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Ten- year follow- up investigation of stroke risk in systemic lupus erythematosus

Stroke & Vascular Neurology 2024年第1期9卷 1-7页

作者： Jin-An Huang Ching-Heng Lin Ming-Ju Wu Yi-Hsing Chen Kuo-Cheng Chang Chung-wei hou Division of Neurology Neurological InstituteTaichung Veterans General HospitalTaichungTaiwanChina Department of Health Business Administration Hungkuang UniversityTaichungTaiwanChina Department of Medical Research Taichung Veterans General HospitalTaichungTaiwanChina Division of Nephrology Department of Internal MedicineTaichung Veterans General HospitalTaichungTaiwanChina School of Medicine Chung Shan Medical UniversityTaichungTaiwanChina College of Medicine Taiwan Chung Hsing UniversityTaichungTaiwanChina Division of Allergy Immunology and RheumatologyDepartment of Internal MedicineTaichung Veterans General HospitalTaichungTaiwanChina School of Medicine Taiwan Yang-Ming Chiao Tung UniversityTaichungTaiwanChina

Background and purpose To analyse the long-term risk of ischaemic stroke and the clinical effects of antithrombotics on the risk of haemorrhagic stroke in patients with systemic lupus erythematosus(SLE).Methods A retrospective cohort study was conducted using a population-based database taken from Taiwan region Health Insurance Research *** with SLE between 2000 and 2008 were registered and matched with two controls by the index date,age,gender and Charlson Comorbidity Index(CCI).These subjects were followed until either stroke event or 31 December *** HRs(aHRs)for strokes were estimated with Cox regression models,and the cumulative incidence of ischaemic stroke was analysed by log-rank test and Kaplan-Meier survival *** In total,8310 patients with SLE and 16620 patients without SLE were *** general,patients with SLE had higher rates of ischaemic stroke(5.4%vs 3.3%)and haemorrhagic stroke(1.5%vs 0.6%)than in *** multivariate analysis adjusted to age,gender,CCI,urbanisation level and antithrombotics uses,aHRs of all strokes,ischaemic stroke and haemorrhagic stroke were 1.73(95%CI:1.54 to 1.94),1.65(95%CI:1.45 to 1.87)and 2.24(95%CI:1.71 to 2.95),respectively,in patients with *** with SLE were significantly more likely to suffer ischaemic stroke than patients without SLE,even 10 years after SLE diagnosis(6.12%vs 3.50%,phould be carefully administered to prevent cardiovascular events in patients with SLE due to the risk of haemorrhagic stroke.

关键词： erythematosus diagnosis likely

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K_0超固结土的统一硬化模型

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岩土工程学报 2008年第3期30卷 316-322页

作者：姚仰平侯伟北京航空航天大学土木工程系北京100083

将所建立的超固结土模型推广为能够反映超固结土的初始应力各向异性的弹塑性模型。它是通过将潜在强度Mf、特征应力比M和状态应力比ηk引入到模型的统一硬化参数中,使模型具有预测超固结土的初始应力各向异性、剪缩、剪胀、硬化、软化... 详细信息

将所建立的超固结土模型推广为能够反映超固结土的初始应力各向异性的弹塑性模型。它是通过将潜在强度Mf、特征应力比M和状态应力比ηk引入到模型的统一硬化参数中,使模型具有预测超固结土的初始应力各向异性、剪缩、剪胀、硬化、软化和应力路径依赖性等基本特性的功能。采用SMP强度准则并结合变换应力方法对模型实现了三维化。通过与试验结果比较表明,提出的模型能够较好地描述初始应力各向异性超固结土的应力应变特性。

关键词：超固结土本构模型初始应力各向异性三维化

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Clinical features of multiple myeloma invasion of the central nervous system in Chinese patients

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Chinese Medical Journal 2010年第11期123卷 1402-1406页

作者： QU Xiao-yan FU wei-jun XI Hao Zhou Fan wei wei hou Jian Department of Hematology Changzheng Hospital Second Hospital Affiliated to the Second Military Medical University Shanghai 200003 China

