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Analysis of Serum Antibody Level after COVID-19 Vaccine and Side Effects after Vaccine

Advances in Infectious Diseases 2023年第2期13卷 249-262页

作者： Hiromi Nagashima Shinji Chiba Shinnosuke Oura Itaru Fujimura Masachika Akiyama Yu Utsumi Hironori Sakai wataru hojo Takuya Iwabuchi Makoto Maemondo Department of Internal Medicine Division of Pulmonary Medicine Iwate Medical University Yahaba Japan R&D Cellspect Co. Ltd. Morioka Japan Department of Medicine Division of Pulmonary Medicine Jichi Medical University Shimotsuke Japan

Background: COVID-19 has caused a large number of deaths, in the elderly. In this situation, vaccines have been considered the main strategy to combat COVID-19 and were developed worldwide in 2020. One problem with COVID-19 vaccination is side effects after vaccination. In this report, we identify the relationship between side effects and elevation of antibodies as determined by monitoring several kinds of antibodies against COVID-19. Objective: We investigated whether the antibody level changed depending on side effects after COVID-19 vaccination. Methods: Healthy volunteers, who received two vaccinations between 10 March and 7 May 2021, were collected for this study. Information including age, gender, smoking history, medical history including allergies and side reactions after vaccination was obtained by questionnaire. Serum levels of antibodies of IgG and IgM against each S1, SP, and NP antigens of COVID-19 were evaluated frequently for 3 - 4 months after the first vaccination. Result: Ten employees working at Iwate Medical University were evaluated in this study. Side effects were observed in 7 of 10 patients, and grade 2 side effects in all 3 patients with a history of allergic disease. Serum S1 and SP IgG were elevated sufficiently in all patients. In all patients, IgG antibody titers fell below the cutoff point in approximately 3 months. No cases had elevated NP antibodies. SP IgM was elevated in three cases;all three cases with elevated IgM had allergic disease and the degree of side effects was relatively higher. Subjects with long-lasting elevated SPIgM were observed. Conclusion: S1 IgG and SP IgG exceeded the cutoff in all subjects after vaccination but decreased below the cutoff in all subjects within 4 months, regardless of side effects or allergic history. On the other hand, elevated SPIgM was suspected to be related to side effects and history of allergies, and cases with persistent elevation of SPIgM were observed.

关键词： COVID-19 Vaccination History of Allergic Disease Side Effect S1 IgG SP IgG SP IgM

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γ-Butyrolactone Synthesis from Allylic Alcohols Using the CO_(2)Radical Anion

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Precision Chemistry 2024年第3期2卷 88-95页

作者： Saeesh R.Mangaonkar Hiroki Hayashi wataru Kanna Suvankar Debbarma Yu Harabuchi Satoshi Maeda Tsuyoshi Mita Institute for Chemical Reaction Design and Discovery(WPI-ICReDD) Hokkaido UniversitySapporoHokkaido 001-0021Japan JST ERATO Maeda Artificial Intelligence in Chemical Reaction Design and Discovery ProjectSapporoHokkaido 060-0810Japan Department of Chemistry Faculty of ScienceHokkaido UniversitySapporoHokkaido 060-0810Japan Research and Services Division of Materials Data and Integrated System(MaDIS) National Institute for Materials Science(NIMS)TsukubaIbaraki 305-0044Japan

γ-Butyrolactone structures are commonly found in various natural products and serve as crucial building blocks in organic ***,the development of methods for synthesizingγ-butyrolactones has garnered significant interest within the organic synthesis *** this study,we present a direct and highly efficient approach for the synthesis ofγ-butyrolactones from allylic ***,this study represents the first instance ofγ-butyrolactone synthesis initiated by radical hydrocarboxylation using CO_(2)^(•–),generated from metal formates,followed by *** two-step process is achieved through the synergistic interaction of photoredox and hydrogen atom transfer(HAT)catalysis,resulting in the production ofγ-butyrolactones with exceptional ***,when employingα,α-diaryl allylic alcohol derivatives as substrates,the reaction involves 1,2-aryl migration,which occurs concomitantly with CO_(2)^(•–)addition,leading to the formation of 4,5-substituted lactones in a good *** artificial force induced reaction(AFIR)method identified the preferred 1,2-aryl migration pathway along with potential byproduct pathways,in which the targeted 1,2-migration was found to be the most plausible pathway.

