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Effectivenss of electroacupuncture for skeletal muscle pain in Parkinson's disease:a Clinical randomized controlled trial

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Journal of Traditional Chinese Medicine 2024年第2期44卷 388-395页

作者： wang Shaosong SUN Jingqing FENG Qingyin LI Bin wang xin YUAN Fan CUI Yingxue Department of acupuncture Beijing Hospital of Traditional Chinese MedicineBeijing 100010China

OBJECTIVE:To explore the effect of electroacupuncture on skeletal muscle pain in Parkinson's disease(PD).METHODS:A single-center randomized controlled trial was conducted with sixty patients with Parkinson's disease with skeletal muscle pain we.e randomly divided into electroacupuncture group and sham acupuncture control group with 30 patients *** electric acupuncture group was treated with electric acupuncture,while the control group was treated with Park needle *** groups we.e treated 5 times a we.k for a total of 4 we.ks,and both groups completed 20 ***'s Parkinson's Pain Scale(KPPS)and visual analog scale(VAS)we.e used before and after treatment to evaluate the pain degree of *** shear wave elastography(Swe.and modified Ashworth score(MAS)we.e used to evaluate the changes of muscle ***'s comprehensive Score Scale(MDS-UPDRS,including UPDRS Ⅱ and UPDRS Ⅲ)was used to evaluate exercise *** Depression Scale(HAMD)score was used to evaluate the emotional changes of *** correlation analysis was used to explore the correlation betwe.n pain degree and muscle tone,exercise ability and ***:During the study,one case fell off in the control group,and 30 cases we.e eventually included in the analysis and treatment group and 29 cases in the control *** treatment,Young's modulus of biceps and quadriceps and shear wave velocity of biceps we.e decreased in electroacupuncture group compared with before treatment,while KPPS score,VAS score,UPDRS Ⅱ,UPDRS Ⅲ and modified Ashworth score we.e decreased,with statistical significance(P0.05).After treatment,KPPS score,VAS score,UPDRS Ⅱ and UPDRS Ⅲ,MAS,HAMD score,Young's modulus of biceps and shear wave velocity in electroacupuncture group we.e significantly lowe. than those in control group(Pwe. that KPPS score was positively correl

关键词： Parkinson disease muscle skeletal pain electroacupuncture muscle tention mood disorders randomized controlled trial

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Mapping soil organic matter in cultivated land based on multi-year composite images on monthly time scales

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Journal of Integrative Agriculture 2024年第4期23卷 1393-1408页

作者： Jie Song Dongsheng Yu Siwe. wang Yanhe Zhao xin wang Lixia Ma Jiangang Li State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Agricultural and Rural Bureau of Luanping County Luanping 068250China Chinese Academy of Sciences University Beijing 100049China

Rapid and accurate acquisition of soil organic matter(SOM)information in cultivated land is important for sustainable agricultural development and carbon balance *** study proposed a novel approach to predict SOM with high accuracy using multiyear synthetic remote sensing variables on a monthly *** obtained 12 monthly synthetic Sentinel-2 images covering the study area from 2016 to 2021 through the Google Earth Engine(GEE)platform,and reflectance bands and vegetation indices we.e extracted from these composite *** the random forest(RF),support vector machine(SVM)and gradient boosting regression tree(GBRT)models we.e tested to investigate the difference in SOM prediction accuracy under different combinations of monthly synthetic *** showe. that firstly,all monthly synthetic spectral bands of Sentinel-2 showe. a significant correlation with SOM(Pwe.e grouped in accordance with the four quarters of the year,the first quarter and the fourth quarter showe. good performance,and any combination of three quarters was similar in estimation *** overall best performance was observed when all monthly synthetic variables we.e incorporated into the ***,among the three models compared,the RF model was consistently more accurate than the SVM and GBRT models,achieving an R^(2)value of *** for band 12 in December,the importance of the remaining bands did not exhibit significant *** research offers a new attempt to map SOM with high accuracy and fine spatial resolution based on monthly synthetic Sentinel-2 images.

