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Exploration of metformin-based drug combination for mitigating diabetes-associated atherosclerotic diseases

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World Journal of Diabetes 2025年第4期16卷 304-309页

作者： Biao Qu Zheng Li wei hu Department of Clinical Pharmacology The Second Hospital of Anhui Medical UniversityHefei 230601Anhui ProvinceChina Jiangsu Engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells College of Health SciencesSchool of Life SciencesJiangsu Normal UniversityXuzhou 221000Jiangsu ProvinceChina

Diabetes mellitus is a substantial global health threat due to its high prevalence and its serious *** hyperglycemic state causes damage to vascular endothelial cells and disturbance of lipid metabolism,thus contributing to the development of vascular disorders,especially atherosclerotic *** glycemic control combined with vascular intervention is critical to the prevention and treatment of diabetes-associated *** is suggested that metformin should be combined with hypoglycemic agents with proven vascular benefits for treating type 2 diabetes(T2DM)complicated with atherosclerotic *** studies indicates that the preferred combination is metformin with either glucagon-like peptide-1 receptor agonist or sodium/glucose cotransporter-2 inhibitor,which could offer additional vascular benefits and reduce the risk of atherosclerotic ***,combination therapy with metformin and hypolipidemic agents has also shown additive effects on glucose control and lipid-lowering in patients with both diabetes and dyslipidemia,whereas extensive clinical trials using atherosclerotic-associated outcomes are required to support the vascular ***,co-administration of metformin with systemic antioxidant or anti-inflammatory therapy may also provide additional vascular benefits as indicated by several animal *** instance,a recent study found that additional supplementation of cholecalciferol and taurine enhanced metformin efficacy in controlling diabetes while reducing the risk of associated atherosclerotic ***,these potential benefits remain need validation by the evidence from clinical *** the limitations,such as heterogeneity across different patient populations,and deficiency in long-term outcomes,such efforts can contribute to finding optimal drug combinations to improve the management of T2DM and reduce its atherosclerotic complications.

关键词： Diabetes Atherosclerotic diseases Metformin Drug combination Hypoglycemic agent Hypolipidemic agent Antioxidant agent

Structural analysis of a neutral polysaccharide ATP-1 from the red seaweed Asparagopsis taxiformis and its immunomodulatory effects on RAW264.7 macrophages

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Food Science and human Wellness 2025年

作者： Kun Yang Baojun Xu wei hu Yifan Tang Amy hui-Mei Lin Saiyi Zhong College of Food Science and Technology， Guangdong Ocean University， Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety，Guangdong Province Engineering Laboratory for Marine Biological Products， Guangdong Provincial Engineering Technology Research Center of Seafood Guangdong Provincial Engineering Technology Research Center of Prefabricated Seafood Processing and Quality Control Food Science and Technology Program， Department of Life Sciences， BNU-HKBU United International College Singapore Institute of Food and Biotechnology Innovation (SIFBI) Shenzhen Research Institute， Guangdong Ocean University

As a seaweed supplement， the powdered， entire herb of Asparagopsis taxiformis can effectively promote immune response in animals. However， the active factors responsible for this effect are currently unknown. A novel polysaccharide， ATP-1， was isolated and purified from the red alga A. taxiformis， and its structural and immunomodulatory properties were determined. ATP-1 is a neutral polysaccharide with a molecular weight of 307.978 kDa and is primarily composed of galactose (94.07%)， glucose (1.27%)， and xylose (4.66%). Scanning electron microscopy and atomic force microscopy revealed that ATP-1 had an amorphous structure and was composed of molecular chain entanglement and intramolecular hydrogen bonding interactions. The microstructure of ATP-1 exhibited asymmetric sheet–like cracks and pores. Results from immunomodulatory activity showed that ATP-1 promoted inducible nitric oxide (NO) synthase and cyclooxygenase (COX)-2 protein expression in RAW264.7 macrophages， improved macrophage phagocytic ability， and stimulated cytokine production (NO， tumor necrosis factor [TNF]-α， and interleukin [IL]-6). Quantitative proteome analysis identified 178 differentially expressed proteins (70 upregulated and 108 downregulated) that were involved in various molecular pathways， among which， TNF was one of the 20 most common and significant signaling pathways in inflammation and immunoregulation. Western blotting indicated that ATP-1 significantly upregulated the expression of IKKα， IKKβ， COX-2， and TNF-α proteins in the TNF pathway. In contrast， ATP-1 downregulated the expression of IκBα， Fas， and AIPI. Results from molecular docking suggested that hydrogen bonding predominantly contributed to the affinity between TNF-α and galactose， glucose， and xylose. These findings indicated that ATP-1 may play an immunomodulatory role by activating the TNF signaling pathway. ATP-1 enhanced macrophage phagocytic capacity and stimulated the production of cytokines NO， TNF-α， and IL-6， thereb