关键词： CO_(2) lactone radical photoredox visible light carboxylation calculation DFT

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Gray zone lymphoma effectively treated with cyclophosphamide,doxorubicin,vincristine,prednisolone,and rituximab chemotherapy:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5708-5716页

作者： Nobumasa hojo Makoto Nagasaki Yasuha Mihara Department of General Medicine National Hospital Organization Hamada Medical CenterHamada City 697-8511ShimaneJapan Department of Pathology National Hospital Organization Hamada Medical CenterHamada City 697-8511ShimaneJapan Clinical Resident National Hospital Organization Hamada Medical CenterHamada City 697-8511ShimaneJapan

BACKGROUND B-cell lymphoma,unclassifiable,with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma(BCLu-DLBCL/cHL),also referred to as gray zone lymphoma(GZL),is known to share features with cHL and ***,GZL is often difficult to *** is no consensus regarding the optimal therapeutic *** reported cases of GZL have been in Caucasian and Hispanic individuals,and its incidence is lower in African-American and Asian populations,including the Japanese *** SUMMARY A 69-year-old female presented at our hospital with a growing mass on the right side of her *** elastic,soft mass measuring 9 cm×6 cm was palpable in the right cervical *** analyses showed pancytopenia,increased serum lactate dehydrogenase levels,and markedly increased levels of soluble interleukin-2 *** computed tomography(CT)and fluorodeoxyglucose positron emission tomography(PET)/CT revealed multiple lesions throughout her *** was diagnosed with GZL based on the characteristic pathological findings,the immunophenotype[CD20+,PAX5+,OCT2+/BOB1(focal+),CD30+,CD15-],and the strong positive expression of neoplastic programmed cell death protein ligand 1(PD-L1)in her lymphoma *** lymphoma was stage IV according to the Lugano classification and high-risk according to the International Prognostic Index for aggressive non-Hodgkin *** patient received cyclophosphamide,doxorubicin,vincristine,prednisolone,and rituximab(R-CHOP)chemotherapy because the tumor cells were CD20+.She has remained in complete remission for 3 *** GZL was diagnosed based on histopathology and immunophenotyping with ancillary PD-L1 positivity.R-CHOP chemotherapy was an effective treatment.

关键词： Classical Hodgkin lymphoma Diffuse large B-cell lymphoma Gray zone lymphoma Programmed cell death protein ligand 1 R-CHOP Case report

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Landscape gradient of autumn photosynthetic decline in Abies sachalinensis seedlings

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Journal of Forestry Research 2023年第1期34卷 187-195页

作者： Tetsuto Sugai wataru Ishizuka Toshihiro Watanabe Hokkaido Research Center Forestry and Forest Products Research InstituteHitsujigaoka 7Sapporo 062-8516Japan Plant Nutrition Laboratory Research Faculty of AgricultureHokkaido UniversitySapporo 060-8689Japan Forest Research Institute Hokkaido Research OrganizationBibaiHokkaido 079-0198Japan

Understanding what environmental factors are genetically linked to a phenologic al event is critical for predicting responses to climate *** synthetic phenology often varies among a species of evergreen conifers due to local ***,few empirical studies have revealed relevant relationships between climatic factors in provenance environments and photosynthetic *** study evaluated the effects of environmental conditions of the growing site and seed source provenance on the seasonal changes in maximal photochemical quantum yield of photo systemⅡ(Fv/Fm)in a common garden experiment with 2-year-old seedlings of Sakhalin fir(Abies sachalinensis),a representative species with local adaptation,from four seed source provenances.A logistic model was constructed to explain the seasonal variation of Fv/Fmfrom July to October and the relationships between the estimated model parameters and representative factors featuring provenance environments were *** landscape gradient of the detected model parameters responsible for the provenance environments was visualized in a map of the distribution *** lowest temperature was the most plausible factor in the growing environment to explain the seasonal changes of Fv/*** the representative meteorological factors of provenance environments,the lowest temperatures in July showed significant relationships with two model parameters,explaining the lower limit of Fv/Fmand the higher sensitivity of autumn Fv/*** estimated spatial maps of model parameters consistently showed that the higher the lowest temperature in July in the provenance environment,the lower the Fv/Fmin October and the greater the decrease in the autumn Fv/***,the lowest summer temperature could be associated with the local adaptation of autumn photosynthetic phenology in ***.

