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失眠患者数字化失眠认知行为治疗选择倾向的影响因素分析

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中华精神科杂志 2024年第9期57卷 579-585页

作者：周娱菁雷彬斌魏婷卢晓茵危咏陈秋强周名清张继辉广州医科大学附属脑科医院睡眠与节律医学中心广州南方医科大学附属广东省人民医院(广东省医学科学院)广东省心血管病研究所广东省精神卫生中心广州南方医科大学第二临床医学院广州

目的初步探索影响失眠患者对数字化失眠认知行为治疗(electronically-delivered cognitive behavioral therapy for insomnia, e-CBTI)选择的因素, 为e-CBTI在临床推广提供实证证据。方法于2022年11月至2023年7月, 采用方便抽样法在全... 详细信息

目的初步探索影响失眠患者对数字化失眠认知行为治疗(electronically-delivered cognitive behavioral therapy for insomnia, e-CBTI)选择的因素, 为e-CBTI在临床推广提供实证证据。方法于2022年11月至2023年7月, 采用方便抽样法在全国38家公立医院门诊及其附近社区收集样本, 共纳入18～65岁失眠患者756例。根据患者是否选择e-CBTI治疗进行分组, 其中605例患者(605/756, 80.0%)选择e-CBTI治疗(e-CBTI组), 151例患者(151/756, 20.0%)未选择参与e-CBTI治疗(对照组)。通过结构化临床访谈, 根据睡眠模式及障碍诊断访谈以及DSM-5中相关诊断标准, 对2组失眠患者的失眠相关症状、精神障碍、其他睡眠障碍及自杀自伤进行他评, 组间差异比较采用t检验或卡方检验, 并采用Logistic回归分析确定e-CBTI选择的影响因素。结果与对照组相比, e-CBTI组女性比例(χ2=4.29)以及文化水平较高(χ2=5.76), 而居住在乡镇(χ2=6.87)比例较低(均P<0.05)。与对照组相比, e-CBTI组日间症状的比例较高, 包括注意力或记忆力下降(χ2=16.42)、功能受损或表现下降(χ2=6.75)、情绪变化(χ2=4.71)以及积极性、精力或动力不足(χ2=4.77, 均P<0.05)。e-CBTI组较对照组睡眠时相延迟倾向(χ2=6.61)、广泛性焦虑障碍(χ2=6.22)、自杀意念(χ2=10.45)和非自杀性自伤(χ2=5.19)比例较高, 差异均有统计学意义(均P<0.05)。多因素Logistic回归分析显示, 居住地类型(OR=0.53, 95%CI=0.29～0.95)、文化程度(OR=2.42, 95%CI=1.34～4.37)、注意力或记忆力(OR=1.95, 95%CI=1.11～3.42)及功能受损或表现受损(OR=1.80, 95%CI=1.15～2.82)以及自杀意念(OR=3.12, 95%CI=1.29～7.58)影响e-CBTI的选择, 失眠的夜间症状, 包括入睡困难、睡眠维持困难和过度早醒与e-CBTI选择倾向未见相关。结论失眠的日间症状和自杀意念是促使失眠患者选择e-CBTI的重要因素。

关键词：睡眠障碍失眠认知行为治疗数字化日间症状昼夜节律自杀

A lithium–tin fluoride anode enabled by ionic/electronic conductive paths for garnet-based solid-state lithium metal batteries

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Rare Metals 2024年第2期43卷 575-587页

作者： Lei Zhang Qian-Kun Meng Xiang-Ping Feng Ming Shen Yu-Qing Zhang Quan-chao Zhuang Run-Guo Zheng Zhi-Yuan Wang Yan-Hua Cui Hong-Yu Sun Yan-Guo Liu School of Materials Science and Engineering Northeastern UniversityShenyang110819China School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao066004China School of Materials and Physics China University of Mining&TechnologyXuzhou221116China Institute of Electronic Engineering China Academy of Engineering PhysicsMianyang621900China

The high energy density and stability of solid-state lithium metal batteries(SSLMBs)have garnered great ***-type oxides,especially Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO),with high ionic conductivity,wide electrochemical window,and stability to Li metal anode,are promising solid-state electrolyte(SSEs)materials for ***,Li/LLZTO interface issues including high interface resistance,inhomogeneous Li deposition,and Li dendrite growth have hindered the practical application of ***,a multi-functional Li–SnF_(2) composite anode with Li,LiF,and Li-Sn alloy was specifically designed and *** composite anode improves the wettability to LLZTO,constructing an intimate contact interface between it and ***,ionic/electronic conductive paths in situ formed at the interface can effectively uniform Li deposition and suppress Li *** solid-state symmetric cell exhibits low interface resistance(11Ω·cm^(2)) and high critical current density(1.3 mA·cm^(−2))at 25℃.The full SSLMB based on LiFePO_(4) or LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2) cathode also shows stable cycling performance and high rate *** work provides a new composite anode strategy for achieving high-energy density and high-safety SSLMBs.

