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Chinese Chemical Letters 2003年第4期14卷 335-337页

作者： wei ming xu Li ming YU Xian HUANG Department of Chemistry Zhejiang University(Xixi Campus)Hangzhou 310028

Polystyrene-supported benzyl selenide has been prepared. This novel reagent was treated with LDA to produce a selenium stabilized carbanion, which reacted with alkyl halide, followed by selenoxide syn-elimination, to... 详细信息

关键词： Solid phase synthesis polystyrene-supported benzyl selenide substituted olefins.

Solid Phase Synthesis of 1,4-Disubstituted 1,2,3-Triazole from Polystyrene-supported Selenium Resin

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Chinese Chemical Letters 2006年第5期17卷 603-605页

作者： wei ming xu Lu Ling WU Xian HUANG Department of Chemistry Zhejiang University （Campus Xixi） Hangzhou 310028 Center of Analysis and Measurement Zhejiang University Hangzhou 310028

We report here a solid-phase synthesis of 1, 4-disubstituted 1, 2, 3-triazole using polystyrene-supported selenium resin. The resin used here not only works as a simple linker, but also assists the crucial α-alkylati... 详细信息

关键词： Solid-phase synthesis 1,3-dipolar cycloaddition α-alkylation reaction 1,2,3-triazole.

Determinants of lexical access in pure-anomic recovery:a longitudinal study

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第5期10卷 341-347页

作者： Xiao ZHOU Hui LIANG ming-wei xu Ben-yan LUO Neuropsychology Laboratory the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Many studies involving lexical access in picture-naming tasks have been undertaken at a point in time,mainly focusing on age of acquisition(AoA).To identify the real determinates of lexical access in recovery and their traces in the brain,we carried out a longitudinal study on a Chinese pure anomic patient using multiple logistic regression *** found that AoA played an important role in early recovery but not in total recovery,whereas familiarity was significant in the whole *** a new dynamic point of view,our results indicate that AoA and familiarity are the main determinants of lexical access in anomia *** suggest that the changing effects of AoA during recovery may be related to the pathologic process;AoA and familiarity should be taken into account in constructing materials to assess and treat anomic patients.

关键词： Object naming Age of acquisition Anomia Therapy

An Efficient Deselenenylation Reaction to the Synthesis of 3, 5-Disubstituted Isoxazoline and Isoxazole

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Chinese Chemical Letters 2005年第8期16卷 995-996页

作者： wei ming xu Yu Guang WANG Zhen Hua CHEN Xian HUANG Department of Chemistry Zhejiang University （Xixi Campus） Hangzhou 310028

A mild deselenenylation reaction protocol for the preparation of 3, 5-disubstituted isoxazolines and their further application to 3-methyl-5-substituted isoxazoles both in solution phase and solid phase was reported.

关键词： Deselenenylation reaction isoxazoline isoxazole.

Green Synthesis of Chemically Recyclable Polyesters via Dehydrogenative Copolymerization of Diols

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Chinese Journal of Polymer Science 2023年第8期41卷 1206-1214,I0006页

作者： wei-ming xu Yuan-Dong Yu Meng-Xiang Ma Hui-Du xu Rui-Qin Wang Yu-Peng Pan Ke-Qin Wu wei-Ran Yang Chang-Guang Yao School of Chemistry and Chemical Engineering Nanchang UniversityNanchang 330031China School of Resource&Environment Nanchang UniversityNanchang 330031China Shenzhen Grubbs Institute and Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China

Preparation of chemically recyclable polyesters by ring-opening polymerization(ROP)has made a considerable progress over the past few ***,this method involves cumbersome synthesis and minimal functional diversity of cyclic ***,it is of great significance to develop novel polymerization methods for direct polymerization of commercially available monomers to prepare recyclable polyesters with versatile *** present work,we report dehydrogenative copolymerization of commercialα,ω-diols to afford high molecular weight chemically recyclable aliphatic copolyesters(65.7 kg·mol^(-1))by using commercially available Milstein catalyst *** thermal properties of the obtained copolymers could be finely tuned by simply adjusting the feeding ratio of two *** incorporation of aliphatic or aromatic rings into polyester mainchain via copolymerization of 1,10-decanediol with 1,4-cyclohexanedimethanol and 1,4-benzenedimethanol could significantly improve the thermal properties of the resulting *** importantly,the obtained copolyesters were able to completely depolymerize back to original diols via hydrogenation by the same catalyst in solvent-free and mild conditions,thus offering a green and cost-effective route toward the preparation of widely used polyesters.

