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家庭认知环境对儿童早期语言发育的影响:一项上海市的回顾性病例对照研究

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中国全科医学 2025年第1期28卷 53-58页

作者：郭志超崔丹包嘉珺施渭青韦康杨兴堂俞文雅上海市宝山区月浦镇社区卫生服务中心预防保健科 200941 上海交通大学医学院公共卫生学院上海市200025

背景儿童早期语言发育迟缓发生率高、早期识别率低,对儿童其他维度的早期发展有显著负面影响。家庭认知环境是影响儿童早期语言发育的关键因素。目的本研究旨在探索家庭认知环境对儿童早期语言发育的影响,从家庭认知环境的社区干预角度... 详细信息

背景儿童早期语言发育迟缓发生率高、早期识别率低,对儿童其他维度的早期发展有显著负面影响。家庭认知环境是影响儿童早期语言发育的关键因素。目的本研究旨在探索家庭认知环境对儿童早期语言发育的影响,从家庭认知环境的社区干预角度,为儿童早期的语言发育促进提供理论证据。方法采用回顾性病例对照研究,对2018—2020年在上海市某社区卫生服务中心儿童保健门诊体检的4307名儿童在1、2、3周岁时采用上海市小儿发育筛查量表Ⅱ(DenveRⅡ)进行发育筛查,将筛查出的语言发育迟缓的172名儿童作为观察组,以年龄作为配对因素,按照1∶3的比例纳入516名语言发育正常的儿童作为对照组。收集两组儿童出生基本特征、父母人口学特征、母亲孕期和分娩特征以及家庭认知环境特征信息。采用Logistic回归分析探讨儿童早期语言发育迟缓的影响因素。结果早期语言发育迟缓的儿童共172名,发生率为3.99%,其中,1岁儿童57名(33.14%),2岁儿童92名(53.49%),3岁儿童23名(13.37%)。病例组儿童男性、早产、母亲文化程度为高中以下比例高于对照组(P<0.05)。病例组儿童的总体家庭认知环境及情感温暖、社会适应、语言环境和忽视环境弱于对照组(P<0.05)。儿童早产、母亲文化程度低(高中以下)、家庭认知环境不良是儿童早期语言发育迟缓的危险因素(P<0.05)。结论在2岁前进行语言发育干预是有效降低儿童语言发育迟缓率的关键。社区儿童保健医生指导优化家庭养育环境、协助建立良好亲子沟通和交流互动,是促进儿童早期语言发育的有效策略,尤其要关注出生胎龄小和母亲文化程度低的家庭,为其提供更有针对性的亲子活动和亲子沟通方面的干预和指导。

关键词：语言发展障碍家庭环境认知环境儿童儿童语言儿童早期发展病例对照研究

Postoperative Early Standard and Sequential Nutritional Support in the Treatment of Gastroesophageal Anastomotic Fistula:a Case Report

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Chinese Medical Sciences Journal 2015年第2期30卷 131-134页

作者： Chang-zhen Zhu kang Li Jian-chun Yu wei-ming kang Zhi-qiang Ma Xin Ye Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College

GASTROESOPHAGEAL anastomotic fistula is aserious and potentially life-threatening complicationafter the resection of esophagus, gastricand cardia tumor.1 Before 1987, the incidenceof gastroesophageal anastomotic fistula is about 2%-4% inChina, and the mortality rate is as high as 50% or more.2 Inthe last 30 years, with the rapid development of clinicalnutrition support method, nutritional support.

关键词： enteral nutrition parenteral nutrition gastroesophageal anastomotic fistula

Efficient removal of Cr(VI) by polydopamine-modified lignin from aqueous solution: Batch and XAFS studies

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Water Science and Engineering 2024年第1期17卷 51-61页

作者： Xiao-jie Guo wei-kang Fu Jing-yuan Ma Bo-jun Xi Chen Wang Meng-yao Guan College of Materials and Environmental Engineering Hangzhou Dianzi UniversityHangzhou 310018China College of Textile and Garment Shaoxing UniversityShaoxing 312000China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China

