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Direct-to-consumer genetic testing in China and its role in GWAS discovery and replication

Quantitative Biology 2021年第2期9卷 201-215页

作者： Kang Kang Xue Sun Lizhong Wang Xiaotian Yao Senwei Tang Junjie Deng Xiaoli Wu wegene research team Can Yang Gang Chen Shenzhen wegene Clinical Laboratory Shenzhen 518118China wegene Shenzhen Zaozhidao Technology Co.Ltd.Shenzhen 518042China Department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina Hunan Provincial Key Lab on Bioinformatics School of Computer Science and EngineeringCentral South UniversityChangsha 410083China

Background:The direct-to-consumer genetic testing(DTC-GT)industry has exploded in recent years,initiated by market pioneers from the United States and quickly followed by companies from Europe and *** addition to their primary objective of providing ancestry and health information to customers,DTC-GT services have emerged as a valuable data resource for large-scale population and genetics ***:We assessed DTC-GT market leaders in the *** China,user participation in research,and academic reports based on this *** also investigated DTC-GT end-user value by tracing key updates of companies provided via health risk reports and evaluating their predictive *** then assessed the replicability of several genome-wide association studies(GWAS)based on a Chinese DTC-GT ***:As recent entrants to the market,Chinese DTC-GT serv ice providers have published less academic research than their Western counterparts;however,a larger proportion of Chinese users consent to participate in research *** increases in user volume and resultant report updates led to reclassification of some users'polygenic risk levels,but within a reasonable scale and with increased predictive *** among GWAS using the Chinese DTC-GT biobank varied by studied trait,population background,and sample ***:We speculate that the rapid growth in DTC-GT services,particularly in non-Caucasian populations,will yield an important and much-needed resource for biobanking,large-scale genetic studies,clinical trials,and post-clinical applications.

关键词： DTC-GT biobank Chinese population polygenic risk GWAS replication

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Error field penetration in J-TEXT tokamak based on two-fluid drift-MHD model

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Chinese Physics B 2024年第4期33卷 545-551页

作者：王文徐涛张仪 the J-TEXT team State Key Laboratory of Advanced Electromagnetic Technology International Joint Research Laboratory of Magnetic Confinement Fusion and Plasma PhysicsSchool of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China

An externally generated resonant magnetic perturbation can induce complex non-ideal MHD responses in their resonant *** have studied the plasma responses using Fitzpatrick's improved two-fluid model and program *** calculated the error field penetration threshold for *** addition,we find that the island width increases slightly as the error field amplitude increases when the error field amplitude is below the critical penetration ***,the island width suddenly jumps to a large value because the shielding effect of the plasma against the error field disappears after the *** scanning the natural mode frequency,we find that the shielding effect of the plasma decreases as the natural mode frequency ***,we obtain the m/n=2/1 penetration threshold scaling on density and temperature.

关键词： plasma responses drift-MHD model error field penetration

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China’s HL-3 tokamak achieves H-mode operation with 1 MA plasma current

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The Innovation 2024年第4期5卷 5-6页

作者： Wulyu Zhong HL-team Southwestern Institute of Physics Chengdu 610225China

In a remarkable achievement,China’s new-generation magnetic confinement fusion device,the HL-3 tokamak(formerly known as HL-2M),achieved highconfinement mode(H-mode)operation with a plasma current of 1 mega amperes(MA)for the first time on August 25th,*** breakthrough signifies a noteworthy milestone in China’s controlled nuclear fusion research,bringing us one step closer to the burning plasma phase.