关键词： Solid-state lithium metal batteries(SSLMBs) Lithium-tin fluoride anode Ionic/electronic conductive Interface resistance Lithium dendrite

Production induced fracture closure of deep shale gas well under thermo-hydro-mechanical conditions

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Petroleum Science 2024年第3期21卷 1796-1813页

作者： Shi-Ming wei Yang Xia Yan Jin Xu-Yang Guo Jing-Yu Zi Kai-Xuan Qiu Si-Yuan Chen College of Science China University of Petroleum(Beijing)Beijing102249China CNOOC Research Institute Ltd Beijing100028China The University of Hong Kong Hong Kong999077China

Deep shale gas reservoirs have geological characteristics of high temperature,high pressure,high stress,and inferior ability to pass through *** multi-stage fractured horizontal well is the key to exploiting the deep shale gas ***,during the production process,the effectiveness of the hydraulic fracture network decreases with the closure of fractures,which accelerates the decline of shale gas *** this paper,we addressed the problems of unclear fracture closure mechanisms and low accuracy of shale gas production prediction during deep shale gas *** we established the fluid—solid—heat coupled model coupling the deformation and fluid flow among the fracture surface,proppant and the shale *** the fluid—solid—heat coupled model was applied to the fracture network,it was well solved by our numerical method named discontinuous discrete fracture *** with the conventional discrete fracture method,the discontinuous discrete fracture method can describe the three-dimensional morphology of the fracture while considering the effect of the change of fracture surface permeation coefficient on the coupled fracture—matrix flow and describing the displacement discontinuity across the *** simulations revealed that the degree of fracture closure increases as the production time proceeds,and the degree of closure of the secondary fractures is higher than that of the primary *** creep and proppant embedment both increase the degree of fracture *** reduction in fracture surface permeability due to proppant embedment reduces the rate of fluid transfer between matrix and fracture,which has often been overlooked in the ***,it significantly impacts shale gas production,with calculations showing a 24.7%cumulative three-year yield *** study is helpful to understand the mechanism of hydraulic fracture ***,it provides the theoretical guidance for maintaining the long

关键词： Shalegas Fracture closure Fluid-solid-heat coupling Discontinuous discrete fracture

Synergy between CSST galaxy survey and gravitational-wave observation: Inferring the Hubble constant from dark standard sirens

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 7-19页

作者： Ji-Yu Song Ling-Feng Wang Yichao Li Ze-wei Zhao Jing-Fei Zhang Wen Zhao Xin Zhang Key Laboratory of Cosmology and Astrophysics(Liaoning)&College of Sciences Northeastern UniversityShenyang 110819China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaChinese Academy of SciencesHefei 230026China School of Astronomy and Space Sciences University of Science and Technology of ChinaHefei 230026China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern UniversityShenyang 110819China Key Laboratory of Data Analytics and Optimization for Smart Industry(Ministry of Education) Northeastern Universty Shenyang 110819China

Gravitational waves(GWs) from compact binary coalescences encode the absolute luminosity distances of GW sources. Once the redshifts of GW sources are known, one can use the distance-redshift relation to constrain cosmological parameters. One way to obtain the redshifts is to localize GW sources by GW observations and then use galaxy catalogs to determine redshifts from a statistical analysis of redshift information of the potential host galaxies, commonly referred to as the dark siren method. The third-generation(3G) GW detectors are planned to work in the 2030s and will observe numerous compact binary *** these GW events as dark sirens requires high-quality galaxy catalogs from future sky survey projects. The China Space Station Telescope(CSST) will be launched in 2024 and will observe billions of galaxies within a 17500 deg^(2) survey area with redshift up to z ~ 4, providing photometric and spectroscopic galaxy catalogs. In this work, we simulate the CSST galaxy catalogs and the 5-year GW data from the 3G GW detectors and combine them to infer the Hubble constant(H_(0)). Our results show that the measurement precision of H0could reach the sub-percent level, meeting the standard of precision cosmology. We conclude that the synergy between CSST and the 3G GW detectors is of great significance in measuring the Hubble constant.

