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Chinese Journal of Aeronautics 2024年第3期37卷 391-403页

作者： Wei HAO andrews LARBI Hongkang DONG Dongyun WANG Shenghu LI Zhejiang Provincial Key Laboratory of Urban Rail Transit Intelligent Operation and Maintenance Technology and Equipment Zhejiang Normal UniversityJinhua 321004China College of Engineering Zhejiang Normal UniversityJinhua 321004China Hangzhou Lilong Hydraulic Co. LtdHangzhou 311200China

The cylinder block/valve plate interface is one of the most critical frictional interfaces of the swashplate-type axial piston ***,the poor lubrication interface caused rapid wear and high friction loss in an elastohydrodynamic lubrication system,decreasing the pump *** resistant bronze coatings were fabricated on 38CrMoAl substrate by Physical Vapor Deposition(PVD)and Chemical Vapor Deposition(CVD),***-on-disc wear tests were performed to comparatively investigate the wear behaviors of the coatings and bulk ductile iron *** can be found that the PVD-bronze coating exhibited better wear resistance than the other two *** enhanced wear resistance was attributed to the unique composite microstructure and desired mechanical strength,which could resist to mechanical shear and spallation,decreasing friction *** appropriate hardness of(1.33±0.07)GPa could be beneficial for enhancing its wear *** PVD-bronze coating possessed a much lower and stable coefficient of friction(about 0.1)and wear rate(about 6000μm3.N-1.m-1)under the loading forces of about 100 N after 20 *** wear mechanism was the abrasive wear.

关键词： Aircraft hydraulic pump Bronze Coatings Wear resistance Mechanisms

Molecular regulation of calcium-sensing receptor(CaSR)-mediated signaling

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Chronic Diseases and Translational Medicine 2024年第3期10卷 167-194页

作者： Li Tian Corey andrews Qiuyun Yan Jenny J.Yang Department of Chemistry Center for Diagnostics and TherapeuticsAdvanced Translational Imaging FacilityGeorgia State UniversityAtlantaGeorgiaUSA

Calcium-sensing receptor(CaSR),a family C G-protein-coupled receptor,plays a crucial role in regulating calcium homeostasis by sensing small concentration changes of extracellular Ca^(2+),Mg^(2+),amino acids(e.g.,L-Trp and L-Phe),small peptides,anions(e.g.,HCO_(3)^(-)and PO_(4)^(3-)),and ***-mediated intracellular Ca^(2+)signaling regulates a diverse set of cellular processes including gene transcription,cell proliferation,differentiation,apoptosis,muscle contraction,and neuronal *** of CaSR with mutations results in diseases such as autosomal dominant hypocalcemia,familial hypocalciuric hypercalcemia,and neonatal severe *** also influences calciotropic disorders,such as osteoporosis,and noncalciotropic disorders,such as cancer,Alzheimer's disease,and pulmonary arterial *** study first reviews recent advances in biochemical and structural determination of the framework of CaSR and its interaction sites with natural ligands,as well as exogenous positive allosteric modulators and negative allosteric *** establishment of the first CaSR protein-protein interactome network revealed 94 novel players involved in protein processing in endoplasmic reticulum,trafficking,cell surface expression,endocytosis,degradation,and signaling *** roles of these proteins in Ca^(2+)-dependent cellular physiological processes and in CaSR-dependent cellular signaling provide new insights into the molecular basis of diseases caused by CaSR mutations and dysregulated CaSR activity caused by its protein interactors and facilitate the design of therapeutic agents that target CaSR and other family C G-protein-coupled receptors.

关键词： calcium signaling calcium-sensing receptor G-protein-coupled receptors structure trafficking

From Hit to Lead:Design and Synthesis of Dihydro-pyrimidones as NNRTIs with Improved Drug Resistance Properties——A Modular Focused Library Design Approach

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From Hit to Lead:Design and Synthesis of Dihydro-pyrimidones...

Considerations for the use of porcine organ donation models in preclinical organ donor intervention research

中国化学会第二十五届学术年会

作者： George Burton Sara Thrall George Freeman webb andrews Benjamin Schwartz Elsie Diaz Jerry Jeffery Edward Garvey Bob Nolte Kirk Weaver Ralph Rivero GlaxoSmithKline Pharmaceuticals 1250 S. Collegeville Road Pennsylvania 19426 . GlaxoSmithKline Pharmaceuticals 1250 S. Collegeville Road Pennsylvania 19426 . GlaxoSmithKline Pharmaceuticals Five Moore Drive Research Triangle Park North Carolina 27709. GlaxoSmithKline Pharmaceuticals Five Moore Drive Research Triangle Park North Carolina 27709. GlaxoSmithKline Pharmaceuticals 1250 S. Collegeville Road Pennsylvania 19426 . GlaxoSmithKline Pharmaceuticals 1250 S. Collegeville Road Pennsylvania 19426 . GlaxoSmithKline Pharmaceuticals Five Moore Drive Research Triangle Park North Carolina 27709. GlaxoSmithKline Pharmaceuticals Five Moore Drive Research Triangle Park North Carolina 27709. GlaxoSmithKline Pharmaceuticals Five Moore Drive Research Triangle Park North Carolina 27709. GlaxoSmithKline Pharmaceuticals Five Moore Drive Research Triangle Park North Carolina 27709. GlaxoSmithKline Pharmaceuticals 1250 S. Collegeville Road Pennsylvania 19426 .

