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PV Roadmap Toward 2030 in Japan

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PV Roadmap Toward 2030 in Japan

11C－羟基麻黄碱PET显像预测左心室功能不全日本患者的全因死亡率（死亡风险）

第十五届国际光伏科学与工程大会

作者： I.Sakata F.Aratani K.Ishiyama K.Kawakami T.Munakata K.Uda H.Kudo T.yasui H.Mitsuyasu Y.Takaka K.Koizawa NEDO New Energy Technology Development Dept.Muza-Kawasaki Build. 18F 1310 Omiya-cho Saiwai-ku Kawasaki-city 212-8554 Japan NEDO New Energy Technology Development Dept.Muza-Kawasaki Build. 18F 1310 Omiya-cho Saiwai-ku Kawasaki-city 212-8554 Japan NEDO New Energy Technology Development Dept.Muza-Kawasaki Build. 18F 1310 Omiya-cho Saiwai-ku Kawasaki-city 212-8554 Japan NEDO New Energy Technology Development Dept.Muza-Kawasaki Build. 18F 1310 Omiya-cho Saiwai-ku Kawasaki-city 212-8554 Japan NEDO New Energy Technology Development Dept.Muza-Kawasaki Build. 18F 1310 Omiya-cho Saiwai-ku Kawasaki-city 212-8554 Japan NEDO New Energy Technology Development Dept.Muza-Kawasaki Build. 18F 1310 Omiya-cho Saiwai-ku Kawasaki-city 212-8554 Japan NEDO New Energy Technology Development Dept.Muza-Kawasaki Build. 18F 1310 Omiya-cho Saiwai-ku Kawasaki-city 212-8554 Japan NEDO New Energy Technology Development Dept.Muza-Kawasaki Build. 18F 1310 Omiya-cho Saiwai-ku Kawasaki-city 212-8554 Japan NEDO New Energy Technology Development Dept.Muza-Kawasaki Build. 18F 1310 Omiya-cho Saiwai-ku Kawasaki-city 212-8554 Japan NEDO New Energy Technology Development Dept.Muza-Kawasaki Build. 18F 1310 Omiya-cho Saiwai-ku Kawasaki-city 212-8554 Japan NEDO New Energy Technology Development Dept.Muza-Kawasaki Build. 18F 1310 Omiya-cho Saiwai-ku Kawasaki-city 212-8554 Japan

＜正＞ New Energy Industrial Technology Development Organization （NEDO） has established the "PV Roadmap toward 2030 （PV2030）" as a long-term strategy for PV R＆D in Japan. In this Roadmap, PV is expected, by 2030, to supply approximately 50% of residential electricity consumption （cumulative installed capacity in the rang of 100GW） in Japan. In terms of economic efficiency, electricity costs are targeted to equal commercial use, approximately 14 Yen/kWh, by 2020 and industrial use, approximately 7 Yen/kWh, by 2030. The PV R＆D program promoted by NEDO in the future will follow this Roadmap. The basic scheme of this program has been described.

关键词： Roadmap Technology Development National Project

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中华核医学与分子影像杂志 2017年第5期 318-319页

作者： wataru Fujita Ichiro Matsunari Hirofumi Aoki Stephan G. Nekolla Kouji Kajinami The Medical and Pharmacological Research Center Foundation, Ishikawa, Japan Division of Nuclear Medicine, Department of Radiology, Saitama Medical University Hospital, Iruma, Japan Division of Nuclear Medicine Department of RadiologySaitama Medical University Hospital The Medical and Pharmacological Research Center Foundation 华中科技大学同济医学院附属协和医院核医学科

目的研究旨在确定11C-羟基麻黄碱(11C-HED)是否可以预测左心室功能不全日本患者包括死亡在内的不良事件。虽然11C-HED PET已被用于评估各种疾病状况下的心脏交感神经支配状况, 但其预后价值方面的数据仍然有限。方法 60例左室功能不全... 详细信息