关键词： Chemically recyclable Dehydrogenative copolymerization Polyester Diol

Extrapontine myelinolysis caused by rapid correction of pituitrin-induced severe hyponatremia: A case report

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World Journal of Clinical Cases 2020年第5期8卷 946-953页

作者： Liang-Jie Fang ming-wei xu Jian-Ying Zhou Zhi-Jie Pan Department of Respiratory Medicine First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009Zhejiang ProvinceChina Department of Neurology First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009Zhejiang ProvinceChina

BACKGROUND Severe hyponatremia is considered a rare complication of pituitrin,which is widely used for the treatment of pulmonary ***,the management of pituitrin-associated hyponatremia can be challenging because a rapid correction of hyponatremia may cause the development of osmotic demyelination syndrome,resulting in life-threatening neurological *** SUMMARY A 20-year-old Chinese man with massive hemoptysis developed symptomatic hyponatremia(116 mmol/L)after therapy by a continuous intravenous drip of *** normalize his serum sodium,a hypertonic saline infusion was applied for 3 d,and the pituitrin administration was stopped ***,an overly rapid increase in serum sodium level(18 mmol/L in 24 h)was detected after *** day later,the patient experienced a sudden onset of generalized tonic-clonic seizures,as well as subsequent dysarthria and *** resonance imaging revealed increased signal intensity in the bilateral symmetric basal ganglia on the T2-weighted images,compatible with a diagnosis of extrapontine *** patient received an intravenous administration of high-dose corticosteroids,rehabilitation,and neurotrophic ***,his clinical abnormalities were vastly improved,and he was discharged with few residual *** Physicians should be fully aware that pituitrin can cause profound hyponatremia and its correction must be performed at a controlled rate to prevent the development of osmotic demyelination syndrome.

关键词： Pituitrin Hyponatremia Extrapontine myelinolysis Case report

Case Report:Pure word deafness associated with extrapontine myelinolysis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第11期11卷 842-847页

作者： Ren-jing ZHU Zhi-su LV Chun-lei SHAN ming-wei xu Ben-yan LUO Department of Neurology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310029 China Department of Neurology Zhongshan Hospital Xiamen University Xiamen 361004 China Department of Ultrasonography Children's Hospital School of Medicine Zhejiang University Hangzhou 310029 China Laboratory for Higher Brain Function Institute of Psychology Chinese Academy of Sciences Beijing 100101 China Department of Rehabilitation Medicine the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China

Extrapontine myelinolysis and pure word deafness are very uncommon ***,we report a case of a 19-year-old woman who suffered from osmotic demyelination syndrome with coincidence of typical pure word *** a consequence of rapid correction of hyponatremia,the patient demonstrated an initial onset of cortical deafness,and then progressed to generalized auditory agnosia,which eventually developed into confined verbal auditory agnosia(pure word deafness) .Bilateral extrapontine myelinolysis was confirmed using brain magnetic resonance *** case suggests that verbal and nonverbal stimuli may involve separate thalamocortical pathways.

关键词： Pure word deafness Auditory agnosia Osmotic demyelination syndrome Extrapontine myelinolysis Cortical deafness

Genetically predicted fatty liver disease and risk of psychiatric disorders: A mendelian randomization study

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World Journal of Clinical Cases 2024年第14期12卷 2359-2369页

作者： wei-ming xu Hai-Fu Zhang Yong-Hang Feng Shuo-Jun Li Bi-Yun Xie Department of Medicine The First People's Hospital of FuyangHangzhou 311400Zhejiang ProvinceChina Department of Internal Medicine The First People's Hospital of FuyangHangzhou 311400Zhejiang ProvinceChina

