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同型半胱氨酸、低密度脂蛋白胆固醇及糖化血红蛋白在2型糖尿病视网膜病变的影响研究

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齐齐哈尔医学院学报 2024年第2期45卷 124-128页

作者：帕里杂·赛力克侯志梅舒哈尔新疆医科大学第二临床医学院新疆乌鲁木齐830000 克拉玛依市中心医院新疆克拉玛依834000

目的探讨血清同型半胱氨酸(Hcy)、低密度脂蛋白胆固醇(LDL-C)及糖化血红蛋白(HbA1c)在2型糖尿病视网膜病变(DR)中的影响。方法回顾性分析2019年4月—2022年6月本院内分泌科住院的2型糖尿病患者有糖尿病视网膜病变组(DR组)患者150例和非... 详细信息

目的探讨血清同型半胱氨酸(Hcy)、低密度脂蛋白胆固醇(LDL-C)及糖化血红蛋白(HbA1c)在2型糖尿病视网膜病变(DR)中的影响。方法回顾性分析2019年4月—2022年6月本院内分泌科住院的2型糖尿病患者有糖尿病视网膜病变组(DR组)患者150例和非糖尿病视网膜病变(NDR组)患者150例的临床资料,包括每位患者的一般资料、生化指标。比较两组间的一般信息;分析DR组与NDR组的影响因素;多元素回归分析DR的危险因素。结果DR及NDR组患者年龄、病程方面差距具有统计学意义(P<0.05)。DR组患者Hcy、FBG、TG、LDL-C、HbA1c水平明显高于NDR组(P<0.05)。Pearson相关系数分析,DR组患者的Hcy与年龄,病程FBG、TG、TC、LDL-c、HbA1c呈正相关关系(P<0.05)。Logistics回归分析结果显示病程、TG、LDL-c、Hcy、HbA1c均是影响2型糖尿病视网膜病变的独立因素(P<0.05)。结论Hcy、LDL-c、HbA1c水平在DR患者中远高于NDR患者,三者与DR发生、发展存在一定联系,临床可根据其表达水平对患者病情变化进行有效评估。

关键词：糖尿病视网膜病变同型半胱氨酸 2型糖尿病低密度脂蛋白糖化血红蛋白

Applicability of public sector reform initiatives of the Yemeni government from the integrated TOE-DOI framework

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International Journal of Innovation Studies 2022年第4期6卷 286-302页

作者： Rami Salmeen Basloom Muslim har Sani Mohamad Sofiah Md Auzair The Faculty of Economics and Management Universiti Kebangsaan MalaysiaBangi43600Malaysia Department of Accounting Kulliyyah of Economics and Management SciencesInternational Islamic University MalaysiaPO Box 1050728Kuala LumpurMalaysia

Effective resource allocation and accountability are critical for public services in countries facing a crisis,to ensure minimum inequality and even save *** innovation is introduced as public sector reform to improve the performance and accountability of public sector *** the said benefit,little has been done to study public administrative innovation in countries under *** study extends the literature by examining the attitude of civil service managers to the administrative innovation in the Yemeni government representing a country in crisis from an integrated perspective of technology-organization-environment(TOE)and diffusion of innovation(DOI)*** was collected from a survey of 200 civil service managers of the Yemeni central *** result shows that the attitude of managers to private sector management style is scored the highest representing the key tool of the public administrative *** the other hand,the downsizing elements were ranked the least significant as public sector reform *** explanatory model highlights the use of information technology,quality of human resources,and budget management orientation as significant factors for the applicability of public administrative innovation in the Yemeni central government.

关键词： Public administrative innovation Yemeni central government Technology-organization-environment Diffusion of innovation theory Country in crisis

Peperomia pellucida(L.) Kunth and eye diseases: A review on phytochemistry, pharmacology and toxicology

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Journal of Integrative Medicine 2022年第4期20卷 292-304页

作者： Keat Lam Ho Phaik har Yong Chee Woon Wang Umah Rani Kuppusamy Chek Tung Ngo Festo Massawe Zhi Xiang Ng School of Biosciences Faculty of Science and EngineeringUniversity of Nottingham Malaysia43500 SelangorMalaysia School of Bioscience Faculty of MedicineBioscience and NursingMAHSA University42610 SelangorMalaysia Department of Biochemistry Faculty of MedicineBioscience and NursingMAHSA University42610 SelangorMalaysia Department of Biomedical Science Faculty of MedicineUniversity of Malaya50603 Kuala LumpurMalaysia Optimax Sunway Eye Specialist Centre Bandar Sunway46150 SelangorMalaysia

