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基于网络药理学探究黄连治疗慢性牙周炎伴牙龈卟啉单胞菌感染的作用机制

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北京口腔医学 2024年第3期32卷 164-170页

作者：宋琳曹子文刘梦蝶张雪岩张慧靓刘思睿戴伟姝吕岩李璐玲首都医科大学口腔医学院牙周科北京100050 首都医科大学口腔医学研究所北京100050 首都医科大学脑重大疾病研究中心解放军总医院第三医学中心口腔科

目的为了探究黄连治疗牙龈卟啉单胞菌相关性慢性牙周炎作用机制,本研究利用网络药理学方法分析黄连的主要活性化合物、潜在靶点和相关通路。方法运用中药系统药理学分析平台(TCMSP)对黄连的药物活性化合物及药物作用靶点基因进行筛选。... 详细信息

目的为了探究黄连治疗牙龈卟啉单胞菌相关性慢性牙周炎作用机制,本研究利用网络药理学方法分析黄连的主要活性化合物、潜在靶点和相关通路。方法运用中药系统药理学分析平台(TCMSP)对黄连的药物活性化合物及药物作用靶点基因进行筛选。通过GeneCards数据库收集疾病相关靶点,对药物作用靶点及疾病相关靶点进行韦恩分析,确定药物作用潜在靶点;应用Cytoscape3.6.1软件以及String数据库分别构建“药物-化合物-潜在靶点”相互作用网络及蛋白相互作用(PPI)网络图。运用DAVID数据库对关键靶点进行基因本体(GO)功能,京都基因及基因组百科全书(KEGG)通路富集分析。结果黄连中槲皮素、小檗碱和小檗红碱等9种药物是黄连治疗牙龈卟啉单胞菌相关性慢性牙周炎的活性化合物,其作用机制涉及IL-1β、IL-6等47个潜在靶点以及TNF-α信号通路。经生物信息学验证,最终筛选出5个在牙周炎患者牙龈组织中上调的靶点,其中以黄连碱的结合能最低。结论黄连治疗慢性牙周炎伴牙龈卟啉单胞菌感染,是通过多成分、多靶点、多途径发挥其抑菌、抗炎、调控炎症进展的作用,这为使用传统中药治疗慢性牙周炎奠定一定的理论基础。

关键词：黄连慢性牙周炎牙龈卟啉单胞菌

Generalization of Reference System for Calculating the Second Dimension Retention Index in GC×GC-MS

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Journal of Analysis and Testing 2018年第3期2卷 263-273页

作者： Md Aminul Islam Prodhan Ahmed A.Sleman Seongho Kim Craig McClain Xiang zhang Department of Chemistry University of Louisville2320 South Brook StreetLouisvilleKY 40292USA University of Louisville Alcohol Research Center 505 South Hancock StreetLouisvilleKY 40202USA University of Louisville Hepatobiology and Toxicology Program 505 South Hancock StreetLouisvilleKY 40202USA Center for Regulatory and Environmental Analytical Metabolomics University of Louisville2210 South Brook StreetLouisvilleKY 40208USA Department of Computer Science and Computer Engineering University of LouisvilleLouisvilleKY 40208USA Department of Pharmacology and Toxicology University of Louisville323 East Chestnut StreetLouisvilleKY 40202USA Department of Medicine University of Louisville550 South Jackson StreetLouisvilleKY 40202USA Department of Oncology Biostatistics CoreKarmanos Cancer InstituteSchool of MedicineWayne State UniversityDetroitMI 48201USA Robley Rex Louisville VAMC LouisvilleKY 40292USA

Using C_(4)-C_(25)fatty acid methyl esters(C_(4)-C_(25)FAMEs)as a sample reference series,a method was developed to generalize the reference system for calculating the second dimension retention index(2I)of compounds analyzed by comprehensive two-dimensional gas chromatography-mass spectrometry(GC×GC-MS).The second dimension elution temperature(2Te),second dimension unadjusted retention time(2tR),and the linear retention index(IT)of C_(4)-C_(25)FAMEs were used to form a second dimension retention index surface(2IS)via a three-dimensional surface fitting *** 2I of an analyte analyzed by GC×GC-MS was then calculated from the 2IS based on its 2tR and *** developed method was validated by calculat-ing the 2I of n-alkanes,80 compounds,and two commercially available mixtures(MegaMix A and MegaMix B).Compared to the conventional method,the developed method keeps the 2I in n-alkane retention index scale,and enables using any compounds as references to obtain a much increased separation space in the second dimension GC.

