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CD87-targeted BiTE and CAR-T cells potently inhibit invasive nonfunctional pituitary adenomas

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Science China Life Sciences 2024年第10期67卷 2169-2185页

作者： Yuan Ren Xinjie Bao Ming Feng Bing Xing wei lian Yong Yao Renzhi Wang Department of Neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College

Recently, bispecific T-cell engagers(BiTEs) and chimeric antigen receptor-modified T cells(CAR-Ts) have been shown to have high therapeutic efficacy in hematological tumors. CD87 is highly expressed in solid tumors with an oncogenic function. To assess their cytotoxic effects on invasive nonfunctioning pituitary adenomas(iNFPAs), we first examined CD87 expression and its effects on the metabolism of iNFPA cells. We generated CD87-specific BiTE and CAR/IL-12 T cells, and their cytotoxic effects on iNFPAs cells and in mouse models were determined. CD87 had high expression in i NFPA tissue and cell samples but was undetected in noncancerous brain samples. CD87×CD3 BiTE and CD87 CAR/IL-12 T-cells showed antigenic specificity and exerted satisfactory cytotoxic effects, decreasing tumor cell proliferation in vitro and reducing existing tumors in experimental mice. Overall, the above findings suggest that CD87 is a promising target for the immunotherapeutic management of iNFPAs using anti-CD87 BiTE and CD87-specific CAR/IL-12 T cells.

关键词： CD87 chimeric antigen receptor T cells invasive non-functional pituitary adenomas bispecific T cell engager Warburg effect

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Comparative studies on Fenton-like reactions catalyzed by Fe_(3)O_(4) loaded inside and outside halloysite nanotubes for the removal of organic pollutants

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Frontiers of Materials Science 2024年第1期18卷 15-28页

作者： Yang Li Jia-Qi Zhou Huan-Yan Xu Li-Min Dong Mao-Chang Cao lian-wei Shan Li-Guo Jin Xiu-Lan He Shu-Yan Qi Heilongjiang Provincial Key Laboratory of CO_(2) Resource Utilization and Energy Catalytic Materials School of Materials Science and Chemical EngineeringHarbin University of Science and TechnologyHarbin 150040China

In this work,Fe_(3)O_(4) nanoparticles(NPs)loaded inside and outside halloysite nanotubes(HNTs)were prepared and developed as the heterogeneous Fenton-like catalysts for the removal of representative organic *** results indicated that the samples with Fe_(3)O_(4) NPs loaded outside the HNTs lumen(Fe_(3)O_(4)/HNTs)and inside the HNTs lumen(Fe_(3)O_(4)@HNTs)were successfully *** samples had typical magnetic hysteresis loops,while Fe_(3)O_(4)@HNTs exhibited higher magnetization *** comparative experiments showed that Fe_(3)O_(4)@HNTs had better Fenton-like catalytic ability than that of Fe_(3)O_(4)/HNTs in the degradation of various organic *** Rhodamine B(RhB)as an example,the adsorption thermodynamics and kinetics of RhB onto Fe_(3)O_(4)/HNTs and Fe_(3)O_(4)@HNTs were also *** comparative results demonstrated that the adsorption ability of Fe_(3)O_(4)/HNTs was better than that of Fe_(3)O_(4)@***,the dissolved concentration of Fe^(2+)and production amount of hydroxyl radical(·OH)in the Fe_(3)O_(4)@HNTs-H_(2)O_(2) system were significantly higher than those in the Fe_(3)O_(4)/HNTs-H_(2)O_(2) *** on aforementioned comparison,the nano-confinement effect in the Fe_(3)O_(4)@HNTs-H_(2)O_(2) system was *** work provides meaningful guidance for the cheap and convenient design of nanoreactors for Fenton-like applications.

关键词： Fe_(3)O_(4) halloysite nanotube adsorption Fenton-like reaction mechanism

Efficacy and Safety of Ganyushu Granule in Treatment of Premenstrual Syndrome with Gan(Liver)Depression and Qi Stagnation Syndrome:A Randomized,Double-Blind,Multicenter,Phase-ⅡClinical Trial

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Chinese Journal of Integrative Medicine 2024年第9期30卷 771-779页

作者： TENG Xiu-xiang XU lian-wei LIN Jie ZHANG Jin-feng ZHANG Qin SUN Yun YANG De-feng LI Hong-mei ZHAO Pei LIU Jun Department of Gynecology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100700China Department of Gynecology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China Department of Gynecology The First Hospital of Hunan University of Chinese MedicineChangsha410021China Department of Gynecology Shanxi Traditional Chinese Medicine HospitalTaiyuan030024China Department of Gynecology Hangzhou Hospital of Traditional Chinese MedicineHangzhou310005China Department of Gynecology Wenzhou Hospital Affiliated to Zhejiang University of Traditional Chinese MedicineWenzhouZhejiang Province325000China Department of Gynecology Luoyang First People’s HospitalLuoyangHenan Province471000China Department of Gynecology The Second Affiliated Hospital of Heilongjiang University of Chinese MedicineHarbin150001China

