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图终身学习:综述

计算机研究与发展 2024年第8期61卷 2067-2096页

作者：刘壮董子宸董宜琳尚家名张帆陈雨然楼佩妍孙欣然王昱赵军 wayne lin 东北财经大学金融科技学院辽宁大连116025 大连理工大学计算机学院辽宁大连116024 南加州大学计算机学院美国加利福尼亚州洛杉矶90007

图终身学习(lifelong graph learning,LGL)是一个新兴领域,旨在实现对图结构数据的持续学习,以解决现有任务上的灾难性遗忘问题,并使得顺序更新的模型能够适应新出现的图任务.尽管LGL展现出良好的学习能力,但如何持续提高其性能仍然是... 详细信息

图终身学习(lifelong graph learning,LGL)是一个新兴领域,旨在实现对图结构数据的持续学习,以解决现有任务上的灾难性遗忘问题,并使得顺序更新的模型能够适应新出现的图任务.尽管LGL展现出良好的学习能力,但如何持续提高其性能仍然是一个至关重要的问题.为填补现有研究对这一方面的空白,对最近在LGL领域的研究进行了全面调查和总结.首先,重新分类了LGL的现有方法,重点关注克服灾难性遗忘的方法.随后,系统地分析了这些方法的优缺点,并探讨了实现持续性能提升的潜在解决方案.该研究着重于如何在持续学习的过程中避免对旧任务的遗忘,同时快速适应新任务的挑战.最后,还就LGL的未来发展方向进行了讨论,涵盖了其在应用领域、开放性问题等方面的潜在影响,并具体分析了这些方向对持续性能改进的潜在影响.这些讨论将有助于指导未来LGL研究的方向,推动这一领域的进一步发展与应用.

关键词：图终身学习(LGL) 图神经网络(GNN) 重放正则化持续学习增量学习灾难性遗忘

Eigenvalue approximation from below using non-conforming finite elements

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Science China Mathematics 2010年第1期53卷 137-150页

作者： YANG YiDu 1 ,ZHANG ZhiMin 2 & lin FuBiao 11 School of Mathematics and Computer Science,Guizhou Normal University,Guiyang 550001,China 2 Department of Mathematics,wayne State University,Detroit,MI 48202,USA 1. School of Mathematics and Computer Science Guizhou Normal University Guiyang 550001 China2. Department of Mathematics Wayne State University Detroit MI 48202 USA

This is a survey article about using non-conforming finite elements in solving eigenvalue problems of elliptic operators,with emphasis on obtaining lower bounds. In addition,this article also contains some new materials for eigenvalue approximations of the Laplace operator,which include:1) the proof of the fact that the non-conforming Crouzeix-Raviart element approximates eigenvalues associated with smooth eigenfunctions from below;2) the proof of the fact that the non-conforming EQ rot1 element approximates eigenvalues from below on polygonal domains that can be decomposed into rectangular elements;3) the explanation of the phenomena that numerical eigenvalues λ 1,h and λ 3,h of the non-conforming Q rot1 element approximate the true eigenvalues from below for the L-shaped domain. Finally,we list several unsolved problems.

关键词： non-conforming element eigenvalue lower bound

Enhancing cartilage repair with optimized supramolecular hydrogel-based scaffold and pulsed electromagnetic field

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Bioactive Materials 2023年第4期22卷 312-324页

作者： Yucong Li linlong Li Ye Li Lu Feng Bin Wang Ming Wang Haixing Wang Meiling Zhu Yongkang Yang Erik IWaldorff Nianli Zhang Ingmar Viohl Sien lin Liming Bian wayne Yuk-Wai Lee Gang Li Department of Orthopaedics&Traumatology Stem Cells and Regenerative Medicine LaboratoryLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongPrince of Wales HospitalShatinHong Kong Special Administrative Region Research&Clinical Affairs Orthofix Medical Inc.LewisvilleTXUSA Department of Rehabilitation Sciences Hong Kong Polytechnic UniversityHong Kong Special Administrative Region Innovation Centre for Advanced Interdisciplinary Medicine Key Laboratory of Biological Targeting DiagnosisTherapy and Rehabilitation of Guangdong Higher Education InstitutesThe Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhenPR China School of Biomedical Sciences and Engineering National Engineering Research Center for Tissue Restoration and ReconstructionKey Laboratory of Biomedical Materials and Engineering of the Ministry of EducationSouth China University of TechnologyGuangzhouPR China Department of Orthopaedics and Traumatology SH Ho Scoliosis Research LaboratoryJoint Scoliosis Research Center of the Chinese University of Hong Kong and Nanjing UniversityThe Chinese University of Hong KongHong Kong Special Administrative Region

