 重庆工商大学重庆400067

大学生返乡创业是推进乡村振兴战略、缓解大学生就业压力的重要途径。基于大学生返乡创业政策文本,通过构建政策工具、发展阶段、利益相关主体的三维框架进行政策评估。研究发现,大学生返乡创业已经吸引了政府的持续关注和高度重视,环... 详细信息

大学生返乡创业是推进乡村振兴战略、缓解大学生就业压力的重要途径。基于大学生返乡创业政策文本,通过构建政策工具、发展阶段、利益相关主体的三维框架进行政策评估。研究发现,大学生返乡创业已经吸引了政府的持续关注和高度重视,环境型和供给型政策工具使用过度,而需求型政策工具使用不足;政策措施主要关注初创阶段和成长阶段,较少涉及成熟阶段;政策注意力主要集中在返乡创业者、返乡创业企业等核心利益主体上,较少关注金融机构、高校等次要利益主体。基于此,建议深度优化政策工具整体结构,增加需求型政策供给;强化政策措施与返乡创业生命周期匹配度,加大成熟期政策支持力度;协调兼顾各个参与主体的利益,推动金融机构、高校等利益相关主体为大学生返乡创业提供支持。

关键词：乡村振兴大学生返乡创业政策文本分析

Characterization of horseshoe vortex in a developing scour hole at a cylindrical bridge pier

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International Journal of Sediment Research 2019年第2期34卷 118-124页

作者： Dawei Guan Yee-Meng chiew Maoxing wei Shih-Chun Hsieh College of Harbour Coastal and Offshore EngineeringHohai University School of Civil and Environmental Engineering Nanyang Technological University

Since local scour at bridge piers in rivers and estuaries is a major cause of bridge failure,estimation of the maximum local scour depth is of great importance to hydraulic and coastal *** numerous studies that focus on scour-depth prediction have been done and published,understanding of the flow and turbulence characteristics of the horseshoe vortex that drives the scour mechanism in a developing scour hole still is *** study aims to quantify the detailed turbulent flow field in a developing clear-water scour hole at a circular pier using Particle Image Velocimetry(PIV).The distributions of velocity fields,turbulence intensities,and Reynolds shear stresses of the horseshoe vortex that form in front of the pier at different scour stages(t = 0,0.5,1,12,24,and 48 h)are presented in this *** scour development,the horseshoe vortex system was found to evolve from one initially small vortex to three *** strength and size of the main vortex are found to increase with increasing scour *** regions of both the maximum turbulence intensity and Reynolds shear stress are found to form at a location upstream of the main vortex,where the large turbulent eddies have the highest possibility of *** from this study not only provide new insight into the complex flow-sediment interaction at bridge piers,but also provide valuable experimental databases for advanced numerical simulations.

关键词： Sediment transport Scour Bridge pier PIV Horseshoe vortex Turbulence Scour hole

Pitch control strategy before the rated power for variable speed wind turbines at high altitudes

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Journal of Hydrodynamics 2019年第2期31卷 379-388页

作者： ming-wei Ge wei-ming Ke Hong-xia Chen School of Renewable Energy North China Electric Power UniversityBeijingl 02206China School of Energy Power and Mechanical Engineering North China Electric Power UniversityBeijing 102206China

The wind turbines in the world's highest wind farm with an altitude of over 4 000 m in Naqu county of China were put into operation in *** with the wind turbines at lower altitudes,the rated wind speed of these wind turbines are much larger,and the corresponding tip-speed ratio at the rated power reduces significantly due to the lower air ***,the power coefficient at the point of the rated power is decreased to a rather low *** improve the performance of the wind turbines at very high altitudes,this paper proposes a new pitch control strategy for variable speed wind turbines at the constant-speed phase,especially at the rated-speed phase before the rated power is *** is shown that the new pitch control strategy works very well for the wind farms at very high altitude and with low air density,with the catch of the wind energy enhaneed and the aerodynamic loads significantly reduced.

关键词： Wind turbine pitch control strategy high altitudes

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微纤维对建筑地聚物砂浆的物理特性影响研究

合成纤维 2025年第1期54卷 82-85页

作者：卢惟铭厦门市湖里区建设服务中心福建厦门361000

在地聚物砂浆中加入不同质量分数(1%、2%、3%)的微纤维,并对地聚物砂浆的物理性能进行系统地试验分析。研究结果表明,微纤维的添加显著提升了砂浆的抗裂性和力学强度。进一步的微观结构分析揭示,微纤维在砂浆中形成的网络结构有效地连... 详细信息

在地聚物砂浆中加入不同质量分数(1%、2%、3%)的微纤维,并对地聚物砂浆的物理性能进行系统地试验分析。研究结果表明,微纤维的添加显著提升了砂浆的抗裂性和力学强度。进一步的微观结构分析揭示,微纤维在砂浆中形成的网络结构有效地连接了材料内部的微裂纹,从而抑制了收缩并增强了整体稳定性。此外,考虑到建筑材料的经济性,还讨论了微纤维添加对成本效益的影响,为预算有限的建筑项目提供了实用的参考。

关键词：微纤维地聚物砂浆物理性能抗裂性成本效益

Unknown Input Observer Design of Switched Systems Based on Iterative Learning

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Journal of Systems Science & Complexity 2019年第3期32卷 875-887页

作者： CAO wei SUN ming College of Computer and Control Engineering Qiqihar University

For a class of discrete switched systems with unknown input, an unknown input observer design method is proposed under the premise of changes along time axis but no changes along iteration axis. This method applies the iterative learning control thought to the design of unknown input observer, construets the unknown input observer by introducing virtual input signal, and uses the error signal generated from the actual system output and the observer output to correct repetitively the virtual input, which gradually approxima tes the actual unknown input as the it erations increase. Moreover, the convergence of the observer is strictly proved based on contraction mapping theory, as well as the convergence condition is given. The theoretical analysis indicates that designed unknown input observer can accurately estimate the state and unknown input of the system simultaneously. Simulation example further verifies the effectiveness of the proposed algorithm.

关键词： Iterative learning control switched system unknown input observer virtual input

Iterative learning based fault diagnosis for discrete linear uncertain systems

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Journal of Systems Engineering and Electronics 2014年第3期25卷 496-501页

作者： wei Cao ming Sun College of Computer and Control Engineering Qiqihar University

In order to detect and estimate faults in discrete lin-ear time-varying uncertain systems, the discrete iterative learning strategy is applied in fault diagnosis, and a novel fault detection and estimation algorithm is proposed. And the threshold limited technology is adopted in the proposed algorithm. Within the chosen optimal time region, residual signals are used in the proposed algorithm to correct the introduced virtual faults with iterative learning rules, making the virtual faults close to these occurred in practical systems. And the same method is repeated in the rest optimal time regions, thereby reaching the aim of fault diagnosis. The proposed algorithm not only completes fault detection and estimation for discrete linear time-varying uncertain systems, but also improves the reliability of fault detection and decreases the false alarm rate. The final simulation results verify the validity of the proposed algorithm.

关键词： discrete linear uncertain system threshold limited technology iterative learning fault estimation.