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表皮组织型血浆酶原活化因子的表达与尿激酶、受体、血浆酶原抑制因子-1不同,在慢性静脉溃疡中升高

世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 13-14页

作者： weckroth m. Vaheri A. Virolainen S. 阎小宁 Dr.Departm.nt of Vir ology Haartman Institute P.O. 21 FI-00014 University of Helsinki Finland

Background:The plasm.nogen activation system.represents a potent m.chanism.of extracellular proteolysis and is an essential com.onent of norm.l wound healing . It has also been im.licated in the pathogenesis of chronic, nonhealing ulcers. Traditionally, urokinase-type plasm.nogen activator (uPA) has been associated with pericellular proteolytic activity involved in tissue rem.delling processes, and tissue-type plasm.nogen activator (tPA) m.inly with intravascular fibrinol ysis. Objectives:The present study was conducted to characterizethe spatial dis tribution of the various plasm.nogen activation system.com.onents in chronic ulc ers and acute, well-granulating wounds. m.thods:The expression of uPA, tPA, ur okinase receptor (uPAR), plasm.nogen activator inhibitor-1 (PAI-1), and vitron ectin was investigated by im.unohistochem.cal staining, in addition to uPA, tPA and PAI-1 expression by in-situ hybridization, in sam.les from.eight chronic v enous ulcers, five decubitus ulcers, five well-granulating acute wounds and fiv e norm.l skin sam.les. Results:In chronic venous leg ulcers tPA m.NA was detect ed in basal and suprabasal keratinocytes at the leading wound edge, while in wel l-granulating wounds and in decubitus ulcers tPA m.NA was expressed only in a f ew keratinocytes. However, tPA was widely expressed in fibroblast-and m.crophag e-like cells in the strom. of well-granulating wounds, while less tPA was dete cted in the granulation tissue of chronic ulcers. tPA m.NA and protein were loca lized in the superficial granular layers in norm.l skin. Although no qualitative differences in expression of uPA, PAI-1 or uPAR in the wound edge keratinocyte s in chronic ulcers vs. nor-m.lly granulating wounds were found, their expressi ons were m.re pronounced in the granulation tissue of well-granulating wounds. Conclusions:These results suggest that in poorly healing venous leg ulcers, the pattern of tPA expression is altered in keratinocytes at the leading edge of th e wou

关键词：静脉溃疡活化因子组织型抑制因子尿激酶受体褥疮溃疡肉芽肿性伤口边缘慢性溃疡纤维溶解

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