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Unusual phenomenon-“polyp”arising from a diverticulum:A case report

World Journal of Clinical Cases 2023年第13期11卷 3070-3075页

作者： Jacqueline Jin Li Liew wei shyann lim Frederick H Koh Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Colorectal Service Department of General SurgerySengkang General HospitalSingapore 544886Singapore

BACKGROUND Sealed perforation of colonic diverticulum is a common clinical condition and may be differentiated from an underlying malignant perforation using interval *** present an uncommon colonoscopy finding of a healed diverticular perforation,mimicking a polyp,6 wk post-diverticulitis-something that has not been reported in *** aim to shed light on the likely process that resulted in the trompe l'oeil after *** also introduces the possibility of more targeted colonic resection in the event of a similar *** SUMMARY A middle-aged Chinese female presented with a 3-d history of non-colicky left iliac fossa *** was associated with fever(Tmax 37.6℃),non-bloody diarrhoea and non-bloody,non-bilious *** had a history of Type 2 diabetes mellitus,well controlled on *** was noted on the left iliac fossa region with no guarding or *** white cell count(11.45×10^(9)/L)and C-reactive protein levels(213.9 mg/L)were *** tomography imaging of the abdomen revealed pericolonic fat stranding and extraluminal air pockets fluid density with peritoneal thickening at the sigmoid colon,likely representing a sealed *** weeks after the episode,she underwent a follow-up *** exophytic polypoid lesion closely associated with a diverticulum was seen in the sigmoid *** lesion was easily“pinched”off without much effort using endoscopic forceps and sent for histology which revealed granulation tissue suggesting a healed diverticular *** Granulation tissue associated with healed diverticular perforations resemble *** around these sites may allow for future targeted colonic resections.

关键词： Diverticulitis Colonoscopy Colonic polyps Colorectal cancer Diverticular perforation Case report

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A short overview of the lead iodide residue impact and regulation strategies in perovskite solar cells

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Journal of Energy Chemistry 2024年第3期90卷 504-510,I0012页

作者： Eng Liang lim Zhanhua wei Xiamen Key Laboratory of Optoelectronic Materials and Advanced Manufacturing Institute of Luminescent Materials and Information DisplaysCollege of Materials Science and EngineeringHuaqiao UniversityXiamen 361021FujianChina

Lead iodide(PbI2) is a vital raw material for preparing perovskite solar cells(PSCs),and it not only takes part in forming the light absorption layer but also remains in the grain boundary as a *** other words,the PbI2 content in the precursor and as formed film will affect the efficiency and stability of the *** moderate residual PbI2,it passivates the bulk/surface defects of perovskite,reduces the interfacial recombination,promotes the perovskite stability,minimizes the device hysteresis,and so *** PbI2 residue will reduce the interfacial passivation effect and device *** addition to facilitating the non-radiative recombination,over PbI2 residue can also lead to electronic insulation in the grain boundary and deteriorate the device ***,the impact and regulation of PbI2 residue on the device performance and stability is still not fully ***,a comprehensive and detailed review is presented by discussing the PbI2 residue impact and its regulation strategies(i.e., elimination,facilitation and conversion of the residue PbI2) to manipulate the PbI2 content,distribution and ***,we also show future outlooks in this field,with an aim to help further the progression of high-efficiency and stable PSCs.

关键词： Lead iodide Residue Regulation Perovskite solar cells Efficiency Stability

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Can two-dimensional graphdiyne-based materials be novel materials for perovskite solar cell applications?

Materials Futures

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Materials Futures 2023年第2期2卷 142-151页

Two-dimensional(2D)graphdiyne(GDY)-based materials have attracted attention in the solar cell research community owing to their unique physicochemical properties and hydrophobic nature which can serve as moisture resistance from the surrounding *** from these,the performance and stability ofperovskite solar cells(PSCs)can be greatly improved via the addition of 2D GDY-based *** mini-review summarizes the recent development of 2D GDY-based materials for PSC *** roles of 2D GDY-based materials,such as hole transporting material,electron transporting material,dopant material in perovskite film and interfacial layer,are discussed in ***,we provide future perspectives in this field,aiming to help further progress efficient and stable 2D GDY-based materials in PSCs.

