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Spatio-temporal evolution of pore and fracture structures in coal induced by initial damage and creep behavior:A real-time NMR-based approach

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International Journal of Mining Science and Technology 2024年第10期34卷 1409-1425页

作者： Lei Zhang Yimeng Wang Mingzhong Gao Wenhao Jia Senlin Xie wei hou Xiangyu Wang Hao Zhang College of Safety&Emergency Management Engineering Taiyuan University of TechnologyTaiyuan 030024China School of Energy and Mining Engineering China University of Mining and Technology-BeijingBeijing 100083China State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering Shenzhen UniversityShenzhen 518060China School of Mechanics and Civil Engineering China University of Mining and Technology-BeijingBeijing 100083China School of Applied Science Taiyuan University of Science and TechnologyTaiyuan 030024China

Understanding the impact of mining disturbances and creep deformation on the macroscopic deformation and the microscopic pore and fracture structures(MPFS)of coal is paramount for ensuring the secure extraction of coal *** study conducts cyclic loading-unloading and creep experiments on coal using a low-field nuclear magnetic resonance(NMR)experimental apparatus which is equipped with mechanical loading units,enabling real-time monitoring the *** experiments indicated that cyclic loading-unloading stress paths initiate internal damage within coal *** identical creep stress conditions,coal samples with more initial damages had more substantial instantaneous deformation and creep deformation during the creep *** undergoing nearly 35 h of staged creep,the total strains for coal samples CC01,CC02,and CC03 reach 2.160%,2.261%,and 2.282%,*** the creep stage,the peak area ratio of seepage pores and microfractures(SPM)gradually diminishes.A higher degree of initial damage leads to a more pronounced compaction trend in the SPM of coal *** the porosity evolution of SPM during the creep process,this study proposes a novel fractional derivative model for the porosity evolution of *** efficacy of the proposed model in predicting porosity evolution of SPM is substantiated through experimental ***,an analysis of the impact mechanisms on key parameters in the model was carried out.

关键词： Coal Microscopic pore and fracture structures Initial damage Creep behavior Fractional porosity model of seepage pores and microfractures Nuclear magnetic resonance

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Association of Serotonin Receptors with Attention Deficit Hyperactivity Disorder： A Systematic Review and Meta-analysis

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Current Medical Science 2018年第3期38卷 538-551页

作者： Yu-wei hou Ping XIONG Xue GU Xin HUANG Min WANG Jing WU Key Laboratory of Environment and Health Ministry of Education & Department of Epidemiology and Biostatistics School of Public Health Tongii Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Rehabilitation Wuhan Children's Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430015 China

Attention deficit hyperactivity disorder （ADHD） is one of the most common mental disorders in childhood, with a high heritability about 60% to 90%. Serotonin is a monoamine neurotransmitter. Numerous studies have reported the association between the serotonin receptor family （5-HTR） gene polymorphisms and ADHD, but the results are still controversial. In this study, we conducted a meta-analysis of the association between 5-HTRIB, 5-HTR2A, and 5-HTR2C genetic variants and ADHD. The results showed that the 861G allele of 5-HTRIB SNP rs6296 could significantly increase the risk of ADHD （OR= 1.09, 95% CI： 1.01-1.18）; the 5-HTR2C gene rs518147 （OR=1.69, 95% CI： 1.38-2.07） and rs3813929 （OR = 1.57, 95% CI： 1.25-1.97） were all associated with the risk of ADHD. In addition, we also carried on a case- control study to explore the relevance between potential candidate genes 5-HTR1A, 5-HTRIE, 5-HTR3A and ADHD. The results indicated that 5-HTRIA rs6295 genotype （CC＋CG vs. GG OR=Z00, 95% CI： 1.23-3.27） and allele （OR=1.77, 95% CI： 1.16-2.72） models were statistically significantly different between case group and control group. This study is the first comprehensive exploration and summary of the association between serotonin receptor family genetic variations and ADHD, and it also provides more evidence for the etiology of ADHD.

