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Workplace Wellness,Mental Health Literacy,and Usage Intention of E-Mental Health amongst Digital Workers during the COVID-19

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International Journal of Mental Health Promotion 2023年第1期25卷 99-126页

作者： Choon-Hong Tan Ah-Choo Koo Hawa Rahmat wei-fern siew Alexius Weng-Onn Cheang Elyna Amir Sharji Faculty of Creative Multimedia Multimedia UniversityCyberjaya63000Malaysia Faculty of Applied Communication Multimedia UniversityCyberjaya63000Malaysia International Medical University(IMU) Bukit Jalil57000Malaysia

The prevalence of mental health problems in both Malaysian and global workplaces has signiﬁcantly increased due to the presence of the coronavirus disease(COVID-19)pandemic,globalization,technology advancement in Industry 4.0,and other contributing *** pervasiveness of the issue poses a huge challenge to improving the occupational safety and health(OSH)of workers in various industries,especially in the digital *** emergence of the innovative industry is evident mainly due to the rapid development of Industry 4.0 and the rele-vant demands of multiple businesses in the digital ***,limited studies and academic dis-cussions were conducted on the OSH topic of digital ***,the current study serves toﬁll the existing gap and provide academic contributions by scrutinising the perceptions of digital workers regarding their work-place well-being,mental health literacy,and the impression of employing e-mental *** objectives of this study are:1)To examine the mental health literacy and workplace wellness of digital workers,2)to explore the e-mental health usage intention and actual e-mental health utilization,and 3)to identify digital workers’feedback on e-mental *** the current context,e-mental health focuses on three dimensions,namely,1)“health in our hand(HIOH)”,2)“interacting for health(IFH)”,and 3)“data enabling health(DEH)”.The present study employed an online cross-sectional survey and received 326 digital workers’completed ***,such as“mental health literacy(MHL)”,“workplace wellness(WW)”,and e-mental health intention and usage were explicated by analysing the data through descriptive *** study results indicated a moderate to a high level of the MHL and the *** than half of the workers possessed a high intention level to employ e-mental health,with the HIOH dimension being the most prevalent ***,the actual e-mental health usage was very low,owing to the online r

关键词： E-mental health intention digital workers digital industry workplace wellness mental health literacy

Fabrication of graphene oxide decorated with poly(dimethyl amino ethyl methacrylate) brush for efficient Cr(Ⅵ) adsorption from aqueous solution

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Chinese Journal of Chemical Engineering 2024年第9期73卷 51-61页

作者： Alireza Nouri siew Fen Chua Ebrahim Mahmoudi Abdul Wahab Mohammad wei Lun Ang Department of Chemical and Process Engineering Faculty of Engineering and Built EnvironmentUniversiti Kebangsaan MalaysiaBangi 43600Malaysia Centre for Sustainable Process Technology(CESPRO) Faculty of Engineering and Built EnvironmentUniversiti Kebangsaan MalaysiaBangi 43600Malaysia Chemical and Water Desalination Engineering Program College of EngineeringUniversity of SharjahSharjah 27272United Arab Emirates

Confronting the severe health threats and environmental impacts of Cr(Ⅵ) in aquatic environments demands innovative and effective remediation approaches. In this study, Graphene oxide(GO)-decorated poly(dimethyl amino ethyl methacrylate)(PDMAEMA) brush nanocomposites(GOP1, GOP2, GOP3, and GOP4) were fabricated using atom transfer radical polymerization(ATRP) by the “graft from” *** resulting nanocomposites were utilized for removing Cr(Ⅵ) with good adsorption performance due to the electrostatic interaction of protonated nitrogen groups in the brush chains with negatively charged particles in the solution. The kinetic model of pseudo-second-order best represented the contaminants' adsorption characteristics. The Weber-Morris model further indicated that surface adsorption and intraparticle diffusion mechanisms primarily controlled the adsorption procedure. Additionally, the Langmuir and Temkin isotherm models were found to most accurately represent the adsorption characteristics of the pollutants on the nanocomposites, and GOP4 can achieve the maximum adsorption capacity of 164.4 mg·g^(-1). The adsorbents' capacity maintains above 85% after five cycles of adsorption-desorption. The nanocomposites in this study demonstrate promising potential for eliminating Cr(Ⅵ) from aqueous solutions.