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)and alcohol-related liver disease(Ar-LD)constitute the primary forms of chronic liver disease,and their incidence is progressively increasing with changes in lifestyle *** studies have do-cumented a correlation between the occurrence and development of prevalent mental disorders and fatty *** To investigate the correlation between fatty liver and mental disorders,thus ne-cessitating the implementation of a mendelian randomization(MR)study to elu-cidate this *** Data on NAFLD and ArLD were retrieved from the genome-wide association studies catalog,while information on mental disorders,including Alzheimer's disease,schizophrenia,anxiety disorder,attention deficit hyperactivity disorder(ADHD),bipolar disorder,major depressive disorder,multiple personality dis-order,obsessive-compulsive disorder(OCD),post-traumatic stress disorder(PTSD),and schizophrenia was acquired from the psychiatric genomics consor-tium.A two-sample MR method was applied to investigate mediators in signifi-cant *** After excluding weak instrumental variables,a causal relationship was identified between fatty liver disease and the occurrence and development of some psychia-tric ***,the findings indicated that ArLD was associated with a significantly elevated risk of developing ADHD(OR:5.81,95%CI:5.59-6.03,P<0.01),bipolar disorder(OR:5.73,95%CI:5.42-6.05,P=0.03),OCD(OR:6.42,95%CI:5.60-7.36,P<0.01),and PTSD(OR:5.66,95%CI:5.33-6.01,P<0.01).Meanwhile,NAFLD significantly increased the risk of developing bipolar disorder(OR:55.08,95%CI:3.59-845.51,P<0.01),OCD(OR:61.50,95%CI:6.69-565.45,P<0.01),and PTSD(OR:52.09,95%CI:4.24-639.32,P<0.01).CONCLUSION Associations were found between genetic predisposition to fatty liver disease and an increased risk of a broad range of psychiatric disorders,namely bipolar disorder,OCD,and PTSD,highlighting the significance of preven-tive measures against psy

关键词： Non-alcoholic fatty liver disease Alcohol-related liver disease Psychiatric disorders Mendelian randomization Single nucleotide polymorphisms

Calibrating the linearity between grayscale and element content for X-ray KES imaging of alloys

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Nuclear Science and Techniques 2022年第1期33卷 1-12页

作者： Xiao-Lu Ju Biao Deng Ke Li Fu-Cheng Yu Hai-Peng Zhang ming-wei xu Guo-Hao Du Hong-Lan Xie Bin Li Ti-Qiao Xiao Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China University of Chinese Academy of Sciences Beijing 100049China

Doped elements in alloys significantly impact their *** methods usually sputter the surface material of the sample,or their performance is limited to the surface of alloys owing to their poor penetration *** X-ray K-edge subtraction(KES)method exhibits great potential for the nondestructive in situ detection of element contents in ***,the signal of doped elements usually deteriorates because of the strong absorption of the principal component and scattering of crystal *** in turn prevents the extensive application of X-ray KES imaging to *** this study,methods were developed to calibrate the linearity between the grayscale of the KES image and element *** methods were aimed at the sensitive analysis of elements in ***,experiments with phantoms and alloys demonstrated that,after elaborate calibration,X-ray KES imaging is capable of nondestructive and sensitive analysis of doped elements in alloys.

关键词： X-ray KES imaging Grayscale calibration Element analysis for alloy Nondestructive imaging of elements

Renoprotective effect of alprostadil in combination with statins in patients with mild to moderate renal failure undergoing coronary angiography

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Chinese Medical Journal 2013年第18期126卷 3475-3480页

作者： LIU wei-jing ZHANG Bu-chun GUO Rong wei Yi-dong LI wei-ming xu Ya-wei Department of Cardiology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai 200072 China

Background The role of alprostadil and statins in contrast-induced acute kidney injury （CI-AKI） is controversial. The purpose of this study was to explore the efficacy of combined therapy with alprostadil and statins in protecting renal function and preventing contrast-induced nephropathy （CIN） in patients undergoing coronary angiography. Methods A total of 156 consecutive patients with mild to moderate renal failure who underwent coronary angiography were enrolled in our study, and randomly categorized into two groups. In the statins group, 80 patients were treated with statins before and after coronary angiography. In the alprostadil plus statins group, 76 patients were treated with statins and alprostadil before and after coronary angiography. Serum creatinine （SCr）, serum cystatin （CysC） and neutrophil gelatinase-associated lipocalin （NGAL） were detected after administration of contrast media, and adverse events were evaluated within six months. Results In both groups, the SCr, CysC and NGAL significantly increased after coronary angiography and peaked at 48, 24 and 6 hours, respectively. SCr, CysC and NGAL were significantly lower in the alprostadil plus statins group than in the statins group （P〈0.05）. The incidence of CIN in the alprostadil plus statins group was slightly lower than in the statins group. The incidence of adverse events within six months in the alprostadil plus statins group was significantly lower than in the statins group （P=0.034）. Conclusions Intravenous alprostadil in combination with oral statins is superior to statins alone for protecting renal function in patients with mild to moderate renal dysfunction who undergo coronary angiography, and can reduce the incidence of adverse events seen within six months.

关键词： alprostadil statins renal failure coronary angiography