目的研究旨在确定11C-羟基麻黄碱(11C-HED)是否可以预测左心室功能不全日本患者包括死亡在内的不良事件。虽然11C-HED PET已被用于评估各种疾病状况下的心脏交感神经支配状况, 但其预后价值方面的数据仍然有限。方法 60例左室功能不全患者被纳入本研究(平均LVEF为42%±14%), 其中42例为缺血性心脏病, 18例为非缺血性心脏病。所有患者均接受11C-HED PET检查。通过11C-HED PET显像计算心肌滞留指数作为心脏交感神经元完整性的指标。使用Cox比例风险回归模型和对数秩检验进行统计分析。结果在平均(33±23)个月的随访期间, 共发生13例死亡(7例心源性死亡、6例非心源性死亡)。与未死亡患者相比, 死亡患者11C-HED滞留明显减低(7.1±2.1和9.0±2.4, P=0.015)。单位时间(min-1)心脏整体11C-HED滞留的风险比为0.762(P=0.039), 其在多元分析中有统计学意义。当将患者分为高(≥8.5)和低(<8.5)11C-HED滞留组时, 低11C-HED滞留组与高11C-HED滞留组相比, 其存活率明显降低(P=0.004)。结论左心室功能不全患者中, 心脏整体11C-HED滞留较低是总体生存率较差的预测指标。

关键词：神经系统放射性同位素交感神经体层摄影术

Skull metastasis from hepatocellular carcinoma with chronic hepatitis B

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World Journal of Gastrointestinal Oncology 2010年第3期2卷 165-168页

作者： Takashi Goto Takahiro Dohmen Kouichi Miura Shigetoshi Ohshima Kazuo Yoneyama Tomomi Shibuya Ei Kataoka Daisuke Segawa wataru Sato Yumiko Anezaki Hajime Ishii Daigo Kon Ikuhiro Yamada Kentaro Kamada Hirohide Ohnishi Department of Gastroenterology Akita University School of Medicine

A 56-year-old male visited our hospital for evaluation of an occipital *** computed tomography showed hypervascular enhancement with osteolytic change in the skull and a huge enhanced mass in the *** resonance imaging showed bone metastasis in the thoracic *** for hepatitis B surface antigen and hepatitis B core antibody were positive and his liver condition was Child-Pugh grade *** diagnosis was hepatocellular carcinoma(HCC) with skull and vertebrae metastases on chronic hepatitis *** was treated with radiation therapy for bone metastases and transcatheter arterial chemoembolization for *** he developed acute respiratory failure because of aspiration pneumonia,congestion and oedema with haemorrhage of the lungs and *** showed HCC with multiple bone *** liver tumor was categorized as well-differentiated HCC,Edmondson classification Ⅰ,trabecular type and pseudoglandular *** the liver mild infiltration of lymphocytes was seen in Glisson's capsules which were signif icantly enlarged with well preserved limiting *** necrosis was not *** fibrosis was *** 8 cm × 7 cm × 3 cm metastatic lesion had formed in the left occipitotemporal part of the cranial *** lesion was osteolytic and showed invasion into the dura *** the subdural cavity nor the brain showed involvement from the metastatic ***,skull metastasis from HCC is very rare and it affects the patient's prognosis and the quality of ***,it is very important to make an early diagnosis and carry out proper management of skull metastasis from HCC.

关键词： Hepatocellular carcinoma Skull metastasis Bone metastasis Osteolytic change Chronic hepatitis B

Clinical study of metachronous multiple oral cancers.

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中国口腔颌面外科杂志 2008年第B5期6卷 130-130页

作者： Beng Gwan Teh wataru Kobayashi Hisashi Sato Hiroto Kimura Department of OralUniversity Hospital 0368562 Japanand MaxillofacialHirosaki UniversitySurgery Hirosaki Hirosaki A omori

Purpose:To clinically study the background of metachronous multiple oral cancers encountered at the Department of Oral and Maxillofacial Surgery, Hirosaki University Hospital. Methods: A total of 9 patients with metachronous multiple oral cancers treated between 1996 and 2007 were included. Results: There were 3 males and 6 females, ranging from 66 to 79 years old with an average age of 71.2 years. The location of primary cancers were as follow: tongue, 2 cases (22.2%); mesopharyngeal, 3 cases (33.3%); and buccalmucosa, hard palate, upper and lower gingival, 1 case (11.1%) respectively. Eight cases were categorized as T1NOM0 and 1 case was termed as T2NOM0 in TNM classification. Four patients consumed alcohol while 3 were smokers. The average time elapsed between the detection of the first cancer and the appearance of the second was 63 months. Histologically, 6 were diagnosed as well differentiated squamous cell carcinomas, 1 was diagnosed as verrucous carcinoma and 2 were unknown. Conclusion:

关键词：口腔癌治疗方法临床研究颌鼻甲骨

Prion Protein Binds to Aldolase A Produced by Bovine Intestinal M Cells

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Open Journal of Veterinary Medicine 2015年第3期5卷 43-60页