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中国式教育治理现代化的法治逻辑及其实现进路

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陕西师范大学学报(哲学社会科学版) 2025年第1期54卷 129-142页

作者：胡伟华中师范大学法学院湖北武汉430079

中国式教育治理现代化是以法治作为依托,而且法治深植于教育治理现代化全过程和各个领域,并将法治的优势全面释放出来,在法治轨道上推进教育治理体系和治理能力现代化。同时,在中国式现代教育治理体系当中,法治是教育领域自主管理的前... 详细信息

中国式教育治理现代化是以法治作为依托,而且法治深植于教育治理现代化全过程和各个领域,并将法治的优势全面释放出来,在法治轨道上推进教育治理体系和治理能力现代化。同时,在中国式现代教育治理体系当中,法治是教育领域自主管理的前提和基础,与教育德治价值取向保持一致。在扎实推进中国式教育治理现代化的背景下,迫切需要现代化的法治治理作保障。但目前存在着教育治理制度体系亟待完善、教育依法治理实践不够充分、多主体参与教育治理的法治化体制机制尚有待健全和教育法治氛围仍有待加强等问题。需要通过加大制度供给、规范主体行为、强化多主体协同、营造法治氛围等手段予以解决,加速推进中国式教育治理法治化进程。

关键词：中国式现代化教育治理现代化法治化

基于铬天青检测法对自来水中铝含量的优化检测研究

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山西化工 2025年第1期45卷 130-131,136页

作者：胡伟深圳市水务(集团)有限公司水质监测中心广东深圳518000

目的:提高铬天青检测法测定自来水中铝含量的效率和准确性。方法:在原方法基础上,对所有玻璃仪器进行硝酸预处理,排除铜、锰、铁和铝等金属离子的干扰;调整pH值后多加2滴硝酸并充分混合;显色过程中所需的4种试剂均需临用前配制,沿比色... 详细信息

目的:提高铬天青检测法测定自来水中铝含量的效率和准确性。方法:在原方法基础上,对所有玻璃仪器进行硝酸预处理,排除铜、锰、铁和铝等金属离子的干扰;调整pH值后多加2滴硝酸并充分混合;显色过程中所需的4种试剂均需临用前配制,沿比色管内壁一次性定容后再摇匀。结果:优化方案在标准曲线0~0.250 mg/L范围内线性提升显著,相关系数r=0.9985~0.9997,标准点回算结果理想,环境标准样品测定结果准确。结论:优化方案简化了操作步骤,减少了系统误差,使结果更为准确。

关键词：金属元素铝自来水卫生铬天青检测法优化检测法

A Review of Bicuspid Aortic Valve Anomaly

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International Journal of Clinical Medicine 2025年第1期16卷 112-126页

作者： wei hu Rubing Wang Yan Zhang Yuxin Qi Jibin Xu Jingjing Wang Junnan Wang weiqing Pu Yufeng Zhang Zhinong Wang Yudi Liu Department of Cardiothoracic Surgery Changzheng Hospital Naval Medical University Shanghai China

Bicuspid aortic valve (BAV) is a common congenital heart valve disease, often accompanied by aortic valve stenosis or regurgitation, infective endocarditis, and aortic diseases such as aortic dilation and dissection. This article aims to review the definition, pathogenesis and genetic basis, classification methods, clinical features and current status of research and treatment and prognosis of BAV, and provide reference for the diagnosis and treatment of BAV. The content and structure of this article are as follows: The first part introduces the definition of BAV;The second part introduces the etiology and classification methods of BAV;The third part briefly describes the clinical manifestations and diagnosis of BAV;The fourth part discusses the treatment strategies and prognosis prediction of BAV;Finally, the article summarizes and looks forward to the future research directions.

关键词： Bicuspid Aortic Valve Congenital Heart Disease Aortic Valve Disease Transcatheter Aortic Valve Replacement

具p-Laplacian算子的Hadamard型分数阶微分方程边值问题的解

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数学的实践与认识 2025年第1期55卷 233-244页

作者：王书越胡卫敏胡芳芳伊犁师范大学数学与统计学院新疆伊宁835000 伊犁师范大学应用数学研究所新疆伊宁835000

主要运用Schauder不动点定理研究了一类具p-Laplacian算子的Hadamard型分数阶微分方程的边值问题,得到了解决这类问题解的存在性的充分条件,并给出实例加以验证,并且验证解满足稳定性条件.