关键词： two-dimensional material graphdiyne perovskite solar cells power conversion efficiency stability

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Investigating factors driving phytoplankton growth and grazing loss rates in waters around Peninsular Malaysia

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Journal of Oceanology and limnology 2021年第1期39卷 148-159页

作者： Joon Hai lim Choon Weng LEE Chui wei BONG Laboratory of Microbial Ecology Institute of Biological SciencesUniversity of MalayaKuala Lumpur 50603Malaysia Institute of Ocean and Earth Sciences University of MalayaKuala Lumpur 50603Malaysia Institute for Advanced Studies University of MalayaKuala Lumpur 50603Malaysia

In tropical waters where temperatures are relatively stable,we investigated whether the relationship between phytoplankton growth and grazing loss rate across diff erent habitats around Peninsular Malaysia can be attributed to its eutrophication *** measured phytoplankton growth(μ)and grazing loss(g)rates in waters off Bachok Marine Research Station(BMRS),located northeast of Peninsular ***-a(chl-a)concentration ranged from 2.90 to 15.78μg/L and was dominated by nanoand micro-phytoplankton(>2μm in size).Using the Landry and Hassett dilution method,μat BMRS ranged from 1.02 to 1.58/d whereas g varied from 0.07 to 0.88/*** accounted for 35%of the primary production at BMRS.A systematic review of available data in waters around Peninsular Malaysia,revealed howμfl uctuated over a wide range(0.01–1.80/d)and correlated with chl a distribution(R 2=0.181,P<0.001).However,the relationship was only signifi cant at<9μg/L chl a for mesotrophic waters and<16μg/L chl a for eutrophic *** contrast,g ranged from 0.00 to 1.01/d,and correlated withμat all *** g/μslope ranged from 19%to 84%,and was generally similar for waters around Peninsular ***,all the g/μslopes had a positive y-intercept except for BMRS,and this seemed to suggest the availability of alternative prey supporting grazing at the other stations.

关键词： phytoplankton growth grazing loss grazing pressure Bachok Marine Research Station(BMRS)

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Proteomic and genomic studies of non-alcoholic fatty liver disease-clues in the pathogenesis

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World Journal of Gastroenterology 2014年第26期20卷 8325-8340页

作者： Jun wei lim John Dillon Michael Miller Department of Gas-troenterology University of DundeeNinewells Hospital and Medical School

Non-alcoholic fatty liver disease(NAFLD)is a widely prevalent hepatic disorder that covers wide spectrum of liver *** is strongly associated with liver inflammation,metabolic hyperlipidaemia and insulin ***,NAFLD has been considered as the hepatic manifestation of metabolic *** pathophysiology of NAFLD has not been fully *** patients can remain in the stage of simple steatosis,which generally is a benign condition;whereas others can develop liver inflammation and progress into non-alcoholic steatohepatitis,fibrosis,cirrhosis and hepatocellular *** mechanism behind the progression is still not fully *** ongoing proteomic researches have focused on discovering the unbiased circulating biochemical markers to allow early detection and treatment of *** genomic studies have also begun to provide new insights into the gene polymorphism to understand patientdisease ***,NAFLD is considered a complex and mutifactorial disease phenotype resulting from environmental exposures acting on a susceptible polygenic *** paper reviewed the current status of proteomic and genomic studies that have contributed to the understanding of NAFLD *** proteomics section,this review highlighted functional proteins that involved in:(1)transportation;(2)metabolic pathway;(3)acute phase reaction;(4)antiinflammatory;(5)extracellular matrix;and(6)immune *** the genomic studies,this review will discuss genes which involved in:(1)lipolysis;(2)adipokines;and(3)cytokines production.