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Animal Models and Experimental Medicine 2024年第3期7卷 283-296页

作者： Frazer I.Heinis Shaheed Merani Nicholas W.Markin Kim F.Duncan Michael J.Moulton Lance Fristoe William E.Thorell Raechel A.Sherrick Tami R.Wells Matthew T.andrews Marian Urban School of Natural Resources Institute of Agriculture and Natural ResourcesUniversity of Nebraska-LincolnLincolnNebraskaUSA Division of Transplantation and Vascular Surgery Department of SurgeryUniversity of Nebraska Medical CenterOmahaNebraskaUSA Department of Anesthesiology University of Nebraska Medical CenterOmahaNebraskaUSA Division of Cardiothoracic Surgery Department of SurgeryUniversity of Nebraska Medical CenterOmahaNebraskaUSA Clinical Perfusion Nebraska Medicine-Nebraska Medical CenterOmahaNebraskaUSA Department of Neurosurgery University of Nebraska Medical CenterOmahaNebraskaUSA Nutrition and Health Sciences College of Education and Human SciencesUniversity of Nebraska-LincolnLincolnNebraskaUSA Department of Comparative Medicine University of Nebraska Medical CenterOmahaNebraskaUSA

Use of animal models in preclinical transplant research is essential to the optimization of human allografts for clinical *** models of organ donation and preservation help to advance and improve technical elements of solid organ recovery and facilitate research of ischemia-reperfusion injury,organ preservation strategies,and future donor-based *** considerations include cost,public opinion regarding the conduct of animal research,translational value,and relevance of the animal model for clinical *** present an overview of two porcine models of organ donation:donation following brain death(DBD)and donation following circulatory death(DCD).The cardiovascular anatomy and physiology of pigs closely resembles those of humans,making this species the most appropriate for pre-clinical *** are also considered a potential source of organs for human heart and kidney *** is imperative to minimize animal loss during procedures that are surgically *** present our experience with these models and describe in detail the use cases,procedural approach,challenges,alternatives,and limitations of each model.

关键词： animal model brain death circulatory death organ transplantation

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混动飞机飞向蓝天

科技纵览 2024年第2期 30-36,4页

作者： Amy Jankovsky Christine andrews Bill Rogers 不详

NASA、通用电气航空公司和波音公司正在合作开发一款混合动力客机。商业航空联结了现代世界。国际民用航空组织(ICAO)的数据表明,在全球新冠疫情之前,每天平均有1200万人乘坐约10万次商业航班。这些数字现在已经大幅回升:预计2023年行... 详细信息

NASA、通用电气航空公司和波音公司正在合作开发一款混合动力客机。商业航空联结了现代世界。国际民用航空组织(ICAO)的数据表明,在全球新冠疫情之前,每天平均有1200万人乘坐约10万次商业航班。这些数字现在已经大幅回升:预计2023年行业收入将达到8030亿美元,比2022年增长9.7%,接近2019年疫情前的峰值。

关键词：商业航空混合动力通用电气合作开发数据表波音公司航空公司疫情

Kinetics of hydrogen peroxide quenching following UV/H_(2)O_(2)advanced oxidation by thiosulfate,bisulfite,and chlorine in drinking water treatment

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Frontiers of Environmental Science & Engineering 2023年第12期17卷 59-69页

作者： Tianyi Chen Lizbeth Taylor-Edmonds Susan andrews Ron Hofmann Department of Civil and Mineral Engineering University of TorontoTorontoOntario M5S 1A4Canada

Residual H_(2)O_(2)from UV/H_(2)O_(2)treatment can be quenched by thiosulfate,bisulfite,and chlorine,but the kinetics of these reactions have not been reported under the full range of practical *** this study,the rates of H_(2)O_(2)quenching by these compounds were compared in different water matrices,temperatures,pH,and when using different forms of bisulfite and *** general,it was confirmed that thiosulfate would be too slow to serve as a quenching agent in most practical *** pH 7-8.5,chlorine tends to quench H_(2)O_(2)more than 20 times faster than bisulfite in the various conditions *** important observation was that in lightly-buffered water(e.g.,alkalinity of 20 mg/L as CaCO_(3)),the form of chlorine can have a large impact on quenching rate,with gaseous chlorine slowing the reaction due to its lowering of the pH,and hypochlorite having the opposite *** impacts will become less significant when water buffer capacity(i.e.,alkalinity)increases(e.g.,to 80 mg/L as CaCO_(3)).In addition,water temperature should be considered as the time required to quench H_(2)O_(2)by chlorine at 4℃is up to 3 times longer than at 20℃.

