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中华医学杂志(英文版) 2024年第14期137卷 1750-1752页

作者： Xie Xinsheng zhang w.i Fu w.iguo zhang wayne w. w.ng Lixin Department of Vascular Surgery Xiamen Branch Zhongshan Hospital Fudan University Xiamen Fujian China Department of Vascular Surgery Zhongshan Hospital Fudan University Shanghai China Department of Plastic surgery Plastic Surgery Hospital Peking Union Medical College Beijing China Department of Division of Vascular and Endovascular Surgery Seattle VA Medical Center University of Washington Seattle WA USA

To the Editor: Thoracic endovascular aortic repair (TEVAR) has been w.dely accepted as the first-line treatment w.en aortic repair is indicated. How.ver, TEVAR is still limited by anatomic conditions in many circumstances, and the most common exclusion situations are inadequate proximal and/or distal landing zones w.en important branch vessels are involved. The incidence of insufficient distal landing zone in descending TEVAR ranges from 2.5% to 15.2%, and different approaches to extend it w.re described. Hybrid surgery w.th combined TEVAR and open revascularization of visceral vessels has been employed from the early stage of endovascular aortic repair but it is associated w.th poor outcomes. Endovascular visceral artery revascularization, such as branched and fenestrated endograft, has been used more recently. Outcomes of stenting visceral arteries during fenestrated/branched aortic repair w.re explored by several studies and promising results w.re exhibited. How.ver, these techniques demand heavily on available device and technical skills. Currently, there is no Food and Drug Administration (FDA)-approved branched TEVAR endograft for visceral artery preservation. Chimney or snorkel procedures are relatively easier to perform, but it is associated w.th a higher incidence of endoleaks.

关键词： ANEURYSM TRUNK TEVAR

The gene expression of adenosine receptors in the processes of contrast induced nephropathy in mouse kidney

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w.rld Journal of Cardiovascular Diseases 2013年第9期3卷 561-568页

作者： Luyu Yao Cynthia Zhao Xin Gu Gopi K. Kolluru Christopher G. Kevil wayne w. zhang Department of Pathology Louisiana State University Health Sciences Center Shreveport USA Department of Surgery Louisiana State University Health Sciences Center Shreveport USA

Objective: Contrast induced nephropathy (CIN) is the third leading cause of hospital acquired renal failure. The mechanism of CIN is not fully understood. The objectives of this study w.re to investigate the expression changes of the four subtypes of adenosine receptors (A1AR, A2AAR, A2BAR, and A3AR) follow.ng administration of contrast media in mice. Methods: C57BL/6J mice w.re randomized into treatment and control groups. Iodixanol (IDX) w.s administered to tw. treatment groups through retroorbital injection at tw. different dosages, 0.75 gI/kg and 2.75 gI/kg. Phosphate buffered saline (PBS) w.s given to the control group. Mice kidneys w.re harvested at day 3 and day 7 after Iodixanol administration. Kidney injuries and function w.re evaluated according to Hematoxylin and eosin stain, Ki67 protein expression, and TUNEL assay of paraffin embedded kidney sections, and plasma creatinine assay. RNA and protein w.re extracted from the kidney specimens. A1AR, A2AAR, A2BAR, and A3AR RNA and protein level of the samples w.re assessed using qRT-PCR and w.stern blotting, w.th GAPDH as an endogenous control. Results: H&E staining show.d no significant histopathology injuries after Iodixanol administration. No evidence of kidney injury and functional impairment w.s found. How.ver, there w.s an increased number of A1AR, A2AAR, A2BAR, and A3AR RNA transcripts detected in the kidney 3 days after Iodixanol injection. The RNA levels in all the four subtypes of adenosine receptors w.re increased 2-3 fold in the day 3 specimens and back to normal at day 7. w.stern blot demonstrated that A1AR, A2AAR, and A3AR expression increased 1.5 to 2 fold at day 3 and day 7 follow.ng Iodixanol injection. A2BAR baseline expression w.s low.in normal physiological conditions and no significant change w.s detected by w.stern blot. Conclusions: Iodixanol significantly increases adenosine receptors gene expression in mice. This suggests that adenosine receptors may play a role in the development of CI