Objective:To confirm the efficacy and safety of Ganyushu Granule(GYSG)in treating premenstrual syndrome(PMS)in patients with Gan(Liver)depression and qi stagnation syndrome(GDQSS)and determine its effective ***:From June 2018 to March 2021,a total of 240 PMS women with GDQSS were included and randomly divided into 3 groups in a 1:1:1 ratio using central block randomization:high-dose GYSG group(n=78,GYSG 2 packs/time),low-dose GYSG group(n=82,GYSG and its simulant 1 pack/time),and placebo group(n=80,GYSG simulant 2 packs/time).Treatment with GYSG or placebo was given thrice daily and for up to 3 menstrual *** outcomes were PMS diary(PMSD)score and premenstrual tension syndrome self-rating scale(PMTS).Secondary outcomes were Chinese medicine(CM)syndrome ***,PMTS,and efficacy of CM were evaluated with menstrual cycles during the treatment *** indicators were analyzed after each menstrual *** analyses were performed using an intention-to-treat method,and clinical safety was ***:Of the 216 patients included in the effectiveness analysis,70,75,and 71 patients were in the high-,low-dose GYSG,and placebo groups,*** the 2nd treatment cycle,the change in PMSD scores in the high-and low-dose groups was lower than that in the placebo group(P<0.05).PMTS scores in the high-dose GYSG group after the 1st treatment cycle was lower than that in the placebo group(P<0.05),while after the 3rd treatment cycle,that in the low-dose group was lower than that in the placebo group(P<0.05).After the 2nd treatment cycle,the high-dose GYSG group had the best CM syndrome efficacy(P<0.05).No serious adverse reactions were ***:GYSG was safe and well-tolerated at both doses for treating PMS patients with ***-dose GYSG might be the optimal dose for a phaseⅢtrial.

关键词： premenstrual syndrome Chinese medicine Ganyushu Granule randomized controlled trial

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小说诗学:从“文化书写”到“书写文化”

中山大学学报（社会科学版） 2024年第2期64卷 105-113页

作者：王威廉中山大学中文系广州510275

“文化书写”是指小说对一个社会空间中的文化形态进行呈现,在许多小说中体现为对民俗风情的展示,这种传统书写往往将文化表现为一种恒定的状态,而忽视了文化在时代、生活中的变迁,尤其会低估个体对置身其中的文化的能动性乃至反向塑形... 详细信息

“文化书写”是指小说对一个社会空间中的文化形态进行呈现,在许多小说中体现为对民俗风情的展示,这种传统书写往往将文化表现为一种恒定的状态,而忽视了文化在时代、生活中的变迁,尤其会低估个体对置身其中的文化的能动性乃至反向塑形能力。这容易令人把“文化”理解为一种教条化的知识结论,但事实上文化跟人的命运具有不可分割性。“书写文化”就是对写作者精神主体自觉的强调,让写作结合个体的生命体验,反思自我置身其中的文化模式,把地方性经验置放到全人类的视野中去考量与思辨,这样才更能“深描”出文化的内质。由此,小说可以被看成是生命主体借助虚构去介入社会文化的一种精神实践,这种实践让文化获得生机并不断生成新的可能性。

关键词：文化书写书写文化小说诗学文学人类学

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基于升降轨SAR数据的连续箱梁桥精细变形

东北大学学报（自然科学版） 2024年第3期45卷 391-400页

作者：魏恋欢王啸天敖萌李鑫东北大学资源与土木工程学院辽宁沈阳110819

针对桥梁精细变形监测问题,提出一种考虑由温度引起的桥梁变形(简称温度变形)的升降轨合成孔径雷达(synthetic aperture radar,SAR)数据融合方法.首先,以连续箱梁桥为研究对象,分别使用升降轨SAR数据集,基于小基线子集干涉测量法(small ... 详细信息

针对桥梁精细变形监测问题,提出一种考虑由温度引起的桥梁变形(简称温度变形)的升降轨合成孔径雷达(synthetic aperture radar,SAR)数据融合方法.首先,以连续箱梁桥为研究对象,分别使用升降轨SAR数据集,基于小基线子集干涉测量法(small baseline subsets interferometric SAR,SBAS-InSAR)提取视线向(line-of-sight,LOS)变形;然后,利用最小二乘法构建温度变形模型,分离周期性温度变形与长期性趋势变形;最后,结合桥梁结构特征,基于时空插值和奇异值分解方法实现升降轨数据融合,提取温度变形、纵桥向(即桥梁延伸方向)及垂直向趋势变形,分析桥梁变形机制及变形成因.结果表明,该方法可提取精确的桥梁温度变形及三维变形,为桥梁健康监测提供可靠的方法支撑.