Peperomia pellucida(L.) Kunth is a medicinal plant used to manage inflammatory illnesses such as conjunctivitis, and gastrointestinal and respiratory tract disorders in tropical and subtropical ***, little is known about its pharmacological mechanism of action against eye diseases. This review aims to critically discuss the phytochemistry, pharmacology and toxicology of P. pellucida as well as its roles in the treatment of cataract, glaucoma and diabetic retinopathy. Recent developments in the uses of P. pellucida for healthcare and nutraceutical products by the pharmaceutical industry are also covered in this review. For this review, a literature search was performed with PubMed, ScienceDirect, SciFinder Scholar and Scopus databases, using relevant keywords. Among the various phytochemicals identified from P. pellucida, β-caryophyllene, carotol, dillapiole, ellagic acid, pellucidin A, phytol and vitexin exhibit strong pharmacological activities within the mitogen-activated protein kinase and nuclear factor-κB signalling pathways in inflammatory eye diseases. The antihypertensive, anti-inflammatory, antioxidant,antihyperglycemic and anti-angiogenic activities displayed by P. pellucida extracts in many in vitro,in vivo and clinical studies suggest its potential role in the management of inflammatory eye diseases.P. pellucida extract was non-toxic against normal cell lines but displayed mild toxicity in animal *** growing public interest in P. pellucida has inspired the nutraceutical and pharmaceutical industries to process the plant into health products. Although the potential pharmacological mechanisms against eye diseases have been summarized, further studies of the interactions among constituent phytochemicals from P. pellucida within various signalling pathways shall support the use of the plant as an alternative therapeutic source.

关键词： Peperomia pellucida Phytochemistry Pharmacology Toxicology Cataract Diabetic retinopathy Glaucoma

Incidence and mortality of female breast cancer in the AsiaPacific region

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Cancer Biology & Medicine 2014年第2期11卷 101-115页

作者： Danny R.Youlden Susanna M.Cramb Cheng har Yip Peter D.Baade Cancer Council Queensland School of Mathematical Sciences Queensland University of Technology Faculty of Medicine University of Malaya Griffith Health Institute Griffith University School of Public Health and Social Work Queensland University of Technology

Objective: To provide an overview of the incidence and mortality of female breast cancer for countries in the Asia-Pacific ***: Statistical information about breast cancer was obtained from publicly available cancer registry and mortality databases(such as GLOBOCAN), and supplemented with data requested from individual cancer registries. Rates were directly age-standardised to the Segi World Standard population and trends were analysed using joinpoint ***: Breast cancer was the most common type of cancer among females in the region, accounting for 18% of all cases in 2012, and was the fourth most common cause of cancer-related deaths(9%). Although incidence rates remain much higher in New Zealand and Australia, rapid rises in recent years were observed in several Asian countries. Large increases in breast cancer mortality rates also occurred in many areas, particularly Malaysia and Thailand, in contrast to stabilising trends in Hong Kong and Singapore, while decreases have been recorded in Australia and New Zealand. Mortality trends tended to be more favourable for women aged under 50 compared to those who were 50 years or older. Conclusion: It is anticipated that incidence rates of breast cancer in developing countries throughout the Asia-Pacific region will continue to increase. Early detection and access to optimal treatment are the keys to reducing breast cancerrelated mortality, but cultural and economic obstacles persist. Consequently, the challenge is to customise breast cancer control initiatives to the particular needs of each country to ensure the best possible outcomes.

关键词： Asia-Pacific region female breast cancer epidemiology incidence mortality

Synthesis, spectral, 3D molecular modeling and antibacterial studies of dibutyltin (IV) Schiff base complexes derived from substituted isatin and amino acids

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Natural Science 2012年第3期4卷 170-178页

作者： har Lal Singh Jangbhadur Singh Department of Chemistry Faculty of Engineering & Technology Mody Institute of Technology and Science Sikar India

New dibutyltin(IV) complexes of Schiff base derived from 5-chloroindoline-2,3-dione, indoline- 2,3-dione with amino acids (tryptophan, alanine and valine) were synthesized and characterized by elemental analysis, IR, electronic spectra, conductance measurements, and biological activity. The analytical data showed that the Schiff base ligand acts as bidentate towards metal ions via the azomethine nitrogen and carboxylate oxygen by a stoichiometric reaction of M:L (1:2) to form metal complexes. NMR (1H, 13C and 119Sn) spectral data of the ligands and metal complex agree with proposed structures. The conductivity values between 14 - 27 ohm-1cm2mol-1 in DMF imply the presence of non-electrolyte species. 3D molecular modeling and analysis of bond lengths and bond angles have also been conducted for a representative compound, [Bu2Sn(L2)2], to substantiate the proposed structures. Antibacterial results indicate that the metal complexes are more active than the free ligands.

