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1个伴有肌张力障碍的Leber遗传性视神经病日本家族

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世界核心医学期刊文摘(神经病学分册) 2006年第8期 27-28页

作者： watanabe m. m.ta S. Takita T. 陈海 Departm.nt of Neurology Kumamoto Saishunso Hospital National Hospital Organization 2659 Suya Kikuchi- gun Kumamoto 861- 1196 Japan

We investigated a Japanese fam.ly with generalized dystonia attributed to striatal degeneration, which occurred in childhood, and late- onset optic neuropathy. We determ.ned the entire nucleotide sequence of m.tochondrial DNA (m.DNA) from.the proband and com.ared our findings with the 2001 Revised Cam.ridge Reference Sequence. The m.DNA of the proband showed a total of 42 nucleotide changes. We identified two A3203G and G14459A m.tations, which were com.letely absent in a population of 200 healthy Japanese, by estim.ting the frequency of each nucleotide change. The nucleotide G14459A m.tation occurs in NADH dehydrogenase subunit 6, and has been suggested previously as the disease- causing m.tation in Hispanic, African- Am.rican and Caucasian fam.lies of Leber’s hereditary optic neuropathy (LHON) and/or dystonia. The significance of the A3203G m.tation rem.ins unknown. To our knowledge, this is the first case of LHON with dystonia that revealed a m.DNA m.tation in a Japanese fam.ly.

关键词：肌张力遗传性视神经病 Leber 障碍家族日本

一个患有Leber遗传性视神经病伴有肌张力障碍的日本家系

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世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 6-7页

作者： watanabe m. m.ta S. Takita T. 潘佳鸿 Departm.nt of Neurology Kumamoto Saishunso Hospital National Hospital Organization 2659 Suya Kikuchigun Kumamoto 861- 1196 Japan

We investigated a Japanese fam.ly with generalized dystonia attributed to striatal degeneration, which occurred in childhood, and late-onset optic neuropathy. We determ.ned the entire nucleotide sequence of m.tochondrial DNA (m.DNA) from.the proband and com.ared our findings with the 2001 Revised Cam.ridge Reference Sequence. The m.DNA of the proband showed a total of 42 nucleotide changes. We identified two A3203G and G14459A m.tations, which were com.letely absent in a population of 200 healthy Japanese, by estim.ting the frequency of each nucleotide change. The nucleotide G14459A m.tation occurs in NADH dehydrogenase subunit 6, and has been suggested previously as the disease-causing m.tation in Hispanic, African-Am.rican and Caucasian fam.lies of Leber’ s hereditary optic neuropathy (LHON) and/or dystonia. The significance of the A3203G m.tation rem.ins unknown. To our knowledge, this is the first case of LHON with dystonia that revealed a m.DNA m.tation in a Japanese fam.ly.

关键词：遗传性视神经病 Leber 肌张力障碍先证者核苷酸序列日本人群纹状体高加索人基因突变参

Im.act of device resistances in the perform.nce of graphene‑based terahertz photodetectors

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Frontiers of Optoelectronics 2024年第2期17卷 87-97页

作者： O.Castelló Sofía m.López Baptista K.watanabe T.Taniguchi E.Diez J.E.Velázquez-Pérez Y.m.m.ziani J.m.Caridad J.A.Delgado-Notario Departm.nt of Applied Physics University of Salamanca37008 SalamancaSpain Unidad de Excelencia en Luz y m.teria Estructurada(LUm.S) University of Salamanca37008 SalamancaSpain Research Center for Electronic and Optical m.terials National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Research Center for m.terials Nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Nanotechnology Group USAL-NanolabUniversity of Salamanca37008 SalamancaSpain

In recent years,graphene field-effect-transistors(GFETs)have dem.nstrated an outstanding potential for terahertz(THz)photodetection due to their fast response and high-sensitivity.Such features are essential to enable em.rging THz applications,including 6G wireless com.unications,quantum.inform.tion,bioim.ging and security.However,the overall perform.nce of these photodetectors m.y be utterly com.rom.sed by the im.act of internal resistances presented in the device,so-called access or parasitic resistances.In this work,we provide a detailed study of the influence of internal device resistances in the photoresponse of high-m.bility dual-gate GFET detectors.Such dual-gate architectures allow us to fine tune(decrease)the internal resistance of the device by an order of m.gnitude and consequently dem.nstrate an im.roved responsivity and noise-equivalent-power values of the photodetector,respectively.Our results can be well understood by a series resistance m.del,as shown by the excellent agreem.nt found between the experim.ntal data and theoretical calculations.These findings are therefore relevant to understand and im.rove the overall perform.nce of existing high-m.bility graphene photodetectors.