Background Although neurologic manifestations often complicate the course of patients with multiple myeloma, direct central nervous system invasion is rare. This study explored the neurologic symptoms, signs, clinical features, therapy and prognosis of Chinese patients with central nervous system myeloma invasion. Methods The diagnosis, therapy and prognosis were analyzed retrospectively in 11 Chinese multiple myeloma patients with central nervous system infiltration from a total of 625 patients who have been treated at Changzheng Hospital （Shanghai, China） between January 1993 and May 2009. Survival curve was constructed with the use of Kaplan-Meier estimates. Results There were 11 patients with central nervous system involvement from 625 multiple myeloma patients. The occurrence rate was 1.8%. Ten of the 11 patients had other extramedullary diseases. Symptoms included cerebral symptoms, cranial nerve palsies, and spinal cord or spinal nerve roots symptoms. Cerebrospinal fluid was abnormal in 7 patients, usually exhibiting pleocytosis and elevated protein content, plus positive cytologic findings. Specific magnetic resonance imaging findings suggestive of central nervous system invasion were found in 9 patients. After a median follow-up of 19 months, 3 patients were alive. The median overall survival for all patients was 23 months, while the median overall survival for patients after central nervous system invasion was merely 6 months. Conclusions It is exceedingly rare for there to be central nervous system infiltration in multiple myeloma patients. When it occurs, the prognosis is extremely poor despite the use of aggressive local and systemic treatment including stem cell transplantation.

关键词： multiple myeloma central nervous system, clinical features therapy, prognosis

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统一硬化模型在复杂加载条件下的应用

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北京航空航天大学学报 2008年第9期34卷 1105-1108页

作者：侯伟姚仰平北京航空航天大学交通科学与工程学院北京100191

超固结土模型是能够描述土的剪缩、剪胀、硬化、软化和应力路径依赖性等特性的简单、实用的模型,与剑桥模型相比,仅增加了一个材料参数(Hvorslev面斜率).采用基于SMP(SpecialyMobilized Plane)强度准则的变换应力方法对模型实现了三维化... 详细信息

超固结土模型是能够描述土的剪缩、剪胀、硬化、软化和应力路径依赖性等特性的简单、实用的模型,与剑桥模型相比,仅增加了一个材料参数(Hvorslev面斜率).采用基于SMP(SpecialyMobilized Plane)强度准则的变换应力方法对模型实现了三维化.在模型中应用加卸载准则来反映复杂加载条件下土体的应力应变特性,模拟了随着循环次数的增加,土体会逐渐变硬,剪切模量逐渐增大、孔隙比减小、超固结程度不断增大等趋势.由循环加载以及真三轴试验数据和预测结果的基本吻合表明了模型能够合理地反映复杂加载条件下土的变形特性.

关键词：超固结土硬化模型三维化复杂加载

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土的基本力学特性及其弹塑性描述

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岩土力学 2009年第10期30卷 2881-2902页

作者：姚仰平侯伟北京航空航天大学交通科学与工程学院北京100191

Cam-clay模型是在等向加载试验基础上建立起来的且能够描述正常固结土在常规三轴试验条件下应力-应变关系的最简单弹塑性模型,是建立各种土的弹塑性本构模型的基础。文中分别按加载方式的不同和土组构的不同,对描述与应力状态、应力历... 详细信息

Cam-clay模型是在等向加载试验基础上建立起来的且能够描述正常固结土在常规三轴试验条件下应力-应变关系的最简单弹塑性模型,是建立各种土的弹塑性本构模型的基础。文中分别按加载方式的不同和土组构的不同,对描述与应力状态、应力历史、应力路径、持荷时间等因素有关的加载方式下土应力应变特性的弹塑性本构模型进行了归纳。对反映不同组构所形成的结构性、各向异性和颗粒破碎等特性的弹塑性本构模型进行了综述,并着重介绍了描述应力状态的三维化方法、反映应力历史影响的超固结土模型和模拟渐近状态路径的渐近状态模型等典型研究成果。

关键词：土加载方式组构应力应变特性弹塑性模型

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RAD51 potentiates synergistic effects of chemotherapy with PCI-24781 and cis-diamminedichloroplatinum on gastric cancer

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World Journal of Gastroenterology 2014年第29期20卷 10094-10107页

作者： wei-Ling He Yu-Huang Li wei-Jian hou Zun-Fu Ke Xin-Lin Chen Li-Ya Lu Shi-Rong Cai Wu Song Chang-Hua Zhang Yu-Long He Department of Gastrointestinal and Pancreatic Surgery The First Affiliated HospitalSun Yat-sen University Department of Molecular and Medical Genetics Oregon Health and Science University Otorhinolaryngology Hospital The First Affiliated HospitalSun Yat-Sen University Department of Pathology the First Affiliated HospitalSun Yat-sen University College of Fundamental Medical Science Guangzhou University of Chinese MedicineGuangzhou Higher Education Mega Center Public Health Institute of Health and WellbeingUniversity of Glasgow

