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Low Selenium and Low Protein Exacerbate Myocardial Damage in Keshan Disease by Affecting the PINK1/Parkin-mediated Mitochondrial Autophagy Pathway

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Current Medical Science 2024年第1期44卷 93-101页

作者： li-wei zhang Hong-qi FENG Song-bo FU Dian-jun SUN Center for Endemic Disease Control Chinese Center for Disease Control and PreventionHarbin Medical UniversityNHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University)Key Lab of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceHarbin 150086China

Objective Keshan disease(KD)is a myocardial mitochondrial disease closely related to insufficient selenium(Se)and protein *** induced putative kinase 1(PINK1)/Parkin mediated mitochondrial autophagy regulates various physiological and pathological processes in the *** study aimed to elucidate the relationship between PINK1/Parkin-regulated mitochondrial autophagy and KD-related myocardial *** A low Se and low protein animal model was *** hundred Wistar rats were randomly divided into 5 groups(control group,low Se group,low protein group,low Se+low protein group,and corn from KD area group).The JC-1 method was used to detect the mitochondrial membrane potential(MMP).EliSA was used to detect serum creatine kinase MB(CK-MB),cardiac troponin I(cTnI),and mitochondrial-glutamicoxalacetic transaminase(M-GOT)***-PCR and Western blot analysis were used to detect the expression of PINK1,Parkin,sequestome 1(P62),and microtubule-associated proteins1A/1B light chain 3B(MAP1LC3B).Results The MMP was significantly decreased and the activity of CK-MB,cTnI,and M-GOT significantly increased in each experimental group(low Se group,low protein group,low Se+low protein group and corn from KD area group)compared with the control group(P<0.05 for all).The mRNA and protein expression levels of PINK1,Parkin and MAP1LC3B were profoundly increased,and those of P62 markedly decreased in the experimental groups compared with the control group(P<0.05 for all).Conclusion Low Se and low protein levels exacerbate myocardial damage in KD by affecting the PINK1/Parkin-mediated mitochondrial autophagy pathway.

关键词： Keshan disease low selenium and low protein myocardial mitochondrial injury PTEN induced putative kinase 1(PINK1)/Parkin mitochondrial autophagy

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Digital generation of super-Gaussian perfect vortex beams via wavefront shaping with globally adaptive feedback

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High Power Laser Science and Engineering 2024年第1期12卷 42-51页

作者： Rui Ma Ke Hai Luo Jing Song He wei li zhang Dian Yuan Fan Anderson S.L.Gomes Jun liu International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhenChina Institute for Advanced Study Shenzhen UniversityShenzhenChina Fiber Optics Research Centre School of Information and Communication EngineeringUniversity of Electronic Science and Technology of ChinaChengduChina Departamento de Física Universidade Federal de PernambucoRecife-PEBrazil

High-intensity vortex beams with tunable topological charges and low coherence are highly demanded in applications such as inertial confinement fusion(ICF) and optical communication. However, traditional optical vortices featuring nonuniform intensity distributions are dramatically restricted in application scenarios that require a high-intensity vortex beam owing to their ineffective amplification resulting from the intensity-dependent nonlinear effect. Here, a low-coherence perfect vortex beam(PVB) with a topological charge as high as 140 is realized based on the super-pixel wavefront-shaping technique. More importantly, a globally adaptive feedback algorithm(GAFA) is proposed to efficiently suppress the original intensity fluctuation and achieve a flat-top PVB with dramatically reduced beam speckle contrast. The GAFA-based flat-top PVB generation method can pave the way for high-intensity vortex beam generation,which is crucial for potential applications in ICF, laser processing, optical communication and optical trapping.

