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Biomedical and Environmental sciences 2024年第8期37卷 834-849页

作者： jing Xie jiaxin Tang Yuan Li Xue Kong wei Wang haibo Wu department of pathology the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036AnhuiChina Intelligent pathology Institute Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036AnhuiChina

Objective Vasculogenic mimicry(VM)is a novel vasculogenic process integral to glioma stem cells(GSCs)in glioblastoma(GBM).However,the relationship between VM and ataxia-telangiectasia mutated(ATM)serine/threonine kinase activation,which confers chemoradiotherapy resistance,remains *** We investigated VM formation and phosphorylated ATM(pATM)levels by CD31/GFApperiodic acid-Schiff dual staining and immunohistochemical staining in 145 GBM *** stem-like cells(GSLCs)derived from the formatted spheres of U87 and U251 cell lines and their pATM level and VM formation ability were examined using western blot and three-dimensional *** the examination of the function of pATM in VM formation by GSLCs,ATM knockdown by shrNAs and deactivated via ATM phosphorylation inhibitor KU55933 were *** VM and high pATM expression occurred in 38.5% and 41.8% of tumors,respectively,and were significantly associated with reduced progression-free and overall *** with VM-positive GBMs exhibited higher pATM levels(r_(s)=0.425,p=0.01).The multivariate analysis established VM as an independent negative prognostic factor(p=0.002).Furthermore,GSLCs expressed high levels of pATM and formed vascular-like networks in *** inactivation or knockdown hindered VM-like network formation concomitant with the downregulation of pVEGFr-2,VE-cadherin,and laminin *** VM may predict a poor GBM prognosis and is associated with pATM *** propose that pATM promotes VM through extracellular matrix modulation and VE-Cadherin/pVEGFr-2 activation,thereby highlighting ATM activation as a potential target for enhancing anti-angiogenesis therapies for GBM.

关键词： Glioblastoma Vasculogenic mimicry Ataxia-telangiectasia mutated(ATM) Glioma stem-like cell

Integrated Guidance and Control Based on Backstepping and Input-to-State Stability

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Integrated Guidance and Control Based on Backstepping and In...

Sparsity-Enhanced Linear Time-Invariant MIMO System Identification

第三十届中国控制会议

作者： YAN Han,ji haibo department of automation,university of science and technology of china,hefei 230026,p.r.china

＜正＞This paper presents an approach of integrated guidance and control（IGC） design for interception of maneuvering targets（evaders）.An IGC model with uncertainties in the pitch plane is formulated,and the IGC approach is developed via backstepping *** analysis is shown that the design approach makes the line-of-sight（LOS） rate be input-to-state stable（ISS） with respect to target maneuvers and missile model uncertainties,and the stability of the missile dynamics can be guaranteed as *** numerical simulation confirms the effectiveness of the proposed design approach.

关键词： Integrated Guidance and Control Backstepping Input-to-State Stability robustness

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progress in research on metal-based materials in stabilized Zn anodes

2011 Chinese Control and Decision Conference（CCDC）

作者： wei Shi,Qing Ling and Gang Wu are with department of automation,university of science and technology of china,hefei,Anhui 230027,p.r.china

This paper addresses the problem of linear timeinvariant multi-input-multi-output （MIMO） system ***,we focus on identifying the finite impulse responses （FIrs） of a MIMO *** that the FIrs are often approximately sparse,namely containing many nearzero elements,this paper proposes to use the e1 regularized least squares （e1-LS） method as the *** to the traditional identification methods,such as least squares,the e1-LS method exploits the sparse nature of the FIrs,hence brings three advantages:（1） better estimation of the timedelays,（2） better estimation of the effective lengths of the FIrs,and （3） lower requirement of input-output *** results validate the efficacy of the proposed sparsity-enhanced identification approach.

关键词： multi-input-multi-output (MIMO) system identification finite impulse response (FIr) sparsity e1 regularized least squares (e1-LS)

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rare Metals 2024年第1期43卷 20-40页

作者： Le Li Shao-Feng jia Ming-Hui Cao Yong-Qiang ji Heng-wei Qiu Dan Zhang Shaanxi Key Laboratory of Industrial automation School of Mechanical EngineeringShaanxi University of TechnologyHanzhong 723001China School of Electronic and Information Engineering Qingdao UniversityQingdao 266071China State Key Laboratory for Artifcial Microstructure and Mesoscopic physics School of PhysicsPeking UniversityBeijing 100871China department of Chemistry Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTsinghua UniversityBeijing 100084China Shaanxi Key Laboratory of Catalysis School of Chemistry and Environment ScienceShaanxi University of TechnologyHanzhong 723001China

Aqueous zinc-ion batteries(ZIBs) combine the benefits of metallic Zn anodes with those of aqueous electrolytes and are well suited for large-scale energy storage because of their inherent high safety, cost-effectiveness, and eco-friendliness. Currently, the practical application of such batteries is hindered by the poor cycling performance of Zn anodes due to uncontrolled dendrite formation and severe side reactions, although recent reports suggest that these problems can be mitigated through the modification of Zn anodes with metal-based *** that the mechanisms of improving Zn deposition and the structural evolution of metal-based materials have not been systematically reviewed, we herein systematically overview the metal-based materials used to stabilize Zn anodes, starting with a brief summary of the anode working mechanism and the challenges faced by stabilized Zn anodes. Subsequently, the design principles of Zn anodes stabilized by metal-based materials and the related recent progress are reviewed, and the key challenges and perspectives for the future development of such Zn anodes are proposed.