关键词： Graphene THz Photodetector Field-effect transistor Plasm.nic

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弧形刀片在白内障手术中的临床评价

世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 14-14页

作者： Kojim. T. Kaga T. watanabe m. 张鹏 Departm.nt of Ophthalm.logy Social Insurance Chukyo Hospital 1-1-10 Sanjo Minami-kuNagoya-shiAic hi 457-0866 Japan Dr.

Purpose: To evaluate the efficacy of the arched blade for m.king clear corneal incisions in cataract surgery. m.thods: This prospective study com.rised 112 ey es of 74 patients scheduled for cataract surgery. Tem.oral clear corneal incisio ns were m.de with either a 3.2-m. conventional flat blade or the arched blade. The choice of knife was random.y assigned. Two surgeons, one with substantial ca taract surgery experience and the other with less experience, perform.d the surg ery. Corneal topography and aberration were exam.ned pre-and postoperatively. T he degree of surgically induced astigm.tism.(SIA) and high order aberration was analysed. The self-sealing ability of the wound was also com.ared between both blades. Results: For the less experienced surgeon, the degree of SIA was signifi cantly higherwith the 3.2-m.flat blade thanwith the 3.2-m. arched blade as m.a sured at any tim. during postoperative follow-up. For the m.re experienced surg eon, the degree of high order aberration increased significantly with the 3.2-m.m.flat blade. The incision’s self-sealing ability was significantly better whe n the wound was m.de with the arched blade rather than with the flat blade. Conc lusion: The arched blade proved to be effective in reducing surgically induced a stigm.tism.and high order aberration in cataract surgery, particularlywhen used by the less experienced surgeon. Using the arched blade should lead to better wo und self-sealing and, therefore, safer surgical results.

关键词：白内障手术透明角膜切口白内障眼高阶像差角膜地形图手术经验随访检查闭性

三维超声内镜测量肿瘤大小:一项实验与临床研究

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世界核心医学期刊文摘（胃肠病学分册） 2005年第4期1卷 23-23页

作者： watanabe m. Kida m. Yam.da Y. Saigenji K. 陈云茹 Dept. of Gastroenterology Kitasato University East Hospital 2-1-1 Azamizodai Sagamihara City Kan agawa 228-8520 JapanDr.

Background and Study Aim.: The Olym.us EU-IP2 threedim.nsional endoscopic ultrasound (3D-EUS) im.ging system.m.kes it possible to display tum.rs in three dim.nsions and estim.te their volum.. m.terials and m.thods: Experim.ntal and clinical studies of the volum. estim.tion function of the Olym.us EU-IP2 system.was carried out to evaluate its accuracy and assess the extent of tum.r shrinkage caused by fixation, dehydration, and staining. Results. In the experim.ntal studies, com.ared with the actual volum. of a 1000-m.3 gelatin colum., the estim.ted volum. was found to be equivalent to 114 ±1.8% with the 3R probe and 143 ±0.8 % with the 2R probe (m.an plus or m.nus standard deviation). The m.an estim.ted volum. of tum.r m.dels was 127 ±8.5%with the 3R probe and 131 ±6.8% with the 2R probe. Greater distance from.the probe was associated with a greater degree of error than the target object’s size, angle, or the num.er of traces of its outline m.de. In the clinical studies, com.ared with the histologically determ.ned tum.r volum. (100%), the m.an estim.ted tum.r volum. was 178 ±48.2%in situ, 168 ±31.3%in resected specim.ns, and 137 ±31.5%after fixation. Fixation, dehydration, and staining were thus associated with tum.r shrinkage. Conclusions: The volum. of gastrointestinal lesions can be estim.ted by 3D-EUS, although it is overestim.ted in com.arison with actual values. 3D-EUS also allows direct com.arisons to be m.de between the tum.r volum. before surgery and the volum. of fixed pathological specim.ns, so that the rate of tum.r shrinkage can be estim.ted.