关键词： Hadamard型分数阶微分方程 p-Laplacian算子 Arzela-Ascoli定理 Schauder不动点定理

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基于改进YOLOv7-Tiny的轻量化激光器芯片缺陷检测算法

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太原理工大学学报 2025年第1期56卷 137-147页

作者：胡玮赵菊敏李灯熬太原理工大学电子信息工程学院山西太原太原理工大学计算机科学与技术学院(大数据学院) 山西太原太原理工大学大数据融合分析与应用山西省重点实验室山西太原太原理工大学山西省智能感知工程研究中心山西太原

【目的】高功率半导体激光器的光学灾变损伤是限制其可靠性和寿命的主要因素,因此,有效的缺陷检测对于优化激光器芯片的制造工艺和结构设计至关重要。提出了一种基于改进YOLOv7-Tiny的轻量化激光器芯片缺陷检测算法,旨在解决深度学习应... 详细信息

【目的】高功率半导体激光器的光学灾变损伤是限制其可靠性和寿命的主要因素,因此,有效的缺陷检测对于优化激光器芯片的制造工艺和结构设计至关重要。提出了一种基于改进YOLOv7-Tiny的轻量化激光器芯片缺陷检测算法,旨在解决深度学习应用于缺陷检测时面临的高计算量和参数量问题。【方法】利用轻量化卷积神经网络替换特征提取主干有效减少对计算资源消耗,有效提取电致发光图像中缺陷特征。为从上下文特征获取更丰富的信息,引入多分支重参数化卷积块重构聚合模块,通过多路径分支丰富特征表示,训练与推理的解耦保证检测效率。此外,结合坐标注意力,提升定位精度。进行了剪枝实验和模型部署,验证算法的初步应用。【结果】在电致发光缺陷数据集上的实验结果显示,本文方法能在较低的参数和计算量下准确地检测出芯片缺陷,展现出良好的性能。

关键词：光学灾变损伤半导体激光器芯片缺陷检测轻量化模型剪枝

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基于IMU的FAST巡检定位系统研究

天文学报 2025年第1期66卷 94-103页

作者：胡玮于东俊孙京海中国科学院国家天文台北京100101 中国科学院大学北京100049

日常巡检是500m口径球面射电望远镜(Five-hundred-meter Aperture Spherical radio Telescope,FAST)运行和维护中的重要工作. FAST部件众多,巡检过程中存在工作量大、寻找部件费时费力的问题.实现巡检定位,可以引导维护人员快速到达故障... 详细信息

日常巡检是500m口径球面射电望远镜(Five-hundred-meter Aperture Spherical radio Telescope,FAST)运行和维护中的重要工作. FAST部件众多,巡检过程中存在工作量大、寻找部件费时费力的问题.实现巡检定位,可以引导维护人员快速到达故障点,对提高巡检效率,保障望远镜正常运行有重要意义.考虑到反射面对卫星信号存在遮挡,采用惯性导航的方式,基于双足脚绑IMU(Inertial Measurement Unit),设计了1套步行导航算法.算法沿用零速修正框架,融合双足信息,并结合磁场信息修正航向误差.在规则轨迹中测试了算法有效性,水平定位误差在行走距离的3%以内.在巡检现场的不规则轨迹中,结合沿途标志点,水平定位误差小于11 m,能够满足日常巡检定位的需要和支撑后续巡检定位系统的实用化.

关键词：望远镜:500 m口径球面射电望远镜技术:步行导航仪器:脚绑惯性测量单元方法:卡尔曼滤波

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High Accuracy Gene Signature for Chemosensitivity Prediction in Breast Cancer

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Tsinghua Science and Technology 2015年第5期20卷 530-536页

作者： wei hu Department of Computer Science Houghton College

Neoadjuvant chemotherapy for breast cancer patients with large tumor size is a necessary *** this treatment patients who achieve a pathologic Complete Response（p CR） usually have a favorable prognosis than those without. Therefore, p CR is now considered as the best prognosticator for patients with neoadjuvant chemotherapy. However, not all patients can benefit from this treatment. As a result, we need to find a way to predict what kind of patients can induce p CR. Various gene signatures of chemosensitivity in breast cancer have been identified, from which such predictors can be built. Nevertheless, many of them have their prediction accuracy around 80%. As such, identifying gene signatures that could be employed to build high accuracy predictors is a prerequisite for their clinical tests and applications. Furthermore, to elucidate the importance of each individual gene in a signature is another pressing need before such signature could be tested in clinical settings. In this study, Genetic Algorithm（GA） and Sparse Logistic Regression（SLR） along with t-test were employed to identify one signature. It had 28 probe sets selected by GA from the top 65 probe sets that were highly overexpressed between p CR and Residual Disease（RD） and was used to build an SLR predictor of p CR（SLR-28）. This predictor tested on a training set（n = 81） and validation set（n = 52） had very precise predictions measured by accuracy,specificity, sensitivity, positive predictive value, and negative predictive value with their corresponding P value all zero. Furthermore, this predictor discovered 12 important genes in the 28 probe set signature. Our findings also demonstrated that the most discriminative genes measured by SLR as a group selected by GA were not necessarily those with the smallest P values by t-test as individual genes, highlighting the ability of GA to capture the interacting genes in p CR prediction as multivariate techniques. Our gene signature produced superior per

关键词： genetic algorithm gene signature breast cancer sparse logistic regression predictor chemosensitivity