关键词： digital micromirror device flat-top beam orbital angular momentum perfect vortex beam random fiber laser

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Application of alginate in inflammatory bowel disease

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Biomedical Engineering Communications 2024年第2期3卷 10-16页

作者： Rui-Xue Kang Ying Zhuang Ming-Jie liu Qi Han wei-li zhang wei-Yu Fan Xue Gao Jia-Zheng Zhou Jian-Bin zhang Collage of Pharmacy Dalian Medical UniversityDalian 116044China Laboratory Animal Center Dalian Medical UniversityDalian 116044China

Inflammatory bowel disease(IBD)represents a chronic inflammatory condition profoundly impacting the gastrointestinal *** prevalence has markedly risen in both developed and developing nations over recent *** the absence of definitive etiological elucidation,therapeutic strategies predominantly revolve around pharmacological interventions aimed at symptom ***(AG)is a polysaccharide of marine origin that has garnered significant attention due to its inherent biocompatibility,pH sensitivity,and *** exploration within drug delivery systems for IBD treatment stems from its natural sourcing,non-cytotoxic nature,and economic ***,AG demonstrates facile interpolymeric cross-linking,facilitating the formation of a cohesive network conducive to sustained drug release ***-based carrier systems for sustained drug release,and targeted drug delivery have been widely *** article reviews the pathogenesis of IBD and the current drugs,AG-based drug delivery systems and their properties in alleviating *** prospect of further development of AG in the field of biopharmaceutical and drug delivery is prospected.

关键词： alginate inflammatory bowel disease drug delivery

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2D Co metal-organic framework nanosheet as an oxidase-like nanozyme for sensitive biomolecule monitoring

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Rare Metals 2023年第3期42卷 797-805页

作者： Jia-wei Guo Zhong-wei Yang Xiu-li liu li-wei zhang wei-Bo Guo Jian zhang Long-Hua Ding Institute for Advanced Interdisciplinary Research School of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China School of Chemistry and Chemical Engineering Linyi UniversityLinyi276005China Department of Biology and Biological Engineering Chalmers University of Technology41296 GoteborgSweden

Nanozyme-based biomolecules sensitive and quantitative detection is an attractive strategy due to their high chemical,thermal stability and reactive ***,we have synthesized a significant number of two-dimensional(2D)cobalt-metal-organic framework(Co-MOF)nanosheets with oxidase(OXD)-like activity using a facile solvothermal method in one pot for biomolecule monitoring.

关键词： attractive cobalt facile

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Surface amorphization oxygen vacancy-rich porous Sn_(3)O_(x)nanosheets for boosted photoelectrocatalytic bacterial inactivation

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Rare Metals 2023年第5期42卷 1508-1515页

作者： Long-wei Wang lin liu Zhen You li-wei zhang Xiao-Di zhang Na Ren Hong liu Xin Yu Institute for Advanced Interdisciplinary Research(iAIR) School of Chemistry and Chemical EngineeringUniversity of JinanJinan250022China Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of Education School of MedicineNorthwest UniversityXi’an710069China Institute for Cell Engineering Department of NeurologyJohns Hopkins University School of MedicineBaltimoreMD21205USA State Key Laboratory of Crystal Material Shandong UniversityJinan250100China

Antibiotic misuse has resulted in the emergence of superbugs,warranting new antibacterial *** amorphisation oxygen vacancy-rich porous Sn_(3)O_(x)nanosheets in situ grown on Ni foam are successfully designed via a simple,one-step hydrothermal method,resulting in enhanced photoelectrochemical(PEC)bacterial *** this system,the porous structure enriches its surface with oxygen vacancies,which can extend the absorption spectrum into the near-infrared region,while oxygen vacancies can enhance the separation of electronhole *** importantly,the sheet-like porous structure enhances surface active sites and increase the contact area between bacteria and ***,the reactive oxygen species produced during the PEC process can directly act on the surface of bacteria and is100%effectively against drug-resistant Gram-positive and Gram-negative bacteria in water within 30 *** study acts as a foundation for the development of novel photoelectrocatalyst electrodes for efficient water purification.

关键词： Oxygen vacancy Photoelectrocatalysis Water purification Sn_(3)O_(x) Bacterial killing

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Humic acid-mediated transport of a typical soil passivation remediation product(chloropyromorphite)in saturated porous media

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Journal of Environmental Sciences 2024年第7期141卷 51-62页

作者： Xinying li Mengjia zhang Siyuan li wei wei School of Environment Jiangsu Engineering Lab of Water and Soil Eco-remediationJiangsu Province Engineering Research Center of Environmental Risk Prevention and Emergency Response TechnologyNanjing Normal UniversityNanjing 210023China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing 210023China