关键词： Graphene oxide PDMAEMA brush Polymerization Nanoparticles Adsorption Chromium

The Strategies of Pathogen-Oriented Therapy on Circumventing Antimicrobial Resistance

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Research 2020年第1期2020卷 238-269页

作者： Zifang Shang siew Yin Chan Qing Song Peng Li wei Huang Frontiers Science Center for Flexible Electronics(FSCFE) Xi’an Institute of Flexible Electronics(IFE)&Xi’an Institute of Biomedical Materials and Engineering(IBME)Northwestern Polytechnical University(NPU)Xi’an 710072China Key Laboratory for Organic Electronics and Information Displays(KLOEID)and Institute of Advanced Materials(IAM) Nanjing University of Posts and Telecommunications(NUPT)Nanjing 210023China Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing Tech University(NanjingTech)Nanjing 211816China

The emerging antimicrobial resistance(AMR)poses serious threats to the global public *** antibiotics have been eclipsed in combating with drug-resistant ***,the developing and deploying of novel antimicrobial drugs have trudged,as few new antibiotics are being developed over time and even fewer of them can hit the *** therapeutic strategies to resolve the AMR crisis are urgently ***-oriented therapy(POT)springs up as a promising approach in circumventing antibiotic *** tactic underling POT is applying antibacterial compounds or materials directly to infected regions to treat specific bacteria species or strains with goals of improving the drug efficacy and reducing nontargeting and the development of drug *** review exemplifies recent trends in the development of POTs for circumventing AMR,including the adoption of antibiotic-antibiotic conjugates,antimicrobial peptides,therapeutic monoclonal antibodies,nanotechnologies,CRISPR-Cas systems,and microbiota *** these alternative approaches alone or in combination shows promising advantages for addressing the growing clinical embarrassment of antibiotics in fighting drug-resistant bacteria.

关键词： drugs fighting alone

Transparent flexible thin-film p-n junction thermoelectric module

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npj Flexible Electronics 2020年第1期4卷 169-177页

作者： Xizu Wang Ady Suwardi siew Lay Lim Fengxia wei Jianwei Xu Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)#08-03Fusionopolis WayInnovisSingapore138634Singapore Department of Chemistry National University of Singapore3 Science Drive 3Singapore117543Singapore

Transparent and flexible thermoelectrics has been highly sought after for future wearable ***,the main stumbling block to prevent its widespread adoption is the lack of p-type transparent thermoelectrics and the stringent criteria of electrical and thermal properties matching appropriately between p-legs and *** work demonstrates the fabrication of p-type PEDOT:PSS films whose optical properties,electrical conductivity,thermal conductivity,and Seebeck coefficient were engineered to perfectly match the n-type indium tin oxide(ITO)*** dense p-type PEDOT:PSS and n-type ITO thin films show a thermoelectric figure of merit of zT=0.30 and 0.29 at 450 K,and a thermal conductivity of 0.22 and 0.32 W m^(−1) K^(−1),respectively.A flexible thermoelectric generator(TEG)module with a high transmittance of>81%in the visible wavelength range of 400-800 nm is fabricated using 10 pairs of p-type PEDOT:PSS and n-type ITO thin film *** ultra-high power density of 22.2 W m^(−2) at a temperature gradient of 80 K was observed,which is the highest power density reported for organic/hybrid-based flexible TEGs so *** transparent flexible thin-film p-n junction thermoelectric module with exceptionally high power generation may take a tremendous step forward towards multi-functional wearable devices.

关键词： film transparent exceptional

Epigallocatechin-3-gallate exerts antihypertensive effects and improves endothelial function in spontaneously hypertensive rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第7期13卷 287-295页

作者： Yucinda YY Khor siew-Keah Lee Dharmani Devi M wei Chih Ling Department of Pre-clinical Sciences M.Kandiah Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanSelangorMalaysia Department of Pharmacology Faculty of MedicineUniversiti MalayaKuala LumpurMalaysia

