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数学学报（中文版） 2014年第5期57卷 961-972页

作者：韦康浙江大学数学科学中心杭州310027

在紧致H-扭广义Calabi-Yau流形得到了一个可以用来检验形变中典范截面是否全纯的式子(?).

关键词：复结构的形变 Hodge理论 Hermitian流形 K(a|¨)hler流形 Calabi-Yau流形

紧致广义Hermite流形上纯型的实d_(H^(-))闭形式的局部延拓

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中国科学：数学 2021年第7期51卷 1163-1190页

作者：韦康上海立信会计金融学院统计与数学学院上海201209

关于满足广义■_(H)■(H^(-))引理的紧致广义Hermite流形的形变,本文给出一个纯型的实dH-闭形式的局部延拓公式.

关键词：复结构的形变 Hodge理论 Hermite和Kahler流形

Orange-red, green, and blue fiuorescence carbon dots for white light emitting diodes

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Journal of Materials Science & Technology 2020年第15期47卷 184-191页

作者： Ling Jin Li Zhang Lei Yang Xingrong Wu Cheng Zhang kang wei Lifang He Xinya Han Hongbin Qiao Abdullah MAsiri Khalid AAlamry Kui Zhang School of Chemistry and Chemical Engineering Anhui University of TechnologyMa'anshan243032China Department of Chemistry University of North Carolina at Chapel HillChapel HillNC27599USA Key Laboratory of Metallurgical Emission Reduction&Resources Recycling Ministry of Education(Anhui University of Technology)Ma'anshan243002China Chemistry Department Faculty of ScienceKing Abdulaziz UniversityJeddah21589Saudi Arabia

Fluorescent carbon dots(CDs) are admirable nanomaterials due to their superior optical properties and low ***,regulation of the emission colors in CDs for lighting device still remains a *** this work,we developed a green hydrothermal method to obtain three emission colors of CDs using L-tyrosine(for blue CDs),o-phenylendiamine(for green CDs) and L-tyrosine/o-phenylendiamine mixture(for orange-red CDs).These CDs possess good water dispersibility,strong emission with high quantum yields,and excellent ***,the resulting CDs were dispersed in polyvinyl alcohol(PVA) matrix to yield solid state films,where the self-quenching effect in solid state was effectively avoided.A full-color light-emitting diode was fabricated by packing the CDs-PVA composites on the top of a UV-chip,which have superior potential applications in CDs-based solid-state lighting system.

关键词： Fluorescence Photoluminescene Carbon dots Self-quenching effect Light-emitting diode

Analysis of semen quality of 38 905 infertile male patients during 2008- 2016 in Wenzhou, China

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Asian Journal of Andrology 2021年第3期23卷 314-318页

作者： Zhi-Gang Wu wei-kang Chen Qian-Jin Fei Yan-Long Liu Xiao-Dong Liu Hong Huang Xue-Jun Shang Department of Andrology Jinling HospitalThe First School of Clinical MedicineSouthern Medical UniversityNanjing 210002China Department of Andrology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Reproductive Medicine Center The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Health Assessment Center for Wenzhou Medical University Wenzhou 325035China Zhejiang Provincial Key Laboratory of Watershed Science and Health College of Public Health and ManagementWenzhou Medical UniversityWenzhou 325035China.

This study analyzed the trend in semen quality of infertile male patients in Wenzhou,China,based on the data obtained from 38905 patients during 2008-2016 in The First Affiliated Hospital of Wenzhou Medical University(Wenzhou,China).The results showed that only 24.9%of the patients had normal semen *** the semen quality of infertile male patients,that of the workers and 40-year-olds was significantly worse than the other occupational and age *** all the infertile patients,low semen volume,asthenozoospermia,and teratozoospermia accounted for 8.4%,50.5%,and 54.1%,*** 2008-2016,the annual mean percentage of fast forward motile spermatozoa,percentage of total forward motile spermatozoa,and percentage of spermatozoa with normal morphology decreased linearly with slopes of-2.11,-2.59,and-0.70,*** proportion of patients with asthenozoospermia and multi-abnormal spermatozoa increased during 2008-2016 with slopes of 4.70 and 4.87,respectively,while for low semen volume,it decreased with a slope of-0.47 in the same time *** proportion of patients with teratozoospermia increased from 2008 to 2011 and from 2011 to 2016 with slopes of 17.10 and 2.09,*** general,the deteriorating trend of semen quality of infertile male patients in Wenzhou was *** efforts should be made to reveal the adverse influences on semen quality,such as occupational exposure,environmental quality,and living ***,more pervasive reproduction health education is necessary.