关键词： soil organic matter Sentinel-2 monthly synthetic images machine learning model spatial prediction

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Quantitative prediction model for the depth limit of oil accumulation in the deep carbonate rocks:A case study of Lowe. Ordovician in Tazhong area of Tarim Basin

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Petroleum Science 2024年第1期21卷 115-124页

作者： we.-Yang wang Xiong-Qi Pang Ya-Ping wang Zhang-xin Chen Fu-Jie Jiang Ying Chen State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Research Institute of Exploration and Development PetroChina Southwest Oil&Gas Field CompanyChengdu610041SichuanChina Chemical and Petroleum Engineering Schulich School of EngineeringUniversity of CalgaryCalgaryT2N 1N4Canada

With continuous hydrocarbon exploration extending to deeper basins,the deepest industrial oil accumulation was discovered below 8,200 m,revealing a new exploration ***,the extent to which oil exploration can be extended,and the prediction of the depth limit of oil accumulation(DLOA),are issues that have attracted significant attention in petroleum *** it is difficult to characterize the evolution of the physical properties of the marine carbonate reservoir with burial depth,and the deepest drilling still cannot reach the ***,the DLOA cannot be predicted by directly establishing the relationship betwe.n the ratio of drilling to the dry layer and the *** this study,by establishing the relationships betwe.n the porosity and the depth and dry layer ratio of the carbonate reservoir,the relationships betwe.n the depth and dry layer ratio we.e obtained *** depth corresponding to a dry layer ratio of 100%is the *** on this,a quantitative prediction model for the DLOA was finally *** results indicate that the porosity of the carbonate reservoir,Lowe. Ordovician in Tazhong area of Tarim Basin,tends to decrease with burial depth,and manifests as an overall low porosity reservoir in deep *** critical porosity of the DLOA was 1.8%,which is the critical geological condition corresponding to a 100%dry layer ratio encountered in the *** depth of the DLOA was 9,000 *** study provides a new method for DLOA prediction that is beneficial for a deeper understanding of oil accumulation,and is of great importance for scientific guidance on deep oil drilling.

关键词： Deep layer Tarim Basin Hydrocarbon accumulation Depth limit of oil accumulation Prediction model

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Incorporation of source contributions to improve the accuracy of soil heavy metal mapping using small sample sizes at a county scale

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Pedosphere 2024年第1期34卷 170-180页

作者： Jie SONG xin wang Dongsheng YU Jiangang LI Yanhe ZHAO Siwe. wang Lixia MA State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Chinese Academy of Sciences University Beijing 100049China Agricultural and Rural Bureau of Luanping County Luanping 068250China

Estimating heavy metal(HM) distribution with high precision is the key to effectively preventing Chinese medicinal plants from being polluted by the native soil. A total of 44 surface soil samples we.e gathered to detect the concentrations of eight HMs(As, Hg, Cu, Cr, Ni, Zn, Pb, and Cd) in the herb growing area of Luanping County, northeastern Hebei Province, China. An absolute principal component score-multiple linear regression(APCS-MLR) model was used to quantify pollution source contributions to soil HMs. Furthermore, the source contribution rates and environmental data of each sampling point we.e simultaneously incorporated into a stepwise linear regression model to identify the crucial indicators for predicting soil HM spatial distributions. Results showe. that 88% of Cu, 72% of Cr, and 72% of Ni came from natural sources;50% of Zn, 49% of Pb, and 59% of Cd we.e mainly caused by agricultural activities;and 44% of As and 56% of Hg originated from industrial activities. When three-type(natural, agricultural, and industrial) source contribution rates and environmental data we.e simultaneously incorporated into the stepwise linear regression model, the fitting accuracy was significantly improved and the model could explain 31%–86% of the total variance in soil HM concentrations. This study introduced three-type source contributions of each sampling point based on APCS-MLR analysis as new covariates to improve soil HM estimation precision, thus providing a new approach for predicting the spatial distribution of HMs using small sample sizes at the county scale.

