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Influence of NUDT15 variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines

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World Journal of Gastroenterology 2018年第4期24卷 511-518页

作者： Yuichiro Kojima Yosuke Hirotsu wataru omata Makoto Sugimori Shinya Takaoka Hiroshi Ashizawa Keiko Nakagomi Dai Yoshimura Kenji Hosoda Yoji Suzuki Hitoshi Mochizuki Masao omata Department of Gastroenterology Yamanashi Prefectural Central Hospital Genome Analysis Center Yamanashi Prefectural Central Hospital Department of Dermatologic Oncology National Cancer Institute Division of Gastroenterology Department of Medicine Yokohama City University Graduate School of Medicine Department of Gastroenterology Genome Analysis Center Yamanashi Prefectural Central Hospital

AIM The single nucleotide polymorphism(SNP) c.415C>T in exon 3 of NUDT15 affects thiopurine-induced leukopenia in Asian patients with Crohn's disease. Meanwhile, three additional genetic variants of NUDT15 were reported in patients with acute lymphoblastic leukemia. We evaluated the effects of these additional genetic variants of NUDT15 in patients with inflammatory bowel disease(IBD) treated with *** Ninety-six Japanese patients with IBD were enrolled. Genotyping for the NUDT15 and TPMT genes was performed using Custom Taq Man SNP genotyping assays or Sanger sequencing. The changes in white blood cell(WBC) count, mean corpuscular volume(MCV), platelet count, hemoglobin, CRP, amylase, albumin, AST, ALT, and ESR were *** Genetic variants of exon 1 and exon 3 of NUDT15 were identified in 24 of 96 patients(25.0%). C.52G > A and c.36_37 insG GAGTC in exon 1 were found in three patients each. All three patients with c.36_37 insG GAGTC in exon 1 were heterozygotes of ***139 Cys in exon 3. Eighteen patients had ***139 Cys in exon 3 alone. The WBC count gradually decreased after initiation of thiopurine treatment in the mutated cases(n = 24), and was significantly lower at 6, 8, 10, and 16 wk(P = 0.0271, 0.0037, 0.0051, and 0.0185, respectively). The WBC counts were also evaluated in patients with and without prednisolone treatment. In the patients with prednisolone treatment, the WBC count tended to show a greater decrease in the mutated cases, with significant differences at 8 and 10 wk(P = 0.012 and 0.029, respectively). In the patients without prednisolone treatment, the WBC count was significantly lower at 2, 4, 8, and 14 wk in mutated cases(P = 0.0196, 0.0182, 0.0237 and 0.0241, respectively). MCV increased after starting thiopurine treatment in the mutated cases, and was significantly higher at 10 wk(P = 0.0085). Platelet count, hemoglobin, CRP, amylase, albumin, AST, ALT and ESR did not differ significantly between the wildtype and

关键词： Inflammatory bowel disease NUDT15 Leukopenia Mean corpuscular volume Japanese

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Phase transition in Pd_(40)Ni_(10)Cu_(30)P_(20) bulk metallic glass under HP & HT

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Science China(Physics,Mechanics & Astronomy) 2005年第6期48卷 716-722页

作者： Utsumi wataru Okada Taku Synchrotron Radiation Research Center Japan Atomic Energy Research Institute 1-1-1 Kout Mikasuki Sayo Hyogo 679-5148 Japan

The phase transitions in Pd40Ni10Cu30P20 bulk metallic glass (BMG) have been studied under high pressure and high temperature (HP & HT) by X-ray diffraction measurements with synchrotron radiation source. We found that the BMG underwent a phase transitions of amorphous-crystalline-amorphous at 10 GPa upon heating. The parallel experiments were carried out at 7 GPa, while we did not observe the amorphous-crystalline-amorphous transitions by increasing temperature. Quenching the melted BMG at 7 GPa, it was found that the phase crystallized from the melt differed from the primary phase crystallized from the starting amorphous solid upon heating, suggesting there existed a distinct mechanism in two cases.

关键词： phase transition, Pd40Ni10Cu30P20, high pressure and high temperature.

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Landscape gradient of autumn photosynthetic decline in Abies sachalinensis seedlings

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Journal of Forestry Research 2023年第1期34卷 187-195页

作者： Tetsuto Sugai wataru Ishizuka Toshihiro Watanabe Hokkaido Research Center Forestry and Forest Products Research InstituteHitsujigaoka 7Sapporo 062-8516Japan Plant Nutrition Laboratory Research Faculty of AgricultureHokkaido UniversitySapporo 060-8689Japan Forest Research Institute Hokkaido Research OrganizationBibaiHokkaido 079-0198Japan