关键词： Phenology Local adaptation Genetic cline Lowest temperature

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Morphology and gene expression of sex‐determining region Y‐box 9 and runt‐related transcription factor 2 in centrifugally compressed cell collagen‐combined constructs (C^(6))

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Biosurface and Biotribology 2023年第3期9卷 78-83页

作者： Xu Ye Masashi Yamazaki wataru Ando Norimasa Nakamura Hiromichi Fujie Faculty of System Design Tokyo Metropolitan UniversityTokyoJapan Research Center for Medicine‐Engineering Collaboration TokyoJapan Department of Orthopaedic Surgery Kansai Rosai HospitalAmagasakiJapan Department of Orthopaedic Surgery Osaka University Graduate School of MedicineSuitaJapan Institute for Medical Science in Sports Osaka Health Science UniversityOsakaJapan Center for Advanced Medical Engineering and Informatics Osaka UniversitySuitaJapan

The authors previously developed a scaffold‐free tissue‐engineered construct(TEC)from mesenchymal stem cells(MSCs).Although the TEC exhibited even cell distribution and was successfully applied for cartilage repair in animal models,it is unsuitable for relatively large‐scale cartilage defects due to its small *** solve the problem,the authors recently developed a novel biomaterial,a centrifugally compressed cell‐collagen combined construct(C^(6))from a mixture of MSCs and atelocollagen,both of which are subjected to *** results of the previous study indicated that C^(6) exhibited high cell viability(70%)and sufficient cell distribution similar to that of the *** the present study,the morphology and gene expression of C^(6) were *** ex-amination indicated that C6 is six times thicker(approximately 1 mm)than the TEC after a 7‐day *** C^(6) remained unchanged in scale with increased cell density after a 21‐day *** electron microscopic observation indicated that C^(6) exhibited interconnected and porous microstructures,while the TEC had close‐knit *** transcriptase‐polymerase chain reaction analysis indicated that the expression of sex‐determining region Y‐box 9 and runt‐related transcription factor 2 was significantly higher in C^(6) than that in TEC.

关键词： biomaterials cartilage microstructures

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Molecular evidence for biochemical diversification of phenolamide biosynthesis in rice plants

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Journal of Integrative Plant Biology 2016年第11期58卷 903-913页

作者： Kimiaki Tanabe Yuko hojo Tomonori Shinya Ivan galis Institute of Plant Science and Resources Okayama University Kurashiki 710-0046 Japan

Two phenolamides （PAs）, p-coumaroylputrescine and feruloylputrescine strongly accumulate in rice （Oryza sativa cv. Nipponbare） leaves subjected to attack of chewing and sucking herbivores. Here we identified and characterized in vitro three novel rice genes that mediated coumaroyI-CoA/ feruloyI-CoA conjugation to polyamines, putrescine and agmatine. Interestingly, two genes were highly specific for their polyamine substrates, encoding putresdne N-hydrox- ycinnamoyltransferase and agmatine N-hydroxycinnamoyl- transferase, while the third enzyme could use both polyamines and it was therefore annotated as putrescine/ agmatine N-hydroxycinnamoyltransferase. All genes were preferentially expressed in rice roots and developing flowers, and in addition, the putrescine/agmatine N-hydroxycinnamoyl- transferase transcripts were strongly induced by wounding in the young rice leaves. Because the wound response of this gene was only partially suppressed in the jasmonoyI-L-isoleucine deficient plants （Osjarl）, it suggests that its upregulation （as well as inducible PAs in rice） may be largely independent of jasmonoyI-L-isoleucine signaling pathway. The finding of three closely related genes with a similar and/or overlapping activity in PA biosynthesis provides another striking example of rapid diversification of plant metabolism in response to environmental stresses in nature.

关键词： Acyltransferase p-coumaroylputrescine defense feruloylputrescine phenolamides rice (Oryza sativa)

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Phase transition in Pd_(40)Ni_(10)Cu_(30)P_(20) bulk metallic glass under HP & HT

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Science China(Physics,Mechanics & Astronomy) 2005年第6期48卷 716-722页

作者： Utsumi wataru Okada Taku Synchrotron Radiation Research Center Japan Atomic Energy Research Institute 1-1-1 Kout Mikasuki Sayo Hyogo 679-5148 Japan

The phase transitions in Pd40Ni10Cu30P20 bulk metallic glass (BMG) have been studied under high pressure and high temperature (HP & HT) by X-ray diffraction measurements with synchrotron radiation source. We found that the BMG underwent a phase transitions of amorphous-crystalline-amorphous at 10 GPa upon heating. The parallel experiments were carried out at 7 GPa, while we did not observe the amorphous-crystalline-amorphous transitions by increasing temperature. Quenching the melted BMG at 7 GPa, it was found that the phase crystallized from the melt differed from the primary phase crystallized from the starting amorphous solid upon heating, suggesting there existed a distinct mechanism in two cases.

关键词： phase transition, Pd40Ni10Cu30P20, high pressure and high temperature.