Lignocellulose has the potential to become a bio-based adsorbent due to its biodegradability and *** this study,a novel polydopamine functionalized-lignin(lignin@PDA),prepared via self-polymerization of dopamine(PDA)on lignin,was used as a bio-based adsorbent for rapid scavenging of hexavalent chromium(Cr(VI)).The morphology,functional groups,crystalline structure,and chemical composition of lignin@PDA were characterized with a scanning electron microscope-energy dispersive spectrometer,Fourier transform infrared spectroscopy,X-ray diffraction,and X-ray photoelectron *** Cr(VI)adsorption process of lignin@PDA was studied using batch experiments as a function of pH,ionic strength,adsorbent dose,and contact time at room *** adsorption rate of lignin@PDA was five times greater than that of the unmodified lignin,with a maximum adsorption capacity of 102.6 mg/g in an acidic *** adsorption of Cr(VI)on lignin@PDA fit the pseudo-secondorder equation and the Freundlich model,indicating that the adsorption process was mainly dominated by chemisorption and surface *** thermodynamic parameters showed that adsorption of Cr(VI)on lignin@PDA was an endothermic and spontaneous *** X-ray absorption fine structure results showed that sorption and reduction of Cr(VI)into Cr(II)occurred simultaneously on ***,PDA coating not only improved the reactivity of lignin but also promoted the complete reduction of Cr(VI)by *** to these results,polydopamine functionalized-lignin is a promising bio-based adsorbent for immobilization of Cr(VI)from wastewater.

关键词： Lignin Polydopamine Hexavalent chromium EXAFS Adsorption mechanism

A two-year(2020–2021)observation of marine phycotoxins in phytoplankton in typical mariculture areas of East China Sea

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Journal of Oceanology and Limnology 2022年第6期40卷 2256-2266页

作者： Xiaoqing TIAN Chengqi FAN Yunyu TANG Haiyan ZHANG wei kang Sha CHEN Chongbin LI Ya’nan LU Key Laboratory of East China Sea&Oceanic Fishery Resources Exploitation and Utilization Ministry of Agriculture and Rural AffairsEast China Sea Fisheries Research InstituteChinese Academy of Fishery SciencesShanghai 200090China Shanghai Ocean University Shanghai 201306China

To learn the marine phycotoxins(MPTs)contamination status in mariculture areas in the East China Sea(ECS),from May 2020 to October 2021,80 net-concentrated phytoplankton samples were collected from 12 stations in three typical areas with high incidence of red tides,namely,Gouqi Island,Sandu’ao-Lianjiang,and Zhangzhou-Dongshan Island in ECS,and MPTs of the samples were *** types of toxins were detected in 24 samples from 9 *** marine toxins(LMTs)were more common and diverse in these *** 2(PTX2)was the main lipophilic marine toxin(LMT)in the concentrated phytoplankton samples and the occurrence showed seasonal differences from north to *** to the potential risks of pectenotoxin(PTXs)to seafood safety,it is suggested to execute regular monitoring on PTXs in ECS and a mandatory standard should be formulated based on the comprehensive analysis of in-situ monitoring and lab ***,contamination risks of cyclic imine toxins in the north and domoic acid(DA)in the south of ECS should also be paid with attention *** 2 paralytic shellfish toxins(PSTs),N-sulfocarbamoyl toxin C2(C2),and decarbamoyl gonyatoxin 3(dcGTX3),were found from spring samples in the north of *** the biggest mussel culture county of China,Gouqi Island showed higher toxin diversity and the toxin detection rate was higher than the other two *** Gouqi Island area,PSTs were a serious potential threat in spring,and LMTs instead of PSTs became the main risk in summer-autumn *** ensure the safety of seafood and marine environmental health,it is recommended to conduct long-term targeted tracking and monitoring of MPTs in this and similar mariculture areas.

关键词： marine phycotoxins(MPTs) pectenotoxin 2(PTX2) mariculture areas East China Sea seafood safety

Comparison of short-and long-term outcomes of laparoscopic vs open resection for gastric gastrointestinal stromal tumors

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World Journal of Gastroenterology 2017年第25期23卷 4595-4603页

作者： Xin Ye wei-Ming kang Jian-Chun Yu Zhi-Qiang Ma Zhi-Gang Xue Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College

