检索结果-南通市图书馆

Biophysics Reports 2017年第Z2期3卷 64-72页

作者： Xingguo Liu Liang Yang Qi Long David weaver Gy?rgy Hajnóczky Key Laboratory of Regenerative Biology Guangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineSouth China Institute for Stem Cell Biology and Regenerative MedicineGuangzhou Institutes of Biomedicine and HealthChinese Academy of Sciences Department of Pathology Mito Care CenterAnatomy and Cell BiologyThomas Jefferson University

Mitochondrial dynamics refers to the processes maintaining mitochondrial homeostasis, including mitochondrial fission, fusion, transport, biogenesis, and mitophagy. Mitochondrial dynamics is essential for maintaining the metabolic function of mitochondria as well as their regulatory roles in cell *** this review, we summarize the recently developed imaging techniques for studying mitochondrial dynamics including: mitochondrial-targeted fluorescent proteins and dyes, live-cell imaging using photoactivation, photoswitching and cell fusion, mitochondrial transcription and replication imaging by in situ hybridization, and imaging mitochondrial dynamics by super-resolution microscopy. Moreover,we discuss examples of how to choose and combine proper fluorescent dyes and/or proteins.

关键词： Imaging Mitochondrial dynamics Photoactivation Photoswitching Super-resolution microscope

The origins of schedule management： the concepts used in planning, allocating, visualizing and managing time in a project

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Frontiers of Engineering Management 2018年第2期5卷 150-166页

作者： Lynda M. BOURNE Patrick weaver Faculty of Information Technology Monash University Melboume 3800 Australia Mosaic Project Services Pry Ltd Melbourne 3205 Australia

Getting the right people in the right place at the right time has always been a major organizational challenge. In ancient times this process seems to have been accomplished based on the scheme of arrangements being contained in the leader＇s mind and instructions communicated verbally. Modem approaches to solving the twin challenges of first thinking through the ＇plan＇ and then communicating the plan to the people who need to do ＇the right work, at the right time, in the right place＇ use sophisticated graphics, charts, diagrams, and computa- tions. This paper traces the development of the concepts most project managers take for granted including bar charts and critical path schedules from their origins （which are far earlier than most people think） through to the modem day. The first section of the paper looks at the development of concepts that allow the visualization of time and other data. The second looks at the shift from static representations to dynamic modeling through the emergence of computers, dynamic calculations and integrated data from the 1950s to the present time.

关键词： time management scheduling CPM PERT Gantt Critical Path bar chart

A Systematic Review of the Literature on the Relationships between Chronic Diseases and Food Insecurity

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Food and Nutrition Sciences 2018年第5期9卷 519-541页

作者： Lesley Jo weaver Connor B. Fasel Department of Anthropology University of Alabama Tuscaloosa USA

Background: The association between food insecurity (FI) and obesity is now so well documented that scholars have dubbed it the “‘new’ food insecurity” and cited it as a leading cause of increased chronic disease (CD) risk. Here, the chain of causality is assumed to be FI → obesity → CD. However, this model overlooks the possible direct associations between FI and CD independent of obesity. Aim: This study assessed the literature on relationships between FI and CD. Methods: We conducted a systematic literature review of electronic databases. Selection criteria were designed to elicit studies that assessed FI and CD using a measure of CD other than obesity. Results: Fifty-one articles met the inclusion criteria. Forty-five studies (87%) reported a statistically significant association between FI and CD, but only 15 adjusted for obesity. The association was less consistent for asthma and dyslipidemia than for diabetes, hypertension, and other dietrelated CDs, and most were conducted in the USA or Canada. Conclusion: There is a body of literature documenting relationships between FI and CD, but it is heavily biased toward Western nations, ecological study designs, and type 2 diabetes as the CD of focus. A small subset of the literature controls for BMI, demonstrating that a portion of the FI-CD relationship cannot be fully explained by obesity. Possible direct pathways linking FI and CD include systematic effects of poverty that accompanies FI, micronutrient deficiencies, and environmental exposure to toxins;however, exploration of these alternative pathways is limited by study designs that fail to include obesity as a control variable.

关键词： Food Insecurity Chronic Diseases Systematic Literature Review Critical Nutrition Studies

中国青少年人群的峰值骨量:充足钙摄入的重要性

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中华内分泌代谢杂志 2020年第6期36卷 453-457页

作者：曹思思 weaver M Connie 贺晓燕洪帆普渡大学营养学系印第安纳州47907美国普渡大学食品科学系印第安纳州47907美国惠氏制药有限公司上海200041

在生命早期阶段达到较高的峰值骨量和强度对于降低未来发生骨质疏松症或降低骨量的风险至关重要。种族和性别等遗传因素在很大程度上影响了峰值骨量的差异性和达到峰值骨量的时机。一般而言,与白种人相比,亚洲人的面积骨矿物质密度较低... 详细信息