作者： Yuya Nagasawa Yu Takahashi wataru Itani Hitoshi Watanabe Yusuke Hidaka Shotaro Morita Kei Suzuki Kouichi Watanabe Shyuichi Ohwada Haruki Kitazawa Morikazu Imamura Takashi Yokoyama Motohiro Horiuchi Suehiro Sakaguchi Shirou Mohri Michael T. Rose Tomonori Nochi Hisashi Aso Cellular Biology Laboratory Tohoku University Sendai Japan Food Immunology Group Tohoku University Sendai Japan Prion Disease Research Center National Institute of Animal Health Tsukuba Japan Laboratory of Veterinary Hygiene Hokkaido University Sapporo Japan Institute for Enzyme Research The University of Tokushima Tokushima Japan Institute of Biological Environmental and Rural Sciences Aberystwyth University Aberystwyth UK

Microfold (M) cells are a kind of intestinal epithelial cell in the follicle-associated epithelium (FAE) of Peyer’s patches. They can transport antigens and microorganisms to lymphoid tissues. Bovine spongiform encephalopathy (BSE) is a fatal neurodegenerative disorder in cattle. It is linked to variant Creutzfeldt-Jakob disease in humans. Although it is thought that M cells transport the BSE agent, the exact mechanism by which it crosses the intestinal barrier is not clear. We have bovine intestinal epithelial cell line (BIE cells), which can differentiate into the M cell type in vitro after stimulation, and which is able to transport the BSE agent. We show here that M cells are able to incorporate large numbers of PrP coated magnetic particles into intracellular vesicles, which we collected. The results of 2-DE show a specific protein associated with the PrP-coated particles, compared with non-coated particles. This protein was identified as aldolase A, a glycolytic pathway enzyme, using LC-MS/MS analysis. Aldolase A was synthesized and secreted by BIE cells, and increased during M cell differentiation. In the villi of the bovine intestine, aldolase A was detected on the surface of the epithelium and in the mucus droplet of goblet cells. In the FAE of bovine jejunal and ileal Peyer’s patches, aldolase A was localized on the surface and the apical part of the M cells. The binding of rbPrP to aldolase A was clearly detected and inhibited by pre-treatment of anti-aldolase A antibody. Aldolase A was co-stained with incorporated PrPSc in M-BIE cells. These results suggest that bovine M cells and goblet cells synthesize aldolase A, and that aldolase A may have the ability to bind PrP and associate with PrP in cellular vesicles. Therefore, aldolase A-positive M cells may play a key role in the invasion of BSE into the body.

关键词： Peyer’s Patch M Cell BIE Cells Aldolase A PrP Binding Protein

Coronary atherosclerosis is already ongoing in pre-diabetic status: Insight from intravascular imaging modalities

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World Journal of Diabetes 2015年第1期6卷 184-191页

作者： Osamu Kurihara Masamichi Takano Yoshihiko Seino wataru Shimizu Kyoichi Mizuno Cardiovascular Center Chiba-Hokusoh Hospital Nippon Medical School Division of Cardiology Nippon Medical School Mitsukoshi Health and Welfare Foundation

Diabetes mellitus is a powerful risk factor of coronary artery disease(CAD), leading to death and disability. In recent years, given the accumulating evidence that prediabetes is also related to increasing risk of CAD including cardiovascular events, a new guideline has been proposed for the treatment of blood cholesterolfor primary prevention of cardiovascular events. This guideline recommends aggressive lipid-lowering statin therapy for primary prevention in diabetes and other patients. The ultimate goal of patient management is to inhibit progression of systemic atherosclerosis and prevent fatal cardiovascular events such as acute coronary syndrome(ACS). Because disruption of atherosclerotic coronary plaques is a trigger of ACS, the high-risk atheroma is called a vulnerable plaque. Several types of novel diagnostic imaging technologies have been developed for identifying the characteristics of coronary atherosclerosis before the onset of ACS, especially vulnerable plaques. According to coronary angioscopic evaluation, atherosclerosis severity and plaque vulnerability were more advanced in prediabetic than in nondiabetic patients and comparable to that in diabetic patients. In addition, pharmacological intervention by statin therapy changed plaque color and complexity, and the dynamic changes in plaque features are considered plaque stabilization. In this article, we review the findings of atherosclerosis in prediabetes, detected by intravascular imaging modalities, and the therapeutic implications.