AIM To compare the short-and long-term outcomes of laparoscopic(LR) vs open resection(OR) for gastric gastrointestinal stromal tumors(g GISTs).METHODS In total, 301 consecutive patients undergoing LR or OR for pathologically confirmed g GISTs from 2005 to 2014 were enrolled in this retrospective study. After exclusion of 77 patients, 224 eligible patients were enrolled(122 undergoing LR and 102 undergoing OR). The demographic, clinicopathologic, and survival data of all patients were collected. The intraoperative, postoperative, and long-term oncologic outcomes were compared between the LR and OR groups following the propensity score matching to balance the measured covariates between the two *** After 1:1 propensity score matching for the set of covariates including age, sex, body mass index, American Society of Anesthesiology score, tumor location, tumor size, surgical procedures, mitotic count, and risk stratification, 80 patients in each group were included in the final analysis. The baseline parameters of the two groups were comparable after matching. TheLR group was significantly superior to the OR group with respect to the operative time, intraoperative blood loss, postoperative first flatus, time to oral intake, and postoperative hospital stay(P 0.05). No significant difference was found in postoperative adjuvant therapy(P = 0.587). The mean follow-up time was 35.30 ± 26.02(range, 4-102) mo in the LR group and 40.99 ± 25.07(range, 4-122) mo in the OR group with no significant difference(P = 0.161). Survival analysis showed no significant difference in the disease-free survival time or overall survival time between the two groups(P > 0.05).CONCLUSION Laparoscopic surgery for g GISTs is superior to open surgery with respect to intraoperative parameters and postoperative outcomes without compromising long

关键词： Gastric gastrointestinal stromal tumor Laparoscopic surgery Open surgery Clinical outcome Prognosis

Analysis of var genes cloned from a Plasmodium falcivarum isolate in China

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Asian Pacific Journal of Tropical Medicine 2012年第2期5卷 85-90页

作者： Ning Jiang Li Meng Hui-Jun Lu wei kang Shuai Peng wei-Qing Pan Ji-Gang Yin Qi-Jun Chen Key Laboratory of Zoonosis Ministry of EducationInstitute of ZoonosisJilin University Department of Pathogen Biology Laboratory of Parasitology Institute of Pathogen BiologyChinese Academy of Medical Sciences

Objective:To analyse the rar gene repertoire and characterise the rhondroitin sulphate A (CSA)-binding activity of the Duffy-binding like(I)BI.) domains encoded by the var2csa gene of a Plasmodium falciparum(***) isolate in Hainan Province,***:The sequences of var DBL1 regions were PCR-amplified,sequenced and the sequence characteristics was bioinformalically *** proteins encoded by the var2csa genes were expressed and *** binding activities of the recombinant proteins to CSA receptor was detected by ELISA ***:Fifty six unique DBI.a sequences were obtained,and the sequences represented similar diversity to the var genes of the genome parasite *** are two var2csa genes in the *** isolated from Hainan *** in other falciparum parasites such as HB3,the two var2csa genes are more *** receptor-binding capacity of DBL-5εand DBI.-6 e domains of HN var2CSA was ***:This work represented the diversity of rar genes of a *** isolate in China.

关键词： Malaria Plasmodium falciparum Antigenic variation Var gene

Wheat silage partially replacing oaten hay exhibited greater feed efficiency and fibre digestion despite low feed intake by feedlot lambs

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Animal Nutrition 2023年第4期15卷 332-340页

作者： Zhao-Yang Cui Wen-Juan Li wei-kang Wang Qi-Chao Wu Yao-Wen Jiang Ailiyasi Aisikaer Fan Zhang He-wei Chen Hong-Jian Yang State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

This study aimed to investigate the feeding effect of wheat silage on growth performance,nutrient digestibility,rumen fermentation,and microbiota composition in feedlot ***-four male crossbred Chinese Han lambs(BW=27.8±0.67 kg,3 months of age)were randomly assigned to four ration groups with wheat silage replacing 0%(WS0),36%(WS36),64%(WS64),and 100%(WS100)of oaten hay on forage dry matter *** concentrate-to-forage ratio was 80:20 and the feeding trial lasted 52 *** wheat silage inclusion linearly decreased dry matter intake by 4%to 27%(P<0.01).However,increasing the wheat silage replacement of oaten hay by no more than 64%improved the feed efficiency by 14%as noted by the feed-to-gain ratio(P=0.04).Apparent digestibility of organic matter(P<0.01),neutral detergent fibre(P=0.04)and acid detergent fibre(P<0.01)quadratically *** nitrogen(P=0.01)decreased while microbial protein production(P<0.01)increased with the increase of wheat silage *** volatile fatty acids concentration increased quadratically with the increase of wheat silage inclusion(P<0.01),and the highest occurred in *** molar proportion of acetate(P<0.01)and acetate-to-propionate ratio(P=0.04)decreased while butyrate(P<0.01)and isovalerate(P=0.04)*** wheat silage inclusion increased the Firmicutes-toBacteroidota ratio by 226%to 357%,resulting in Firmicutes instead of Bacteroidota being the most abundant *** relative abundance of cellulolytic Ruminococcus numerically increased but that of amylolytic Prevotella(P<0.01)decreased as increasing wheat silage *** together,increasing wheat silage replacement of oaten hay by no more than 64%exhibited greater feed efficiency and fibre digestion despite low feed intake by feedlot lambs due to the change of Firmicutes-to-Bacteroidota ratio in the rumen.

