检索结果-南通市图书馆

A comprehensive numerical investigation of the spray characteristics in spill-return atomizers using coupled VOF and Euler-Lagrange approach

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第12期95卷 319-332页

作者： wassim Harizi Fathi Hamdi Mouldi Chrigui Research Unit“Mechanical Modeling Materials and Energy”National School of Engineer of GabesUniversity of GabesGabes6029Tunisia

This research paper investigates a three-dimensional,two-phase flow dynamics,and atomization characteristics of a spill return *** method includes the internal flow field,primary and secondary atomization which are modeled using the hybrid approach Volume of Fluid to Discrete Phase Model(VOF to DPM).A comparison between the Large Eddy Simulation(LES)and The k-omega Shear Stress Transport turbulence model(SST k-ω)in combination with the Volume of Fluid(VOF)model,along with the Adaptive Mesh Refinement(AMR)method,to predict the breakup of the liquid core is carried *** investigation presents axial and tangential distributions of velocity,mean diameter,and spray cone angle of droplets at spray pressures of Spill-to-Feed Ratio(SFR)equal to *** numerical results are validated against the Phase-Doppler Anemometry(PDA)experiment.A relative error,of less than 7.3%,is *** study systematically explores the spatiotemporal evolution of the flow field,including the liquid surface wave motion,liquid film characteristics,and the formation/atomization of the fluid spray cone downstream of the injector.

关键词： VOF to DPM Spill return atomizer AMR Integral sauter mean diameter Turbulence

Feasibility of Solar Tracking System for PV Panel in Sunbelt Region

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2021年第2期9卷 395-403页

作者： Soulayman Soulayman Mohamad Hamoud Mohamad-Amir Hababa wassim Sabbagh the Department of Applied Physics Higher Institute for Applied Sciences and TechnologyDamascusP O Box 31983Syria

In the study of the feasibility of solar tracking systems for crystalline silicon photovoltaic(PV)panels in hot and cold regions,it is argued recently that a tracking system is not necessary for sunbelt countries owing to the overheating that results from excessive exposure to solar *** conclusion has been formulated based on a mathematical model,which in turn is based on the assumption that the PV module temperature can be calculated using an empirical relation of this temperature to ambient temperature,available solar irradiance,and nominal operation cell temperature(NOCT).To support this conclusion,it is claimed that the mathematical model is validated ***,this assumption is vague and widely used in the *** objective of the present work is to reevaluate the above-mentioned assumption and to discuss the results deriving from *** is shown experimentally in the present work that the above-mentioned assumption overestimates the PV module *** a solar irradiance of 900 W/m2,ambient temperature of 25℃,and wind speed of 5 m/s,the measured PV module temperature is lower than the value calculated based on the mentioned assumption by 29.26%.

关键词： Photovoltaic(PV)module temperature wind speed influence PV module efficiency experimental verification Damascus clear-sky conditions

Ownership Structure,National Institutions and Digital Service Innovation:A Configuration Perspective of Global Telecom Operators

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ownership Structure,National Institutions and Digital Servic...

作者： JALIL wassim 北京邮电大学

学位级别：硕士

Existing literature explores the determinants of digital service innovation(DSI)from various perspectives,including country,industry,and firm factors,*** than a list of independent and distinct conditions,the determinants of DSI are more like a complex network of these *** the existing literature has not answered the question of what kind of ownership structure leads to high DSI under various national *** advance a configuration perspective that acknowledges the fit between ownership structure,national institutions,and *** a sample of 33 telecom operators across 11 countries,and by using fuzzy set qualitative comparative analysis,the findings show that high DSI depends on a complex configuration of combinations of ownership structure,national institutions,and firm *** findings highlight the multiple context-dependent paths,which link ownership structure to high digital service *** a result,this work provides both scholars and practitioners with fresh theoretical and empirical insights,as well as consequences for both groups.

关键词： Digital service innovation Telecom operators National institutions Ownership structure Qualitative comparative analysis

Tissue-specific cancer stem/progenitor cells:Therapeutic implications

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2023年第5期15卷 323-341页

作者： Amani Yehya Joe Youssef Sana Hachem Jana Ismael wassim Abou-Kheir Department of Anatomy Cell Biology and Physiological SciencesAmerican University of BeirutBeirut 1107-2020Lebanon

Surgical resection,chemotherapy,and radiation are the standard therapeutic modalities for treating *** approaches are intended to target the more mature and rapidly dividing cancer ***,they spare the relatively quiescent and intrinsically resistant cancer stem cells(CSCs)subpopulation residing within the tumor ***,a temporary eradication is achieved and the tumor bulk tends to revert supported by CSCs'resistant *** on their unique expression profile,the identification,isolation,and selective targeting of CSCs hold great promise for challenging treatment failure and reducing the risk of cancer ***,targeting CSCs is limited mainly by the irrelevance of the utilized cancer models.A new era of targeted and personalized anti-cancer therapies has been developed with cancer patient-derived organoids(PDOs)as a tool for establishing pre-clinical tumor ***,we discuss the updated and presently available tissue-specific CSC markers in five highly occurring solid ***,we highlight the advantage and relevance of the threedimensional PDOs culture model as a platform for modeling cancer,evaluating the efficacy of CSC-based therapeutics,and predicting drug response in cancer patients.

