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COMPOSITE SOFT SWITCHINg CONFIgURATION FOR INVERTERS USINg BRIDgE LEg MODULES

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Journal of Electronics(China) 2001年第1期18卷 61-69页

作者： He Xiangning Yang Yuwen (Dept of Electrical Eng., Zhejiang University, Hangzhou 310027)Kuang Sheng(Department of Engineering, University of Cambridge, Cambridge, U.K.)Barry W. Williams Stephen J. Finney(Dept. of Computing & Electrical Eng., Heriot-watt University, Edinburgh EH14 4AS, U.K.) Dept of Electrical Eng. Zhejiang University Hangzhou Department of Engineering University of Cambridge Cambridge UK Dept. of Computing & Electrical Eng. Heriot-Watt University Edinburgh UK

The use of either lossless snubbers or resonant zero voltage switching (ZVS) and zero current switching (ZCS) techniques can increase efficiency and reduce electromagnetic inter ference (EMI) and noise of industrial power equipment at high switching frequencies. This paper presents an adaptive composite soft switching configuration which combines snubber functions and resonant ZCS circuits for switches in inverters using power bridge leg modules. Simulation and experimental results are included.

关键词： Inverter Snubber Soft switching IgBT modules

A COMPLETE COMPOSITE gTO MODEL FOR CIRCUIT SIMULATIONS

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Journal of Electronics(China) 1998年第2期15卷 130-137页

作者： Barry W. Williams Dept. of Computing & Electrical Eng. Heriot-Watt University Edinburgh EH14 4AS U. K.

The paper presents a complete composite gate turn-off thyristor (gTO) model, which is based on the combination of the p-n-p and n-p-n transistor models. PSpice simulations and parametric sensitive analysis are performed with the complete composite model and calculated results are given, which show that it corresponds statically and dynamically with the practical device. In particular, the gTO gate dynamical characteristics in practical circuits are discussed and experimental results are included.

关键词： gTO Simulation Model

复制叉抑制提高寡核苷酸介导的基因定点修复效率(英文)

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复制叉抑制提高寡核苷酸介导的基因定点修复效率(英文)

中国遗传学会七届一次青年研讨会暨上海高校模式生物E——研究院第一届模式生物学术研讨会

作者：吴雪松辛立殷文璇尚曦莹陆璐 RoryM.watt KathrynS.E.Cheah 黄建东刘德培梁植权中国医学科学院中国协和医科大学医学分子生物学国家重点实验室香港大学生化系 National Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC)Beijing 100005P. R. China

Single-stranded oligonucleotide (SSO)-mediated gene modification provides a potential strategy for studies in genomic engineering and attempts in gene therapy. It has been shown competent to modify target genes in microorganisms and mammalian cells, with varying reproducibility and unknown mechanisms. Of all the impediments in SSOs’ way, chromatin environments in host cells possess important but not exactly deciphered impact The fact that chromatin structure changes in periodic cell cycles suggests us to systematically investigate SSO-mediated gene repair at various stages of cell cycle progression in mammalian cells. We found that S phase when DNA replicated provided an opportunistic window for SSO’s activity. We observed that the activity of SSO was particularly elevated in the thymidine-treated cells to a frequency approximate 10-fold of that in untreated controls. And the increase correlated positively with the duration of SSO/thymidine co-incubation with host cells. Further studies demonstrated mat the increased level of SSO-mediated gene repair arose from a thymidine-induced delay of replication fork progression, which meant the replication fork progressed very slowly, while not totally stopped. Our findings point to a mechanism for SSO-mediated gene repair whereby the slowed progression of replication forks might enable SSOs to stably anneal with their target regions of single-stranded DNA and incorporate into genome DNA as nascent strand. These studies provide a new approach for manipulating SSO-mediated repair and directing how its efficiency may be significantly enhanced within mammalian cells.

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来源： cnki会议评论

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索尼要崴泥

东方企业家 2012年第3期 92-92页

作者： watt Warman 肖妤倩（译）

在大多数客厅里，索尼的影子无处不在。电视、DVD、摄像机、音响……数十年里，这个日本品牌拨动着消费电子业。

关键词：索尼 DVD 摄像机电子业电视音响

Seaweeds’nutraceutical and biomedical potential in cancer therapy:a concise review

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 189-212页

作者： João Cotas Diana Pacheco Ana M.M.gonçalves Paulo Silva Loïc g.Carvalho Leonel Pereira University of Coimbra MARE-Marine and Environmental Sciences CentreDepartment of Life SciencesCalçada Martim de FreitasCoimbra 3000-456Portugal Department of Biology and CESAM University of AveiroAveiro 3810-193Portugal UCIBIO-REQUIMTE Departamento de QuímicaFaculdade de Ciências e TecnologiaUniversidade Nova de LisboaCaparica 2829-516Portugal The James Hutton Institute Dundee DD25DAScotlandUK Heriot-watt University Edinburgh EH144ASScotlandUK.