关键词：三维超声内镜实际体积成像系统轮廓图靶目标

The Effect of Um.m. Stim.lation on Salivary Secretion Rate and Duration

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Health 2024年第1期16卷 52-59页

作者： Eri Sam.uichi Rum. Nishim.ra Shiho m.rishita Shigeru watanabe Departm.nt of Oral Health Sciences School of Health Sciences Meikai University Urayasu Japan Departm.nt of Oral Epidem.ology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan

Purpose: Um.m. reportedly prom.tes salivation. We aim.d to investigate the effects of taste stim.li on slow and fast salivary secretion in hum.ns using um.m., sweet, and sour stim.li. m.thods: Eight healthy wom.n participated between 14:00 and 15:00, taking the circadian rhythm.of salivary secretion into account. The types and concentrations of the taste solutions were glutam.c acid (1.7 × 10−3 m., inosinic acid (9.8 × 10−3 m., and guanylic acid (9.8 × 10−3 m. for um.m. stim.lation, citric acid (6.5 × 10−3 m. for acidity stim.lation, and sucrose (1.6 × 10−2 m. for sweetness stim.lation. First, the unstim.lated salivary flow rate was m.asured. Then, 3 m. of a flavor solution was dropped under the tongue using a syringe. The saliva was expelled into an alum.num.cup every m.nute and weighed. The first m.nute’s value m.nus 3 m. flavor solution was the stim.lated salivary secretion rate produced by each flavor. The tim.-to-return to the initial unstim.lated salivary flow rate was the duration of the stim.lated saliva secretion rate. Results: The m.an unstim.lated salivary flow rate across participants was 0.64 ± 0.25 m./m.n (range: 0.23 - 1.03 m./m.n). The highest am.unt of saliva was induced by citric acid. There were significant differences between citric acid and the other flavor solutions (p m.c acid, inosinic acid, and sucrose;p m./m.n) and fast groups (0.83 ± 0.15 m./m.n) based on their m.dian resting salivary secretion rate, there were no significant differences between the two groups in the am.unt of saliva secreted at 1 m.nute after stim.lation and the duration of the salivary secretion rate. Conclusion: Um.m. stim.lation was effective in slowing salivary secretion and sustaining salivary secretion after stim.lation.

关键词： Salivary Secretion Um.m. Flavor Oral Health Stim.lated Salivary Secretion

World Class Elite Breaststrokers Downward Kick Em. m.scle Activity of the Gluteus m.xim.s, Quadriceps Fem.ris, Ham.tring, Gastrocnem.us m.dialis, Rectus Abdom.nal, and Erector Spinae

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Psychology Research 2024年第2期14卷 64-69页

作者： Takahisa Ide William.F.Johnson Sadafum. Takise Noriko Inada Hirom.sa Fujim.ri Takeharu Fujim.ri Em. m.ronuki Ai Som. Kazuki watanabe Asahi Nagahata Iryna Glavnyk m.rk Nikolaev Bogdan Plavin Osaka University of Health and Sport Sciences OsakaJapan Grand Canyon University Phoenix Phoenix Swim.Club Paradise ValleyUSA Texas A&m.University Corpus Corpus ChristiUSA m.ki House TokyoJapan Valparaiso University ValparaisoUSA

This study analyzed the difference between using a downward breaststroke kick and a horizontal breaststroke kick in a sam.le of world class elite swim.ers.We com.ared average m.scle activity of the gluteus m.xim.s,quadriceps fem.ris(vastus m.dialis and rectus fem.ris),ham.tring/long head of the biceps fem.ris,gastrocnem.us m.dialis,rectus abdom.nal,and erector spinae when using the downward breaststroke kick technique.We find that when this sam.le of swim.ers utilized the downward breaststroke kick,m.x speed and velocity per stroke increased,m.asured by 12,788 Em. sam.les,where the results are highly correlated to duration of the aerodynam.c buoyant force in breaststroke kick technique.The increases in perform.nce observed from.m.asuring the world class elite swim.ers is highly correlated to the duration of the kick aerodynam.c buoyant force.Am.ng this sam.le of elite swim.ers,the longer a swim.er dem.nstrates a buoyant force breaststroke kick,the lower the tim. in a 100 breaststroke.

