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Distinctive serotypes of SARS-related coronaviruses defined by convalescent sera from unvaccinated individuals

hLife 2023年第1期1卷 26-34页

作者： chee Wah Tan Feng Zhu Wan Ni Chia #Barnaby EYoung Aileen Ying Yan Yeoh Thomas Althaus chee Fu Yung wee chee yap Beng Lee Lim Mark I-C Chen Jinyan Zhang Yun Yan Mah Eric Voiglio Alex Sigal Jianxin Huo Shengli Xu Yee Joo Tan Kong-Peng Lam David Lye Lin-Fa Wang Programme in Emerging Infectious Diseases Duke-NUS Medical SchoolSingapore National Center of Infectious Diseases Singapore Tan Tock Seng Hospital Singapore Lee Kong Chian School of Medicine Nanyang Technology UniversitySingapore Centre Scientifique de Monaco Monaco Direction de I’Action Sanitaire de Monaco Monaco Infectious Disease Service Department of PediatricsKK Women’s and Children’s HospitalSingapore Duke-NUS Medical School Singapore African Health Research Institute DurbanSouth Africa Singapore Immunology Network Agency for ScienceTechnology and ResearchSingapore Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore Department of Microbiology and Immunology Yong Loo Lin School of MedicineNational University of SingaporeSingapore Infectious Diseases Translational Research Programme National University of SingaporeSingapore 14School of Biological SciencesNanyang Technological UniversitySingapore Singhealth Duke-NUS Global Health Institute Singapore

Multiple Omicron sub-lineages have emerged,with Omicron XBB and XBB.1.5 subvariants becoming the dominant variants globally at the time of this *** key feature of new variants is their ability to escape humoral immunity despite the fact that there are limited genetic changes from their preceding *** raises the question of whether Omicron should be regarded as a separate serotype from viruses serologically clustered with the ancestral severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)***,we present cross-neutralization data based on a pseudovirus neutralization test using convalescent sera from naïve individuals who had recovered from primary infection by SARS-CoV-1 and SARS-CoV-2 strains/variants including the ancestral virus and variants Beta,Delta,Omicron BA.1,Omicron BA.2 and Omicron *** results revealed no significant cross-neutralization in any of the three-way testing for SARS-CoV-1,ancestral SARS-CoV-2 and SARS-CoV-2 Omicron *** data argue for the assignment of three distinct serotypes for the currently known human-infecting SARS-related coronaviruses.

关键词： SARS-CoV-2 SARS-CoV-1 serotype Omicron primary infection convalescent sera

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An integrated approach for machine-learning-based system identification of dynamical systems under control:application towards the model predictive control of a highly nonlinear reactor system

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Frontiers of Chemical Science and Engineering 2022年第2期16卷 237-250页

作者： Ewan chee wee Chin Wong Xiaonan Wang Department of Chemical&Biomolecular Engineering Faculty of EngineeringNational University of SingaporeSingapore 117585Singapore Chemical Engineering&Food Technology Cluster Singapore Institute of TechnologySingapore 138683Singapore

Advanced model-based control strategies,e.g.,model predictive control,can offer superior control of key process variables for multiple-input multiple-output *** quality of the system model is critical to controller performance and should adequately describe the process dynamics across its operating range while remaining amenable to fast *** work articulates an integrated system identification procedure for deriving black-box nonlinear continuous-time multiple-input multiple-output system models for nonlinear model predictive *** showcase this approach,five candidate models for polynomial and interaction features of both output and manipulated variables were trained on simulated data and integrated into a nonlinear model predictive controller for a highly nonlinear continuous stirred tank reactor *** procedure successfully identified system models that enabled effective control in both servo and regulator problems across wider operating *** controllers also had reasonable per-iteration times of ca.0.1 *** demonstration of how such system models could be identified for nonlinear model predictive control without prior knowledge of system dynamics opens further possibilities for direct data-driven methodologies for model-based control which,in the face of process uncertainties or modelling limitations,allow rapid and stable control over wider operating ranges.

