检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

BIM技术在电网工程建设中的应用研究

电力设备管理 2024年第3期 172-174页

作者：齐立忠韩念遐隗刚国网经济技术研究院有限公司北京道亨软件股份有限公司

本文主要分析了BIM技术在电网工程建设中的实际应用,使其在电网工程建设中带来较好的条件,可使电网工程建设及运行水平全面提升,为电网建设领域的发展建立良好的基础,推动输配电体系的发展。

关键词： BIM技术电网工程建设应用策略

Exploring the interaction patterns among taxa and environments from marine metagenomic data

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Electrical and Electronic Engineering in China 2016年第2期4卷 84-91页

作者： Ze-gang wei Shao-Wu Zhang Fang Jing Key Laboratory of Information Fusion Technology of Ministry of Education College of Automation Northwestern PolytechnicalUniversity Xi'an 710072 China

The sequencing revolution driven by high-throughput technologies has generated a huge amount of marine microbial sequences which hide the interaction patterns among microbial species and environment factors. Exploring these patterns is helpful for exploiting the marine resources. In this paper, we use the complex network approach to mine and analyze the interaction patterns of marine taxa and environments in spring, summer, fall and winter seasons. With the 16S rRNA pyrosequencing data of 76 time point taken monthly over 6 years, we first use our MtHc clustering algorithm to generate the operational taxonomic units （OTUs）. Then, employ the k-means method to divide 76 time point samples into four seasonal groups, and utilize mutual information （MI） to construct the four correlation networks among microbial species and environment factors. Finally, we adopt the symmetrical non-negative matrix factorization method to detect the interaction patterns, and analysis the relationship between marine species and environment factors. The results show that the four seasonal microbial interaction networks have the characters of complex networks, and interaction patterns are related with the seasonal variability; the same environmental factor influences different species in the four seasons; the four environmental factors of day length, photosynthetically active radiation, NO2＋ NO3 and silicate may have stronger influences on microbes than other environment factors.

关键词： marine microbe operational taxonomic unit interaction pattern network clustering

Reference device for calibration of radon exhalation rate measuring instruments and its performance

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2023年第8期34卷 131-141页

作者： wei-gang Li De-Tao Xiao Zheng-Zhong He Xiang-Yuan Deng Shou-Kang Qiu School of Nuclear Science and Technology Hunan Provincial Key Laboratory of RadonUniversity of South ChinaHengyang 421001China

Environmental radon emanates from the exhalation and release of soil,rocks,and building *** radon contamination tracing and radon pollution prevention and control require the measurement of the radon exhalation rate on media *** measurements of the radon exhalation rate cannot be achieved without regular calibration of the measuring instrument with a high-performance reference *** this study,a reference device for the calibration of radon exhalation rate measuring instruments was developed using a diffusion solid radon source with a high and stable radon emanation coefficient,an integrated diffusion component composed of a plasterboard and a high-density wooden board,an air pressure balance device,a radon accumulation chamber,and a support *** uniformity and stability of the reference device were evaluated using the activated carbon-γspectrum and open-loop method,respectively,to measure the radon exhalation *** reference device achieved different radon exhalation rates by using different activities of diffusion solid radon *** measurement points were regularly selected on the radon exhalation surface of the reference device,and the uniformity of the radon exhalation rate exceeded 5%.The short-term stability of the reference device was better than 5%under different environmental conditions and was almost unaffected by the ambient air pressure,environmental temperature,and relative humidity.

关键词： Radon exhalation rate Stability Uniformity High-density wooden board Plasterboard

Characterization of three Arabidopsis AP2/EREBP family transcription factors involved in ABA sensitivity, freeze and salt tolerance

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2007年第13期52卷 1746-1753页

作者： MEI WenQian LEI Juan Xu Yu wei gang ZHU YuXian National Laboratory of Protein Engineering and Plant Genetic Engineering College of Life Sciences Peking University Beijing 100871 China