Objective:To investigate the effect of epigallocatechin-3-gallate(EGCG)on endothelial dysfunction in spontaneously hypertensive rats(SHR).Methods:Wistar-Kyoto(WKY)rats and SHR were divided into four groups;WKY control,SHR control and SHR treated with EGCG(50 mg/kg/day)or losartan(10 mg/kg/day).The treatment was given daily for 4 weeks by oral gavage and the blood pressure was monitored by tail-cuff method every 3 *** endothelium-dependent relaxations were assessed in isolated phenylephrine-precontracted aortic rings at the end of *** vascular levels of reactive oxygen species,nitric oxide,tetrahydrobiopterin,and cyclic guanosine monophosphate were also ***,the expression of angiotensinⅡtype 1(AT_(1))receptor protein was ***:The systolic blood pressure was significantly decreased in SHR treated with *** impaired endothelium-dependent relaxation was significantly improved in aortic ring isolated from the EGCG-treated SHR *** also significantly increased the levels of nitric oxide,tetrahydrobiopterin,and cyclic guanosine monophosphate,while decreasing the level of reactive oxygen species and the protein expression of AT_(1)receptor in ***:EGCG attenuates endothelial dysfunction in SHR by decreasing oxidative stress and increasing vascular nitric oxide bioavailability,which may be modulated partly by inhibition of vascular AT_(1)*** increase in endothelium-dependent relaxation may contribute to a decrease in blood pressure in hypertensive animals.

关键词： Epigallocatechin-3-gallate Vascular protection Antihypertension Tetrahydrobiopterin Cyclic guanosine monophosphate Angiotensin typeⅠreceptor Spontaneously hypertensive rats

Bioenergetic alteration in gastrointestinal cancers:The good,the bad and the ugly

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World Journal of Gastroenterology 2023年第29期29卷 4499-4527页

作者： Yu-De Chu Chun-wei Chen Ming-wei Lai siew-Na Lim Wey-Ran Lin Liver Research Center Linkou Chang Gung Memorial HospitalTaoyuan 333TaiwanChina Department of Gastroenterology and Hepatology Linkou Chang Gung Memorial HospitalTaoyuan 333TaiwanChina Department of Pediatrics Linkou Chang Gung Memorial HospitalTaoyuan 333TaiwanChina Department of Neurology Linkou Chang Gung Memorial HospitalTaoyuan 333TaiwanChina Department of Medicine Chang Gung UniversityTaoyuan 333TaiwanChina

Cancer cells exhibit metabolic reprogramming and bioenergetic alteration,utilizing glucose fermentation for energy production,known as the Warburg ***,there are a lack of comprehensive reviews summarizing the metabolic reprogramming,bioenergetic alteration,and their oncogenetic links in gastrointestinal(GI)***,the efficacy and treatment potential of emerging anticancer drugs targeting these alterations in GI cancers require further *** review highlights the interplay between aerobic glycolysis,the tricarboxylic acid(TCA)cycle,and oxidative phosphorylation(OXPHOS)in cancer cells,as well as hypotheses on the molecular mechanisms that trigger this *** role of hypoxia-inducible transcription factors,tumor suppressors,and the oncogenetic link between hypoxia-related enzymes,bioenergetic changes,and GI cancer are also *** review emphasizes the potential of targeting bioenergetic regulators for anti-cancer therapy,particularly for GI *** the potential of targeting bioenergetic regulators for GI cancer therapy,the review categorizes these regulators into aerobic glycolysis/lactate biosynthesis/transportation and TCA cycle/coupled *** also detail various anti-cancer drugs and strategies that have produced pre-clinical and/or clinical evidence in treating GI cancers,as well as the challenges posed by these *** we highlight that understanding dysregulated cancer cell bioenergetics is critical for effective treatments,although the diverse metabolic patterns present challenges for targeted *** research is needed to comprehend the specific mechanisms of inhibiting bioenergetic enzymes,address side effects,and leverage high-throughput multi-omics and spatial omics to gain insights into cancer cell heterogeneity for targeted bioenergetic therapies.

关键词： Energy metabolism Mitochondria Hypoxia Oxidative phosphorylation Glycolysis Gastrointestinal neoplasms

Additive manufacturing of high-entropy alloys by thermophysical calculations and in situ alloying

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Journal of Materials Science & Technology 2021年第35期94卷 53-66页

作者： Mehmet Cagirici Pan Wang fern Lan Ng Mui Ling Sharon Nai Jun Ding Jun wei Singapore Institute of Manufacturing Technology 73 Nanyang Drive637662Singapore Department of Materials Science and Engineering National University of Singapore117576Singapore

Electron beam melting(EBM)is a promising technology to manufacture various alloys with outstanding properties;however,the number of available alloys is *** propose in situ alloying to accelerate the development of advanced and novel alloys,based on thermophysical calculations and CALPHAD approach,during the EBM *** demonstrate our concept through the design and fabrication of high entropy alloys(HEAs).Three CoCrFeNiMn-xTi(x=0.18,0.50,2.00,in molar%)HEAs are ***-built HEAs achieve a homogeneous distribution of elements while forming multiphase alloys resulted from the hot powder *** topological structures formed by secondary phases contribute to an increase in the hardness of EBM-built HEAs up to 900 *** alloy design,a systematic analysis on Co Cr Fe Ni Mn-0.18 Ti HEA elucidates the microstructural evolution in *** findings provide a deep understanding of in situ alloying and pave the way to develop new alloys specific to the EBM process.