Seaweeds have been a food source since ancient times(600 BC)and are still widely used in Asia,mainly in traditional Chinese medicine and Japanese folk ***,seaweed compounds and extracts have been gaining interest from the biomedical and pharmaceutical market *** have been referenced as feasible solutions in finding new potential compounds and therapies in prevention,control,and reduction of cancer development due to the multirole of some bioactive components(e.g,phenolic compounds and sulphated polysaccharides).Moreover,seaweeds are rich in important health-promoting molecules[such as poly and highly unsaturated fatty acids(PUFAs and HUFAs),essential amino acids,vitamins,and dietary fibers]and minerals(calcium,iron,iodine,magnesium,phosphorus,potassium,zinc,copper,manganese,selenium,and fluoride).In this review,the potential therapeutic effects of seaweed in the prevention and treatment of cancer are approached,as well as nutraceutical properties of seaweed to promote cell homeostasis.

关键词： Seaweed compounds nutraceutical bioactive molecules cancer prevention cancer treatment

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家制能源且歌且行

财经文摘 2008年第11期 75-75页

作者： Jonathan Leake Holly watt 天韵（编译）

在房顶安装太阳能电板和风力涡轮发电机，这样的家庭将得到额外的财政补贴，这是英国雄心勃勃的绿色能源计划，以降低对石油的依赖。这个价值1000亿英镑的可再生能源战略将已经开始实行，而其核心部分是鼓励家庭生产能源自给自足。

关键词：能源计划风力涡轮发电机家庭生产财政补贴能源战略自给自足太阳能石油

gaAs-chip-based mid-infrared supercontinuum generation

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Light(Science & Applications) 2023年第11期12卷 2443-2450页

作者： geoffroy granger Myriam Bailly Hugo Delahaye Cristian Jimenez Idris Tiliouine Yann Leventoux Jean-Christophe Orlianges Vincent Couderc Bruno gérard Rezki Becheker Said Idlahcen Thomas godin Ammar Hideur Arnaud grisard Eric Lallier Sébastien Février Universitéde Limoges XLIM UMR CNRS 7252 123 Av.A.Thomas87060 LimogesFrance Thales Research&Technology 1 Av.Augustin Fresnel91767 Palaiseau CedexFrance III-V Lab 1 Av.Augustin Fresnel91767 Palaiseau CedexFrance CORIA(UMR 6614) CNRS-INSA Rouen-Universitéde Rouen NormandieNormandie UniversitéSaint-Etienne du RouvrayFrance

The mid-infrared spectral region opens up new possibilities for applications such as molecular spectroscopy with high spatial and frequency *** example,the mid-infrared light provided by synchrotron sources has helped for early diagnosis of several ***,alternative light sources at the table-top scale would enable better access to these state-of-the-art characterizations,eventually speeding up research in biology and *** supercontinuum generation in highly nonlinear waveguides pumped by compact fiber lasers represents an appealing alternative to ***,we introduce orientation-patterned gallium arsenide waveguides as a new versatile platform for mid-infrared supercontinuum *** and fiber-based pump lasers are optimized in tandem to allow for the group velocities of the signal and the idler waves to match near the degeneracy *** configuration exacerbates supercontinuum generation from 4 to 9μm when waveguides are pumped at 2750 nm with few-nanojoule energy *** brightness of the novel mid-infrared source exceeds that of the thirdgeneration synchrotron source by a factor of *** also show that the nonlinear dynamics is strongly influenced by the choice of waveguide and laser parameters,thus offering an additional degree of freedom in tailoring the spectral profile of the generated *** an approach then opens new paths for high-brightness mid-infrared laser sources development for high-resolution spectroscopy and ***,thanks to the excellent mechanical and thermal properties of the waveguide material,further power scaling seems feasible,allowing for the generation of watt-level ultra-broad frequency combs in the mid-infrared.