AP2/EREBP transcription factors (TFs) play very important roles in plant development, hormonal regulation and stress response. Upon genome-wide cDNA cloning, phylogenetic and expression pattern analyses of this plant specific TF family, we found that three of the members including At1g71450, At1g50680 and At5g13910, were likely involved in responses to ABA, cold and salt. Complementary DNAs containing putative full-length ORFs of these three TFs were obtained and fused individually to the GAL4 DNA-binding domains. All the 3 genes functioned effectively as trans-activators using yeast one-hybrid assays. RT-PCR experiments showed that the At1g71450 gene was induced by ABA and low temperature; the At1g50680 gene was responsive to quite a few stress conditions, but especially to freezing temperature; and the At5g13910 gene was induced by high salt treatment, drought and ethyl-ene. By searching the ABRC T-DNA insertion mutant stocks, we obtained knockout lines for these TFs. Homozygous ko1 (At1g71450) plants showed a hypersensitive response to ABA during seed germina-tion and also in stomata movement. Homozygous ko2 (At1g50680) plants showed a significant reduc-tion in plant freezing tolerance compared to the wild type after chilling treatment. Homozygous ko3 (At5g13910) were less tolerant to high salinity than wild type plants. Our data suggest that At1g71450 is a negative regulator in ABA signaling, while At1g50680 and At5g13910 are positive regulators in cold and salt stress responses, respectively.

关键词：阿布属灵敏度土壤冻结盐碱地

Antihyperglycemic and antioxidant activities of total alkaloids from Catharanthus roseus in streptozotocin-induced diabetic rats

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2016年第1期27卷 167-174页

作者： Lin Zhang gang wei Yang Liu Yuangang Zu Qinghui Gai Lei Yang Key Laboratory of Forest Plant Ecology Ministry of Education Northeast Forestry University

We evaluated the hypoglycemic and antioxi- dant effects of the total alkaloids of leaves and twigs of Catharanthus roseus Linn. （CTA） in streptozotocin （STZ）- induced diabetic rats. The hypoglycemic effect was mea- sured by blood glucose and plasma insulin level. Oxidative stress was measured in heart, liver and kidney by levels of antioxidant markers, free radical scavengers and lipid peroxides i.e. superoxide dismutase （SOD）, catalase （CAT）, glutathione （GSH） and thiobarbituric acid reactive substances （TBARS）. Biochemical parameters, i.e. aspar- tate aminotransferase （AST）, alanine aminotransferase （ALT）, alkaline phosphate （ALP） were observed in diabetic control and treated rats. Oral administration of CTA for 30 days was followed by a significant （P 〈 0.05） decrease in fasting blood glucose and increase in insulin level as compared with untreated diabetic rats. Also it significantly （P 〈 0.05） reduced ALT, AST and ALP. The treatment also resulted in significant （P 〈 0.05） reductions in GSH, SOD, CAT, and decrease in TBARS in the heart, liver and kidney of diabetic rats. The results suggest that CTA can effectively normalize the impaired antioxidant status in STZ-induced diabetes in a dose-dependent *** exerted rapid protective effects against lipid peroxi- dation by scavenging of free radicals and reducing the risk of diabetic complications.

关键词： Antihyperglycemic activity Antioxidantactivity Catharanthus roseus Streptozotocin-induceddiabetic rats Total alkaloids

Mesohepatectomy versus extended hemihepatectomy for centrally located hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2014年第3期13卷 264-270页

作者： Xi Chen Bo Li wei He Yong-gang wei Zheng-Gui Du Li Jiang Department of Liver Surgery and Liver Transplantation Center West China Hospital Sichuan University

BACKGROUND: Extended hemihepatectomy is usually recommended to treat large centrally located hepatocellular carcinoma (HCC). However, the morbidity and mortality are high because of the postoperative liver failure. Mesohepatectomy is seldom used because of its technical complexity This study aimed to evaluate the short-term and long-term curative effect of mesohepatectomy. METHODS: From January 2002 to September 2008, a total of 198 consecutive patients with centrally located HCC underwent hepatectomy in our department. According to the surgical procedures, they were divided into mesohepatectomy (group M, n=118), extended right hemihepatectomy (group RE, n=47) and extended left hemihepatectomy (group LE, n=33) groups. The surgical techniques, clinical pathological characteristics and outcomes were compared between group M, group RE and group LE. RESULTS: The operative time of group M was significantly longer than that of the other two groups (P0.05). The morbidity rate in group M was significantly lower than that in group RE (37.3% vs 55.3%, P=0.034), but not in group LE (37.3% vs 24.2%, P=0.163). The biliary leakage tended to be more common in group M (10.2%, P>0.05). The incidence of postoperative liver failure in group M was significantly lower than that in group RE (1.7% vs 10.6%, P=0.032), but not in group LE (1.7% vs 6.1%, P=0.208). The 1-, 3- and 5-year tumor-free survival rates and the overall survival rates after mesohepatectomy were 53.4%, 30.5% and 16.9% and 67.8%, 45.5% and 28.9%, respectively. CONCLUSIONS: Mesohepatectomy is a safe and effective technique for centrally located HCC patients. Compared with extende