Functional tissue engineering strategies provide innovative approach for the repair and regeneration of damaged *** is widely used because it could provide rapid defect filling and proper structure support,and is biocompatible for cell aggregation and matrix *** have been made to seek suitable scaffolds for cartilage tissue *** Alg-DA/Ac-β-CD/gelatin hydrogel was designed with the features of physical and chemical multiple crosslinking and self-healing *** time,swelling ratio,biodegradability and biocompatibility of the hydrogels were systematically characterized,and the injectable self-healing adhesive hydrogel were demonstrated to exhibit ideal properties for cartilage ***,the new hydrogel design introduces a pre-gel state before photo-crosslinking,where increased viscosity and decreased fluidity allow the gel to remain in a semi-solid *** granted multiple administration routes to the hydrogels,which brings hydrogels the ability to adapt to complex clinical *** electromagnetic fields(PEMF)have been recognized as a promising solution to various health problems owing to their noninvasive properties and therapeutic *** treatment offers a better clinical outcome with fewer,if any,side effects,and wildly used in musculoskeletal tissue *** we propose PEMF as an effective biophysical stimulation to be 4th key element in cartilage tissue *** this study,the as-prepared Alg-DA/Ac-β-CD/gelatin hydrogels were utilized in the rat osteochondral defect model,and the potential application of PEMF in cartilage tissue engineering were *** treatment were proven to enhance the quality of engineered chondrogenic constructs in vitro,and facilitate chondrogenesis and cartilage repair in *** of the results suggested that with the injectable self-healing adhesive hydrogel and PEMF treatment,this newly proposed tissue engineering strategy r

关键词： Supramolecular hydrogels Pulsed electromagnetic field Cartilage tissue engineering Mesenchymal stem cells Chondrogenesis

Network Robustness Depth and Topology Management of Networked Dynamic Systems

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Journal of Systems Science & Complexity 2016年第1期29卷 1-21页

作者： WANG Leyi lin Feng YIN George Department of Electrical and Computer Engineering Wayne State University Department of Mathematics Wayne State University

Networked control systems are subject to adversary conditions that affect their network *** ensure reliable system operations,network topologies need to be characterized and managed for their impact on the overall system *** paper introduces the concept of network robustness depth for this *** event systems are used as a foundation to model dynamic behavior of network topologies,support their analysis,and carry out their *** analysis relates the link reliability probabilities to a probabilistic characterization of network robustness *** topology management strategies are discussed,including passive methods,random strategies,and optimization *** respective benefits and limitations are *** using platoon control as a platform of hybrid(continuous and discrete event) systems and packet erasure channels as a communication protocol,the results are demonstrated with case studies.

关键词： Network depth network topology robustness

Biofunctionality Studies of <i>Cudrania cochinchinensis</i>Extracts

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American Journal of Analytical Chemistry 2018年第1期9卷 1-14页

作者： wayne C. Liao Chwan-Fwu lin Chia-Ching lin Rui-Fen He Chien-Chih Chen Wen-Ying Huang Department of Nursing Chang Gung University of Science and Technology Chia-Yi Campus Taiwan Department of Cosmetic Science Chang Gung University of Science and Technology Tao-Yuan Campus Taiwan Department of Applied Cosmetology Hung-Kuang University Taichung Taiwan Department of Biotechnology Hung-Kuang University Taichung Taiwan

Cudrania cochinchinensis has been found to show remarkable medicinal values. The total phenolic and flavonoid contents of C. cochinchinensis extracts were analyzed, and the antioxidant activity and reducing ability of C. cochinchinensis extracts were also evaluated. Tetrahydroxyflavanonol (THF) was isolated from the xylem and pith portions of C. cochinchinensis stem;however, the bark portion of C. cochinchinensis stem was found to contain no THF. Consequently, solutions extracted from the xylem and pith portions of C. cochinchinensis showed good antioxidant activity. The IC50 values of pith, xylem, and bark extracts were 0.779, 3.020, and 3.507 mg/mL, respectively. As the pith portion of C. cochinchinensis stem contained more THF and had a higher flavonoid content, it exhibited better antioxidant activity and reducing ability. In addition, C. cochinchinensis pith extracts reduced tyrosinase activity in a dose-dependent manner with IC50 = 16.1 μg/mL. The inhibitory activity was determined to be noncompetitive with Km = 0.23 mM.