关键词： attention deficit hyperactivity disorder serotonin receptor genetic variations meta-analysis association study

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Synthesis and characterization of high density and high aspect ratio Ag_2S nanoparticle nanowires from a paired cell method

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Chinese Science Bulletin 2011年第17期56卷 1828-1831页

作者： LI XiaoNing YANG XiuChun HAN ShanShan LU wei hou Junwei LIU Yan School of Materials Science and Engineering Tongji University Shanghai 200092 China

Ag_2S nanoparticle nanowires were prepared in a porous anodic aluminum oxide template by a simple paired cell method,and were characterized by XRD,FESEM,HRTEM and *** results showed that the as-prepared nanowires were composed of monoclinic Ag_2S *** nanowire diameters ranged from 165 to 270 nm,and Ag_2S nanoparticles were nearly spherical with diameters of 40 to 60 *** paired cell method is simple,low cost and easy to control for the fabrication of high density and high aspect ratio Ag_2S nanoparticle nanowires.A formation mechanism for the nanoparticle nanowires was suggested.

关键词：纳米粒子纳米线高宽比高密度细胞配对多孔阳极氧化铝 Ag2S

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State of China’s climate in 2021

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Atmospheric and Oceanic Science Letters 2022年第4期15卷 52-57页

作者： wei Li Shanshan Zhao Yu Chen Ling Wang wei hou Yundi Jiang Xukai Zou Shuai Shi National Climate Center China Meteorological AdministrationBeijingChina Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjingChina

This report is a summary of China’s climate,as well as major weather and climate events,during *** 2021,the mean temperature in China was 10.5°C,which was 1.0°C above normal(1981–2010 average)and broke the highest record since *** annual rainfall in China was 672.1 mm,which was 6.7%above ***,the annual rainfall in northern China was 40.2%above normal,which ranked second highest since *** rainstorm intensity in the rainy season was strong and featured significant extremes,and disasters caused by rainstorms and flooding were more serious than the average in the past *** particular,the extremely strong rainstorm in Henan during July and autumn caused flooding in the middle and lower reaches of the Yellow River with severe *** occurred more frequently than normal,and their durations in southern China were longer than normal in summer and *** drought was obvious,and caused serious impacts in South *** number of generated and landfalling typhoons was lower than normal;however,Typhoon In-fa broke the record for the longest overland duration,held since 1949,and affected a wide *** convective weather and extreme windy weather occurred frequently,causing serious *** number of cold waves was more than normal,which caused wide-ranging extremely low temperatures in many *** appeared earlier than normal in 2021,and the number of strong dust storm processes was more than normal.

关键词： Climate state Meteorological disasters Rainstorm Convective weather events 2021

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A novel homozygous intronic variant affecting splicing in the RYR1 gene contributes to fetal hydrops

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Genes & Diseases 2024年第6期11卷 107-110页

作者： wei hou Guifang Huang Hongyu wei Wenwei Li houfeng Huang Yuling Qiu Hengying Zhu Huifeng Han Ping Chen Xue Zhang Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Developmentand Application Coconstructed by the Province and Ministry Guangxi Medical UniversityNanningGuangxi 530021China NHC Key Laboratory of Thalassemia Medicine NanningGuangxi 530021China Guangxi Key Laboratory of Thalassemia Research Life Sciences InstituteGuangxi Medical UniversityNanningGuangxi 530021China Department of Eugenic Genetics Baise Maternal and Child Health HospitalBaiseGuangxi 533000China Department of Organic Chemistry and Medicinal Chemistry Pharmaceutical CollegeGuangxi Medical UniversityNanningGuangxi 530021China Department of Ultrasound Imaging Baise Maternal and Child Health HospitalBaiseGuangxi 533000China Department of Bioinformatics Berry Genomics Co.Ltd.Beijing 102206China McKusick-Zhang Center for Genetic Medicine Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100730China

Fetal hydrops is a rare but serious fetal developmental abnormality characterized by the abnormal accumulation of large amounts of fluid in the fetus resulting in generalized edema,and clinically manifested by abnormal functioning of multiple organs and systems.1 The ryanodine receptor 1(RYR1)gene encodes the ryanodine receptor found in skeletal muscle and is expressed predominantly in cardiac and skeletal muscle.