关键词： hepatocellular carcinoma mesohepatectomy extended hemihepatectomy complication survival

Direct coordination of metal ions to cucurbit[n]urils

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2010年第32期55卷 3633-3640页

作者： CONG Hang ZHU QianJiang XUE SaiFeng TAO Zhu wei gang Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province Guizhou University Guiyang 550025 China CSIRO Materials Science and Engineering Lindfield 2070 Australia

Cucurbit[n]urils (Q[n]) are promising ligands for the coordination of metal ions, metal complexes or clusters, and form various Q[n]-based complexes. Among the Q[n] complexes, those formed by direct coordination between Q[n]s and metal ions are particularly important. The direct coordination of metal ions to cucurbit[n]urils leads to the formation of Q[n]-based molecular capsules, tubular polymers and molecular bracelets, which could have nanoscale applications in drug delivery, molecular devices and new materials.

关键词：金属离子瓜环葫芦金属配合物纳米新材料分子胶囊管状分子药物输送

Amino-functionalized poloxamer 407 with both mucoadhesive and thermosensitive properties:preparation, characterization and application in a vaginal drug delivery system

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2017年第5期7卷 593-602页

作者： Liqian Ci Zhigang Huang Yu Liub Zhepeng Liu gang wei weiyue Lu School of Medical Instrument and Food Engineering University of Shanghai for Science and Technology Department of Pharmaceutics School of Pharmacy Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University)Ministry of Education

Lack of mucoadhesive properties is the major drawback to poloxamer 407(F127)-based in situ hydrogels for mucosal administration. The objective of the present study was to construct a novel mucoadhesive and thermosensitive in situ hydrogel drug delivery system based on an aminofunctionalized poloxamer for vaginal administration. First, amino-functionalized poloxamer 407(F127-NH2) was synthesized and characterized with respect to its micellization behavior and interaction with mucin. Then using acetate gossypol(AG) as model drug, AG-loaded F127-NH2-based in situ hydrogels(NFGs) were evaluated with respect to rheology, drug release, ex vivo vaginal mucosal adhesion, in vivo intravaginal retention and local irritation after vaginal administration to healthy female mice. The results show that F127-NH2 is capable of forming a thermosensitive in situ hydrogel with sustained drug release properties. An interaction between positively charged F127-NH2 and negatively charged mucin wasrevealed by changes in the particle size and zeta potential of mucin particles as well as an increase in the complex modulus of NFG caused by mucin. Ex vivo and in vivo fluorescence imaging and quantitative analysis of the amount of AG remaining in mouse vaginal lavage all demonstrated greater intravaginal retention of NFG than that of an unmodified F127-based in situ hydrogel. In conclusion, amino group functionalization confers valuable mucoadhesive properties on poloxamer 407.

关键词： Poloxamer 407 Amino group Acetate gossypol In situ hydrogel Mucoadhesive gel

Hydrated nickel(Ⅱ) halides mediated ring opening reaction with N-tosylaziridines

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2012年第3期23卷 285-288页

作者： Wan Xuan Zhang wei gang Hu Li Su Li Qin Liu Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules Hubei UniversityWuhan 430062China

An efficient and water tolerant method for the synthesis ofβ-haloamines is described utilizing hydrated nickel（Ⅱ） halides （NiX_2ⅩnH_2O X = Cl,Br,I） and aziridines as starting materials.N-Tosylaziridines reacted with NiCl_2·6H_2O or NiI_2·6H_2O givingβ-chloro -orβ-iodoamines in high yields（73-99%） within a short time,but 10 mol%of n-Bu_4NBr should be added in the reactions of N-tosylaziridines with NiBr_2·3H_2O in order to obtain the high yields of correspondingβ-*** played an important role in the *** proper solvent for the reaction of NiCl_2·6H_2O was DMF,while NiBr_2·3H_2O or NiI_2·6H_2O proceeded well in 1,4-dioxane.

关键词： N-Tosylaziridines Hydrated nickel(Ⅱ) halides Ring opening reaction β-Haloamines