关键词： CSST galaxy survey galaxy catalogs gravitational waves dark sirens the Hubble constant

Ultrahigh-brightness 50 MeV electron beam generation from laser wakefield acceleration in a weakly nonlinear regime

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Matter and Radiation at Extremes 2024年第3期9卷 4-10页

作者： Zhongtao Xiang Changhai Yu Zhiyong Qin Xuhui Jiao Jiahui Cheng Qiaoxuan zhou Gatie Axi Jianghua Jie Ya Huang Jintan Cai Jiansheng Liu Department of Physics Shanghai Normal UniversityShanghai 200234China

We propose an efficient scheme to produce ultrahigh-brightness tens of MeV electron beams by designing a density-tailored plasma to induce a wakefield in the weakly nonlinear regime with a moderate laser energy of 120 *** this scheme,the second bucket of the wakefield can have a much lower phase velocity at the steep plasma density down-ramp than the first bucket and can be exploited to implement longitudinal electron injection at a lower laser intensity,leading to the generation of bright electron beams with ultralow emittance together with low energy ***-dimensional particle-in-cell simulations are carried out and demonstrate that high-quality electron beams with a peak energy of 50 MeV,ultralow emittance of28 nm rad,energy spread of 1%,charge of 4.4 pC,and short duration less than 5 fs can be obtained within a 1-mm-long tailored plasma density,resulting in an ultrahigh six-dimensional brightness B6D,n of2×1017 A/m2/0.1%.By changing the density parameters,tunable bright electron beams with peak energies ranging from 5 to 70 MeV,a small emittance of B0.1 mm mrad,and a low energy spread at a few-percent level can be *** bright MeV-class electron beams have a variety of potential applications,for example,as ultrafast electron probes for diffraction and imaging,in laboratory astrophysics,in coherent radiation source generation,and as injectors for GeV particle accelerators.

关键词： weakly nonlinear acceleration

Rice stripe mosaic virus hijacks rice heading‐related gene to promote the overwintering of its insect vector

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Journal of Integrative Plant Biology 2024年第9期66卷 2000-2016页

作者： Siping Chen Xinyi Zhong Zhiyi Wang Biao Chen Xiuqin Huang Sipei Xu Xin Yang Guohui zhou Tong Zhang Guangdong Province Key Laboratory of Microbial Signals and Disease Control College of Plant ProtectionSouth China Agricultural UniversityGuangzhou 510642China State Key Laboratory of Green Pesticide South China Agricultural UniversityGuangzhou 510642China

Rice stripe mosaic virus(RSMV)is an emerging pathogen which significantly reduces rice yields in the southern region of *** is transmitted by the leafhopper Recilia dorsalis,which overwinters in rice *** field investigations revealed that RSMV infection causes delayed rice heading,resulting in a large number of green diseased plants remaining in winter rice *** creates a favorable environment for leafhoppers and viruses to overwinter,potentially contributing to the rapid spread and epidemic of the ***,we explored the mechanism by which RSMV manipulates the developmental processes of the rice plant.A rice heading‐related E3 ubiquitin ligase,Heading date Associated Factor 1(HAF1),was found to be hijacked by the RSMV‐encoded *** impairment of HAF1 function affects the ubiquitination and degradation of downstream proteins,HEADING DATE 1 and EARLY FLOWERING3,leading to a delay in rice *** results provide new insights into the development regulation‐based molecular interactions between virus and plant,and highlights the importance of understanding virus‐vector‐plant tripartite interactions for effective disease management strategies.

关键词： HAF1 heading leafhoppers overwintering RSMV

Combatting Pathogenic Bacteria with Synthetic Immunotherapeutics from Chitosan:Antibody Recruiting at Engineered Bacterial Surface with Peptidoglycan Analogs

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CCS Chemistry 2024年第6期6卷 1448-1457页

作者： Yuan Xu Shihao Song Hongwei Duan Yinyue Deng Xue-wei Liu School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological UniversitySingapore 637371 Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikou 570228 School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversitySun Yat-sen UniversityShenzhen 518107

The emergence of microbial drug resistance,coupled with the paucity of new antibiotics poses an impending threat to public *** this work,we drew inspiration from synthetic peptidoglycan oligomers and successfully constructed antibody-recruiting peptidoglycan analogs,2a-d,with excellent safety profiles and high efficiencies in recruiting antibodies across different ***,we demonstrated that these peptidoglycan analogs could be readily incorporated into bacteria cell walls,whereby both simple monoclonal and pooled human serum antibodies effectively congregated to the surfaceengineered bacteria,leading to the complete extermination of the engineered bacterial cells both in vitro and in *** peptidoglycan analog agents for recruiting endogenous antibodies to combat pathogenic bacteria enable further development of promising broad-spectrum immunotherapeutics.