关键词： fetal organs fetus

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Coupling mechanism of THM fields and SLG phases during the gas extraction process and its application in numerical analysis of gas occurrence regularity and effective extraction radius

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Petroleum Science 2022年第3期19卷 990-1006页

作者： Hui-Huang Fang Chun-Shan Zheng Ning Qi Hong-Jie Xu Hui-Hu Liu Yan-Hui Huang Qiang wei Xiao-wei hou Lei Li Shuai-Liang Song State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainanAnhui 232001China Institute of Energy Hefei Comprehensive National Science CenterHefeiAnhui 230000China School of Earth and Environment Anhui University of Science and TechnologyHuainanAnhui 232001China Great Institute of Standardization China National Institute of Standardization's High Quality and Green Development Innovation R&D BaseJinanShandong 250101China State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China School of Resources and Civil Engineering Suzhou UniversitySuzhouJiangsu 234000China School of Resources and Environmental Engineering Hefei University of TechnologyHefeiAnhui 230009China The Third Exploration Team of Shandong Coalfield Geologic Bureau TaianShandong 250102China Shandong Provincial Lunan Geo-engineering Exploration Instituts JiningShandong 272100China

The analysis of the coupling mechanism of thermal-hydraulic-mechanical(THM)fields,and solid-liquidgas(SLG)phases during gas extraction process is of profound significance to explore its numerical application in the gas occurrence regularity and its effective extraction *** this study,the Hudi coal mine in Qinshui basin is taken as the research area,the influencing factors of gas occurrence were analyzed,the differences in overburden load for gas pressure distribution and the factors influencing the effective extraction radius were further discussed by using the COMSOL *** results show that the derivation of mathematical model in gas extraction shows that the process is a process the THM fields restrict each other,and the SLG phases influence each *** longer the extraction time,the larger the influencing range of borehole,and the better the extraction *** larger the diameter of borehole,the larger the effective extraction radius,and the influence on gas extraction effect is smaller in the early stage and larger in the late *** borehole arrangement should be flexibly arranged according to the actual extraction *** higher the porosity,the higher the permeability,the better the gas extraction *** larger the overburden load of reservoir,the stronger the effective stress,which will result in the more severe the strain,and the closure of pore and fracture,which in turn will lead to the decrease of permeability and slow down the gas *** relationship among extraction time,borehole diameter,negative pressure of gas extraction,permeability with effective extraction radius is *** study has important theoretical and practical significance for clarifying and summarizing the gas occurrence regularity and its engineering practice.

关键词： Gas occurrence regularity Effective extraction radius THM fields and SLG phases Numerical simulation COMSOL Multiphysics Hudi coal mine

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Interaction between catechol-O-methyltransferase Val/Met polymorphism and cognitive reserve for negative symptoms in schizophrenia

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World Journal of Psychiatry 2024年第5期14卷 695-703页

作者： Wen-Peng hou Xiang-Qin Qin wei-wei hou Yun-Yi Han Qi-Jing Bo Fang Dong Fu-Chun Zhou Xian-Bin Li Chuan-Yue Wang Beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders&National Center for Mental DisordersBeijing Anding HospitalCapital Medical UniversityBeijing 100088China Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 100069China

BACKGROUND Cognitive reserve(CR)and the catechol-O-methyltransferase(COMT)Val/Met polymorphism are reportedly linked to negative symptoms in ***,the regulatory effect of the COMT genotype on the relationship between CR and negative symptoms is still *** To investigate whether the relationship between CR and negative symptoms could be regulated by the COMT Val/Met *** In a cross-sectional study,54 clinically stable patients with schizophrenia underwent assessments for the COMT genotype,CR,and negative *** was estimated using scores in the information and similarities subtests of a short form of the Chinese version of the Wechsler Adult Intelligence *** COMT Met-carriers exhibited fewer negative symptoms than Val *** the total sample,significant negative correlations were found between negative symptoms and information,*** between information,similarities and negative symptoms were observed in Val homozygotes only,with information and similarities showing interaction effects with the COMT genotype in relation to negative symptoms(information,β=-0.282,95%CI:-0.552 to-0.011,P=0.042;similarities,β=-0.250,95%CI:-0.495 to-0.004,P=0.046).CONCLUSION This study provides initial evidence that the association between negative symptoms and CR is under the regulation of the COMT genotype in schizophrenia.