Conversion of labile Pb species into chloropyromorphite(CPY)using phosphorus-bearing amendments was considered to be an ideal strategy in soil passivation ***,the fate and transport of CPY in the soil are poorly *** study aims to fill the knowledge gap by evaluating the fate and transport of CPY under environmentally relevant conditions of humic acid(HA),pH,electrolyte concentration,and species through the saturated sandy *** showed that bare CPY colloids are basically immobile in sandy porous media while the co-existence of HA made the transport of CPY improved by30%-93.5%.Facilitated transport of CPY was attributed to the increased stability of CPY and the repulsive interaction between CPY particles and sands due to HA *** mobility of CPY was also increased with increasing pH from 5.0 to *** the pH was 9 with a10 mmol/L NaCl background solution,the stronger energy barrier between CPY and sand led to enhanced transport *** divalent Ca^(2+)had a more dramatic effect than monovalent Na^(+)on the aggregation and sedimentation of CPY colloids due to its effectivescreening of the surface charge of CPY and bridging interaction with CPY ***-LandauVerwey-Overbeek theory and attachment efficiency calculation indicated that high energy barriers were responsible for the high mobility of CPY colloids,while the retention of CPY in sands was mainly caused by secondary energy minimum and physically *** findings of this work can help to evaluate the fate of soil passivation remediation products in natural water and soil.

关键词： Chloropyromorphite DLVO theory Stability Saturated porous medium Transport

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Coupled simulation of fluid-particle interaction for large complex granules:A resolved CFD-DEM method for modelling the airflow in a vertical fixed bed of irregular sinter particles

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Particuology 2024年第7期90卷 292-306页

作者： Chengzhi li Yu zhang Jiahe Shen wei zhang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China School of Transportation and Logistics Engineering Wuhan University of TechnologyWuhan 430063China Centre for Bulk Solids and Particulate Technologies The University of NewcastleCallaghan NSW 2308Australia

A resolved CFD-DEM method is proposed to simulate the fluid-particle interaction for large complex *** airflow in a vertical sinter fixed bed is numerically studied using this *** multi-sphere clumped method is used to create irregular sinter particles in *** immersed boundary method and dynamic cell refinement are applied to describe the fluid flow around particles with higher resolution,by which the fluid-particle interaction can be simulated more *** simulation results presented the packing voidage distributions and the airflow fields in the sinter beds of different single and mixed particle size *** bed pressure drops were simulated and the results were compared with the corresponding experimental *** good agreement indicated that the proposed resolved CFD-DEM method is an effective tool to model the fluid-particle interaction for irregular large granules in the gas-solid multi-phase systems.

关键词： Resolved CFD-DEM method Irregular sinter particles Multi-sphere clumped method Immersed boundary method Dynamic cell refinement

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Improving hydrogen storage thermodynamics and kinetics of Ce-Mg-Ni-based alloy by mechanical milling with TiF_(3)

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Journal of Magnesium and Alloys 2024年第4期12卷 1593-1607页

作者： Hongwei Shang wei zhang Xin wei Yaqin li Zeming Yuan Jun li Yanghuan zhang School of Mechanical and Electrical Engineering Chuzhou UniversityChuzhou 239000China Department of Functional Material Research Central Iron and Steel Research InstituteNo.76 Xueyuannan RoadHaidian DistrictBeijing 100081China Key Laboratory of Integrated Exploitation of Bayan-Obo Multi-Metal Resources Inner Mongolia University of Science and TechnologyBaotou 014010China China Rare Earth New Material(weishan)Co. Ltd.Jining 277600China

Mg-based hydrides are too stable and the kinetics of hydrogen absorption and desorption is not *** efficient way to improve these shortcomings is to employ reactive ball milling to synthesize the nanocomposite materials of Mg and *** this experiment,TiF_(3)was selected as an additive,and the mechanical milling method was employed to prepare the experimental *** alloys used in this experiment were the as-cast Ce_(5)Mg_(85)Ni_(10),as-milled Ce_(5)Mg_(85)Ni_(10)and Ce_(5)Mg_(85)Ni_(10)+3 wt.%*** phase transformation,structural evolution,isothermal and non-isothermal hydrogenation and dehydrogenation performances of the alloys were inspected by XRD,SEM,TEM,Sievert apparatus,DSC and *** revealed that nanocrystalline appeared in the as-milled *** with the as-cast alloy,ball milling made the particle dimension and grain size decrease dramatically and the defect density increase *** addition of TiF_(3)made the surface of ball milling alloy particles markedly coarser and more *** milling and adding TiF_(3)distinctly improved the activation and kinetics of the ***,ball milling along with TiF_(3)can decrease the onset dehydrogenation temperature of Mg-based hydrides and slightly ameliorate their thermodynamics.

