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Journal of Life Sciences 2010年第7期4卷 22-29页

作者： Geurmazi wassim Drira Zaher Elloumi Jannet Bourn Abderrahmen Ayadi Habib Biodiversity and Aquatic Ecosystems Research Unit UR/O5ES05 Faculty of Sciences of Sfax University of Sfax Street Soukra Km3.5 BP 1171 CP 3000 Sfax Tunisia

Spatial and vertical distribution of phytoplankton community were examined in the coast of the south of the Kerkennah Islands at three different depths 0, 2 and 6 m during the winter 2009 at 6 sampling stations. A total of 49 taxa belonging to five phytoplankton groups were identified （H＇=1.7 to 3.5 bits＇cell^-1）. Dinoflagellates and Diatoms were the most abundant phytoplankton groups which reached 27 and 71% of total abundance, respectively. The spatial distribution of the phytoplankton abundance showed a significant variation between the stations （P 〈 0.001）. While the vertical distribution of total phytoplankton showed a clear pattem, ANOVA test showed only an insignificant variation between the different depths at each station （P 〉 0.01）. On the whole, the maximum abundance of phytoplankton was recorded at the depths of 2 and 6 m （6 ×10^3 ind..Ll）. This might be due to the decrease of the nutrient concentrations in deeper water specially those of phosphate.

关键词： Kerkennah Islands phytoplankton spatial and vertical distribution environmental factors.

On Semistability of Nonlinear Switched Systems

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On Semistability of Nonlinear Switched Systems

Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and threedimensional in vitro models

Joint 48th IEEE Conference on Decision and Control and 28th Chinese Control Conference

作者： Qing Hui wassim M.Haddad Department of Mechanical Engineering Texas Tech University School of Aerospace Engineering Georgia Institute of Technology

This paper develops semistability analysis results for nonlinear switched *** is the property whereby the solutions of a dynamical system converge to Lyapunov stable equilibrium points determined by the system initial *** main results of the paper involve sufficient conditions for semistability using multiple Lyapunov functions and integral-type inequalities.

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World Journal of Gastroenterology 2022年第33期28卷 4787-4811页

作者： Alissar Monzer Kevork Wakimian Farah Ballout Samar Al Bitar Amani Yehya Mariam Kanso Nour Saheb Ayman Tawil Samer Doughan Maher Hussein Deborah Mukherji Walid Faraj Hala Gali-Muhtasib wassim Abou-Kheir Department of Biology American University of BeirutBeirut 1107-2020Lebanon Department of Anatomy Cell Biology and Physiological SciencesAmerican University of BeirutBeirut 1107-2020Lebanon Department of Surgery American University of Beirut Medical CenterBeirut 1107-2020Lebanon Department of Pathology and Laboratory Medicine American University of Beirut Medical CenterBeirut 1107-2020Lebanon Department of Internal Medicine American University of Beirut Medical CenterBeirut 1107-2020Lebanon Department of Biology and Center for Drug Discovery American University of BeirutBeirut 1107-2020Lebanon

BACKGROUND Colorectal cancer(CRC) is the second leading cause of cancer-related *** stem cells(CSCs) in CRC, which are spared by many chemotherapeutics,have tumorigenic capacity and are believed to be the reason behind cancer relapse. So far, there have been no effective drugs to target colon CSCs. Diiminoquinone(DIQ) has shown promising effects on targeting colon ***, there is limited research on the effects of DIQ on eradicating CSCs in *** To investigate the anticancer potential of DIQ on colon CSCs in two-dimensional(2D) and three-dimensional(3D) models using colonospheres and patient-derived *** Various 2D methods have been used to assess the effect and the mechanism of DIQ on HCT116and HT29 cell lines including cell proliferation and viability assays, migration and invasion assays,immunofluorescence staining, and flow cytometry. The potency of DIQ was also assessed in 3D culture using the sphere formation assay and colon cancer patient-derived organoid *** Our results showed that DIQ significantly inhibited cell proliferation, migration, and invasion in HCT116 and HT29 cell lines. DIQ treatment induced apoptosis along with an accumulation of HCT116 and HT29 cancer cells in the sub-G1 region and an increase in reactive oxygen species in both CRC cell lines. DIQ reduced sphere-forming and self-renewal ability of colon cancer HCT116and HT29 stem/progenitor cells at sub-toxic doses of 1 μmol/L. Mechanistically, DIQ targets CSCs by downregulating the main components of stem cell-related-catenin, AKT, and ERK oncogenic signaling pathways. Potently, DIQ displayed a highly significant decrease in both the count and the size of the organoids derived from colon cancer patients as compared to control and 5-fluorouracil *** This study is the first documentation of the molecular mechanism of the novel anticancer therapeutic DIQ via targeting CSC, a promising compound that needs further investigation.