关键词： Retention index Second dimension retention index GC-MS GC×GC-MS

Identification of Wiener Models with Binary-Valued Output Observations

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Identification of Wiener Models with Binary-Valued Output Ob...

Interaction between stress responses and circadian metabolism in metabolic disease

第25届中国控制会议

作者： Zhao Yanlong ,Wang Leyi, Yin Gang, zhang Jifeng Academy of Mathematics and Systems Science,Chinese Academy of Sciences,Beijing 100080 Department of Electrical and Computer Engineering,wayne State University,Detroit,Michigan 48202,U. S. A. Department of Mathematics,wayne State University,Detroit,Michigan 48202,U. S. A.

＜正＞This work focuses on system identification forWiener models,whose outputs are measured by binary sensors. It begins with the development of joint identifiability. Then, using periodic inputs, empirical distributions are used to construct identification algorithms. Convergence of the algorithms is established,and associated recursive algorithms are also developed.

关键词： Identification binary-valued observations Wiener model joint identifiability.

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Liver Research 2017年第3期1卷 156-162页

作者： Zhao Yang Hyunbae Kim Arushana Ali Ze Zheng Kezhong zhang Center for Molecular Medicine and Genetics Wayne State University School of MedicineMIUSA Department of Microbiology Immunologyand BiochemistryWayne State University School of MedicineMIUSA Karmanos Cancer Institute Wayne State University School of MedicineDetroitMIUSA

Circadian rhythms play crucial roles in orchestrating diverse physiological processes that are critical for health and *** circadian rhythms are closely associated with various human metabolic diseases,including type 2 diabetes,cardiovascular disease,and non-alcoholic fatty liver *** lifestyles are frequently associated with an irregular circadian rhythm,which poses a significant risk to public *** the central clock has a set periodicity,circadian oscillators in peripheral organs,particularly in the liver,can be entrained by metabolic alterations or stress *** the molecular level,the signal transduction pathways that mediate stress responses interact with the key determinants of circadian oscillation to maintain metabolic homeostasis under physiological or pathological *** the liver,a number of nuclear receptors or transcriptional regulators,which are regulated by metabolites,hormones,the circadian clock,or environmental stressors,serve as direct links between stress responses and circadian *** this review,we summarize recent advances in the understanding of the interactions between stress responses(endoplasmic reticulum stress response,oxidative stress response,and inflammatory responses)and circadian metabolism,and the role of these interactions in the development of metabolic diseases.

关键词： Stress response Circadian metabolism Metabolic disease Non-alcoholic fatty liver disease(NAFLD) Hepatic lipid metabolism

Measurement and analysis of content diffusion characteristics in opportunity environments with Spark

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Frontiers of Information Technology & Electronic Engineering 2019年第10期20卷 1404-1414页

作者： Xiao-hong zhang Kai QIAN Jian-ji REN Zong-pu JIA Tian-peng JIANG Quan zhang College of Computer Science and Technology Henan Polytechnic UniversityJiaozuo 454000China Beijing Anqi Zhilian Technology Co. Ltd.Beijing 100000China Department of Computer Science Wayne State UniversityDetroit 48202USA

Opportunity networks provide a chance to offload the tremendous cellular traffic generated by sharing popular content on mobile networks. Analyzing the content spread characteristics in real opportunity environments can discover important clues for traffic offloading decision making. However, relevant published work is very limited since it is not easy to collect data from real environments. In this study, we elaborate the analysis on the dataset collected from a real opportunity environment formed by the users of Xender, which is one of the leading mobile applications for content sharing. To discover content transmission characteristics, scale, speed, and type analyses are implemented on the dataset. The analysis results show that file transmission has obvious periodicity, that only a very small fraction of files spread widely, and that application files have much higher probability to be popular than other files. We also propose a solution to maximize file spread scales, which is very helpful for forecasting popular files. The experimental results verify the effectiveness and usefulness of our solution.