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Estimating freight production/attraction using nighttime satellite imagery

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Communications in Transportation Research 2022年第1期2卷 167-180页

作者： Tomoya Kawasaki wataru Nakanishi Satoshi Hyodo Yusaku Namba Hirokazu Mori Hirotoshi Kishi Department of Systems Innovation The University of TokyoTokyo113-8656Japan Institute of Science and Engineering Kanazawa UniversityIshikawa920-1192Japan Department of Transportation Systems Engineering Nihon UniversityChiba274-8501Japan Nomura Research Institute Tokyo100-0004Japan

An appropriate understanding and accurate estimation of zonal freight production(FP)and attraction(FA)volume is one of the most important topics and the initial step in developing the origin and destination(OD)*** general,zonal FP and FA are difficult to be obtained as observed data,particularly in developing countries,owing to the lack of large-scale freight ***,several proxy indicators are often used for estimating FP and FA,such as the gross regional product(GRP),population,and the number of ***,these indicators do not often estimate the zonal FP and FA accurately and are even not available *** nighttime light intensity(NLI)data that is human-induced light emission data and one of the open alternative data,possibly improves the accuracy of FP and FA ***,few studies have examined the relationship between NLI and FP/***,the objectives of this study are to examine whether NLI can be a significant indicator for estimating zonal FP and FA relative to other socio-economic indicators and to examine the types of NLIs that can accurately estimate the FP and FA through a case study in *** a result of the analysis,NLI data are identified as a significant variable for the estimation of FP and FA among various socio-economic *** some of the indicators related to secondary industries provide higher accuracy,NLI exhibits better estimates than the popular indicators such as GRP and *** addition,we propose three types of total NLI that multiply the unit NLI by the zonal area and this generates higher accuracy of unit NLI,the average light intensity of all pixels in a *** have also found that the use of habitable area for the estimation of total NLI provides the highest accuracy among the four types of NLIs including unit *** the analysis,NLI data is sufficiently applicable for estimating zonal FP and FA,relative to other important socio-economic indicators,although space tr

关键词： Nighttime light intensity Freight production and attraction Land cover data Elastic net Regression analysis

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Full polarimetric PALSAR-based land cover monitoring in Cambodia for implementation of REDD policies

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International Journal of Digital Earth 2013年第3期6卷 255-275页

作者： Ram Avtar wataru Takeuchi Haruo Sawada Institute of Industrial Science The University of TokyoTokyoJapan

Forest cover monitoring plays an important role in the implementation of climate change mitigation policies such as Kyoto protocol and Reducing Emissions from Deforestation and Forest Degradation(REDD).In this study,we have monitored land cover using the PALSAR(Phased Array type L-band Synthetic Aperture Radar)full polarimetric data based on incoherent target *** classification technique has been applied on CloudePottier decomposition,FreemanDurden three component,and Yamaguchi four component decomposition for accurate mapping of different types of land cover *** on confusion matrix derived from the predicted and defined pixels,the evergreen and sparsely deciduous forests have shown high producer’s accuracy by FreemanDurden three component and Yamaguchi four component classifica*** overall accuracy of Maximum Likelihood Classification by Yamaguchi four component is 94.1%with 0.93 kappa coefficient as compared to the 90.3%with 0.88 kappa coefficient by FreemanDurden three component and 89.7%with 0.88 kappa coefficient by CloudePottier *** accuracy of classification in a forested area using full polarimetric PALSAR data may have been because of high penetration of L-band *** content of this study could be useful for the forest cover mapping during cloudy days needed for proper implementation of REDD policies in Cambodia.

关键词： global climate change REDD PALSAR forest cover mapping

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Essentials of Proteolytic Machineries in Chloroplasts

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Molecular Plant 2017年第1期10卷 4-19页

作者： Kenji Nishimura Yusuke Kato wataru Sakamoto Institute of Plant Science and Resources Okayama University 2-20-1 Chuo Kurashiki Okayama 710-0046 Japan

Plastids are unique organelles that can alter their structure and function in response to environmental and developmental stimuli. Chloroplasts are one type of plastid and are the sites for various metabolic pro- cesses, including photosynthesis. For optimal photosynthetic activity, the chloroplast proteome must be properly shaped and maintained through regulated proteolysis and protein quality control mechanisms. Enzymatic functions and activities are conferred by protein maturation processes involving consecutive proteolytic reactions. Protein abundances are optimized by the balanced protein synthesis and degrada- tion, which is depending on the metabolic status. Malfunctioning proteins are promptly degraded. Twenty chloroplast proteolytic machineries have been characterized to date. Specifically, processing peptidases and energy-driven processive proteases are the major players in chloroplast proteome biogenesis, remod- eling, and maintenance. Recently identified putative proteases are potential regulators of photosynthetic functions. Here we provide an updated, comprehensive overview of chloroplast protein degradation ma- chineries and discuss their importance for photosynthesis. Wherever possible, we also provide structural insights into chloroplast proteases that implement regulated proteolysis of substrate proteins/peptides.

关键词： chloroplast biogenesis protease protein homeostasis

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