AIM:To explore the efficacy of PCI-24781,a broadspectrum,hydroxamic acid-derived histone deacetylase inhibitor,in the treatment of gastric cancer(GC).METHODS:With or without treatment of PCI-24781and/or cis-diamminedichloroplatinum(CDDP),GC cell lines were subjected to functional analysis,including cell growth,apoptosis and clonogenic *** immunoprecipitation and luciferase reporter assays were used to determine the interacting molecules and the activity of the *** in vivo study was carried out in GC xenograft *** culture-based assays were represented as mean±*** tests were used to assess differences across *** pairwise comparisons between tumor weights among treatment groups were made using the Tukey-Kramer method for multiple comparison adjustment to control experimental-wise typeⅠ error *** was set at Pweight in vivo was obtained following PCI-24781 treatment,which synergized with the anticancer effect of ***:These data suggest that RAD51 potentiates the synergistic effects of chemotherapy with PCI-24781 and CDDP on GC.

关键词： Chemotherapy Combination Gastric cancer Histone deacetylase inhibitor Homologous recombination

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Relationships between endothelial nitric oxide synthase gene polymorphisms and osteoporosis in postmenopausal women

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第8期10卷 609-618页

作者： Shun-zhi LIU Hong YAN wei-kun hou Peng XU Juan TIAN Li-fang TIAN Bo-feng ZHU Jie MA She-min LU Department of Public Health School of Medicine Xi 'an Jiaotong University Xi 'an 710061 China Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education Xi 'an Jiaotong University Xi 'an 710061 China Department of Genetics and Molecular Biology School of Medicine Xi 'an Jiaotong University Xi 'an 710061 China Department of Bone and Joint Diseases of Xi 'an Red Cross Hospital Xi 'an 710054 China Department of Forensic Medicine School of Medicine Xi 'an Jiaotong University Xi'an 710061 China

Objective： To investigate the relationships between endothelial nitric oxide synthases （eNOS） G894T and 27 bpvariable number tandem repeat （VNTR） gene polymorphisms and osteoporosis in the postmenopausal women of Chinese Han nationality. Methods： In the present study, 281 postmenopausal women from Xi＇an urban area in West China were recruited, and divided into osteoporosis, osteopenia, and normal groups according to the diagnostic criteria of osteoporosis proposed by World Health Organization （WHO）. The bone mineral density （BMD） values of lumbar vertebrae and left hips were determined by QDR-2000 dual energy X-ray absorptiometry. Blood samples were tested for plasma biochemical indicators including testosterone, estradiol, calcitonin, osteocalcin, and procollagen type I amino-terminal propeptide by enzyme-linked immunosorbent assay （ELISA）, tartrate-resistant acid phosphatase by spectrophotometric method, and the content of nitric oxide by Griess method. Genome DNA was extracted from whole blood, and G894T polymorphism of eNOS gene was analyzed by using polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） method and 27 bp-VNTR polymorphism of eNOS gene was genotyped by PCR method. Then the relationships between genotypes and biochemical indicators, genotypes and osteoporosis, and haplotypes and osteoporosis were analyzed. Results： The average BMD values of the femoral neck, ward＇s triangle and lumbar vertebrae 1-4 （LI-L4） in the subjects with T/T genotype in eNOS G894T locus were significantly higher than those in the subjects with G/T and G/G genotypes （P〈0.05）. The average BMD of the femoral neck in the subjects with a/a genotype of eNOS 27 bp-VNTR locus was evidently higher than that in the subjects with b/b genotype （P〈0.05）. The plasma testosterone and osteocalcin concentrations in the subjects of eNOS G894T G/T genotype were evidently higher than those in the subjects of other genotypes （P〈0.05）; the plasma estradiol concentration in

关键词： Postmenopausal women Osteoporosis Endothelial nitric oxide synthase Gene polymorphisms Bone mineral density

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液氮快速冷冻对地龙中水溶性蛋白组成和活性的影响

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中草药 2007年第7期38卷 999-1003页

作者：王厚伟山东中医药大学药学院山东济南250014

目的探讨低温炮制工艺对地龙水溶性蛋白质组成以及溶栓与抗肿瘤活性的影响。方法地龙的炮制采用传统与低温两种工艺,低温炮制采用液氮快速冷冻与冷冻干燥技术;采用SDS-PAGE与ImageTool软件,对两种炮制工艺的地龙蛋白质组成的差异进行定... 详细信息