关键词： Non-alcoholic fatty liver disease Proteomics Genomics Metabolic syndrome Pathophysiology

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Matryoshka-caged gold nanorods： Synthesis, plasmonic properties, and catalytic activity

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Nano Research 2016年第2期9卷 415-423页

作者： wei Xiong Debabrata Sikdar lim wei Yap Pengzhen Guo Malin Premaratne Xinyong Li Wenlong Cheng Department of Chemical Engineering Monash University Clayton VIC 3800 Australia The Melbourne Centre for Nanofabrication 151 Wellington Road Clayton VIC 3168 Australia Key Laboratory of Industrial Ecology and Environmental Engineering and State Key Laboratory of Fine Chemicals School of Environmental Sciences and Technology Dalian University of Technology Dalian 116024 China Advanced Computing and Simulation Laboratory (AχL) Department of Electrical and Computer Systems Engineering Monash University Clayton VIC 3800 Australia

Matryoshka-caged gold nanorods （mCGNRs） were successfully synthesized by alternating between a seed-mediated silver-coating method and galvanic replacement reactions （GRRs）. As the number of matryoshka layers of the mCGNRs increased, the plasmon resonance peak broadened and was red-shifted, and the catalytic activity towards the reduction of 4-nitrophenol （4-NTP） increased. When mCGNRs with 6 layers were used as nanocatalysts in the reduction of 4-nitrophenol, the reaction rate coefficient was 5.2- and 3.7-times higher than that of the gold-nanorod- and caged-gold-nanorod-catalyzed reductions of 4-nitrophenol, respectively. In addition, the surface-plasmon-resonance-based absorption of light enhanced the catalytic performance of the mCGNRs. With the support of a polyurethane foam, the mCGNRs synthesized in this study can be applied as recydable heterogeneous catalysts for the reduction of 4-nitrophenol.

关键词： matryoshka-caged gold nanorods galvanic replacement reaction 4-nitrophenol catalysis surface plasmon resonance

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Soft piezoresistive pressure sensing matrix from copper nanowires composite aerogel

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Science Bulletin 2016年第20期61卷 1624-1630页

作者： lim wei Yap Shu Gong Yue Tang Yonggang Zhu Wenlong Cheng Department of Chemical Engineering Monash UniversityClayton VIC 3800 Australia Melbourne Centre for Nanofabrication Clayton VIC 3168Australia CSIRO Manufacturing Flagship Clayton VIC 3168 Australia

We report on a simple yet efficient approach to fabricate soft piezoresistive pressure sensors using copper nanowires-based *** sensors exhibit excellent sensitivity and durability and can be easily scalable to form l... 详细信息

关键词： Copper nanowires Aerogel Piezoresistive Pressure sensing matrix

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Enhanced energy-absorbing and sound-absorbing capability of functionally graded and helicoidal lattice structures with triply periodic minimal surfaces

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International Journal of Minerals,Metallurgy and Materials 2023年第10期30卷 1973-1985页

作者： Miao Zhao Zhendong Li Jun wei Chua Chong Heng lim Xinwei Li Department of Mechanical Engineering National University of SingaporeSingapore 117411Singapore Chongqing Key Laboratory of Metal Additive Manufacturing(3D Printing) Chongqing UniversityChongqing 400044China Department of Mechanical Engineering Newcastle UniversitySingapore 567739Singapore

Lattice structures have drawn much attention in engineering applications due to their lightweight and multi-functional *** this work,a mathematical design approach for functionally graded(FG)and helicoidal lattice structures with triply periodic minimal surfaces is *** types of lattice structures including uniform,helicoidal,FG,and combined FG and helicoidal are fabricated by the additive manufacturing *** deformation behaviors,mechanical properties,energy absorption,and acoustic properties of lattice samples are thoroughly *** load-bearing capability of helicoidal lattice samples is gradually improved in the plateau stage,leading to the plateau stress and total energy absorption improved by over 26.9%and 21.2%compared to the uniform sample,*** phenomenon was attributed to the helicoidal design reduces the gap in unit cells and enhances fracture *** acoustic properties,the design of helicoidal reduces the resonance frequency and improves the peak of absorption coefficient,while the FG design mainly influences the peak of absorption *** broad range of frequency from 1000 to 6300 Hz,the maximum value of absorption coefficient is improved by18.6%-30%,and the number of points higher than 0.6 increased by 55.2%-61.7%by combining the FG and helicoidal *** study provides a novel strategy to simultaneously improve energy absorption and sound absorption properties by controlling the internal architecture of lattice structures.