关键词： Catechol-O-methyltransferase Val/Met polymorphism Cognitive reserve Crystallized intelligence Negative symptoms Schizophrenia

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Traceless photodegradable polymer cocoons for universal protein delivery and light-controlled gene editing

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Science China Chemistry 2024年第2期67卷 664-676页

作者： Huaibin Yu Meron Tsegay Kifle Lili Chen Feihong Xiong Yan Zhang Shangbang Gao wei hou Shuliang Chen weining Zhao Yuzhou Wu Hubei Engineering Research Center for Biomaterials and Medical Protective Materials Hubei Key Laboratory of Bioinorganic Chemistry&Materia MedicaKey Laboratory of Material Chemistry for Energy Conversion and StorageMinistry of EducationSchool of Chemistry and Chemical EngineeringHuazhong University of Science and Technology(HUST)Wuhan430074China Zhengzhou Research Institute Harbin Institute of TechnologyZhengzhou450000China College of Life Science and Technology Huazhong University of Science and Technology(HUST)Wuhan430074China Institute of Medical Virology School of Basic Medical SciencesWuhan UniversityWuhan430071China College of Pharmacy Shenzhen Technology UniversityShenzhen518118China

Polymer conjugation was found highly valuable in clinic to improve the bioavailability of protein ***,it is still a tremendous challenge to achieve a complete release of original proteins from the conjugated hybrid under external stimulus to recover active proteins in the targeted ***,we report a general light-controlled protein delivery methodology by weaving a photodegradable polymer cocoon around proteins,which could reliably protect them from degradation in the dark while efficiently releasing them under illumination without any residual *** surface charge of the polymer shell is easily tunable to facilitate efficient cell *** versatility of this strategy is demonstrated by the delivery of the Cas9/sg RNA complex that realized light-controlled gene editing both in vitro and in vivo,and such repertoire is of particular value in regard to minimizing the off-target toxicity of CRISPR-Cas9-based gene therapy.

关键词： photodegradable polymer-protein conjugate protein delivery light control gene editing

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Design and Investigation of a High-Sensitivity Tilt Sensor Based on FBG

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Photonic Sensors 2023年第2期13卷 45-55页

作者： Jianjun PAN Liangying WANG wei hou Hanyang Lv National Engineering Research Center of Fiber Optic Sensing Technology and Networks Wuhan University of TechnologyWuhan 430070China School of Mechanical and Electronic Engineering Wuhan University of TechnologyWuhan 430070China School of Information Engineering Wuhan University of TechnologyWuhan 430070China

In this paper,a high-sensitivity fiber Bragg grating(FBG)tilt sensor using a cantilever-based structure is *** FBGs are fixed on a specially designed *** end of the elastomer is connected to the mass block,and the other end is connected to the *** principle of the tilt sensor is introduced in detail,and the mathematical model is *** performance of the sensor is *** results show that there is a good linear relationship between the central wavelength difference of the two FBGs and the tilt angle in the range of-5°to 5°.The repeatability of the sensor is good,and the tilt sensitivity can reach 231.7 pm/°.The influence of the silicone oil on the damping capacity of the sensor is *** results show that the damping capacity of the sensor has been improved by sealing the silicone oil inside the shell of the *** field test is carried out on a pier of an elevated bridge,and the result is good,which verifies the practicability of the sensor.

关键词： Tilt sensor FBG temperature self-compensation silicon oil vibration damping

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Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1357-1368页

作者： Miao-Miao Zhao wei-Li Yang Fang-Yuan Yang Li Zhang wei-Jin Huang wei hou Chang-Fa Fan Rong-Hua Jin Ying-Mei Feng You-Chun Wang Jin-Kui Yang Department of Endocrinology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Division of HIV/AIDS and Sex-Transmitted Virus Vaccines Institute for Biological Product ControlNational Institutes for Food and Drug Control(NIFDC)BeijingChina Department of Science and Technology Beijing Youan HospitalCapital Medical UniversityBeijingChina Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug ControlBeijingChina

To discover new drugs to combat COVID-19,an understanding of the molecular basis of SARS-CoV-2 infection is urgently ***,for the first time,we report the crucial role of cathepsin L(CTSL)in patients with *** circulating level of CTSL was elevated after SARS-CoV-2 infection and was positively correlated with disease course and ***,SARS-CoV-2 pseudovirus infection increased CTSL expression in human cells in vitro and human ACE2 transgenic mice in vivo,while CTSL overexpression,in turn,enhanced pseudovirus infection in human *** functionally cleaved the SARS-CoV-2 spike protein and enhanced virus entry,as evidenced by CTSL overexpression and knockdown in vitro and application of CTSL inhibitor drugs in ***,amantadine,a licensed anti-influenza drug,significantly inhibited CTSL activity after SARS-CoV-2 pseudovirus infection and prevented infection both in vitro and in ***,CTSL is a promising target for new anti-COVID-19 drug development.

关键词： infection drugs ACE2

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