Understanding what environmental factors are genetically linked to a phenologic al event is critical for predicting responses to climate *** synthetic phenology often varies among a species of evergreen conifers due to local ***,few empirical studies have revealed relevant relationships between climatic factors in provenance environments and photosynthetic *** study evaluated the effects of environmental conditions of the growing site and seed source provenance on the seasonal changes in maximal photochemical quantum yield of photo systemⅡ(Fv/Fm)in a common garden experiment with 2-year-old seedlings of Sakhalin fir(Abies sachalinensis),a representative species with local adaptation,from four seed source provenances.A logistic model was constructed to explain the seasonal variation of Fv/Fmfrom July to October and the relationships between the estimated model parameters and representative factors featuring provenance environments were *** landscape gradient of the detected model parameters responsible for the provenance environments was visualized in a map of the distribution *** lowest temperature was the most plausible factor in the growing environment to explain the seasonal changes of Fv/*** the representative meteorological factors of provenance environments,the lowest temperatures in July showed significant relationships with two model parameters,explaining the lower limit of Fv/Fmand the higher sensitivity of autumn Fv/*** estimated spatial maps of model parameters consistently showed that the higher the lowest temperature in July in the provenance environment,the lower the Fv/Fmin October and the greater the decrease in the autumn Fv/***,the lowest summer temperature could be associated with the local adaptation of autumn photosynthetic phenology in ***.

关键词： Phenology Local adaptation Genetic cline Lowest temperature

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Full polarimetric PALSAR-based land cover monitoring in Cambodia for implementation of REDD policies

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International Journal of Digital Earth 2013年第3期6卷 255-275页

作者： Ram Avtar wataru Takeuchi Haruo Sawada Institute of Industrial Science The University of TokyoTokyoJapan

Forest cover monitoring plays an important role in the implementation of climate change mitigation policies such as Kyoto protocol and Reducing Emissions from Deforestation and Forest Degradation(REDD).In this study,we have monitored land cover using the PALSAR(Phased Array type L-band Synthetic Aperture Radar)full polarimetric data based on incoherent target *** classification technique has been applied on CloudePottier decomposition,FreemanDurden three component,and Yamaguchi four component decomposition for accurate mapping of different types of land cover *** on confusion matrix derived from the predicted and defined pixels,the evergreen and sparsely deciduous forests have shown high producer’s accuracy by FreemanDurden three component and Yamaguchi four component classifica*** overall accuracy of Maximum Likelihood Classification by Yamaguchi four component is 94.1%with 0.93 kappa coefficient as compared to the 90.3%with 0.88 kappa coefficient by FreemanDurden three component and 89.7%with 0.88 kappa coefficient by CloudePottier *** accuracy of classification in a forested area using full polarimetric PALSAR data may have been because of high penetration of L-band *** content of this study could be useful for the forest cover mapping during cloudy days needed for proper implementation of REDD policies in Cambodia.

关键词： global climate change REDD PALSAR forest cover mapping

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Essentials of Proteolytic Machineries in Chloroplasts

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Molecular Plant 2017年第1期10卷 4-19页

作者： Kenji Nishimura Yusuke Kato wataru Sakamoto Institute of Plant Science and Resources Okayama University 2-20-1 Chuo Kurashiki Okayama 710-0046 Japan

Plastids are unique organelles that can alter their structure and function in response to environmental and developmental stimuli. Chloroplasts are one type of plastid and are the sites for various metabolic pro- cesses, including photosynthesis. For optimal photosynthetic activity, the chloroplast proteome must be properly shaped and maintained through regulated proteolysis and protein quality control mechanisms. Enzymatic functions and activities are conferred by protein maturation processes involving consecutive proteolytic reactions. Protein abundances are optimized by the balanced protein synthesis and degrada- tion, which is depending on the metabolic status. Malfunctioning proteins are promptly degraded. Twenty chloroplast proteolytic machineries have been characterized to date. Specifically, processing peptidases and energy-driven processive proteases are the major players in chloroplast proteome biogenesis, remod- eling, and maintenance. Recently identified putative proteases are potential regulators of photosynthetic functions. Here we provide an updated, comprehensive overview of chloroplast protein degradation ma- chineries and discuss their importance for photosynthesis. Wherever possible, we also provide structural insights into chloroplast proteases that implement regulated proteolysis of substrate proteins/peptides.

关键词： chloroplast biogenesis protease protein homeostasis

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Simultaneous Oxidization of NO_x and SO_2 by a New Non-thermal Plasma Reactor Enhanced by Catalyst and Additive

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Plasma Science and Technology 2008年第1期10卷 53-56页

作者： Heejoon KIM 韩军 Yuhei SAKAGUCHI wataru MINAMI Department of Ecological Engineering Toyohashi University of Technology Hnbei Province Key Laboratory of Coal Conversion and New Carbon Materials Wuhan University of Science and Technology

The non-thermal plasma as one of the most promising technologies for removing NOx and SO2 has attrm^ted much attention. In this study, a new plasma reactor combined with catalyst and additive was developed to effectively oxidize and remove NOx and SO2 in the flue gas. The experimental results showed that TiO2 could improve the oxidation efficiency of SO2 in the case of applying plasma while having a negative effect on the oxidation process of NO and NOx. With the addition of NH3, the oxidation rates of NOx, NO and SO2 were slightly increased. However, the effect of adding NH3 on NOx oxidation was negative when the temperature was above 200℃.