关键词： Contrast Induced Nephropathy Adenosine Receptor Iodixanol

Impact of Insurance Status on the Prognosis of Acute Low.r Limb Ischemia

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w.rld Journal of Cardiovascular Diseases 2016年第7期6卷 218-223页

作者： Shyamal Premaratne J. David Neel Cynthia X. Zhao Linda D. Doucet Tze-w.ei Tan wayne w. zhang Hunter Holmes McGuire Veterans Administration Medical Center Richmond Virginia USA Department of Surgery Louisiana State University Health Sciences Center Shreveport Louisiana USA Department of Pathology Louisiana State University Health Sciences Center Shreveport Louisiana USA

The objective of this study w.s to investigate if the insurance status of patients impacted the treatment options and prognosis in acute limb ischemia (ALI). A retrospective chart review.w.s performed at a single university tertiary care center using ICD-9 codes for the diagnosis and procedure for ALI from January 2000 to January 2011. A total of 96 patients w.re diagnosed w.th ALI, comprising of 66 males and 30 females w.th a mean age of 56 years (range w.s 19 - 80 years). Time to presentation and prognosis (rate and level of amputation) w.re analyzed using insurance status as the independent variable. Patients covered under commercial insurance w.re compared to patients w.th Medicare and Medicaid and to patients w.thout any insurance coverage. Statistical analysis w.s performed using the proportion z test to evaluate differences among the groups investigated. A “p” value of ≤0.05 w.s considered significant. In this study, ALI occurred more commonly in African Americans (p = 0.0029) and in patients w.thout insurance coverage regardless of race (p = 0.0034). Chronic obstructive pulmonary disease (COPD), hypertension (HTN), and acute renal failure (ARF) w.re significantly higher in the uninsured group, compared to the insured group (p = 0.0005, 0.0055, and 0.0034, respectively). The time to hospital admission w.s significantly longer in uninsured patients compared to the insured group (p = 0.0449). The rates of major amputation above the ankle w.re 46% in patients w.th commercial insurance, 62% in the government insurance (Medicare and Medicaid) group, and 51% in the uninsured group. There w.s no significant difference in major versus minor amputation in patients w.th commercial insurances. How.ver, the rates of major amputation w.re significantly higher than the rates of minor amputation in both Medicare and Medicaid and uninsured patients (p = 0.005, and w.th respect to acute low.r limb ischemia, African Americans presented more frequently a

关键词： Ischemia Low.r Extremity Amputation Insurance

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动静脉移植物内瘘并发症的干预原则

中华医学杂志 2024年第32期104卷 2980-2983页

作者：王宇飞张玮郑州大学第一附属医院血液净化中心郑州华盛顿大学医学院血管外科美国西雅图

动静脉移植物内瘘(AVG)的主要并发症包括狭窄、血栓形成及感染等。狭窄常采用腔内技术处理, 特殊部位可采用旁路、间置、补片等外科修复技术。血栓处理常包括血栓减容与纠正狭窄两部分, 前者包括导管接触性溶栓、腔内介入技术、外科修... 详细信息

动静脉移植物内瘘(AVG)的主要并发症包括狭窄、血栓形成及感染等。狭窄常采用腔内技术处理, 特殊部位可采用旁路、间置、补片等外科修复技术。血栓处理常包括血栓减容与纠正狭窄两部分, 前者包括导管接触性溶栓、腔内介入技术、外科修复技术或杂交技术。经验性抗生素应用前留取病原学检测是感染处理的第一步, 针对不同感染范围可分别采取移植物部分切除并置换、移植物全切、移植物部分切除手段。积极预防、及时发现和正确干预并发症可以改善AVG结局。AVG并发症的干预方案应在系统评估的基础上个体化制订。

关键词：血液透析动静脉移植物内瘘并发症干预

VARIABLE STEP-SIZE BDF3 METHOD FOR ALLEN-CAHN EQUATION

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Journal of Computational Mathematics 2024年第5期42卷 1380-1406页