关键词： 3D printing Cost reduction Electron beam melting High entropy alloy Mechanical properties Phase prediction

Effects of elevated temperatures on growth and photosynthetic performance of polar Chlorella

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Advances in Polar Science 2020年第2期31卷 124-131页

作者： Syazana ANUWAR Ming-Li TEOH wei-Hsum YAP Fong-Lee NG siew-Moi PHANG School of Biosciences Taylor’s UniversityLakeside Campus47500 Subang JayaSelangor Darul EhsanMalaysia Institute of Ocean and Earth Sciences(IOES) University of Malaya50603 Kula LumpurMalaysia National Antarctic Research Centre Institute of Graduate Studies50603 Kula LumpurMalaysia Faculty of Applied Sciences UCSI University56000 Kuala LumpurMalaysia

Global warming has been the subject of concern in today’s world with elevating temperature causing the melting of polar ice and increasing sea *** aim of this study was to investigate the physiological and photosynthetic performance of two polar Chlorella,namely Chlorella UMACC 250 and Chlorella UMACC 234 to elevating temperatures as might be experienced under future warming *** cultures were exposed to three different temperatures of 4℃,8℃and 12℃.The growth and photosynthetic activity were determined every 2 d for a period of 10 *** the end of the experiment,the cultures were harvested and analysed for biochemical *** Chlorella strains were able to tolerate higher temperatures than their ambient *** final pigments content showed an increasing trend with increased temperatures for both *** photosynthetic activities were measured using pulse-amplitude modulation(PAM)*** photosynthetic parameters including maximum quantum efficiency(Fv/Fm),maximum relative electron transport rate(r ETRmax),light harvesting efficiency(a)and photoadaptive index(Ek)were derived from the rapid light curves(RLCs).Both Chlorella strains showed a slight decline in growth and photosynthetic activities at the initial part of the ***,they showed the ability to recuperate with Chlorella UMACC 250 recovers better compared to Chlorella UMACC *** Chlorella strains showed similar trend in their carbohydrate content at 12℃,while the protein content of Chlorella UMACC 234 decreased when exposed to increasing *** results indicated that polar Chlorella are able to survive at increased temperatures throughout the experiment.

关键词： polar Chlorella photosynthesis pulse-amplitude modulation(PAM)fluorometry

Bioregeneration of spent activated carbon:Review of key factors and recent mathematical models of kinetics

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Chinese Journal of Chemical Engineering 2018年第5期26卷 893-902页

作者： Kwok-Yii Leong siew-Leng Loo Mohammed J.K.Bashir Wen-Da Oh Pasupuleti Visweswara Rao Jun-wei Lim Centre for Water Research Department of Civil and Environmental Engineering National University of Singapore Singapore Membrane Technology Centre Nanyang Environment and Water Research Institute Nanyang Technological University Department of Environmental Engineering Faculty of Engineering and Green Technology (FEGT) Universiti Tunku Abdul Rahman Residues & Resource Reclamation Centre Nanyang Environment and Water Research Institute (NEWRI) Nanyang Technological University Bio Product Development Program Faculty of Agro-Based Industry Universiti Malaysia Kelantan Institute of Food Security and Sustainable Agriculture Universiti Malaysia Kelantan Department of Fundamental and Applied Sciences Universiti Teknologi PETRONAS

The disposal of spent activated carbon(AC) will inevitably create secondary pollution. In overcoming this problem, the spent AC can be regenerated by means of biological approach. Bioregeneration is the phenomenon in which through the action of microorganisms, the adsorbed pollutants on the surface of the AC will be biodegraded and this enables further adsorption of pollutants to occur with time elapse. This review provides the challenges and perspectives for effective bioregeneration to occur in biological activated carbon(BAC)column. Owing to very few reported works on the bioregeneration rate in BAC column, emphasis is put forward on the recently developed models of bioregeneration kinetic in batch system. All in all, providing potential solutions in increasing the lifespan of AC and the enhancement of bioregeneration rate will definitely overcome the bottlenecks in spent AC bioregeneration.

关键词： Bioregeneration Spent activated carbon Modeling of bioregeneration kinetic Concentration gradient Exoenzyme