关键词： distribution infertile male patient semen quality symptoms time trend

Exploring the regulatory mechanism of tRNA-derived fragments 36 in acute pancreatitis based on small RNA sequencing and experiments

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World Journal of Gastroenterology 2023年第30期29卷 4642-4656页

作者： Xi-Rui Fan Yun Huang Yu Su Si-Jin Chen Yu-Lu Zhang wei-kang Huang Hui Wang Department of Gastroenterology The Affiliated Yan’an Hospital of Kunming Medical UniversityKunming 650051Yunnan ProvinceChina Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province Yan’an Hospital of KunmingKunming 650051Yunnan ProvinceChina

BACKGROUND Acute pancreatitis(AP)is a disease featuring acute inflammation of the pancreas and histological destruction of acinar *** 20%of AP patients progress to moderately severe or severe pancreatitis,with a case fatality rate of up to 30%.However,a single indicator that can serve as the gold standard for prognostic prediction has not been ***,gaining deeper insights into the underlying mechanism of AP progression and the evolution of the disease and exploring effective biomarkers are important for early diagnosis,progression evaluation,and precise treatment of *** To determine the regulatory mechanisms of tRNA-derived fragments(tRFs)in AP based on small RNA sequencing and *** Small RNA sequencing and functional enrichment analyses were performed to identify key tRFs and the potential mechanisms in *** transcription quantitative polymerase chain reaction(RT-qPCR)was conducted to determine tRF *** cell and mouse models were created to investigate the role of tRF36 in AP ***,amylase,and cytokine levels were assayed to examine AP *** expression,reactive oxygen species,malondialdehyde,and ferric ion levels were assayed to evaluate cellular *** pull down assays and methylated RNA immunoprecipitation were performed to explore the molecular *** RT-qPCR results showed that tRF36 was significantly upregulated in the serum of AP patients,compared to healthy *** enrichment analysis indicated that target genes of tRF36 were involved in ferroptosisrelated pathways,including the Hippo signaling pathway and ion ***,the occurrence of pancreatic cell ferroptosis was detected in AP cells and mouse *** results of interference experiments and AP cell models suggested that tRF-36 could promote AP progression through the regulation of ***,ferroptosis gene microarray,database prediction,and immunopreci

关键词： Acute pancreatitis tRNA-derived fragments tRNA-derived fragments 36 Mouse models Ferroptosis Reverse transcription quantitative polymerase chain reaction

Frost-heave properties of saturated compacted silty clay under one-side freezing condition

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Research in Cold and Arid Regions 2017年第3期9卷 273-279页

作者： Hong Yan Ma Feng Zhang De Cheng Feng kang wei Tang College of Civil Engineering Fuzhou University School of Transportation Science and Engineering Harbin Institute of Technology

In seasonally frozen regions,the frost-heave properties of soil play a significant role in its upper-structure performance and *** investigate the frost-heave behaviors of saturated,compacted silty clay soil widely used as subgrade material,a series of one-side freezing tests was carried out;and the freezing depth and frozen front effected by the compactness,temperature,overburden pressure,and water-supply condition were analyzed and *** results show that the moving speed of the frozen front and growth rate of the frozen depth are positively *** frost heave is maximum in the frost-heave stability *** frost ratio of saturated soil is proportional to the water supply and cooling temperature under a one-side freezing *** frost ratio of saturated soil is inversely proportional to the initial compactness of the soil specimen and the overburden pressure.