关键词： Diiminoquinone Anticancer activity Colorectal cancer Cancer stem cells Patient-derived organoids Colonospheres

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一种应用于文本分类的段落向量正向激励方法

中文信息学报 2023年第7期37卷 51-60页

作者：钱亚冠方科彬康明顾钊铨潘俊王滨 wassim Swaileh 浙江科技学院大数据学院浙江杭州310023 海康威视-浙江科技学院边缘智能安全联合实验室浙江杭州310023 南京航空航天大学经济与管理学院江苏南京211106 广州大学网络空间先进技术研究院广东广州510006 塞尔齐.巴黎大学ETIS国家实验室巴黎法国95032

文本分类广泛应用于文档检索、网络搜索等领域,其中文本的向量化表示对于分类性能的提高具有重要的影响。在将变长文本表示成定长向量时,传统的段落向量化算法Doc2Vec忽视了该算法每轮训练的次数与段落长度高度相关的问题,以及长段落包... 详细信息

文本分类广泛应用于文档检索、网络搜索等领域,其中文本的向量化表示对于分类性能的提高具有重要的影响。在将变长文本表示成定长向量时,传统的段落向量化算法Doc2Vec忽视了该算法每轮训练的次数与段落长度高度相关的问题,以及长段落包含短段落信息的情况,限制了分类模型准确率的进一步提升。针对该问题,该文提出一种应用于文本分类的基于段落向量正向激励的方法。首先,根据中位数划分长、短段落向量,然后在分类模型输入过程中提升长段落向量的权重,实现提高模型分类准确率的目的。在Stanford Sentiment Treebank、IMDB和Amazon Reviews三个数据集上的实验结果表明,通过选择适当的激励系数,采用段落向量正向激励的分类模型可以获得更高的分类准确率。

关键词：正向激励段落向量文本分类

Giant Cell Tumor of the Wrist: Rare Location of the Distal Ulna

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Open Journal of Orthopedics 2021年第3期11卷 67-72页

作者： Siniki Fandebnet Ngamai Kotyade A. D. Mahamat Nour Ngarieguem O. wassim Brahim Massar Orthopedics Department Renaissance University Hospital N’Djamena Chad Faculty of Human Health Sciences University of N’Djamena N’Djamena Chad

Giant cell tumor of the wrist is a rare, benign and usually symptomatic condition. The discovery is sometimes made following a medical imaging examination or a painful symptomatology or more often a visible or palpable swelling with or without vascular and/or nerve compression. At an advanced stage, the X-ray is of paramount importance. The well codified complete surgical resection is part of the therapeutic arsenal. We present a clinical case report of a young woman with a giant cell tumor localized in the wrist in N’Djamena, Chad. This case concerns a 25-year-old patient who presented in July 2020 of a painful swelling lateral to her left wrist bone and whose X-ray radiography showed lysis of the cortical bone in the lower third of the ulna. After the operative resection of the tumor mass, the pathological examination of the operative specimen revealed the diagnosis of a giant cell tumor. A giant cell tumor is a benign condition, with a few symptoms and the location at the ulna is exceptional. Complete surgical resection is a viable treatment option.

关键词： Giant Cell Tumor Complete Surgical Resection Ulna

An unusual case of chest pain and dyspnea on exertion

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Case Reports in Clinical Medicine 2013年第2期2卷 108-110页

作者： Geetinder Goyal Isabel Oliva Pramod Bonde Clemente Britto wassim H. Fares Department of Cardiac Surgery Yale University of School of Medicine New Haven USA Department of Radiology Yale University of School of Medicine New Haven USA Pulmonary Critical Care & Sleep Medicine Yale University of School of Medicine New Haven USA

Congenital coronary artery anomalies occur in less than 1% of the general population with clinical consequences ranging from benign incidental findings to sudden cardiac death. More often than not this diagnosis is made on a postmortem examination but up to one third of the patients have symptoms such as exertional chest pain and dyspnea. Due to the correctable nature of this entity and the fact that anomalous origins of coronary arteries can be readily diagnosed by noninvasive cardiac imaging modalities, timely clinical suspicion based on symptoms is critical. We present a case of a 37 years old with exertional chest pain and dyspnea of several years duration who was found to have an anomalous origin of the left main coronary artery. A surgical correction was undertaken which resulted in resolution of his symptoms. Our case highlights the importance of keeping congenital coronary anomalies on the differential diagnosis for exertional chest pain and dyspnea in young individuals and following inconclusive noninvasive testing with more definitive diagnostic modalities.

关键词： Congenital Coronary Anomaly Exertional Dyspnea Exertional Chest Pain

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用软件实现对称密钥算法“加速”

电子设计应用 2010年第1期8卷 70-72页

作者： wassim Bassalee Yosef Stein ADI公司

本文主要在Blackfin处理器上讨论对称密钥密码的软件实现,同时介绍几种算法级优化和底层指令选择方法。

关键词：密钥安全协议软件

Tissue-engineered constructs for peripheral nerve repair:current research concepts and future perspectives

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Plastic and Aesthetic Research 2015年第1期2卷 213-219页