关键词： Mg-based hydrides TiF_(3) Ball milling Thermodynamics Kinetics

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Enhanced photocatalytic performance by regulating the Ce^(3+)/Ce^(4+)ratio in cerium dioxide

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Frontiers of Chemical Science and Engineering 2024年第3期18卷 75-87页

作者： Zhi li Dongsheng Jia wei zhang Ying li Mitang Wang Dongliang zhang School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai200093China

Cerium dioxide(CeO_(2))photocatalysts are used in treating environmental pollution and addressing the energy crisis due to their excellent oxygen storage capacities and abundant oxygen *** this paper,CeO_(2)precursors were synthesized with different water-alcohol ratios via a solvothermal method,and CeO_(2)photocatalysts with different Ce^(3+)/Ce^(4+)ratios were obtained by changing the precursor calcination atmospheres(air,Ar)as well as the calcination *** effects of CeO_(2)with different Ce^(3+)/Ce^(4+)ratios in photocatalytic degradations of methylene blue under visible light were investigated.X-ray photoelectron spectroscopy results showed that the surfaces of the samples calcined under Ar had higher Ce^(3+)/Ce^(4+)ratios and oxygen vacancy concentrations,which reduced the band gaps of the catalysts and improved their utilization of visible *** addition,the many Ce^(3+)/Ce^(4+)redox centers and oxygen vacancies on the sample surfaces improved the separation and transfer efficiencies of the photogenerated *** sample C2-Ar calcined under Ar showed a high adsorption capacity and excellent photocatalytic activity by removing 96%of the methylene blue within 120 min,which was more than twice the degradation rate of the sample(C2-air)prepared via calcination under *** experiments showed that photogenerated holes played a key role in the photocatalytic *** addition,a synergistic photocatalytic mechanism for the Ce^(3+)/Ce^(4+)redox centers and oxygen vacancies was elucidated in detail,and the sensitization of cerium dioxide by dyes aided the degradation of methylene blue.

关键词： CeO_(2) oxygen vacancies Ce^(3+)/Ce^(4+)ratios photocatalytic dye-sensitization

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Optimal Planning of Hybrid AC/DC Low-voltage Distribution Networks Considering DC Conversion of Three-phase Four-wire Low-voltage AC Systems

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 141-153页

作者： Bo zhang Lu zhang wei Tang Gen li Chen Wang the College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083China the Electric Energy Group Department of Engineering TechnologyTechnical University of Denmark(DTU)2750 BallerupDenmark the Power Distribution Technology Center State Grid Beijing Electric Power Research InstituteBeijing 100075China

The increasing integration of distributed household photovoltaics(PVs)and electric vehicles(EVs)may further ag gravate voltage violations and unbalance of low-voltage distribu tion networks(LVDNs).DC distribution networks can increase the accommodation of PVs and EVs and mitigate mutilple pow er quality problems by the flexible power regulation capability of voltage source *** paper proposes schemes to es tablish hybrid AC/DC LVDNs considering the conversion of the existing three-phase four-wire low-voltage AC systems to DC op *** characteristics and DC conversion constraints of typical LVDNs are *** addition,converter configura tions for typical LVDNs are proposed based on the three-phase four-wire characteristics and quantitative analysis of various DC ***,an optimal planning method of hybrid AC/DC LVDNs is proposed,which is modeled as a bi-level programming model considering the annual investments and three-phase *** are conducted to verify the effectiveness of the proposed optimal planning *** ulation results show that the proposed optimal planning method can increase the integration of PVs while simultaneously reduc ing issues related to voltage violation and unbalance.

关键词： Optimal planning low-voltage distribution net work three-phase unbalance DC conversion

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