关键词： absolute principal component score-multiple linear regression Chinese herbal medicine influencing factors spatial distribution stepwise multiple regression

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Pressure stimulated current in progressive failure process of combined coal-rock under uniaxial compression:Response and mechanism

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International Journal of Mining Science and Technology 2024年第2期34卷 227-243页

作者： Tiancheng Shan Zhonghui Li xin Zhang Haishan Jia Xiaoran wang Enyuan wang Yue Niu Dong Chen we.chen Sun Dongming wang State Key Laboratory of Coal Mine Disaster Prevention and Control China University of Mining and TechnologyXuzhou 221116China National Engineering Research Center for Coal Gas Control China University of Mining and TechnologyXuzhou 221116China School of Safety Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory for Fine Exploration and Intelligent Development of Coal Resources China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China

Effective monitoring of the structural health of combined coal-rock under complex geological conditions by pressure stimulated currents(PSCs)has great potential for the understanding of dynamic disasters in underground *** reveal the effect of this way,the uniaxial compression experiments with PSC monitoring we.e conducted on three types of coal-rock combination samples with different strength *** mechanism explanation of PSCs are investigated by resistivity test,atomic force microscopy(AFM)and computed tomography(CT)methods,and a PSC flow model based on progressive failure process is *** influence of strength combinations on PSCs in the progressive failure process are *** results show the PSC responses betwe.n rock part,coal part and the two components are different,which are affected by multi-scale fracture characteristics and electrical *** the rock strength decreases,the progressive failure process changes obviously with the influence range of interface constraint effect decreasing,resulting in the different responses of PSC strength and direction in different parts to fracture *** PSC flow model is initially validated by the relationship betwe.n the accumulated charges of different *** results are expected to provide a new reference and method for mining design and roadway quality assessment.

关键词： Combined coal-rock Pressure stimulated current Progressive failure process Mechanism Flow model

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Climate change,ambient air pollution,and students'mental health

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World Journal of Psychiatry 2024年第2期14卷 204-209页

作者： Jing-Xuan wang xin-Qiao Liu School of Education Tianjin UniversityTianjin 300350China

The impact of global climate change and air pollution on mental health has become a crucial public health *** public awareness of health,advancements in medical diagnosis and treatment,the way media outlets report environmental changes and the variation in social resources affect psychological responses and adaptation methods to climate change and air *** the context of climate change,extreme we.ther events seriously disrupt people's living environments,and unstable educational environments lead to an increase in mental health issues for *** pollution affects students'mental health by increasing the incidence of diseases while decreasing contact with nature,leading to problems such as anxiety,depression,and decreased cognitive *** call for joint efforts to reduce pollutant emissions at the source,improve energy structures,strengthen environmental monitoring and governance,increase attention to the mental health issues of students,and help student groups build resilience;by establishing public policies,enhancing social support and adjusting lifestyles and habits,we.can help students cope with the constantly changing environment and maintain a good level of mental *** these comprehensive measures,we.can more effectively address the challenges of global climate change and air pollution and promote the achievement of the United Nations Sustainable Development Goals.

关键词： Climate change Ambient air pollution Mental health Energy structure Public policy Sustainable development

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Kaempferol ameliorated levodopa-induced dyskinesia in experimental rats: A role of brain monoamines, cFOS, FosB, Parkin, Pdyn, TH, and p-JNK

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BIOCELL 2024年第3期48卷 513-523页

作者： PEI QIN MIAO LIU xin wang JIANHUA MA Geriatrics Department Chengde Central HospitalChengde067000China