关键词： Wheat silage Oaten hay Growth performance Nutrient digestibility Rumen fermentation Feedlot lamb

Rutaecarpine attenuates monocrotaline-induced pulmonary arterial hypertension in a Sprague-Dawley rat model

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Traditional Medicine Research 2023年第1期8卷 26-35页

作者： Xiao-wei Gong Yan-Ling Sheng Shi-wei kang Bo-Yun Yuan Ya-Dong Yuan Department of Respiratory and Critical Care Medicine The Second Hospital of Hebei Medical UniversityShijiazhuang 050000China Department of Respiratory and Critical Care Medicine Huabei Petroleum Administration Bureau General HospitalRenqiu 062550China.

Background:Pulmonary arterial hypertension presents with obliterative remodeling of the pulmonary arteries and progressive elevation of pulmonary vascular resistance,which increase the risk of right ventricular failure and *** has been reported in previous studies that rutaecarpine plays a crucial role in anti-inflammatory and antioxidant activities,which may help regulate cell apoptosis and cell *** purpose of this study was to determine the effects of rutaecarpine in the rat model of monocrotaline-induced pulmonary ***:We induced pulmonary arterial hypertension in adult Sprague-Dawley rats by injecting monocrotaline(60 mg/kg)and then treated with rutaecarpine(40 mg/kg·d)or sildenafil(30 mg/kg·d)(positive control).Subsequently,pulmonary function,inflammation,cytokines and pulmonary vascular remodeling or proliferation were ***:Rutaecarpine was found to improve monocrotaline-induced mean pulmonary artery pressure,cardiac index,right heart index,right ventricular hypertrophy index,pulmonary artery remodeling and pulmonary *** transcription-quantitative polymerase chain reaction demonstrated a decrease in tumor necrosis factor-α,interleukin-6 and interleukin-1β,whereas western blots a significantly decrease in the expression of nuclear factor kappa-B,endothelin-1,extracellular signal-regulated kinases 1/2,B cell lymphoma-2,Beclin1 and microtubule-associated protein1 light chain 3-II protein,and increase in the expression of Bax,caspase-3 and p62 ***:Rutaecarpine attenuated pulmonary arterial hypertension by inhibiting inflammation,oxidative stress,cell proliferation and autophagy,while promoting apoptosis.

关键词： rutaecarpine pulmonary arterial hypertension inflammatory response oxidative stress vascular proliferation

Molecular Cloning of Myostatin Partial cDNA of Beijing Duck and Its Expression in Breast Muscle

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Agricultural Sciences in China 2006年第6期5卷 468-472页

作者： WANG Yong-sheng HOU Shui-sheng HUANG wei kang Jun-mei State Key Laboratory of Animal Nutrition Institute of Animal Science Chinese Academy of Agricultural Sciences Beijing 100094 P.RChina

In this experiment, 500 bp cDNA of myostatin gene was cloned from a Beijing duck＇s breast, The duck myostatin gene was found to have 98, 96, 95, 88, and 87% sequence similarity at the cDNA level with domestic goose, chicken, domestic pigeon, human, and pig, respectively. The predicted amino acid sequence has an overall similarity with a comparable region of turkey 99%, domestic goose 98%, and chicken 99%. Conserved domains of deduced amino acids showed that it belonged to the TGF-beta family. Myostatin expression in breast muscle was higher at 28, 35, and 42 days than at 7, 14, and 21 days. The pattern of myostatin expression was closely parallel to the trend of breast muscle growth, suggesting that myostatin might play an important role in breast muscle development. It was possible to postulate that myostatin may be a major determinant of muscle mass in breast muscle, as shown in other species.

关键词： Beijing duck myostatin cloning and sequence analysis expression