关键词： Diabetes Prediabetes Statin therapy Coronary artery disease Intravascular imaging modality

Concurrent chemoradiation with intra-arterial docetaxel-nedaplatin for advanced oral cancers

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中国口腔颌面外科杂志 2008年第B5期6卷 129-129页

作者： wataru Kobayashi Beng Gwan Teh Hirotaka Sakaki Hiroto Kimura Morio Nagahata Department of Oral and Maxillofacial Surgery Hirosaki University School of Medicine. 5-Zaifu-cho Hirosaki 036-8562 Japan Department of radiology Hirosaki University School of Medicine. 5-Zaifu-cho Hirosaki 036-8562 Japan

Purpose: To evaluate the effect and complication of concurrent chemoradiation with intra-arterial docetaxel-nedaplatin infusion。Methods: Fourteen patients with advanced oral cancers were treated between 2003 and 2007 at the Department of Oral and Maxillofacial Surgery, Hirosaki University Hospital。A total of 66Gy of external beam was irradiated for a period of seven weeks concurrent with two or three courses of intra-arterial infusion chemotherapy using a combination of docetaxel (40mg/mm2) and nedaplatin (80mg/mm2)。Treatment effect was evaluated by computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography-CT (PET-CT)。Results: Thirteen out of fourteen patients (93%) were evaluated as complete response。The rate of gradeⅢtoⅣchemotoxicity was 93%。All patients developed reversible mucositis and dermatitis but the major adverse effects were leucopenia and alopecia。There has been no central nervous system complication related to the infusion technique。Two years survival rate was 72.9% with a median follow-up duration of 11 months。Conclusions: Intra-arterial docetaxel-nedaplatin infusion concurrent with radiotherapy is an effective treatment for advanced oral cancers but severe。complication is a problem that needs to be solved。

关键词：口腔癌动脉患者临床分析

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NRD波导中多种弯波导之间的耦合特性

红外与毫米波学报 2000年第2期19卷 149-152页

作者：刘发林中条涉米山务中国科学技术大学电子工程与信息科学系安徽合肥230027 日本东北大学电气通信研究所

针对 NRD波导中不同半径的弯波导之间的耦合特性 ,提出了一种新的通用的分析方法 .当耦合结构分别简化为非对称结构 (即直波导与弯波导耦合 )和对称结构 (即两个半径相同的弯波导的耦合 )时 ,该方法也可相应简化 ,与已有的分析结果完全... 详细信息

针对 NRD波导中不同半径的弯波导之间的耦合特性 ,提出了一种新的通用的分析方法 .当耦合结构分别简化为非对称结构 (即直波导与弯波导耦合 )和对称结构 (即两个半径相同的弯波导的耦合 )时 ,该方法也可相应简化 ,与已有的分析结果完全一致 .本文还就不同半径的弯波导构成的耦合器的频率响应和带宽特性 ,在 6 0 GHz时给出了实验验证。

关键词： NRD波导耦合 V波段

Neoatherosclerosis:Coronary stents seal atherosclerotic lesions but result in making a new problem of atherosclerosis

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World Journal of Cardiology 2015年第11期7卷 776-783页

作者： Hidenori Komiyama Masamichi Takano Noritake Hata Yoshihiko Seino wataru Shimizu Kyoichi Mizuno Cardiovascular Center Chiba Hokusou HospitalNippon Medical School Cardiology Nippon Medical School Mitsukoshi Health and Welfare Foundation

Chronic inflammation of the native vessel wall with infiltration of lipid-laden foamy macrophages through impaired endothelium results in atherosclerosis. Percutaneous coronary intervention, including metallic stent implantation, is now widely utilized for the treatment of atherosclerotic lesions of the coronary artery. Baremetal stents and the subsequently developed drugeluting stents seal the atherosclerosis and resolve lumen stenosis or obstruction of the epicardial coronary artery and myocardial ischemia. After stent implantation, neointima proliferates within the stented segment. Chronic inflammation caused by a foreign body reaction to the implanted stent and subsequent neovascularization, which is characterized by the continuous recruitment of macrophages into the vessel, result in the transformation of the usual neointima into an atheromatous neointima. Neointima with an atherosclerotic appearance, such as that caused by thin-cap fibroatheromas, is now recognized as neoatherosclerosis, which can sometimes cause in-stent restenosis and acute thrombotic occlusion originating from the stent segment following disruption of the atheroma. Neoatherosclerosis is emerging as a new coronary stent-associated problem that has not yet been resolved. In this review article, we will discuss possible mechanisms, clinical challenges, and the future outlook of neoatherosclerosis.

关键词： Neoatherosclerosis Percutaneous coronary intervent