Background:L-dopa(Levodopa)is we.l known for managing PD(Parkinson’s disease);howe.er,its prolonged use caused dyskinesia(LID).Due to the varied presentation of LID,effective treatment options are *** reported their neuroprotective activity by ameliorating acetylcholinesterase,monoamine oxidase,and neuroinﬂ*** is anotherﬂavonoid bearing these ***:To evaluate neuroprotective activity of kaempferol in dyskinetic ***:PD was developed in Sprague-Dawley rats by injecting combination of L-ascorbic acid(10µL)+6-OHDA(12µg)in medial forebrain bundle to induce neuronal damage in substantial nigra(SNr).LID was induced by administrating combination of L-dopa(20 mg/kg)+benserazide HCl(5 mg/kg)for 42 *** we.e concomitantly treated with amantadine(40 mg/kg)or kaempferol(25,50,and 100 mg/kg,p.o.).Results:Kaempferol(50 and 100 mg/kg)markedly(pwe.n cFOS,FosB,Parkin,Pdyn,apoptosis,and TH with ***:Kaempferol effectively attenuated L-dopa-induced AIMs and dyskinesia via amelioration of alterations in cFOS,FosB,Parkin,Pdyn,Tyrosine hydroxylase,and apoptosis in the brain SNr.

关键词： AIMs cFOS Kaempferol Levodopa-induced dyskinesia Pdyn

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A Dietary Supplement Jinghuosu Ameliorates Reproductive Damage Induced by Tripterygium Glycosides

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Chinese Journal of Integrative Medicine 2024年第4期30卷 330-338页

作者： MA Jing SUN Bo TE Li-ger HUANG xin ZUO xin HAN Xiao-ke wang Shu-song Hebei Key Laboratory of Reproductive Medicine Hebei Institute of Reproductive HealthHebei Reproductive Health HospitalShijiazhuang(050071)China Graduate School of Hebei Medical University Shijiazhuang(050017)China School of Chemistry and Materials Science Hebei Normal UniversityShijiazhuang(050024)China xingtai Infertility Specialist Hospital XingtaiHebei Province(054000)China

Objective To determine the possible protective effects of Jinghuosu,a dietary supplement(DS),on tripterygium glycosides(TG)-induced reproductive system injury in rats and its underlying *** A reproductive damage model was established in rats by feeding of ***-eight male Sprague Dawley rats we.e randomly divided into 4 groups using a random number table(n=7 in each):control(C)group,model(M)group,DS group and L-carnitine(LC)*** in M,DS and LC groups received 40 mg/kg TGs *** from the 5th we.k,after administration of TGs for 4 h every day,rats in DS and LC groups we.e administered with 2.7 g/kg DS and 0.21 g/kg LC,respectively,for protective treatment over the next 4 *** in Group C continued to receive the control ***-eosin staining was used for histopathological analysis of rat testicular ***-linked immunosorbent assay was performed to measure alkaline phosphatase(ALP),lactate dehydrogenase,alcohol dehydrogenase,total antioxidant capacity(T-AOC),superoxide dismutase,glutathione peroxidase(GSH-Px),and malondialdehyde(MDA)*** assay was used to determine the serum testosterone *** real-time PCR and we.tern blotting we.e conducted to analyze the expression of genes and proteins related to the testosterone synthesis pathway and the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 antioxidant *** Oral administration of TGs induced significant increases in the testicular levels of zinc transporter 1 and MDA(P<0.05).On the other hand,sperm concentration,sperm motility,and serum testosterone,serum zinc,testicular zinc,Zrt-,Irt-like protein 1,ALP,luteinizing hormone(LH)receptor,steroidogenic acute regulatory protein,Cytochrome P450 family 11 subfamily A member 1,3β-hydroxysteroid dehydrogenase 1 T-AOC,GSH-Px,nuclear factor erythroid 2-related factor 2,heme oxygenase-1 and NAD(P)H:quinone oxidoreductase 1 levels decreased following TG

关键词： dietary supplement Jinghuosu tripterygium glycosides reproductive damage infertility

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Dry environment on the expression of lacrimal gland S100A9,Anxa1,and Clu in rats via proteomics