关键词： Schiff Base Isatins Amino Acids Dibutyltin (IV) Complexes Spectral Studies Antimicrobial Activity

Accommodation of China's Industrial Heritage in Urban Conservation Practices (Ⅱ)

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China City Planning Review 2012年第1期21卷 14-19页

作者： Peter G. Rowe har Ye Kan Architecture and Urban Design and University Harvard University Graduate School of Design Harvard University

In recent years, the conservation of industrial heritage in China has gained increasing attention within the broader context of urban conservation practices. For both policy-makers and scholars, accommodating this industrial heritage will emerge as a pertinent issue for consideration as a growing number of industrial architectural legacies dating from the Republican and Maoist eras come under (re)development pressures. This paper thus traces the development of industrial heritage conservation practices in China and discusses several dilemmas intrinsic to this type of conservation, including issues of authenticity, representativeness, and distinction. Based on comparative case studies from China and other international precedents, this paper also seeks to illustrate the different approaches that could be pursued while still attaining a balance between competing interests and claims.

关键词： industrial heritage urban conservation adaptive reuse comparative international conservation practices

Cdx1和Cdx2基因表达异常与先天性结肠性肠炎的关系

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中华小儿外科杂志 2003年第5期24卷 406-408页

作者：李龙 Vincent Lui Mai har Sham 谭广北京大学第一医院小儿外科 100034 香港大学玛丽医院小儿外科香港大学生物化学系

目的结肠炎是先天性巨结肠患儿常见的并发症,组织学研究表明巨结肠性肠炎患儿肠粘膜内的内分泌细胞减少和粘膜内分泌型 IgA不足。而Cdx1和Cdx2基因调控结肠粘膜上皮细胞的分化和增殖,本研究的目的是明确Cdx1和Cdx2基因表达与先天性巨... 详细信息

目的结肠炎是先天性巨结肠患儿常见的并发症,组织学研究表明巨结肠性肠炎患儿肠粘膜内的内分泌细胞减少和粘膜内分泌型 IgA不足。而Cdx1和Cdx2基因调控结肠粘膜上皮细胞的分化和增殖,本研究的目的是明确Cdx1和Cdx2基因表达与先天性巨结肠性肠炎之间的关系。方法采用半定量RT-PCR反应和原位杂交方法,11例先天性巨结肠患儿(年龄1～30个月,4例合并结肠炎)的无神经节细胞段、移行段和扩张段的手术切除标本为病例组,12例年龄相符(1～30个月)的非巨结肠患儿的远端结肠标本为对照组,观察Cdx1和Cdx2基因在其中的表达情况。结果Cdx1和Cdx2基因在对比组和先天性巨结肠的结肠粘膜上皮细胞均有表达,但是此二基因在先天性巨结肠性肠炎患儿的标本中表达明显减弱。结论本研究结果表明Cdx1和Cdx2基因表达减弱与先天性巨结肠性肠炎的病因密切相关。

关键词： Cdx1 Cdx2 基因表达异常先天性结肠性肠炎

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颞动脉炎

国外医学（耳鼻咽喉科学分册） 1989年第3期13卷 141-142页

作者： har-El G 常惠玉

颞动脉炎系指发生在颞动脉及头颈部中等大动脉的血栓性炎症,形成对各相应部位所在器官血供障碍引起的病变,耳及咽喉亦可受累,且易误诊。为此,本文重点对本病主要临床表现、诊断及治疗作一概要介绍。

关键词：颞动脉炎临床诊断

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热带有限型和无限型大豆产量构成因素分析

大豆科学 1992年第4期11卷 308-311页

作者： P. K. Bhattacharyya hari har Ram

本研究以10个有限型和10个无限型(或亚有限型)栽培大豆品种为材料,采用逐步回归方法分析了大豆产量的构成因素。试验设计为随机区组,4次重复。结果表明:单株荚数一个因素即可分别解释有限型、中间型、无限型大豆产量变异的72.80％、79.9... 详细信息

本研究以10个有限型和10个无限型(或亚有限型)栽培大豆品种为材料,采用逐步回归方法分析了大豆产量的构成因素。试验设计为随机区组,4次重复。结果表明:单株荚数一个因素即可分别解释有限型、中间型、无限型大豆产量变异的72.80％、79.93％和80.80％。单株荚数、生育期、主茎上始花到终花的日数和株高在三种类型的品种中都是重要的产量构成因素。

关键词：大豆品种产量构成因素