关键词： Content dissemination Device-to-device communication Opportunity network Linear threshold model

Prediction of Grinding Force by an Electroplated Grinding Wheel with Orderly-Micro-Grooves

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Chinese Journal of Mechanical Engineering 2023年第4期36卷 56-66页

作者： Cong Mao Jiali Wang Mingjun zhang Xincheng Wang Yuanqiang Luo Weidong Tang Kun Tang Zhuming Bi Yongle Hu Zhenheng Lin Hunan Provincial Key Laboratory of Intelligent Manufacturing Technology for High-performance Mechanical Equipment Changsha University of Science and TechnologyChangsha 410114China Hunan Wuxin Intelligence Technology Co. LtdChangsha 410199China Department of Civil and Mechanical Engineering Purdue University Fort WayneFort WayneIN 46805USA School of Mechanical and Electrical Engineering Putian UniversityPutian 351100China

The ability to predict a grinding force is important to control,monitor,and optimize the grinding *** theoretical models were developed to predict grinding forces when a structured wheel was used in a grinding *** paper aimed to establish a single-grit cutting force model to predict the ploughing,friction and cutting forces in a grinding *** took into the consideration of actual topography of the grinding wheel,and a theoretical grinding force model for grinding hardened AISI 52100 by the wheel with orderly-micro-grooves was *** model was innovative in the sense that it represented the random thickness of undeformed chips by a probabilistic expression,and it reflected the microstructure characteristics of the structured wheel *** that the microstructure depended on the randomness of the protruding heights and distribution density of the grits over the *** proposed force prediction model was validated by surface grinding experiments,and the results showed(1)a good agreement of the predicted and measured forces and(2)a good agreement of the changes of the grinding forces along with the changes of grinding parameters in the prediction model and *** research proposed a theoretical grinding force model of an electroplated grinding wheel with orderly-micro-grooves which is accurate,reliable and effective in predicting grinding forces.

关键词： Electroplated grinding wheel Orderly-micro-grooves Grinding force Force prediction Undeformed chip thickness Experimental validation

Recent progress in lantha-nide-catalyzed organic reactions in protic media

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Chinese Science Bulletin 2001年第20期46卷 1673-1681页

作者： LUO Sanzhong zhang Baolian XIAN Ming Adam Janczuk XIE Wenhua CHENG Jinpei Peng George Wang Department of Chemistry Nankai UniversityTianjin 300071China Department of Chemistry Wayne State UniversityDetroit MI 48202-3489USA

Lanthanide triflates are stable in water. It is possible for lanthanides to undergo many organic reactions in environmentally friendly solvents. This makes lanthanides very promising in the field of green chemistry. This review describes the recent development of the lanthanide-catalyzed organic reactions in protic solvents. Those reac-tions include Diels-Alder, Aldol, Allylation, acetalization, pericyclization, radical reactions as well as some newly-developed lanthnides-based catalysts.

关键词： green chemistry lanthanide triflate aqueous media organic syntheses.

第一届全球农药小使用工作峰会暨美国IR4“特色作物研究项目”最新进展

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农药科学与管理 2015年第11期36卷 1-5页

作者：张宏军姜文议农业部农药检定所北京100125 美国密歇根州立大学昆虫学系/美国农业部IR-4项目中北部中心美国密歇根48824

本文概述第一届全球农药小使用工作峰会暨美国IR项目2015年技术工作会相关情况,并根据议题的讨论情况,结合我国生产实际,提出了有必要进一步加强我国特色作物用药情况调研、借鉴美国IR-4项目经验、加强推进国内特色作物安全用药登记及MR... 详细信息

本文概述第一届全球农药小使用工作峰会暨美国IR项目2015年技术工作会相关情况,并根据议题的讨论情况,结合我国生产实际,提出了有必要进一步加强我国特色作物用药情况调研、借鉴美国IR-4项目经验、加强推进国内特色作物安全用药登记及MRL制定等,将有利于保障我国特色农产品质量安全。

关键词：农药特色作物管理 IR-4

miRNA-Mediated Suppression of a Cardioprotective Cardiokine as a Novel Mechanism Exacerbating Post-MI remodeling by Sleep Breathing Disorders

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miRNA-Mediated Suppression of a Cardioprotective Cardiokine ...