关键词： Zinc-ion batteries(ZIBs) Zn anode Metalbased materials Alloying metal Stabilized Zn anodes

基于支持向量机和距离度量的管道内表面图像分类方法研究

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数据采集与处理 2002年第2期17卷 151-155页

作者：马永军方凯王定成方廷健陈卫中国科学技术大学自动化系合肥230027 中国科学院合肥智能机械研究所合肥230031

针对管道内表面图像的分类问题 ,提出了一种将支持向量机和距离度量相结合 ,构成组合分类器的分类方法。分类时先采用距离度量进行前级分类 ,符合条件则给出分类结果 ,否则拒识并转入 SVM分类器进行分类。该方法充分利用了 SVM识别率高... 详细信息

针对管道内表面图像的分类问题 ,提出了一种将支持向量机和距离度量相结合 ,构成组合分类器的分类方法。分类时先采用距离度量进行前级分类 ,符合条件则给出分类结果 ,否则拒识并转入 SVM分类器进行分类。该方法充分利用了 SVM识别率高和距离度量速度快的优点 ,并且利用距离度量的结果去指导 SVM的训练和测试。实验表明本方法具有较高的效率和识别精度。

关键词：支持向量机距离度量管道内表面图像分类油田输油管道

Estimating SVCV waterborne transmission and predicting experimental epidemic development:A modeling study using a machine learning approach

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Water Biology and Security 2024年第1期3卷 60-70页

作者： jiaji pan Qijin Zeng wei Qin jixiang Chu haibo jiang Haiyan Chang Jun Xiao Hao Feng State Key Laboratory of Developmental Biology of Freshwater Fish College of Life ScienceHunan Normal UniversityChangsha410081China College of Engineering and Design Hunan Normal UniversityChangsha410081China

Viral infectious diseases significantly threaten the sustainability of freshwater fish *** lack of studies on epidemic transmission patterns and mechanisms inhibits the development of containment strategies from the viewpoint of veterinary public *** study raises an epidemic mathematical model considering water transmission with the aim of analyzing the transmission process more *** basic reproduction number r0 was derived by the model parameter including the water transmission coefficient and was used for the analysis of the virus *** viremia of carp virus(SVCV)and zebrafish were used as model viruses and animals,respectively,to conduct the transmission *** through water was achieved by connecting two aquarium tanks with a water channel but blocking the fish movement between the *** the collected experimental data,we determined the optimal hybrid machine learning algorithm to analyze the transmission process using an established mathematical *** addition,future transmission was predicted and validated using the epidemic model and an optimal ***,the sensitivity of model parameters and the simulations of r0 variation were performed based on the modified complex epidemic *** study is of significance in providing theoretical guidance for minimizing r0 by manipulating model parameters with containment *** importantly,since the modified model and algorithm demonstrated better performance in handling freshwater fish transmission problems,this study advances the future application of transmissible disease modeling with larger datasets in freshwater fish aquaculture.

关键词： Epidemic mathematical model Hybrid machine learning algorithm reproduction number Sensitivity analysis SVCV transmission

Guest Editorial for Special Issue on Human-centered Intelligent robots:Issues and Challenges

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IEEE/CAA Journal of Automatica Sinica 2017年第4期4卷 599-601页

作者： Zhijun Li C.L.philip Chen wei He IEEE College of automation science and Engineering South China University of Technology department of Computer and Information science Faculty of Science and Technology University of Macao School of automation and Electrical Engineering University of Science and Technology Beijing

The special issue aims to address a broad spectrum of topics ranging from human-centered intelligent robots acting as a servant,secretary,or companion to intelligent robotic *** special issue publishes original papers of innovative ideas and concepts,new discoveries,and novel applications and business models relevant to the field of human-centered intelligent *** this special issue,modeling,intelligent control,

关键词： In Guest Editorial for Special Issue on Human-centered Intelligent robots:Issues and Challenges

Multi-objective robust control based on fuzzy singularly perturbed models for hypersonic vehicles

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science china(Information sciences) 2011年第3期54卷 563-576页

作者： HU YeNan 1 , YUAN Yuan 2 , MIN haibo 2,3 & SUN FuChun 1 1 department of Computer science and technology, Tsinghua university, Beijing 100084, china 2 department of automation, Xi’an research Institute of High-Tech, Xi’an, Shaanxi 710025, china 3 Beijing Institute of Astronautical System Engineering, Beijing 100076, china department of Computer science and technology Tsinghua University department of automation Xi"an Research Institute of High-Tech Beijing Institute of Astronautical System Engineering

In this paper, we propose a multi-objective robust controller based on fuzzy singularly perturbed models (FSpM) for the longitudinal motion of an air-breathing hypersonic vehicle. The control objective is to provide velocity and altitude tracking in the presence of the uncertainties and unknown nonlinearities in the model caused by variations in flight conditions. By approximating the multi-time-scale model with FSpM, ill-posed matrix calculations are circumvented. Under this framework, a fuzzy multi-objective robust controller is developed, and the linear matrix inequalities (LMI) condition is derived. Numerical simulation using the longitudinal model of a hypersonic aircraft is provided to demonstrate the effectiveness of the proposed strategy.

关键词： FSpM multi-objective robust control intelligent control hypersonic vehicle

Lactate aggravates inflammation through the upregulation of ICAM-1 via Gpr81-HSpA12B-mediated signaling in acute lung injury

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中华医学杂志(英文版) 2024年第15期137卷 1885-1887页

作者： Chang wei Liu Xu Wang Haofei Zhu Xingxing Huang wei Liu Ling Qiu haibo Yang Yi department of Critical Care Medicine Jiangsu Provincial Key Laboratory of Critical Care Medicine Zhongda Hospital School of Medicine Southeast University Nanjing Jiangsu China The Medical School Southeast University Nanjing Jiangsu China