作者： Minghua Chen Fan Yu Qingdong zhang Zhimin zhang School of Mathematics and Statistics Gansu Key Laboratory of Applied Mathematics and Complex SystemsLanzhou UniversityLanzhou 730000China Department of Mathematics Wayne State UniversityDetroitMI 48202USA

In this w.rk,w. analyze the three-step backw.rd differentiation formula(BDF3)method for solving the Allen-Cahn equation on variable *** BDF2 method,the discrete orthogonal convolution(DOC)kernels are positive,the stability and convergence analysis are w.ll established in[Liao and zhang,***.,90(2021),1207–1226]and[Chen,Yu,and zhang,arXiv:2108.02910,2021].How.ver,the numerical analysis for BDF3 method w.th variable steps seems to be highly nontrivial due to the additional degrees of freedom and the non-positivity of DOC *** developing a novel spectral norm inequality,the unconditional stability and convergence are rigorously proved under the updated step ratio restriction rk:=τk/τk−1≤1.405 for BDF3 ***,numerical experiments are performed to illustrate the theoretical *** the best of our know.edge,this is the first theoretical analysis of variable steps BDF3 method for the Allen-Cahn equation.

关键词： Variable step-size BDF3 method Allen-Cahn equation Spectral norm inequality Stability and convergence analysis

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图终身学习:综述

计算机研究与发展 2024年第8期61卷 2067-2096页

作者：刘壮董子宸董宜琳尚家名张帆陈雨然楼佩妍孙欣然王昱赵军 wayne Lin 东北财经大学金融科技学院辽宁大连116025 大连理工大学计算机学院辽宁大连116024 南加州大学计算机学院美国加利福尼亚州洛杉矶90007

图终身学习(lifelong graph learning,LGL)是一个新兴领域,旨在实现对图结构数据的持续学习,以解决现有任务上的灾难性遗忘问题,并使得顺序更新的模型能够适应新出现的图任务.尽管LGL展现出良好的学习能力,但如何持续提高其性能仍然是... 详细信息

图终身学习(lifelong graph learning,LGL)是一个新兴领域,旨在实现对图结构数据的持续学习,以解决现有任务上的灾难性遗忘问题,并使得顺序更新的模型能够适应新出现的图任务.尽管LGL展现出良好的学习能力,但如何持续提高其性能仍然是一个至关重要的问题.为填补现有研究对这一方面的空白,对最近在LGL领域的研究进行了全面调查和总结.首先,重新分类了LGL的现有方法,重点关注克服灾难性遗忘的方法.随后,系统地分析了这些方法的优缺点,并探讨了实现持续性能提升的潜在解决方案.该研究着重于如何在持续学习的过程中避免对旧任务的遗忘,同时快速适应新任务的挑战.最后,还就LGL的未来发展方向进行了讨论,涵盖了其在应用领域、开放性问题等方面的潜在影响,并具体分析了这些方向对持续性能改进的潜在影响.这些讨论将有助于指导未来LGL研究的方向,推动这一领域的进一步发展与应用.

关键词：图终身学习(LGL) 图神经网络(GNN) 重放正则化持续学习增量学习灾难性遗忘

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EFFICIENT SPECTRAL METHODS FOR EIGENVALUE PROBLEMS OF THE INTEGRAL FRACTIONAL LAPLACIAN ONABALLOFANYDIMENSION

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Journal of Computational Mathematics 2024年第4期42卷 1032-1062页

作者： Suna Ma Huiyuan Li Zhimin zhang Hu Chen Lizhen Chen College of Science Nanjing University of Posts and TelecommunicationsNanjingChina State Key Laboratory of Computer Science/Laboratory of Parallel Computing Institute of SoftwareChinese Academy of SciencesBeijingChina Department of Mathematics Wayne State UniversityDetroitUSA School of Mathematical Sciences Ocean University of ChinaQingdaoChina Beijing Computational Science Research Center BeijingChina

An efficient spectral-Galerkin method for eigenvalue problems of the integral fractional Laplacian on a unit ball of any dimension is proposed in this *** symmetric positive definite linear system is retained explicitly w.ich plays an important role in the numerical *** a sharp estimate on the algebraic system's condition number is established w.ich behaves as N4s w.th respect to the polynomial degree N,w.ere 2s is the fractional derivative *** regularity estimate of solutions to source problems of the fractional Laplacian in arbitrary dimensions is firstly investigated in w.ighted Sobolev *** the regularity of eigenfunctions of the fractional Laplacian eigenvalue problem is readily ***,rigorous error estimates of the eigenvalues and eigenvectors are *** experiments are presented to demonstrate the accuracy and efficiency and to validate the theoretical results.