在生命早期阶段达到较高的峰值骨量和强度对于降低未来发生骨质疏松症或降低骨量的风险至关重要。种族和性别等遗传因素在很大程度上影响了峰值骨量的差异性和达到峰值骨量的时机。一般而言,与白种人相比,亚洲人的面积骨矿物质密度较低,并且达到峰值骨量的时间更早。在不同生活方式的影响因素中,有强有力的证据表明饮食中钙摄入和体育锻炼对骨骼累积具有积极作用。研究表明,各个年龄段中国人的钙摄入量都远低于建议的摄入量。为了能够达到其遗传潜能的峰值骨量和骨强度,强烈建议中国人群通过促进饮食摄入和(或)服用补充剂来获得足够的钙和维生素D摄入,尤其是中国青少年群体。

关键词：峰值骨量钙摄入

Pregnancy Outcomes Associated with Ovarian Hyperstimulation Syndrome:A Retrospective Cohort Study of Infertile Women

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Maternal-Fetal Medicine 2023年第3期5卷 144-154页

作者： Ajleeta Sangtani Maryama lsmail Amy weaver Zaraq Khan Department of Obstetrics and Gynecology Mayo ClinicRochesterMN 55905USA Mayo Clinic Alix School of Medicine Mayo ClinicRochesterMN 55905USA Department of Health Sciences Research Mayo ClinicRochester.MN55905.USA

Objective To assess the relationship between ovarian hyperstimulation syndrome(OHSS)and adverse outcomes using population-based data in the United *** hypothesis is that patients with OHSS were more likely to deliver preterm and more likely to have hypertensive *** This retrospective cohort study identified 94 patients with OHSS and 183 matched referents in eight counties in *** were collected regarding pregnancy history,infertility treatment,and pregnancy *** the Rochester Epidemiology Project,study subjects were identified from female patients,aged 18 to 49 years,who were diagnosed with infertility from January 2,1995 to December 1,2017,and had a pregnancy greater than 20 weeks'*** primary outcome was preterm delivery or hypertensive disorder of pregnancy incidence in the OHSS group when compared with control ***-squared test,t test,and multivariate logistic models were used where *** Patients with OHSS were more likely to deliver preterm(odds ratio,2.14;95%confidence interval,1.26–3.65;P<0.01),and their neonates were more likely to be small for gestational age(odds ratio,4.78;95%confidence interval,1.61–14.19;P<0.01).No significant differences between the groups were observed in any other *** with OHSS are more likely to deliver preterm if they undergo fresh transfer compared with a freeze all and subsequent frozen transfer(odds ratio,3.03,95%confidence interval,1.20–7.66,P=0.02).Conclusion OHSS may lead to preterm birth and small-for-gestational-age neonates,which changes patient counseling and leads to arranging specialized obstetrical care for these patients with OHSS.

关键词： Obstetric labor,premature Hypertension Frozen cycle Fresh cycle

IL-10 Inhibits LPS-Induced Expression of miR-147 in Murine Macrophages

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Advances in Biological Chemistry 2014年第4期4卷 261-273页

作者： Leah N. Cardwell Brian K. weaver Department of Biology Missouri State University Springfield USA

Interleukin-10 (IL-10) mediates an anti-inflammatory response that constrains immune responses and limits inflammation-associated pathology. IL-10 does so, in part, by selectively inhibiting pro-inflammatory cytokine and chemokine expression induced in macrophages in response to Toll-like receptor (TLR) signaling. The IL-10-mediated anti-inflammatory response is executed through the activation of STAT3 leading to induction of target genes referred to as IL-10-induced genes. As miRNAs have emerged as important negative regulators of gene expression in various systems, we sought to address whether the IL-10-mediated anti-inflammatory response acts through regulated expression of miRNA genes. Using quantitative PCR-based arrays, we examined 140 miRNA genes with putative roles in inflammation for changes in expression in response to IL-10 and lipopoly-saccharide (LPS) in primary mouse macrophages. IL-10 stimulation resulted in the inhibition of miR-147 expression induced in response to LPS, while having a potentiating effect on the induction of miR-455. miR-147 is the second TLR-induced miRNA, in addition to miR-155, identified to be counter-regulated by IL-10. Its suppression by IL-10 suggests that miR-147 may have an unknown pro-inflammatory function in TLR-triggered macrophages. The results extend the notion that IL-10 selectively regulates expression of miRNA genes, and that miRNA-mediated pathways are a component of the IL-10-mediated anti-inflammatory response.