关键词： tokamak mode bringing

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Conceptual design of the tail research experiment at the Space Plasma Environment research Facility(SPERF-TREX)

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Plasma Science and Technology 2024年第8期26卷 44-49页

作者：肖青梅毛傲华何向磊邹继同杨肖易孙萌萌李丰汤鹏飞周田春王晓钢 the SPERF team Laboratory for Space Environment and Physical Sciences Harbin Institute of TechnologyHarbin 150001People’s Republic of China School of Physics Harbin Institute of TechnologyHarbin 150001People’s Republic of China Heilongjiang Provincial Key Laboratory of Plasma Physics and Application Technology Harbin Institute of TechnologyHarbin 150001People’s Republic of China

The Space Plasma Environment research Facility(SPERF)for ground simulation of the space plasma environment is a key component of the Space Environment Simulation research Infrastructure(SESRI),a major national science and technology infrastructure for fundamental *** is designed to investigate outstanding issues in the space plasma environment,such as energetic particle acceleration,transport,and interaction with electromagnetic waves,as well as magnetic reconnection processes,in magnetospheric *** Tail-research EXperiment(TREX)is part of the SPERF for laboratory studies of space physics relevant to magnetic reconnection,dipolarization and hydromagnetic wave excitation in the *** is designed to carry out three types of experiments:the tail plasmoid for magnetic reconnection,dipolarization front formation,and magnetohydrodynamic waves excited by highspeed plasma *** this paper,the scientific goals and three scenarios of SPERF-TREX for typical processes in space plasmas are presented,and experimental plans for SPERF-TREX are also reviewed,together with the plasma sources applied to generate the plasma with the desired parameters and various magnetic configurations.

关键词： SPERF-TREX wave-particle interaction magnetic reconnection dipolarization

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Mammal-bearing Pleistocene deposits,Vranic,southwestern Pannonian Basin System

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Journal of Palaeogeography 2024年第3期13卷 430-452页

作者： Adriano Banak Zsòfia Ruszkiczay-Rüdiger Anita Grizelj Martina Đuras Kresimir Petrinjak ASTER team Alexander Wieser Monika Milosevic Davor Pavelic Department of Geology Croatian Geological SurveyMilana Sachsa 2HR-10000 ZagrebCroatia Institute for Geological and Geochemical research HUN-REN Research Centre for Astronomy and Earth Sciences(MTA Centre of Excellence)Budaorsi Street 451112 BudapestHungary The Faculty of Veterinary Medicine University of ZagrebHeinzelova 55HR-10000 ZagrebCroatia CEREGE CNRS-IRD-College de France-INRAE UM34Aix-Marseille UniversiteAix-en-ProvenceFrance Faculty of Physics-Isotope Physics University of ViennaWahringer Straße 171090 ViennaAustria Faculty of Mining Geology and Petroleum EngineeringUniversity of ZagrebPierottijeva 6HR-10000 ZagrebCroatia

Vranic site is a sand quarry that is located on the southern foothills of Papuk *** bottom to top of the succession,three sedimentary units have been recognized as:Unit 1 containing massive sand with scattered gravel-sized clasts,marl cobbles and boulders,and abundant marine mammal and fish fossils;Unit 2 consisting of sand intercalated with silt,clay and gravel,which may be horizontally bedded;and Unit 3,which is an erosionally-based lenticular matrix to clast-supported structureless *** basal part of Unit 1 shows numerous reworked skeletal remains of Miocene marine *** radionuclides constrain the age of burial of Unit 1 to 895±211 ka,while the source area of Unit 1 had a quick *** massive sands deposited on the slopes of Papuk Mountain were vulnerable to erosion due to the absence of *** rainfall or water from snow melting created flash floods that infiltrated the sands,thereby causing slope destabilization and *** process led to slumps that were transformed into a sandy debris *** sediment was probably deposited during the interglacial marine isotope age(MIS)21 period when the scarce vegetation and a warmer climate favored the melting of permafrost ice and consequently triggered slope movements during MIS *** reworked skeletal material sampled at the Vranic site comprises fossilized fish along with mammal bones and ***,the Vranic site represents an important site for cetacean fossil remains and serves as an important data source for marine life in the Central Paratethys.