关键词： seasonally frozen regions saturated silty clay soil frost heave freezing front factor-sensitivity analysis

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西十高铁汉江特大桥主桥设计

桥梁建设 2024年第2期54卷 106-111页

作者：康炜卢皓西南交通大学土木工程学院四川成都610031 中铁第一勘察设计院集团有限公司陕西西安710043

西十高铁汉江特大桥主桥为主跨420 m的梁桁组合结构双塔斜拉桥,采用半飘浮体系。主梁采用钢桁加劲PC箱梁,梁高3.0 m,桥面全宽17 m。PC箱梁采用C55混凝土,单箱四室等高截面,加劲桁采用渐变三角桁式,材质为Q370qE钢,桁高9.4 m。斜拉索采... 详细信息

西十高铁汉江特大桥主桥为主跨420 m的梁桁组合结构双塔斜拉桥,采用半飘浮体系。主梁采用钢桁加劲PC箱梁,梁高3.0 m,桥面全宽17 m。PC箱梁采用C55混凝土,单箱四室等高截面,加劲桁采用渐变三角桁式,材质为Q370qE钢,桁高9.4 m。斜拉索采用标准抗拉强度1770 MPa的镀锌平行钢丝,双索面扇形布置。桥塔采用花瓶式钢筋混凝土框架结构,塔高186.5 m,基础采用∅3 m的钻孔灌注桩,按长短桩设计。结构受力分析结果表明:该桥力学性能指标均满足相关规范要求,整体刚度性能优越,具有良好的颤振稳定性,设置的风嘴能有效抑制涡激振动,采取加劲钢桁上弦杆灌注混凝土、延迟铺轨时间等措施能有效控制主梁的收缩徐变,桥面线形满足铺设无砟轨道的要求。

关键词：高速铁路桥斜拉桥半飘浮体系钢桁加劲PC箱梁斜拉索受力分析桥梁设计

Prevalence of Metabolic Syndrome and Its Associations with Other Metabolic Disorders and Cardiovascular Changes in Health Examination Population in Beijing

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Chinese Medical Sciences Journal 2009年第4期24卷 227-230页

作者： wei-ming kang Jie-shi Zhang Min-shan Wang Ying-chao Gu Jian-chun Yu Department of General Surgery Health Examination Center Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To investigate the prevalence of metabolic syndrome(MS) and its associations with other metabolic disorders and cardiovascular changes in health examination population in *** Totally,10 916 individuals who received health examination in Health Examination Center of Peking Union Medical College Hospital were *** height,weight,blood pressure,serum levels of triglyceride,high-density lipoprotein cholesterol(HDL-C),and fasting blood glucose were *** was diagnosed based on the working criteria of Chinese Diabetes Society 2004(CDS2004).Meanwhile,other metabolic disorders,including fatty liver and hyperuricemia,were *** cardiovascular changes were reflected by the reports of electrocardiogram(ECG) ST-T changes and atherosclerosis of retinal *** The overall prevalence rate of MS was 6.1%(666/10 916) in the *** prevalence rate of MS in male was much higher than that in female(9.0% vs.2.7%,P=0.000).For individuals with MS,the prevalence rates of fatty liver and hyperuricemia were significantly higher than those without MS,respectively(70.4% vs.35.4%,P=0.000;29.9% vs.17.7%,P=0.000).As for cardiovascular changes,the prevalence rates of ECG ST-T changes and atherosclerosis of retinal arteries were significantly higher in individuals with MS than those without MS,respectively(13.8% vs.11.7%,P=0.012;12.0% vs.6.8%,P=0.000).Conclusions The prevalence of MS in Beijing population is *** individuals with MS have a higher risk for other metabolic disorders and cardiovascular changes.