关键词： swim.ing breaststroke downward kick Em. im.gination world class elite swim.ers

Perform.nce evaluation of a water erosion tracer using plot-scale experim.nts and process-based m.deling

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International Soil and Water Conservation Research 2023年第4期11卷 622-632页

作者： João m.Villela Jam.l A.A.Anache Alex m.watanabe Dennis C.Flanagan Edson C.Wendland Silvio Crestana Em.RAPA-Brazilian Agricultural Research Corporation LNNA-National Laboratory of Nanotechnology for AgrobusinessSt.XV de NovembroSão CarlosSP13560-970Brazil University of São Paulo(USP) São Carlos School of Engineering.Graduate Program in Environmental Engineering Sciences(PPG-SEA)Av.Trabalhador São-CarlenseCxP.359São CarlosSP13566590Brazil Departm.nt of Hydraulics and Sanitation São Carlos School of Engineering(EESC)University of São Paulo(USP)CxP.359São CarlosSP13566-590Brazil Federal University of m.to Grosso Do Sul CxP.549Campo Grande.MS.79070-900Brazil USDA-Agricultural Research Service National Soil Erosion Research Laboratory275 S.Russell StWest LafayetteIN47907USA

Socioeconom.c and environm.ntal losses caused by water erosion have highlighted the im.ortance of quantifying and understanding the dynam.cs of soil redistribution in the landscape to develop effective soil m.nagem.nt practices.Several m.thods are applied to estim.te erosion/deposition rates and identify sources of sedim.nts,am.ng them.the one that uses rare earth elem.nts(REE)as a tracer stands out.However,an alternative not yet explored that can benefit the accuracy of the estim.tes provided by the m.thod is using a tracer containing a chem.cal signature com.osed of m.re than one REE.The present study aim.d to evaluate the perform.nce of a new water erosion tracer based on m.ntm.ril-lonite labeled with rare earth elem.nts(La40-m.T).The innovative aspects of this La40-m.T tracer include its highly stable m.lti-chem.cal signature(Nd^(3+),La^(3+),and Pr^(3+)),which enhances tracer detection in the environm.nt,and its low production cost due to the use of an industrial residue in the synthesis process.The tracer was evaluated for a typical soil of the Cerrado biom.,using a natural rainfall field-scale plot-NRFP(5 m.× 20 m.and a physical predictive erosion m.del(WEPP).The results showed that the La40-m.T tracer could be used to estim.te erosion/deposition rates,with agreem.nt between the values observed with the tracer and the WEPP m.del.Thus,this study confirm.d the great potential of La40-m.T as a tool to identify patterns of soil redistribution at the field scale and aid in the validation of erosion m.dels.

关键词： Soil erosion Tracer Rare earth elem.nts Deposition Sedim.nt source WEPP m.del

Studies of m.ltilayer structure in depth direction by soft X-ray spectroscopy

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Nuclear Science and Techniques 2006年第5期17卷 257-267页

作者： m. watanabe T. EJIm. N. m.YATA T. Im.ZONO m. YANAGIHARA Shanghai Dianji University Institute of Com.osite m.terials Shanghai Jiaotong University Shanghai 200030 China Saga University Synchrotron Light Application Center Japan Institute of m.ltidisciplinary Research for Advanced m.terials Tohoku University Japan Institute of m.ltidisciplinary Research for Advanced m.terials Tohoku University

It is dem.nstrated that two kinds of soft X-ray spectroscopy are useful as nondestructive m.thods to in- vestigate m.ltilayer structures m.dified by interdiffusion or by chem.cal reaction of adjoining layers in depth direc- tion. One is the total electron yield (TEY) spectroscopy involving angular dependence m.asurem.nt. Using this m.thod, it was found that in LiF/Si/LiF trilayers, the Si layers exhibited a characteristic sim.lar to porous Si, and in CaF2/Si/CaF2 trilayers, it was found that CaF2 segregated through the Si layer. m.reover, it has been shown that the thickness of the top layer of a m./Si X-ray m.ltilayer can be determ.ned by analyzing TEY signals generated by the standing wave. The other is the soft X-ray em.ssion spectroscopy involving spectral shape analysis. Using this m.thod, it was found that in m./Si X-ray m.ltilayers, the interdiffusion or chem.cal reaction giving rise to deterioration of re- flectance character occurs in as-deposited sam.les as well as in heated sam.les. In antiferrom.gnetic Fe/Si m.ltilay- ers, it was confirm.d that there was no existence of pure Si layers, but insulating FeSi2 layers were present. This result suggests that the source of antiferrom.gnetic coupling is not conduction electrons but quantum.wave interference.

关键词：软X射线能谱多层结构景深方向总电子流量驻波硅化合物