关键词： Miocene marine mammals Alluvial slope deposit Pleistocene Cosmogenic nuclides Pannonian Basin System

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Development of a toroidal soft x-ray imaging system and application for investigating three-dimensional plasma on J-TEXT

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Plasma Science and Technology 2024年第3期26卷 94-99页

作者：赵传旭李建超张晓卿王能超丁永华杨州军江中和严伟李杨波毛飞越任正康 the J-TEXT team International Joint research Laboratory of Magnetic Confinement Fusion and Plasma Physics State Key Laboratory of Advanced Electromagnetic Engineering and TechnologySchool of Electrical and Electronic Engineering and School of PhysicsHuazhong University of Science and TechnologyWuhan 430074People's Republic of China Hubei Key Laboratory of Optical Information and Pattern Recognition Wuhan Institute of TechnologyWuhan 430205People's Republic of China International Joint research Laboratory of Magnetic Confinement Fusion and Plasma Physics State Key Laboratory of Advanced Electromagnetic Engineering and TechnologySchool of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074People's Republic of China

A toroidal soft x-ray imaging(T-SXRI)system has been developed to investigate threedimensional(3D)plasma physics on *** T-SXRI system consists of three sets of SXR *** sets are newly developed and located on the vacuum chamber wall at toroidal positionsφof 126.4°and 272.6°,respectively,while one set was established previously atφ=*** set of SXR arrays consists of three arrays viewing the plasma poloidally,and hence can be used separately to obtain SXR images via the tomographic *** sawtooth precursor oscillations are measured by T-SXRI,and the corresponding images of perturbative SXR signals are successfully reconstructed at these three toroidal positions,hence providing measurement of the 3D structure of precursor *** observed 3D structure is consistent with the helical structure of the m/n=1/1 *** experimental observation confirms that the T-SXRI system is able to observe 3D structures in the J-TEXT plasma.

关键词： SXR imaging J-TEXT tokamak three-dimensional measurement MHD

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Experimental confirmation of the linear relation between plasma current and external vertical magnetic field in EXL-50 spherical torus energetic electron plasmas

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Plasma Science and Technology 2024年第8期26卷 32-36页

作者：董力立王明远刘文军石跃江董家齐郭栋孙恬恬顾翔宋显明袁保山彭元凯 the ENN team Hebei Key Laboratory of Compact Fusion Langfang 065001People’s Republic of China School of Mathematics and Physics Anqing Normal UniversityAnqing 246133People’s Republic of China ENN Science and Technology Development Co.Ltd. Langfang 065001People’s Republic of China

A three-fluid equilibrium plasma with bulk plasma and energetic electrons has been observed on the Xuanlong-50(EXL-50) spherical torus, where the energetic electrons play a crucial role in sustaining the plasma current and pressure. In this study, the equilibrium of a multi-fluid plasma was investigated by analyzing the relationship between the external vertical magnetic field(B_(V)),plasma current(I_(p)), the poloidal ratio(β_(p)) and the Shafranov formula. Remarkably, our research demonstrates some validity of the Shafranov formula in the presence of multi-fluid plasma in EXL-50 spherical torus. This finding holds significant importance for future reactors as it allows for differentiation between alpha particles and background plasma. The study of multi-fluid plasma provides a significant reference value for the equilibrium reconstruction of burning plasma involving alpha particles.

关键词： plasma equilibrium Shafranov formula multi-fluid plasma

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The tri-band high spectral resolution spectrometer with gratings in tandem for the charge-exchange recombination spectroscopy diagnostic system on HL-2A tokamak

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Plasma Science and Technology 2024年第6期26卷 103-110页

作者：刘亮余德良马倩何小斐 Maarten DE BOCK Manfred von HELLERMANN Michael WALSH 陈文锦何小雪魏彦玲张能李栋魏会领 the HL-2A team Southwestern Institute of Physics Chengdu 610041People’s Republic of China College of Physics and Optoelectronic Technology Baoji University of Arts and SciencesBaoji 721000People’s Republic of China ITER Organization Route de Vinon-sur-VerdonCS 90046St.Paul Lez Durance Cedex 13067France Fusion Spectroscopy Markgraf-Albrecht Str.14Berlin 10711Germany