关键词： waveguide pumped pump

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还原病毒营销真相

广告主 2007年第10期 67-67页

作者： Duncan J.watt Jonah Peretti 全智

要可靠地设计出具有病毒性特征的信息是极端困难的,要预测出哪些特定的个人一定会传播这些信息也是如此。

关键词：病毒营销真相还原信息

Building Expertise on FAIR Through Evolving Bring Your Own Data(BYOD) Workshops: Describing the Data, Software, and Management-focused Approaches and Their Evolution

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Data Intelligence 2024年第2期6卷 429-456页

作者： César H.Bernabé Lieze Thielemans Rajaram Kaliyaperumal Claudio Carta Shuxin Zhang Celia W.g.van gelder Nirupama Benis Luiz Olavo Bonino da Silva Santos Ronald Cornet Bruna dos Santos Vieira Nawel Lalout Ines Henriques Alberto Camara Ballesteros Kees Burger Martijn g.Kersloot Friederike Ehrhart Esther van Enckevort Chris T.Evelo Alasdair J.g.gray Marc Hanauer Kristina Hettne Joep de Ligt Arnaldo Pereira Nuria Queralt-Rosinach Erik Schultes Domenica Taruscio Andra Waagmeester Mark D.Wilkinson Egon L.Willighagen Mascha Jansen Barend Mons Marco Roos Annika Jacobsen Biosemantics group Department of Human GeneticsLeiden University Medical CentreLeidenThe Netherlands NIHR Academic Fellow in general Practice University College London and The Royal Free NHS Foundation Trust National Centre for Rare Diseases Istituto Superiore di SanitaRomeItaly Department of Medical Informatics Amsterdam UMC location University of AmsterdamMeibergdreef 9AmsterdamThe Netherlands Amsterdam Public Health Methodology&Digital HealthAmsterdamThe Netherlands Health-Rl UtrechtThe Netherlands Semantics Services and Cybersecurity groupUniversity of TwenteEnschedeThe Netherlands Department of Medical Imaging Radboud Institute for Health SciencesRadboud University Medical CenterNijmegenThe Netherlands Department of Medical BioSciences Radboud University Medical CenterNijmegenThe Netherlands The Duchenne Parent Project VeneendaalThe Netherlands Departamento de Biotecnologia-Biologia Vegetal Escuela Tecnica Superior de Ingenieria AgronomicaAlimentaria y de BiosistemasCentro de Biotecnologia y Genomica de PlantasUniversidad Politecnica de Madrid(UPM)-Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria-CSIC(INIA-CSIC).Campus MontegancedoPozuelo de Alarcon(Madrid)Spain Castor AmsterdamThe Netherlands Department of Bioinformatics-BigCaT Maastricht UniversityMaastrichtThe Netherlands University Medical Center groningen University of GroningenGroningenThe Netherlands Maastricht Centre for Systems Biology(MaCSBio) Maastricht UniversityMaastrichtThe Netherlands Department of Computer Science Heriot-Watt UniversityEdinburghUK INSERM US14-OrphanetPlateforme Maladies RaresParisFrance Centre for Digital Scholarship Leiden University LibrariesThe Netherlands Center for Molecular Medicine Cancer Genomics NetherlandsDepartment of GeneticsUniversity Medical Center UtrechtUniversity UtrechtThe Netherlands University of Aveiro DETI/IEETAAveiroPortugal gO FAIR Foundation LeidenThe Netherlands The Leiden Academic Center for Drug Research LeidenThe Netherlands Micel

Since 2014,"Bring Your Own Data"workshops(BYODs)have been organised to inform people about the process and benefits of making resources Findable,Accessible,Interoperable,and Reusable(FAIR,and the FAIRification process).The BYOD workshops'content and format differ depending on their goal,context,and the background and needs of ***-focused BYODs educate domain experts on how to make their data FAIR to find new answers to research ***-focused BYODs promote the benefits of making data FAIR and instruct project managers and policy-makers on the characteristics of FAIRification ***-focused BYODs gather software developers and experts on FAIR to implement or improve software resources that are used to support ***,these BYODs intend to foster collaboration between different types of stakeholders involved in data management,curation,and reuse(*** experts,trainers,developers,data owners,data analysts,FAIR experts).The BYODs also serve as an opportunity to learn what kind of support for FAIRification is needed from different communities and to develop teaching materials based on practical examples and *** this paper,we detail the three different structures of the BYODs and describe examples of early BYODs related to plant breeding data,and rare disease registries and biobanks,which have shaped the structure of the *** discuss the latest insights into making BYODs more productive by leveraging our almost ten years of training experience in these workshops,including successes and encountered ***,we examine how the participants'feedback has motivated the research on FAIR,including the development of workflows and software.

关键词： FAIR FAIRification FAIR expertise Bring Your Own Data Workshop BYOD