关键词： nonlinear model predictive control black-box modeling continuous-time system identification machine learning industrial applications of process control

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2D/2D heterojunction interface:Engineering of 1T/2H MoS_(2) coupled with Ti_(3)C_(2)Tx heterostructured electrocatalysts for pH-universal hydrogen evolution

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Journal of Materials Science & Technology 2024年第12期179卷 86-97页

作者： Jian Yiing Loh Feng Ming yap wee-Jun Ong School of Energy and Chemical Engineering Xiamen University MalaysiaSepangSelangor Darul Ehsan 43900Malaysia Center of Excellence for NaNo Energy&Catalysis Technology(CONNECT) Xiamen University MalaysiaSepangSelangor Darul Ehsan 43900Malaysia State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Gulei Innovation Institute Xiamen UniversityZhangzhou 363200China Shenzhen Research Institute of Xiamen University Shenzhen 518057China

Two-dimensional(2D)materials have come to light due to their unique thickness that owns abundant exposed edges with enhanced electrocatalytic properties.2D molybdenum disulfide(MoS_(2))nanosheet has aroused considerable attention due to its tunable surface chemistry and high electrochemical sur-face ***,several shortcomings associated with MoS_(2),such as its naturally existing semi-conducting 2H phase,which has limited active sites due to the inert basal plane,restrict its application in water *** into account the benefits of the 1T/2H phase of MoS_(2),as well as the importance of engineering 2D/2D heterojunction interface for boosted electrocatalysis,metallic Ti_(3)C_(2)Tx was integrated with 1T/2H MoS_(2) to develop 2D/2D 1T/2H MoS_(2)/Ti_(3)C_(2)Tx heterostructured ***,with only 25%of the intercalating agent,1T/2H MoS_(2) with the highest 1T phase content of~82%was successfully *** was further incorporated with 1 wt%of Ti_(3)C_(2)Tx through a com-bination of ultrasonication and mechanical stirring *** 1T/2H MoS_(2)(25D)/Ti_(3)C_(2)Tx-1(MTC-1)manifested outstanding electrocatalytic performance with an overpotential and Tafel slope of 280 mV(83.80 mV dec^(-1))and 300 mV(117.2 mV dec^(-1)),for catalyzing acidic and alkaline medium HER,***,the as-prepared catalysts also illustrated long-term stability for more than 40 *** coupling method for the 2D nanosheets is crucial to suppress the oxidation of Ti_(3)C_(2)Tx and the restack-ing issue of 2D *** superior HER activity is ascribed to the synergistic effect between the heterostructure,enhancing the electronic structure and charge separation *** intrinsic prop-erty of the catalyst further confirms by turnover frequency(TOF)*** such,this research paves the way for designing high-efficiency 2D electrocatalysts and sheds light on the further advancement of tunable 2D electrocatalysts for robust wa

关键词： 2D/2D electrocatalysts Phase engineering pH universal Molybdenum disulfide Ti_(3)C_(2)Tx

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Synergistic integration of self-supported 1T/2H-WS_(2) and nitrogendoped rGO on carbon cloth for pH-universal electrocatalytic hydrogen evolution

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Nano Research 2024年第3期17卷 1267-1280页

作者： Feng Ming yap Jian Yiing Loh wee-Jun Ong School of Energy and Chemical Engineering Xiamen University MalaysiaSelangor Darul Ehsan 43900Malaysia Center of Excellence for NaNo Energy&Catalysis Technology(CONNECT) Xiamen University MalaysiaSelangor Darul Ehsan 43900Malaysia State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Gulei Innovation Institute Xiamen UniversityZhangzhou 363200China Shenzhen Research Institute of Xiamen University Shenzhen 518057China

Hydrogen economy based on electrochemical water splitting exemplified one of the most promising means for overcoming the rapid consumption of fossil fuels and the serious deterioration of global *** development of earth-abundant,efficient,and durable electrocatalysts for hydrogen evolution reaction(HER)plays a vital role in the commercialization of water ***,the self-supported electrode with unique nitrogen-doped reduced graphene oxide(N-rGO)nanoflakes and WS_(2) hierarchical nanoflower that were grown directly on carbon cloth(CC)substrate(WS_(2)/N-rGO/CC)was successfully synthesized using a facile dual-step hydrothermal *** as-synthesized 50%1T/2H-WS_(2)/N-rGO/CC(WGC),which possessed high metallic 1T phase of 57%not only efficiently exposed more active sites and accelerated mass/charge diffusion,but also endowed excellent structural lustiness,robust stability,and durability at a high current *** a result,the 50%WGC exhibited lower overpotentials and Tafel slopes of 21.13 mV(29.55 mV∙dec^(-1))and 80.35 mV(137.02 mV∙dec^(-1))as compared to 20%Pt-C/CC,respectively for catalyzing acidic and alkaline hydrogen evolution ***,the as-synthesized 50%WGC also depicted long-term stability for more than 8 h in the high-current-density regions(100 and 220 mA∙cm^(-2)).In brief,this work reveals a self-supported electrode as an extraordinary alternative to Pt-based catalysts for HER in a wide pH range,while paving a facile strategy to develop advanced electrocatalysts with abundant heterointerfaces for practical applications in energy-saving hydrogen production.