关键词： Cudrania cochinchinensis Tetrahydroxyflavanonol Antioxidant Activity Reducing Ability Tyrosinase

SUPER-GEOMETRIC CONVERGENCE OF A SPECTRAL ELEMENT METHOD FOR EIGENVALUE PROBLEMS WITH JUMP COEFFICIENTS

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Journal of Computational Mathematics 2010年第3期28卷 418-428页

作者： lin Wang Ziqing Xie Zhimin Zhang College of Mathematics and Computer Science Hunan Normal University Changsha 410081 China and College of Information Technical Science Nankai University Tianjin 300071 China College of Mathematics and Computer Science Hunan Normal University Changsha 310081 China Department of Mathematics Wayne State University Detroit MI 48202 USA and College of Mathematics and Computer Science Hunan Normal University Changsha 410081 China

We propose and analyze a C^0 spectral element method for a model eigenvalue problem with discontinuous coefficients in the one dimensional setting. A super-geometric rate of convergence is proved for the piecewise constant coefficients case and verified by numerical tests. Furthermore, the asymptotical equivalence between a Gauss-Lobatto collocation method and a spectral Galerkin method is established for a simplified model.

关键词： Eigenvalue Spectral method Collocation Galerkin finite element method.

How much information is needed in quantized nonlinear control?

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Science China(Information Sciences) 2018年第9期61卷 205-217页

作者： Chuang ZHENG lin LI Leyi WANG Chanying LI School of Mathematical Sciences Beijing Normal University Department of Electrical and Computer Engineering Wayne State University Key Laboratory of Systems and Control Academy of Mathematics and Systems ScienceChinese Academy of Sciences

Quantization rate is a crucial measure of complexity in determining stabilizability of control systems subject to quantized state measurements. This paper investigates quantization complexity for a class of nonlinear systems which are subjected to disturbances of unknown statistics and unknown bounds. This class of systems includes linear stablizable systems as special cases. Two lower bounds on the quantization rates are derived which guarantee input-to-state stabilizability for continuous-time and sampled-data feedback strategies, respectively. Simulation examples are provided to validate the results.

关键词： nonlinear systems disturbances input-to-state stabilizability sampled systems quantization rate

Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine(5hmC)

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Genomics, Proteomics & Bioinformatics 2018年第3期16卷 172-186页

作者： Yajing Chu Zhigang Zhao David wayne Sant Ganqian Zhu Sarah M. Greenblatt lin Liu Jinhuan Wang Zeng Cao Jeanette Cheng Tho Shi Chen Xiaochen Liu Peng Zhang Jaroslaw P. Maciejewski Stephen Nimer Gaofeng Wang Weiping Yuan Feng-Chun Yang Mingjiang Xu State Key Laboratory of Experimental Hematology Institute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China Department of Hematology and Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China Department of Oncology The Second Affiliated Hospital of Tianjin Medical UniversityTianjin 300211China Sylvester Comprehensive Cancer Center University of Miami Miller School of MedicineMiamiFL 33136USA Department of Human Genetics University of Miami Miller School of MedicineMiamiFL 33136USA Department of Biochemistry and Molecular Biology University of Miami Miller School of MedicineMiamiFL 33136USA Department of Medicine University of Miami Miller School of MedieineMiamiFL 33136USA Department of Translational Hematology and Oncology Research Taussig Cancer InstituteCleveland ClinicClevelandOH 44195USA

As a dioxygenase. Ten-Eleven Translocation 2 （TET2） catalyzes subsequent steps of 5-methylcytosine （5mC） oxidation. TET2 plays a critical role in the self-renewal, proliferation, and differentiation of hei-natopoietic stem cells, but its impact on mature hematopoietic cells is not well-characterized. Here we show that Tet2 plays an essential role in osteoclastogenesis. Dele- tion of Tet2 impairs the differentiation of osteoclast precursor cells （macrophages） and their matu- ration into bone-resorbing osteoclasts in vitro. Furthermore, Tet2 / mice exhibit mild osteopetrosis, accompanied by decreased number of osteoclasts in vivo. Tet2 loss in macrophages results in the altered expression of a set of genes implicated in osteoclast differentiation, such as Cehpa, Mafb, and Nfkbiz. Tet2 deletion also leads to a genome-wide alteration in the level of 5-hydroxymethylcytosine （ShmC） and altered expression of a specific subset of macrophage genes associated with osteoclast differentiation. Furthermore, Tet2 interacts with Runxl and negatively modulates its transcriptional activity. Our studies demonstrate a novel molecular mechanism controlling osteoclast differentiation and function by Tet2, that is, through interactions with Runxl and the maintenance of genomie 5hmC. Targeting Tet2 and its pathway could be a potential therapeutic strategy for the prevention and t,＇eatment of abnormal bone mass caused by the deregulation of osteoclast activities.

关键词： Tet2 5hmC Macrophage Osteoclast Runxl

Control of Networked Discrete Event Systems

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Control of Networked Discrete Event Systems