关键词： metabolic syndrome prevalence metabolic disorders cardiovascular changes

MiR-30b suppresses tumor migration and invasion by targeting EIF5A2 in gastric cancer

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World Journal of Gastroenterology 2015年第31期21卷 9337-9347页

作者： Shu-Bo Tian Jian-Chun Yu Yu-Qin Liu wei-Ming kang Zhi-Qiang Ma Xin Ye Chao Yan Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College Cell Centre Institute of Basic Medical SciencesChinese Academy of Medical Sciences

AIM: To elucidate the potential biological role of mi R-30 b in gastric cancer and investigate the underlying molecular mechanisms of mi R-30 b to inhibit metastasis of gastric cancer ***: The expression of mi R-30 b was detected in gastric cancer cell lines and samples by reverse transcription-polymerase chain reaction. CCK-8 assays were conducted to explore the impact of mi R-30 b overexpression on the proliferation of gastric cancer cells. Flow cytometry was used to examine the effect of mi R-30 b on the apoptosis. Transwell test was used for the migration and invasion assays. Luciferase reporter assays and Western blot were employed to validate regulation of putative target of mi R-30 ***: The results showed that mi R-30 b was downregulated in gastric cancer tissues and cancer cell lines and functioned as a tumor suppressor. Overexpression of mi R-30 b promoted cell apoptosis,and suppressed proliferation,migration and invasion of the gastric cancer cell lines AGS and MGC803. Bioinformatic analysis identified the 3'-untranslated region of eukaryotic translation initiation factor 5A2(EIF5A2) as a putative binding site of mi R-30 b. Luciferase reporter assays and Western blot analysis confirmed the EIF5A2 gene as a target of mi R-30 b. Moreover,expression levels of theEIF5A2 targets E-cadherin and Vimentin were altered following transfection of mi R-30 b ***: Our findings describe a link between mi R-30 b and EIF5A2,which plays an important role in mediating epithelial-mesenchymal transition.

关键词： mi R-30b Gastric cancer EIF5A2 Migration Invasion

Identifying key genes associated with Hirschsprung's disease based on bioinformatics analysis of RNA-sequencing data

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World Journal of Pediatrics 2017年第3期13卷 267-273页

作者： wei-kang Pan Ya-Fei Zhang Hui Yu Ya Gao Bai-Jun Zheng Peng Li Chong Xie Xin Ge Department of Pediatric Surgery The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004China Department of Endoscopy Shaanxi Nuclear Industry 215 HospitalXianyang 712000China

Background:Hirschsprung's disease (HSCR) is a type of megacolon induced by deficiency or dysfunction of ganglion cells in the distal intestine and is associated with developmental disorders of the enteric nervous *** explore the mechanisms of HSCR,we analyzed the RNA-sequencing data of the expansion and the narrow segments of colon tissues separated from children with ***:RNA-sequencing of the expansion segments and the narrow segments of colon tissues isolated from children with HSCR was *** differentially expressed genes (DEGs) were identified using the edgeR package in R,functional and pathway enrichment analyses of DEGs were carried out using DAVID *** further screen the key genes,protein-protein interaction (PPI) network and module analyses were conducted separately using Cytoscape ***:A total of 117 DEGs were identified in the expansion segment samples,including 47 up-regulated and 70 down-regulated *** enrichment analysis suggested that FOS and DUSP1 were implicated in response to endogenous *** the PPI network analysis,FOS (degree=20),EGR1 (degree=16),ATF3 (degree=9),NOS1 (degree=8),CCL5 (degree=8),DUSP1 (degree=7),CXCL3 (degree=6),VIP (degree=6),FOSB (degree=5),and NOS2 (degree=4) had higher degrees,which could interact with other *** addition,two significant modules (module 1 and module 2) were identified from the PPI ***:Several genes (including FOS,EGR1,ATF3,NOS1,CCL5,DUSP1,CXCL3,VIP,FOSB,and NOS2) might be involved in the development of HSCR through their effect on the nervous system.

关键词： differentially expressed genes functional and pathway enrichment analysis Hirschsprung's disease protein-protein interaction network