关键词： additive manufacturing lattice structure triply periodic minimal surface energy absorption sound absorption

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Probing 10μK stability and residual drifts in the cross-polarized dual-mode stabilization of single-crystal ultrahigh-Q optical resonators

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Light(Science & Applications) 2019年第1期8卷 1170-1178页

作者： Jinkang lim wei Liang Anatoliy A.Savchenkov Andrey B.Matsko Lute Maleki Chee wei Wong Fang Lu Mesoscopic Optics and Quantum Electronics Laboratory University of CaliforniaLos AngelesCA 90095USA OEwaves Inc. 465 North Halstead StreetSuite 140PasadenaCA 91107USA

The thermal stability of monolithic optical microresonators is essential for many mesoscopic photonic applications such as ultrastable laser oscillators,photonic microwave clocks,and precision navigation and *** fundamental performance is largely bounded by thermal *** thermal monitoring can be achieved by utilizing cross-polarized dual-mode beat frequency metrology,determined by the polarization-dependent thermorefractivity of a single-crystal microresonator,wherein the heterodyne radio-frequency beat pins down the optical mode volume temperature for precision ***,we investigate the correlation between the dualmode beat frequency and the resonator temperature with time and the associated spectral noise of the dual-mode beat frequency in a single-crystal ultrahigh-Q MgF_(2) resonator to illustrate that dual-mode frequency metrology can potentially be utilized for resonator temperature stabilization reaching the fundamental thermal noise limit in a realistic *** show a resonator long-term temperature stability of 8.53μK after stabilization and unveil various sources that hinder the stability from reaching sub-μK in the current system,an important step towards compact precision navigation,sensing,and frequency reference architectures.

关键词： resonator polarization stabilization

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Intestine-derived α-synuclein initiates and aggravates pathogenesis of Parkinson’s disease in Drosophila

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Translational Neurodegeneration 2022年第1期11卷 262-279页

作者： wei Liu Kah-Leong lim Eng-King Tan School of Plant Protection Anhui Province Key Laboratory of Crop Integrated Pest ManagementAnhui Province Engineering Laboratory for Green Pesticide Development and ApplicationAnhui Agricultural UniversityHefei 230036China Department of Neurology National Neuroscience InstituteSingapore 308433Singapore Department of Research National Neuroscience InstituteSingaporeSingapore Research Lee Kong Chian School of Medi-cineSingaporeSingapore Neuroscience and Behavioural Disorders Program Duke-NUS Medical SchoolSingapore 169857Singapore.

Background:Aberrant aggregation ofα-synuclein(α-syn)is a key pathological feature of Parkinson’s disease(PD),but the precise role of intestinalα-syn in the progression of PD is *** a number of genetic Drosophila models of PD,α-syn was frequently ectopically expressed in the neural system to investigate the ***:We investigated the potential role of intestinalα-syn in PD pathogenesis using a Drosophila ***α-syn was overexpressed in Drosophila guts,and life span,survival,immunofluorescence and climbing were ***,Western blotting and reactive oxygen species(ROS)staining were performed to assess the effects of intestinalα-syn on intestinal ***‐throughput RNA and 16S rRNA gene sequencing,quantitative RT‐PCR,immunofluorescence,and ROS staining were performed to determine the underlying molecular ***:We found that the intestinalα-syn alone recapitulated many phenotypic and pathological features of PD,including impaired life span,loss of dopaminergic neurons,and progressive motor *** intestine-derivedα-syn disrupted intestinal homeostasis and accelerated the onset of intestinal ***,intestinal expression ofα-syn induced dysbiosis,while microbiome depletion was efficient to restore intestinal homeostasis and ameliorate the progression of ***α-syn triggered ROS,and eventually led to the activation of the dual oxidase(DUOX)-ROS-Jun N-terminal Kinase(JNK)*** addition,α-syn from both the gut and the brain synergized to accelerate the progression of ***:The intestinal expression ofα-syn recapitulates many phenotypic and pathologic features of PD,and induces dysbiosis that aggravates the pathology through the DUOX-ROS-JNK pathway in *** findings provide new insights into the role of intestinalα-syn in PD pathophysiology.

关键词： Intestine α-Synuclein Parkinson’s disease Microbiome

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