作者： Alba C.de Luca wassim Raffoul Francesco Giacalone Maddalena Bertolini Pietro G.di Summa EPFL Centre for NeuroprostheticsLaboratory for Soft Bioelectronic Interfaces1015 LausanneSwitzerland Department of Plastic Reconstructive and Hand SurgeryUniversity Hospital of Lausanne(Centre Hospitalier Universitaire Vaudois)1011 LausanneSwitzerland Department of Hand Surgery and Microsurgery CTO-Maria Adelaide Trauma Center10126 TorinoItaly

Traumatic injuries resulting in peripheral nerve lesions lead to important morbidity with devastating social and economic *** the lesioned nerve cannot be sutured directly,a nerve graft is generally required to bridge the *** autologous nerve grafting is still the first choice for reconstruction,it has the severe disadvantage of the sacrifice of a functional *** in tissue engineering and nerve regeneration may have a dramatic impact on clinical and surgical treatment of such nerve *** authors review the latest concepts in tissue engineering for nerve repair,including scaffold engineering of neural guides,biomaterial modification,cell therapy,growth factors delivery,and electrical *** literature is reviewed in detail,pointing out the most interesting present achievements and perspectives for future clinical *** search of the literature was performed using MEDLINE,Embase,and the Cochrane Library to identify research studies on peripheral nerve regeneration through tissue-engineered *** following medical subject headings were used to carry out a systematic search of the literature:“nerve regeneration”,“stem cells”,“biomaterial”,“extracellular matrix”,“functional regeneration”,“growth factors”and“microchannels”.Included literature was published between 1991 and *** reference lists from the retrieved articles were also reviewed for additional *** total,76 articles were included in this study.

关键词： Cell transplantation extracellular matrix growth factors nerve guidance conduit peripheral nerve repair surface modification

Nuclear Protein in Testis Midline Carcinoma Simulating Germ Cell Tumor of the Mediastinum

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Case Reports in Clinical Medicine 2018年第4期7卷 288-296页

作者： K. Oualla K. messoudi N. Acharfi I. Ahalli Samia Arifi F. Z. Elmrabet Z. Benbrahim M. Serraj L. Chbani A. Amarti N. Mellas Department of Medical Oncology Hassan II Unversity Hospital Fes Morocco Department of Pneumology Hassan II Unversity Hospital Fes Morocco Department of Pathology Hassan II Unversity Hospital Fes Morocco Laboratory of Pathology Al Azhar Fes Morocco

Nuclear protein in testis (NUT) midline carcinoma (NMC) is a very rare and aggressive human cancer characterized by overexpression of the nuclear protein in testis (NUT) most commonly due to a chromosomal translocation that fuses the NUT gene on chromosome 15 with the BRD4 gene on chromosome19. It has been described mainly in younger individuals in the mediastinum and head and neck regions and known to be highly aggressive with poor outcomes. We report the case of 23 years old male, diagnosed with locally advanced mediastinal malignancy metastatic to the lung with elevated serum alpha-fetoprotein (AFP) suggestive of germ cell tumor. However, pathology with immunohistochemistry excluded the dignosis of germ cell tumor and confirmed the diagnosis of poorly differentiated carcinoma. Despite aggressive treatment, evolution was marked by rapid clinical deterioration leading to death within 1 month of initial diagnosis. We report this case to underline the rarity of this disease, clinico-radiological and pathologic features, especially misleading presentation with germ cell tumors, treatment management and prognosis.

关键词： NUT Midline Carcinoma Mediastinal Mass Alpha-Fetoprotein Germ Cell Tumor

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妊娠期间糖尿病管理

临床荟萃 2019年第2期34卷 184-188页

作者： wassim El-Harake 谈力欣王晓昆许樟荣伊利诺斯州朱利叶市Endo-Med Clinic内分泌代谢病科美国60435 石家庄市第二医院康复国际部河北石家庄050051 解放军306医院全军糖尿病诊疗中心北京100101

美国妊娠期间的糖尿病患病率一直在增加,多数是妊娠期糖尿病(GDM),其余主要是1型糖尿病和2型糖尿病合并妊娠。妊娠期间糖尿病血糖控制不佳导致流产、死胎等各种风险增加。妊娠期间的糖尿病管理包括糖尿病及糖尿病前期患者应进行孕前咨... 详细信息

美国妊娠期间的糖尿病患病率一直在增加,多数是妊娠期糖尿病(GDM),其余主要是1型糖尿病和2型糖尿病合并妊娠。妊娠期间糖尿病血糖控制不佳导致流产、死胎等各种风险增加。妊娠期间的糖尿病管理包括糖尿病及糖尿病前期患者应进行孕前咨询、孕前化验和就诊、血糖监测,知晓妊娠期间的血糖和HbA_1c控制目标,GDM的管理包括筛查和诊断、生活方式管理如医学营养疗法和药物治疗等。此外,还包括1型糖尿病和2型糖尿病合并妊娠的管理,应用阿司匹林对先兆子痫的影响,妊娠期高血压监测及用药注意,还有产后护理、哺乳期以及避孕等多方面内容。

关键词：妊娠糖尿病,1型糖尿病,2型血红蛋白A,糖基化营养疗法