关键词：小基线子集连续箱梁桥温度变形建模数据融合三维变形

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基于DS-InSAR的蒲河煤矿采空区地表形变监测与开采参数反演

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东北大学学报（自然科学版） 2024年第6期45卷 866-873,882页

作者：敖萌孙颖魏恋欢张化南东北大学资源与土木工程学院辽宁沈阳110819 辽宁省地质矿产调查院有限责任公司辽宁沈阳110031

合成孔径雷达干涉测量(InSAR)技术在有植被覆盖的矿区难以识别到足够多的监测点目标,导致形变结果无法反映矿区真实形变特征.采用分布式散射体InSAR分析方法,能够有效提高植被密集区域雷达相干目标数量,从而准确描述矿区形变的时间演化... 详细信息

合成孔径雷达干涉测量(InSAR)技术在有植被覆盖的矿区难以识别到足够多的监测点目标,导致形变结果无法反映矿区真实形变特征.采用分布式散射体InSAR分析方法,能够有效提高植被密集区域雷达相干目标数量,从而准确描述矿区形变的时间演化规律和空间分布特征.矿区长期高强度开采会引发采空区的地表变形,严重威胁矿区基础设施建设和人员生命财产安全.基于沈阳蒲河煤矿采空区InSAR高精度监测数据,通过地球物理建模反演得到矿区地下关键开采参数,模拟的矿区形变场与InSAR监测结果较为一致,且反演开采参数符合真实开采情况.结合InSAR监测结果与Okada模型反演矿区参数,能够准确描述由采矿造成的采空区地表形变,为科学制定地下开采计划及矿区可持续开发提供重要信息.

关键词：矿区地面沉降合成孔径雷达干涉测量分布式散射体地球物理建模形变监测

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对大数据时代高校思政课教学的几点思考

金融理论与教学 2024年第1期42卷 106-108,113页

作者：魏连齐鲁工业大学马克思主义学院山东济南250353

当前网络信息技术发展迅速,大数据时代下的高校思政课正在发生变化。为了能够丰富相关资源内容,提高学生参与学习活动的积极性,需探究大数据在高校思政课教学中的主要作用,大数据时代高校思政课程教学面临的挑战及应对策略,使之更加符... 详细信息

当前网络信息技术发展迅速,大数据时代下的高校思政课正在发生变化。为了能够丰富相关资源内容,提高学生参与学习活动的积极性,需探究大数据在高校思政课教学中的主要作用,大数据时代高校思政课程教学面临的挑战及应对策略,使之更加符合大学生的成长、成才、成人规律,提高思政课立德树人的育人效果。

关键词：大数据时代高校思政课思政课教学

浦东新区公园特色打造和提升城市公园管养水平探索

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上海建设科技 2024年第2期 144-148页

作者：连炜浦东新区绿化管理事务中心上海201210

为顺应游客对公园日益多元化、多样化,打造各具特色的公园是浦东新区绿化管理重点工作。以浦东新区部分城市公园为例,从游客需求、绿化景观、公益服务、文化活动等四方面,分析了浦东新区公园特色化改造、差异化服务的方案,形成公园专属... 详细信息

为顺应游客对公园日益多元化、多样化,打造各具特色的公园是浦东新区绿化管理重点工作。以浦东新区部分城市公园为例,从游客需求、绿化景观、公益服务、文化活动等四方面,分析了浦东新区公园特色化改造、差异化服务的方案,形成公园专属特色,更好地服务游客,并提升城市公园管养水平,为后续公园特色打造起到抛砖引玉的作用。

关键词：城市公园特色打造绿化景观管养水平

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食物成瘾及其神经环路调控机制

生物化学与生物物理进展 2024年第4期51卷 881-889页

作者：牟连伟王雅榕严梦思舒麟捷广州体育学院科学实验中心广州510500

食物成瘾是指人们对某些特定食物(高度加工、可口、高热量的食物)的依赖性达到难以控制的程度,并表现出一系列成瘾样的行为学变化,具有强迫性、长期性和反复性的特点。食物成瘾可引起肥胖症,而且是大部分人不能维持减肥效果或坚持限制... 详细信息

食物成瘾是指人们对某些特定食物(高度加工、可口、高热量的食物)的依赖性达到难以控制的程度,并表现出一系列成瘾样的行为学变化,具有强迫性、长期性和反复性的特点。食物成瘾可引起肥胖症,而且是大部分人不能维持减肥效果或坚持限制性饮食以保持健康体重的核心因素。深入理解食物成瘾及其神经生物学机制,将为干预食物成瘾以改善肥胖提供准确的靶点。食物成瘾的诊断标准是耶鲁大学食物成瘾量表,而食物成瘾的动物模型为小鼠食物自我管理模型。外侧下丘脑-腹侧被盖区-伏隔核神经环路、腹侧被盖区-前边缘皮质-伏隔核神经环路和外侧隔核-结节核神经环路是调控食物成瘾的关键神经环路机制。

关键词：食物成瘾耶鲁大学食物成瘾量表神经环路外侧下丘脑腹侧被盖区伏隔核前边缘皮质