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 435-443页

作者： Yi-Lin Sun A-Yuan Cui Li-xin wang wang-wang Zhang Hong Shi College of Traditional Chinese Medicine Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionChina Research on High Incidence of Diseases in xinjiang Region Key Laboratory of the Ministry of Education(Xinjiang Medical University)Urumqi 830011Xinjiang Uygur Autonomous RegionChina

●AIM:To investigate the underlying mechanism of dry environment(autumn dryness)affecting the lacrimal glands in rats.●METHODS:Twe.ty Sprague-Dawley rats we.e randomly divided into two *** rats we.e fed in specific pathogen free environment as the control group(n=10),and the rats fed in dry environment as the dryness group(n=10).After 24d,lacrimal glands we.e collected from the *** tissues morphology was observed by hematoxylineosin(HE)*** mass tags(TMT)quantitative proteomics analysis technology was used to screen the differential expressed proteins of lacrimal glands betwe.n the two groups,then bioinformatics analysis was ***,the immunohistochemical(IHC)method was used to verify the target proteins.●RESULTS:In dryness group,the lacrimal glands lobule atrophied,the glandular cavities enlarged,the sparse nuclear distribution and scattered inflammatory infiltration betwe.n the acinus we.e *** proteomics exhibited that a total of 195 up-regulated and 236 downregulated differential expressed proteins screened from the lacrimal glands of *** was indicated that the biological processes(BP)of differential expressed proteins mainly included cell processes and single *** cellular compositions of differential expressed proteins mainly located in cells,*** molecular functions of differential expressed proteins mainly included binding,catalytic ***,the Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis showe. that the differential expressed proteins mainly involved lysosome,complement and coagulation cascade,and ribosome *** IHC result verified that the up-regulated expression proteins of Protein S100A9(S100A9),Annexin A1(Anxa1),and Clusterin(Clu)in lacrimal glands of rats in dryness group we.e higher than control group.●CONCLUSION:The up-regulated expression proteins of S100A9,Anxa1,and Clu may be the potential mechanisms of dry eye symptoms caused by dry *** study pr

关键词： dry eye lacrimal gland S100A9 Clu Anxa1 environment rats

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A Gaussian Noise-Based Algorithm for Enhancing Backdoor Attacks

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Computers, Materials & Continua 2024年第7期80卷 361-387页

作者： Hong Huang Yunfei wang Guotao Yuan xin Li School of Computer Science and Engineering Sichuan University of Science&EngineeringYibin644000China

Deep Neural Networks(DNNs)are integral to various aspects of modern life,enhancing work ***-less,their susceptibility to diverse attack methods,including backdoor attacks,raises security *** aim to investigate backdoor attack methods for image categorization tasks,to promote the development of DNN towards higher *** on backdoor attacks currently faces significant challenges due to the distinct and abnormal data patterns of malicious samples,and the meticulous data screening by developers,hindering practical attack *** overcome these challenges,this study proposes a Gaussian Noise-Targeted Universal Adversarial Perturbation(GN-TUAP)*** approach restricts the direction of perturbations and normalizes abnormal pixel values,ensuring that perturbations progress as much as possible in a direction perpendicular to the decision hyperplane in linear *** limits anomalies within the perturbations improves their visual stealthiness,and makes them more challenging for defense methods to *** verify the effectiveness,stealthiness,and robustness of GN-TUAP,we.proposed a comprehensive threat *** on this model,extensive experiments we.e conducted using the CIFAR-10,CIFAR-100,GTSRB,and MNIST datasets,comparing our method with existing state-of-the-art attack *** also tested our perturbation triggers using various defense methods and further experimented on the robustness of the triggers against noise filtering *** experimental outcomes demonstrate that backdoor attacks leveraging perturbations generated via our algorithm exhibit cross-model attack effectiveness and superior ***,they possess robust anti-detection capabilities and maintain commendable performance when subjected to noise-filtering methods.

关键词： Image classification model backdoor attack gaussian distribution Artificial Intelligence(AI)security

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