关键词： chitosan bacterial infection endogenous antibodies bacterial surface engineering peptidoglycan analogs

Tuning microstructures of TC4 ELI to improve explosion resistance

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Defence Technology（防务技术） 2024年第3期33卷 78-99页

作者： Changle Zhang Yangwei Wang Lin Wang Zixuan Ning Guoju Li Dongping Chen Zhi-wei Yan Yuchen Song Xucai Wang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China National Key Laboratory of Science and Technology on Materials under Shock and Impact Beijing 100081China State Key Laboratory of Explosive Science and Technology Beijing Institute of TechnologyBeijing 100081China Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China School of Aeronautical Engineering Zhengzhou University of AeronauticsHenan ProvinceZhengzhou 450046China Shanxi Jiangyang Chemical Co. Ltd.Shanxi ProvinceTaiyuan 030041China Shandong Institute of Non-metallic Materials Shandong ProvinceJinan 250031China

A reasonable heat treatment process for TC4 ELI titanium alloy is crucial to tune microstructures to improve its explosion ***,there is limited investigation on tuning microstructures of TC4 ELI to improve explosion ***,the current challenge is quantifying microstructural changes'effects on explosion resistance and incorporating microstructural changes into finite element *** work aims to tune microstructures to improve explosion resistance and elucidate their anti-explosion mechanism,and find a suitable method to incorporate microstructural changes into finite element *** this work,we systematically study the deformation and failure characteristics of TC4 ELI plates with varying microstructures using an air explosion test and LS-DYNA finite element *** Johnson-Cook(JC)constitutive parameters are used to quantify the effects of microstructural changes on explosion resistance and incorporate microstructural changes into finite element *** of the heat treatment,one plate has equiaxed microstructure and the other has bimodal *** convex of the plate after the explosion has a quadratic relationship with the charge mass,and the simulation results demonstrate high reliability,with the error less than 17.5%.Therefore,it is feasible to obtain corresponding JC constitutive parameters based on the differences in microstructures and mechanical properties and characterize the effects of microstructural changes on explosion *** bimodal target exhibits excellent deformation *** response of bimodal microstructure to the shock wave may be more intense under explosive *** well-coordinated structure of the bimodal target enhances its resistance to deformation.

关键词： Microstructure Finite element modelling Parameter optimization Failure characteristics Explosion resistance

Recent advances on thermosensitive hydrogels-mediated precision therapy

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Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 5-25页

作者： Hao Chen Jiangmei Xu Jiangwei Sun Yongxin Jiang Wang Zheng wei Hu Haisheng Qian Department of Clinical Pharmacology The Second Hospital of Anhui Medical UniversityAnhui Medical University Department of Dermatology and Rheumatology Immunology Xinqiao HospitalArmy Medical University School of Biomedical Engineering Anhui Provincial Institute of Translational MedicineAnhui Medical University

Precision therapy has become the preferred choice attributed to the optimal drug concentration in target sites, increased therapeutic efficacy, and reduced adverse *** the past few years, sprayable or injectable thermosensitive hydrogels have exhibited high therapeutic potential. These can be applied as cell-growing scaffolds or drug-releasing reservoirs by simply mixing in a free-flowing sol phase at room temperature. Inspired by their unique properties, thermosensitive hydrogels have been widely applied as drug delivery and treatment platforms for precision medicine. In this review, the state-of-theart developments in thermosensitive hydrogels for precision therapy are investigated,which covers from the thermo-gelling mechanisms and main components to biomedical applications, including wound healing, anti-tumor activity, osteogenesis, and periodontal,sinonasal and ophthalmic diseases. The most promising applications and trends of thermosensitive hydrogels for precision therapy are also discussed in light of their unique features.

关键词： Thermosensitive hydrogels Injectable Sprayable Stimuli-responsive Precision therapy