目的探讨低温炮制工艺对地龙水溶性蛋白质组成以及溶栓与抗肿瘤活性的影响。方法地龙的炮制采用传统与低温两种工艺,低温炮制采用液氮快速冷冻与冷冻干燥技术;采用SDS-PAGE与ImageTool软件,对两种炮制工艺的地龙蛋白质组成的差异进行定性与定量分析;应用纤维蛋白平板法与体外溶栓试验,定性与定量分析两种炮制工艺的纤溶活性的差异;应用显微观察与MTT法,对两种炮制工艺体外抑制人肝癌细胞增殖活性进行定性与定量比较分析。结果低温炮制工艺地龙的水溶性蛋白组成比传统炮制工艺丰富,SDS-PAGE的蛋白条带数与浓度明显高于传统工艺;两种炮制工艺的地龙蛋白液均具有显著的抗人肝癌细胞与纤溶活性,但低温炮制工艺的两种活性显著高于传统工艺。结论不同炮制工艺对地龙水溶性蛋白组成及其抗肿瘤与溶栓活性有显著影响;在保全地龙的蛋白质类药效成分的生物活性方面,低温炮制工艺优于传统炮制工艺。

关键词：地龙炮制SDS-PAGE 纤溶活性抗肿瘤活性

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斑点免疫印迹法快速测定4品种家蚕蛾下颚溶茧酶含量

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中药材 2008年第11期31卷 1619-1621页

作者：王厚伟山东中医药大学药学院山东济南250355

目的:测定4品种家蚕蛾下颚溶茧酶含量,并建立斑点免疫印迹法在中药材药效成分含量的测定方法。方法:以兔抗溶茧酶多抗为一抗,应用斑点免疫印迹法对4品种家蚕蛾下颚溶茧酶含量作定性检测,杂交信号应用Quantity one软件作定量分析。结果:... 详细信息

目的:测定4品种家蚕蛾下颚溶茧酶含量,并建立斑点免疫印迹法在中药材药效成分含量的测定方法。方法:以兔抗溶茧酶多抗为一抗,应用斑点免疫印迹法对4品种家蚕蛾下颚溶茧酶含量作定性检测,杂交信号应用Quantity one软件作定量分析。结果:4品种家蚕蛾下颚的个体溶茧酶平均含量分别为6.41、8.09、7.62、1.88μg/头。结论:不同品种家蚕蛾间下颚溶茧酶含量差异显著。斑点免疫印迹法简便快捷,结果准确,无需大型设备,可用于类似中药材药效物质的含量测定与品质评价。

关键词：家蚕蛾溶茧酶斑点印迹

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斑点免疫印迹法快速测定地龙炮制品中蚓激酶及其水解产物

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中草药 2008年第11期39卷 1652-1655页

作者：王厚伟山东中医药大学药学院山东济南250355

目的测定参环毛蚓、秉氏环毛蚓、日本杜拉蚓和天锡杜拉蚓炮制品中蚓激酶及其水解产物,建立斑点免疫印迹法评价相应生药材药效成分明确的中药炮制品质量新方法。方法以兔抗蚓激酶单抗为一抗,应用斑点免疫印迹法对地龙炮制品中蚓激酶及其... 详细信息

目的测定参环毛蚓、秉氏环毛蚓、日本杜拉蚓和天锡杜拉蚓炮制品中蚓激酶及其水解产物,建立斑点免疫印迹法评价相应生药材药效成分明确的中药炮制品质量新方法。方法以兔抗蚓激酶单抗为一抗,应用斑点免疫印迹法对地龙炮制品中蚓激酶及其水解产物作定性检测,杂交信号应用Quantity One软件作定量分析。结果现行中药材参环毛蚓与山东产地方品种:秉氏环毛蚓、日本杜拉蚓、天锡杜拉蚓炮制品中蚓激酶及其水解产物的质量分数分别为125.23、118.34、81.05、72.13μg/g。结论秉氏环毛蚓炮制品中蚓激酶及其水解产物与现行地龙炮制品参环毛蚓无显著差异,理论上可作为广地龙的替代品。斑点免疫印迹法简便快捷,结果准确,无需大型设备,可用于地龙与类似中药材炮制品的品质评价。

关键词：地龙斑点印迹蚓激酶

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