关键词： self-supported electrocatalyst carbon-based substrate phase engineering pH-universal water splitting

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Risk assessment for the daily intake of polycyclic aromatic hydrocarbons from the ingestion of cockle (Anadara granosa) and exposure to contaminated water and sediments along the west coast of Peninsular Malaysia

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Journal of Environmental Sciences 2011年第2期23卷 336-345页

作者： Seiedeh Aghileh Mirsadeghi Mohamad Pauzi Zakaria chee Kong yap Azadeh Shahbazi Centre of Excellence for Environmental Forensics Faculty of Environmental StudiesUniversity Putra Malaysia43400 UPMSerdangSelangorMalaysia Faculty of Science Department of BiologyUniversity Putra Malaysia43400 UPMSerdangSelangorMalaysia

The concentration of carcinogenic polycyclic aromatic hydrocarbons （c-PAHs） present in the sediment and water of Peninsular Malaysia as well as in the cockle Anadara granosa was investigated. Samples were extracted and analysed with gas chromatographymass spectrometry. The concentrations of total carcinogenic polycyclic aromatic hydrocarbons （t-PAHs） were measured between 0.80±0.04 to 162.96 ±14.74 ng/g wet weight （ww） in sediment, between 21.85± 2.18 to 76.2± 10.82 ng/L in water samples and between 3.34 ±0.77 to 46.85 ± 5.50 ng/g ww in the cockle tissue. The risk assessment of probable human carcinogens in the Group B2 PAHs was calculated and assessed in accordance with the standards of the United States Environmental Protection Agency （US EPA）. Case I in the toxicity assessment analysed the cancer risk to consumers of Malaysian blood cockle. Case II assessed the risk of cancer from exposure to PAHs from multiple pathways. The average cancer risk of case I and case II were found to be classifiable as unsafe according to the US EPA standard. The cancer risk due to c-PAHs acquired by the ingestion of blood cockle was （8.82 ± 0.54） × 10^ 6 to （2.67 ± 0.06） × 10^-2, higher than the US EPA risk management criterion. The non-cancer risks associated with multiple pathways in Kuala Gula, Kuala Juru and Kuala Perlis were higher than the US EPA safe level, but the non-cancer risk for eating blood cockle was below the level of US EPA concern.

关键词： toxicity assessment carcinogenic polycyclic aromatic hydrocarbons group B2 of US EPA Anadara granosa

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Application of NOMA for cellular-connected UAVs:opportunities and challenges

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Science China(Information Sciences) 2021年第4期64卷 26-39页

作者： wee Kiat NEW chee Yen LEOW Keivan NAVAIE Yanshi SUN Zhiguo DING Wireless Communication Centre School of Electrical Engineering Faculty of EngineeringUniversiti Teknologi Malaysia Key Laboratory of Wireless-Optical Communications Chinese Academy of SciencesSchool of Information Science and Technology University of Science and Technology of China School of Electrical and Electronic Engineering The University of Manchester School of Computing and Communications Lancaster University

Unmanned aerial vehicles(UAVs) have gained considerable interests in numerous civil applications. To push forward its potentials, cellular-connected UAVs have been introduced. Nevertheless, cellular networks face several bottlenecks such as spectrum scarcity and limited concurrent connectivity. To address these issues, non-orthogonal multiple access(NOMA) can be adopted. NOMA provides several opportunities for cellular-connected UAVs such as larger rate region, balanced performance between system throughput and fairness, and reduced delay. In this paper, we review important findings of the related studies, and outline new opportunities and challenges in NOMA for cellular-connected UAVs. Monte-Carlo simulations are then performed to analyze the new aerial user’s(AU)’s signal characteristics and evaluate the NOMA performance for co-existence of AU and terrestrial user(TU). Our preliminary results show that NOMA is a promising strategy for cellular-connected UAVs.

关键词： cellular-connected UAVs non-orthogonal multiple access signal characteristics aerial user rate terrestrial user rate

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Fuzzy Logic Controller-based Synchronverter in Grid-connected Solar Power System with Adaptive Damping Factor

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Chinese Journal of Electrical Engineering 2021年第2期7卷 37-49页

作者： Kah Yung yap chee Ming Beh Charles R.Sarimuthu Department of Electrical and Computer Systems Engineering(ECSE) School of EngineeringMonash University MalaysiaSubang Jaya 47500Malaysia

In recent years,renewable energy sources,specifically solar power systems,have developed rapidly owing to their technological maturity and cost ***,its grid integration deteriorates frequency stability because of insufficient rotating masses and inertial ***,a synchronverter,which is an inverter that mimics the operation of a synchronous generator,is crucial to interface solar power in a power *** stabilizes the power grid by emulating a virtual ***,a conventional proportional-integral(PI)-based synchronverter is not equipped with an adaptive damping factor(Dp)or a digitalized smart controller to manage fast-responding solar ***,a novel fuzzy logic controller(FLC)framework is proposed such that the synchronverter can operate in a grid-connected solar power *** this study,Dp is controlled in real time using an FLC to achieve balance between speed and stability for frequency error correction based on frequency *** of four case studies performed in Matlab/Simulink show that the proposed FLC-based synchronverter can stabilize the grid frequency by reducing the frequency deviation by at least 0.2 Hz(0.4%),as compared with the conventional PI-based synchronverter.