关键词： additive catalyst NOx SO2 oxidation rate plasma

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Involvement of insulin receptor substrates in cognitive impairment and Alzheimer’s disease

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Neural Regeneration Research 2019年第8期14卷 1330-1334页

作者： Daisuke Tanokashira wataru Fukuokaya Akiko Taguchi Department of Integrative Aging Neuroscience National Center for Geriatrics and Gerontology Obu Aichi Japan Division of Neurology Endocrinology and Metabolism Faculty of Medicine University of Miyazaki Miyazaki Japan

Type 2 diabetes一associated with impaired insulin/insulin-like growth factor-1 (IGF1) signaling (IIS)一is a risk factor for cognitive impairment and dementia including Alzheimer's disease (AD). The insulin receptor substrate (IRS) proteins are major components of IIS, which transmit upstream signals via the insulin receptor and/or IGF1 receptor to multiple intracellular signaling pathways, including AKT/protein kinase B and extracellular-signal-regulated kinase cascades. Of the four IRS proteins in mammals, IRS1 and IRS2 play key roles in regulating growth and survival, metabolism, and aging. Meanwhile, the roles of IRS1 and IRS2 in the central nervous system with respect to cognitive abilities remain to be clarified. In contrast to IRS2 in peripheral tissues, inactivation of neural IRS2 exerts beneficial effects, resulting in the reduction of amyloid p accumulation and premature mortality in AD mouse models. On the other hand, the increased phosphorylation of IRS 1 at several serine sites is observed in the brains from patients with AD and animal models of AD or cognitive impairment induced by type 2 diabetes. However, these serine sites are also activated in a mouse model of type 2 diabetes, in which the diabetes drug metformin improves memory impairment. Because IRS1 and IRS2 signaling pathways are regulated through complex mechanisms including positive and negative feedback loops, whether the elevated phosphorylation of IRS1 at specific serine sites found in AD brains is a primary response to cognitive dysfunction remains unknown. Here, we examine the associations between IRS 1 /1 RS2-mediated signaling in the central nervous system and cognitive decline.

关键词： type 2 diabetes insulin/insulin^like growth factor-1 insulin receptor substrate Alzheimer's disease aging serine phosphorylation metformin neuroprotective effects high-fat-diet

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BAYESIAN IMAGE SUPERRESOLUTION AND HIDDEN VARIABLE MODELING

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Journal of Systems Science & Complexity 2010年第1期23卷 116-136页

作者： Atsunori KANEMURA Shin-ichi MAEDA wataru FUKUDA ShinI SHII Graduate School of Informatics Kyoto University

Superresolution is an image processing technique that estimates an original high-resolutionimage from its low-resolution and degraded *** superresolution tasks,there have beenproblems regarding the computational cost for the estimation of high-dimensional *** are now being overcome by the recent development of fast computers and the developmentof powerful computational techniques such as variational Bayesian *** paper reviewsa Bayesian treatment of the superresolution problem and presents its extensions based on hierarchicalmodeling by employing hidden variables.

关键词： Bayesian estimation hidden variables image superresolution Markov random fields variational estimation.

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Synthesis of CuInS_2 nanocrystals and their structural transformation triggered by ligand exchange

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Chinese Science Bulletin 2009年第21期54卷 4005-4008页

作者： KATSUHIRO Nose YUKI Soma TAKAHISA omata SHINYA Otsuka-Yao-Matsuo Division of Materials and Manufacturing Science Graduate School of Engineering Osaka University 2-1 Ymadaoka Suita 565-0871 Japan

Chalcopyrite-type CuInS2 NCs was synthesized by the hot-soap method. Mixed solutions, CuI and InCl3 dissolved in the mixture of the tri-octylphosphite and 1-octadecene and the sulfur dissolved in tri-phenylphosphite, were used as source solutions; the hexadecylamine was additionally mixed as a surfactant before the reaction. It was observed that the product CuInS2 NCs structurally transformed from the chalcopyrite(CP)-or zincblende(ZB)-to the wurtzite(WZ)-type depending on the amount of the surfactant and a storage time after the surfactant addition. Very weak photoluminescence in the near-infrared region was observed for the CP-or ZB-type NCs. This band was attributable to the electronhole recombination via defect levels. No photoluminescence was detected for the wurtzite-type NCs.

关键词：电脑合成脑结构配体交换纳米晶体红外光致发光表面活性剂网络电脑引发

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INTRACELLULAR MANIPULATION BY FEMTOSECOND LASERS:REVIEW

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Journal of Innovative Optical Health Sciences 2009年第1期2卷 1-8页

作者： wataru WATANABE SACHIHIIRO MATSUNAGA KIICHI FUKUI KAZUYOSHI ITOH Photonics Research Institute National Institute of Advanced Industrial Science and Technology Midorigaoka IkedaOsakaJapan Department of Biotechnology Graduate School of Engineering Osaka UniversityYamadaokaSuitaOsakaJapan Department of Material and Life Science Graduate School of Engineering Yamadaoka SuitaOsakaJapan

Multiphoton absorption of femtosecond laser pulses focused through an objective with high numerical aperture(NA)can be used to image and manipulate cellular and intracellular *** review highlights recent advances in i... 详细信息

关键词： Femtosecond laser nanosurgery ablation multiphoton microscopy photoconvertible fluorescent protein

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