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Effect of ABCB1 3435C>T transporter gene polymorphism on plasma efavirenz concentration in HIV-1 infected Thai adults

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Asian Pacific Journal of Tropical Medicine 2020年第6期13卷 266-271页

作者： Sahapat Barusrux Napatrupron Koomdee Rattanaporn Sukprasong weerawat manosuthi Monpat Chamnanphon Apichaya Puangpetch Chonlaphat Sukasem Veeranoot Nissapatorn Maria de Lourdes Pereira School of Allied Health Sciences and Research Excellence Center for Innovation and Health Products Walailak UniversityNakhon Si ThammaratThailand Division of Pharmacogenomics and Personalized Medicine Department of PathologyFaculty of Medicine Ramathibodi HospitalMahidol UniversityBangkokThailand Laboratory for Pharmacogenomics Somdech Phra Debaratana Medical CenterRamathibodi HospitalThailand Bamrasnaradura Infectious Diseases Institute Ministry of Public HealthThailand Clinical Pharmacokinetics and Pharmacogenomics Research Unit Department of PharmacologyFaculty of MedicineChulalongkorn UniversityBangkokThailand CICECO-Aveiro Institute of Materials and Department of Medical Sciences University of Aveiro3810-193 AveiroPortugal

Objective:To investigate the influence of ABCB1 polymorphisms on the plasma level of efavirenz in Thai adult cases infected with ***:A single nucleotide polymorphism of ABCB13435 C>T(rs1045642)in the gene encoding ABCB1 was genotyped using real-time PCR-based alleles in 149 HIV-infected Thai adults receiving efavirenz *** concentrations of efavirenz were measured by high-performance liquid chromatography 12 hr after *** relationship between plasma efavirenz concentrations and ABCB13435 C>T polymorphisms was ***:Logistic regression analysis showed no significant predictors of high plasma efavirenz concentration in relation to age,gender,body weight,CD4 count and plasma HIV-1 RNA,blood biochemical parameters,antiretroviral duration or ABCB13435 C>T polymorphisms,except for height(OR=0.902,95%CI:0.835-0.973)(PT *** frequency of the heterozygous mutant ABCB13435 C/T was 53.02%(n=79),ABCB13435 T/T homozygous mutant was 18.12%(n=21)and the wild type ABCB13435 C/C genotype was 28.86%(n=43).The overall median plasma concentration of efavirenz in 149 HIV-infected Thai cases was 2.41 mg/L[IQR:(1.46-4.12)mg/L].The plasma concentration of efavirenz was higher in cases with ABCB13435 T/T homozygous mutant[2.73 mg/L,IQR:(2.02-4.19)mg/L]and ABCB13435 C/T heterozygous mutant[2.29 mg/L,IQR:(1.41-4.28)mg/L]genotypes compared to the wild type ABCB13435 C/C homozygous[2.1 mg/L,IQR:(1.37-3.53)mg/L].However,there was no statistically significant difference in the efavirenz concentration between the different genotypes(P>0.05).Objective:To investigate the influence of ABCB1 polymorphisms on the plasma level of efavirenz in Thai adult cases infected with ***:A single nucleotide polymorphism of ABCB13435 C>T(rs1045642)in the gene encoding ABCB1 was genotyped using real-time PCR-based alleles in 149 HIV-infected Thai adults receiving efavirenz *** concentrations

关键词： Transporter gene ABCB13435C>T Efavirenz HIV-1 Thai

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