Charge-exchange(CX) recombination spectroscopy is a powerful tool monitoring ion temperature and plasma rotation with good temporal and spatial resolutions. A compact, new design for a high-throughput, tri-band high spectral resolution spectrometer has been developed for the charge-exchange recombination spectroscopy measurement on the HL-2A tokamak. The simultaneous measurements of He II(468.57 nm), C VI(529.1 nm), and Dα(656.1 nm accompanied by beam emission spectra) with an acquisition frequency up to 400 Hz are achieved by vertically binning the spectrum from each fiber in experiments. Initial results indicate that the system can provide radial profiles of not only ion temperature and rotation velocity,but also concentration of carbon. For the case of helium, the measurements for the ion temperature and rotation velocity are straightforward but the apparent concentration associated with the observed CX intensity is obviously too high. Modeling of the active He II CX feature including plume contributions needs to be carried out to extract the true helium *** spectrometer could become a prototype for the ITER charge-exchange recombination spectroscopy diagnostic and the pilot experiments, as presented here, demonstrate the possibility of impurity concentrations measurements based on the combined measurement of local beam emission and charge-exchange recombination spectroscopy spectra.

关键词： CXRS ion temperature plasma rotation impurity concentration

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中国国有企业估值体系优化研究

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证券市场导报 2024年第10期 3-14页

作者：湘财证券课题组高振营许雯湘财证券股份有限公司上海200120 湘财证券研究所行业部

西方传统估值体系没有充分反映中国基本国情,存在中国资产尤其是国有资产被低估的现象。建立符合中国国情、能够体现国有企业社会责任和长期价值的中国特色估值体系十分必要。本文在分析我国A股市场的估值特征、存在的问题及原因的基础... 详细信息

西方传统估值体系没有充分反映中国基本国情,存在中国资产尤其是国有资产被低估的现象。建立符合中国国情、能够体现国有企业社会责任和长期价值的中国特色估值体系十分必要。本文在分析我国A股市场的估值特征、存在的问题及原因的基础上,采用AHP层次分析法和案例分析法,构建中国特色估值体系并对其实际运用效果进行分析。研究发现,A股市场国企估值普遍低于非国企,其根本原因在于受经济发展、产业结构与企业性质差异的影响,西方传统估值模型不能很好地反映企业社会价值。通过建立中国特色估值指标体系,将社会责任因子纳入估值模型,国有企业的估值将得到优化。同时,本文从企业端、资金端、市场端提出了完善我国国有企业估值体系的政策建议。本文丰富了企业估值体系的研究,为国有企业估值体系优化提供了经验借鉴。

关键词：中国特色估值体系国有企业 AHP层次分析法综合责任价值

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证券公司数字化转型价值评价体系建设研究

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证券市场导报 2024年第10期 57-68页

作者：中泰证券课题组王洪慕庆宇中泰证券股份有限公司山东济南250002

巨额且仍快速增长的证券行业数字化转型投入亟需相应的保障配套机制进行合理支撑。本文结合证券业务和管理特点,基于“宏观与微观相结合、理论与实证相结合”的研究思路,系统分析了数字化转型价值评价体系构建的关键内容,搭建起一套包... 详细信息

巨额且仍快速增长的证券行业数字化转型投入亟需相应的保障配套机制进行合理支撑。本文结合证券业务和管理特点,基于“宏观与微观相结合、理论与实证相结合”的研究思路,系统分析了数字化转型价值评价体系构建的关键内容,搭建起一套包含宏观指标体系、宏观分析模型、微观评价框架、微观度量方法在内的证券经营机构数字化转型价值评价体系。结合历史数据,本文对评价体系进行了系统应用,验证了数字化转型助力券商营收增长的“赋能效应”,发现了数字化转型助力券商营收增长的业务异质性与区域异质性,对数字化转型影响券商发展的非线性特征与具体阈值进行了检验。基于研究发现,本文从提高转型效率、优化转型布局、塑造差异化优势、建立健全保障机制等方面提出证券公司数字化转型的优化建议。

关键词：证券公司数字化转型价值评价体系宏观感知异质性影响

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