关键词： Fuzzy logic controller(FLC) synchronverter renewable energy system(RES) grid stability solar power system

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Heavy Metal Concentrations in Sediment and Intertidal Gastropod Nerita lineata from Two Opposing Sites in the Straits of Malacca

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湿地科学 2008年第3期6卷 411-421页

作者： Bintal Amin Ahmad Ismail chee Kong yap Department of Biology Faculty of Science University Putra Malaysia UPM43400 Serdang Selangor Malaysia Department of Marine Science Faculty of Fisheries and Marine Science University of Riau Pekanbaru 28293 Indonesia

The concentrations of Cd,Cu,Pb,Zn,Ni and Fe were determined in the surface sediment and marine gastropod Nerita lineata collected in May 2005 from the intertidal zone of Dumai,Sumatera,Indonesia and Johor,Peninsular *** results showed that metal concentrations in sediment and the soft tissue of *** varied at different sampling *** heavy metal concentrations were 0.92 μg/g(Cd);6.40 μg/g(Cu);32.77 μg/g(Pb);54.41 μg/g(Zn);11.56 μg/g(Ni) and 2.97%(Fe) in sediment from Dumai and 1.15 μg/g(Cd);26.73 μg/g(Cu);53.45 μg/g(Pb);130.77 μg/g(Zn);20.79 μg/g(Ni) and 2.72%(Fe) in sediment from *** of metals in gastropod *** were 0.71 μg/g(Cd);15.16 μg/g(Cu);9.35 μg/g(Pb);94.69 μg/g(Zn);5.08 μg/g(Ni) and 397.97 μg/g(Fe) in samples from Dumai and 1.24 μg/g(Cd);18.02 μg/g(Cu);19.75 μg/g(Pb);95.09 μg/g(Zn);5.57 μg/g(Ni) and 473.56 μg/g(Fe) in samples from *** they were not statistically significant(p>0.05),heavy metal concentrations in *** were correlated with the concentrations of respective metals in sediment in both samples from Dumai and *** general,samples of sediment and gastropod from Johor accumulated significantly higher heavy metal concentrations when compared to samples from Dumai(p<0.05).Higher concentrations of metals were recorded in samples collected from the stations close to the industrial and anthropogenic activities in both Dumai and Johor ***,most of the concentrations were still comparable to the previous reported studies from other geographical areas.

关键词：重金属腹足动物马六甲海峡沉积物

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Artificial intelligence(AI)and management analytics

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Journal of Management Analytics 2019年第4期6卷 341-343页

作者： Michael Haenlein Andreas Kaplan chee-wee Tan Pengzhu Zhang 不详

Artificial Intelligence(AI),defined as“a system’s ability to correctly interpret external data,to learn from such data and to use those learnings to achieve specific goals and tasks through flexible adaptation”(Kaplan&Haenlein,2019b,p.17),has attracted immense attention among academics,business managers,entrepreneurs,and politicians *** alleged by Huang and Rust(2018,p.155),AI,despite“constituting a major source of innovation”,is“threatening human jobs”.

关键词： const analytic intelligence

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Natural language processing(NLP)in management research:A literature review

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Journal of Management Analytics 2020年第2期7卷 139-172页

作者： Yue Kang Zhao Cai chee-wee Tan Qian Huang Hefu Liu School of Management University of Science and Technology of ChinaHefeiPeople’s Republic of China Nottingham University Business School China University of Nottingham Ningbo ChinaNingboPeople’s Republic of China cDepartment of Digitalization Copenhagen Business SchoolCopenhagenDenmark

Natural language processing(NLP)is gaining momentum in management research for its ability to automatically analyze and comprehend human ***,despite its extensive application in management research,there is neither a comprehensive review of extant literature on such applications,nor is there a detailed walkthrough on how it can be employed as an analytical *** this end,we review articles in the UT Dallas List of 24 Leading Business Journals that employ NLP as their focal analytical technique to elucidate how textual data can be harnessed for advancing management theories across multiple *** describe the available toolkits and procedural steps for employing NLP as an analytical technique as well as its advantages and *** so doing,we highlight the managerial and technological challenges associated with the application of NLP in management research in order to guide future inquires.

关键词： natural language processing literature review sentiment analysis machine learning

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