关键词： IL-10 Lipopolysaccharide Macrophage Inflammation MicroRNA

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生态旅游引进版

Lateral migration with telescoping of a trochanteric fixation nail in the treatment of an intertrochanteric hip fracture

丛书名： 21世纪高等院校旅游专业引进教材系列

2004年

作者：（澳）David weaver 杨桂华等译

本书论述了生态旅游的标准与起源，生态旅游市场、环境、影响、产业，生态旅游的外部环境、组织与政策，并介绍典型的生态旅游活动等。

ISBN: (纸本)7310019954

本书论述了生态旅游的标准与起源，生态旅游市场、环境、影响、产业，生态旅游的外部环境、组织与政策，并介绍典型的生态旅游活动等。

关键词：生态型旅游高等学校教材

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Chinese Medical Journal 2014年第4期127卷 680-684页

作者： Liu Wanjun Michael J.weaver Mark S.Vrahas Zhou Dongsheng Department of Orthopaedics Shandong Provincial HospitalShandong University Jinan Shandong 250021 China Department of Orthopaedics Beijing Jishuitan Hospital Beijing 100035 China Partners Orthopaedics Massachusetts General Hospital Harvard School of Medicine Boston MA 02114 USA

Background The trochanteric fixation nail （TFN） can be used to treat stable and unstable fractures of intertrochanteric hip *** study the common lateral migration that occurs with telescoping of intertrochanteric hip fractures treated with TFN and identify the predictors and relationships to clinical *** Patient demographic information,fracture type （Arbeitsgemeinschaft f＆#252;r Osteosynthesefragen （AO）/Orthopaedic Trauma Association （OTA） classification）,radiographic data,and clinical data were *** migration with telescoping was *** analyses were performed to determine which variables predicted lateral migration with *** outcome scores were recorded using the Modified Harris Hip Score （MHHS）,Hip Outcome Score-Activity of Daily Living （HOS-ADL）,and Visual Analog Scale for *** Two hundred and twenty-three patients （67 males,156 females） fitted the radiographic and follow-up （average 24.6 months） *** average age was 77.2 *** average lateral migration with telescoping was 4.8 ***-one patients （9.4%） had excessive lateral migration with telescoping （≥10 mm）.The quality of calcar reduction （P=0.01） and unstable fracture patterns （P=0.006） were significant predictive factors of lateral migration with *** mean outcome scores （MHHS and HOS-ADL） were 80.1 points and 78.7 points,*** subjects had no significant relationship to lateral migration with telescoping （P 〉0.05）.Of all the patients who developed lateral migration with telescoping,only one required removal of the blade for hip pain and all patients went on to uneventful union at an average time of 4.5 *** Lateral migration with telescoping is a common mechanical complication of intertrochanteric hip fracture treated with the TFN *** was predicted by the quality of calcar reduction and fracture ***,this did not affect stable fixation and fracture healing,so rarely l

关键词： trochanteric fixation nail intertrochanteric hip fracture fracture fixation helical blade complications

Electricity consumption patterns within cities:application of a data-driven settlement characterization method

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International Journal of Digital Earth 2020年第1期13卷 119-135页

作者： Pranab K.Roy Chowdhury Jeanette E.weaver Eric M.Weber Dalton Lunga St.Thomas M.LeDoux Amy N.Rose Budhendra L.Bhaduri Urban Dynamics Institute&Geographic Information Science and Technology Group Oak Ridge National LaboratoryOak RidgeTNUSA Bredesen Center For Interdisciplinary Research and Graduate Education University of TennesseeKnoxvilleTNUSA

Urban areas presently consume around 75%of global primary energy supply,which is expected to significantly increase in the future due to urban *** sustainable,universal energy access is a pressing challenge for most parts of the *** urban energy consumption patterns may help to address the challenges to urban sustainability and energy ***,urban energy analyses are severely limited by the lack of urban energy *** datasets are virtually non-existent for the developing *** per current projections,most of the new urban growth is bound to occur in these data-starved ***,there is an urgent need of research methods for monitoring and quantifying urban energy utilization ***,we apply a data-driven approach to characterize urban settlements based on their formality,which is then used to assess intraurban urban energy consumption in Johannesburg,South Africa;Sana’a,Yemen;and Ndola,*** is the fastest growing energy *** analyzing the relationship between the settlement types and the corresponding nighttime light emission,a proxy of electricity consumption,we assess the differential electricity consumption *** study presents a simple and scalable solution to fill the present data void to understand intra-city electricity consumption patterns.

关键词： Settlement characterization cities urban electricity consumption VIIRS nighttime lights developing countries

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洋岛玄武岩成因的微量元素证据

地质地球化学 1992年第2期20卷 54-58页

作者： B.L.weaver 曲晓明山东地矿局第六地质队

在具有端员放射成因同位素特征的洋岛之间高度不相容微量元素比值上,各洋岛玄武岩(OIB)岩套显示出重大而始终一致的差异。来源于具高U/Pb比值源区的OIB,其微量元素特征与以再循环古老洋壳为主的源区是一致的,而来自明显富集同位素的地... 详细信息

在具有端员放射成因同位素特征的洋岛之间高度不相容微量元素比值上,各洋岛玄武岩(OIB)岩套显示出重大而始终一致的差异。来源于具高U/Pb比值源区的OIB,其微量元素特征与以再循环古老洋壳为主的源区是一致的,而来自明显富集同位素的地幔源区的OIB,其微量元素特征能很好地解释作为具高U/Pb比值的OIB与少量(百分之几)再循环沉积(深海的和陆源的)组分的混合物的源区。

关键词：玄武岩成因微量元素