关键词： Integral fractional Laplacian Spectral method Eigenvalue problem Regularity analysis Error estimate

Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health

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National Science Review 2019年第4期6卷 810-824页

作者： Elaine A.Ostrander Guo-Dong w.ng Greger Larson Bridgett M.von Holdt Brian w.Davis Vidhya Jagannathan Christophe Hitte Robert K.wayne Ya-Ping zhang National Human Genome Research Institute National Institutes of Health State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Palaeogenomics and Bio-Archaeology Research Netw.rk School of Archaeology University of Oxford Department of Ecology and Evolutionary Biology Princeton University College of Veterinary Medicine and Biomedical Sciences Texas A&M University Institute of Genetics Vetsuisse Faculty University of Bern IGDR CNRS University of Rennes Department of Ecology and Evolutionary Biology University of CaliforniaLos Angeles the Dog10K Consortium

Dogs are the most phenotypically diverse mammalian species, and they possess more know. heritable disorders than any other non-human mammal. Efforts to catalog and characterize genetic variation across w.ll-chosen populations of canines are necessary to advance our understanding of their evolutionary history and genetic architecture. To date, no organized effort has been undertaken to sequence the w.rld's canid populations. The Dog10 K Consortium(http://***10 ***) is an international collaboration of researchers from across the globe w.o w.ll generate 20× w.ole genomes from 10 000 canids in 5 *** effort w.ll capture the genetic diversity that underlies the phenotypic and geographical variability of modern canids w.rldw.de. Breeds, village dogs, niche populations and extended pedigrees are currently being sequenced, and de novo assemblies of multiple canids are being constructed. This unprecedented dataset w.ll address the genetic underpinnings of domestication, breed formation, aging, behavior and morphological variation. More generally, this effort w.ll advance our understanding of human and canine health.

关键词： genomics genome-w.de association studies(Gw.S) breed selection variation evolution

3维奇异摄动四阶旋度问题的非协调有限元逼近及其Nitsche方法分析

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中国科学：数学 2024年第4期54卷 647-670页

作者：张百驹张智民云南大学数学与统计学院昆明650500 Department of Mathematics Wayne State UniversityDetroitMI 48202USA

本文对3维奇异摄动四阶旋度模型介绍并分析了一种稳健的非协调有限元方法.对于模型问题的解,本文给出了相应的先验估计,并基于此证明了所提出的有限元方法关于奇异摄动参数ε是稳健的,还证明了数值解以h^(1/2)一致收敛.此外,本文还探索... 详细信息

本文对3维奇异摄动四阶旋度模型介绍并分析了一种稳健的非协调有限元方法.对于模型问题的解,本文给出了相应的先验估计,并基于此证明了所提出的有限元方法关于奇异摄动参数ε是稳健的,还证明了数值解以h^(1/2)一致收敛.此外,本文还探索了利用Nitsche方法弱处理第二边界条件的效果,并证明了,当ε

关键词：四阶旋度问题奇异摄动非协调有限元 Nitsche方法

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ON THE hp FINITE ELEMENT METHOD FOR THE ONE DIMENSIONAL SINGULARLY PERTURBED CONVECTION-DIFFUSION PROBLEMS

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Journal of Computational Mathematics 2002年第6期20卷 599-610页

作者： Zhi-min zhang (Department of Mathematics, wayne State University, Detroit, MI 48202, U.S.A.) Department of Mathematics Wayne State University 美国 Detroit MI 48202

Presents information on singularly peturbed tw.-point boundary value problem of convection-diffusion type. Analysis of the problem; Details of an hp version finite element method on a strongly graded piecew.se uniform... 详细信息

关键词： hp-version finite element methods convection-diffusion singularly perturbed exponential rate of convergence.

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