关键词： UV/H_(2)O_(2) H_(2)O_(2) quenching Chlorine type Water alkalinity Temperature

南非部落的新城市设计,传统祖鲁文化的古韵新生

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工业设计 2024年第8期 20-20页

作者： andrews University

这个项目起始于安德鲁斯大学一名学生的南非返乡之旅,他的旅程引发了一场为期八天的公共建筑和设计过程。他与自己的大学同学合作,与当地祖鲁部落当局、市政代表、非营利组织、高中生和公民合作,制定了一个80英亩的整村计划。尊重当地... 详细信息

这个项目起始于安德鲁斯大学一名学生的南非返乡之旅,他的旅程引发了一场为期八天的公共建筑和设计过程。他与自己的大学同学合作,与当地祖鲁部落当局、市政代表、非营利组织、高中生和公民合作,制定了一个80英亩的整村计划。尊重当地文化的真实愿景,与村民保持深厚的联系,同时以社区为导向展开设计。

关键词：祖鲁公共建筑安德鲁斯非营利组织高中生南非新生合作

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遍布火山的卫星

环球科学 2024年第3期 12-14页

作者：罗宾·乔治·安德鲁斯巢栩嘉(译) 不详

关于木卫一(lo),科学家可以肯定两件事情。一是,木星的这颗卫星是目前宇宙中已知的火山最多的天体。它的地表布满了大量火山口,这些火山口不断地喷出熔岩,就像一个在烤箱里烘烤过的奶酪披萨.

关键词：火山口木星木卫一宇宙天体熔岩

Resting-state functional connectivity in lifelong musicians

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Psychoradiology 2023年第1期3卷 154-161页

作者： Cyrus Eierud Andrew Michael David Banks Edna andrews Linguistics Program Duke UniversityDurhamNC 27708USA Duke Institute for Brain Sciences Duke UniversityDurhamNC 27708USA Department of Statistical Science Duke UniversityDurhamNC 27708USA Center for Cognitive Neuroscience Duke UniversityDurhamNC 27708USA

Background:It has been postulated that musicianship can lead to enhanced brain and cognitive reserve,but the neural mechanisms of this effect have been poorly *** professional musicianship in conjunction with novel brain imaging techniques offers a unique opportunity to examine brain network differences between musicians and matched ***:In this study we aim to investigate how resting-state functional networks(FNs)manifest in lifelong active *** will evaluate the FNs of lifelong musicians and matched healthy controls using resting-state functional magnetic resonance ***:We derive FNs using the data-driven independent component analysis approach and analyze the functional network con-nectivity(FNC)between the default mode(DMN),sensory-motor(SMN),visual(VSN),and auditory(AUN)*** examine whether the linear regressions between FNC and age are different between the musicians and the control ***:The age trajectory of average FNC across all six pairs of FNs shows significant differences between musicians and *** show an increase in average FNC with age while controls show a decrease(P=0.013).When we evaluated each pair of FN,we note that in musicians FNC values increased with age in DMN–AUN,DMN–VSN,and SMN–VSN and in controls FNC values decreased with age in DMN–AUN,DMN–SMN,AUN–SMN,and SMN–***:This result provides early evidence that lifelong musicianship may contribute to enhanced brain and cognitive *** of this study are preliminary and need to be replicated with a larger number of participants.

关键词： resting-state fMRI lifelong musicianship default mode network sensory-motor network functional network connectivity cognitive reserve

Underground mine stream crossing assessment:A multi-disciplinary approach

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International Journal of Mining Science and Technology 2021年第1期31卷 59-65页

作者： Kevin andrews Steve Keim Marshall Miller&Associates BluefieldVA 24605USA

Underground mine designs typically try to avoid extraction beneath streams and rivers of any significant size,especially when the overburden rock thickness between the stream bed and the mine is *** issues with mining beneath streams include excessive groundwater inflow to the mine,weak ground(roof,floor,and pillar)conditions,horizontal stress effects,as well as stream loss and other potential adverse environmental ***,there are times when crossing beneath a stream or river is necessary to move into a new area of mineral reserve without creating additional mine access points from the ground ***,stream crossings are completed without thorough assessment,potentially resulting in increased costs,decreased safety,and,in some cases,failure to advance the *** of the most favorable location(s)to cross the stream must account for numerous factors and the associated assessment often requires a multi-disciplinary *** crossing investigations often require geological,hydrogeological,geotechnical,and geophysical *** of stream crossing investigations include desktop evaluation of maps and aerial photography,stream bed observations,drilling,detailed rock core logging,downhole geophysical surveying,hydraulic conductivity testing(packer testing),geotechnical laboratory testing,assessment,and *** deliverables from a stream crossing assessment typically include geological,geotechnical,and hydrogeological characterization of potential stream crossing locations,classification of favorable and unfavorable crossing locations,recommendations for entry design and pillar sizing,and recommendations for if,and how,to conduct pre-grouting *** of technical aspects of data collection and assessment are provided based on decades of industry experience conducting stream crossing assessments in various underground mining scenarios.

关键词： Underground mining Geotechnical Stream-crossing Hydrogeology Characterization