关键词： Cancer stem cells Therapy resistance Tissue-specific cancer stem cell markers Patient-derived organoids Pre-clinical cancer models

A New Kind of Atomic Force Microscopy Scan Control Enabled by Artificial Intelligence:Concept for Achieving Tip and Sample Safety Through Asymmetric Control

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nanomanufacturing and Metrology 2024年第2期7卷 50-59页

作者： Johannes Degenhardt Mohammed wassim Bounaim Nan Deng Rainer Tutsch Gaoliang Dai Physikalisch-Technische Bundesanstalt Bundesallee 10038116 BrunswickGermany Institut Für Prozessmess-und Sensortechnik Technische Universität Ilmenau EhrenbergstraBe 2998693 IlmenauGermany Institute of Production Metrology TU Braunschweig SchleinitzstraBe 2038106 BrunswickGermany

This paper introduces a paradigm shift in atomic force microscope(AFM)scan control,leveraging an artificial intelligence(AI)-based *** contrast to conventional control methods,which either show a limited performance,such as proportional integral differential(PID)control,or which purely focus on mathematical optimality as classical optimal control approaches,our proposed AI approach redefines the objective of control for achieving practical *** presented AI controller minimizes the root-mean-square control deviations in routine scans by a factor of about 4 compared to PID control in the presented setup and also showcases a distinctive asymmetric response in complex situations,prioritizing the safety of the AFM tip and sample instead of the lowest possible control *** development and testing of the AI control concept are performed on simulated AFM scans,demonstrating its huge potential.

关键词： Atomic force microscopy Artificial intelligence Deep reinforcement learning Optimal control

维普期刊数据库

Molecular mechanisms targeting drug-resistance and metastasis in colorectal cancer:Updates and beyond

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第9期29卷 1395-1426页

作者： Samar Al Bitar Marwan El-Sabban Samer Doughan wassim Abou-Kheir Department of Anatomy Cell Biology and Physiological SciencesAmerican University of BeirutBeirut 1107-2020Lebanon Department of Surgery American University of Beirut Medical CenterBeirut 1107-2020Lebanon

Colorectal cancer(CRC)is the third most diagnosed malignancy and a major leading cause of cancer-related deaths *** advances in therapeutic regimens,the number of patients presenting with metastatic CRC(mCRC)is increasing due to resistance to therapy,conferred by a small population of cancer cells,known as cancer stem *** therapies have been highly successful in prolonging the overall survival of patients with *** are being developed to target key molecules involved in drug-resistance and metastasis of CRC,and these include vascular endothelial growth factor,epidermal growth factor receptor,human epidermal growth factor receptor-2,mitogen-activated extracellular signal-regulated kinase,in addition to immune ***,there are several ongoing clinical trials of newly developed targeted agents,which have shown considerable clinical efficacy and have improved the prognosis of patients who do not benefit from conventional *** this review,we highlight recent developments in the use of existing and novel targeted agents against drug-resistant CRC and ***,we discuss limitations and challenges associated with targeted therapy and strategies to combat intrinsic and acquired resistance to these therapies,in addition to the importance of implementing better preclinical models and the application of personalized therapy based on predictive biomarkers for treatment selection.

关键词： Colorectal cancer Metastatic colorectal cancer Targeted therapy Drugresistance Personalized medicine

Oxylipin Pathway in Rice and Arabidopsis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2007年第1期49卷 43-51页

作者： E. wassim Chehab John V. Perea Banu Gopalan Steve Theg Katayoon Dehesh Section of Plant Biology University of California-Davis Davis CA 95616 USA

Plants have evolved complex signaling pathways to coordinate responses to developmental and environmental Information. The oxylipin pathway Is one pivotal lipid-based signaling network, composed of several competing branch pathways, that determines the plant＇s ability to adapt to various stimuli. Activation of the oxyllpln pathway Induces the de novo synthesis of biologically active metabolltes called ＂oxyllplns＂. The relative levels of these metabolltes are a distinct indicator of each plant species and determine the ability of plants to adapt to different stimuli. The two major branches of the oxyllpln pathway, allene oxide synthase （AOS） and hydroperoxlde lyase （HPL） are responsible for production of the signaling compounds, jasmonates and aldehydes respectively. Here, we compare and contrast the regulation of AOS and HPL branch pathways In rice and Arabidopsis as model monocotyledonous and dicotyledonous systems. These analyses provide new Insights Into the evolution of JAs and aldehydes signaling pathways, and the complex network of processes responsible for stress adaptations In monocots and dicots.

关键词： aldehydes allene oxide synthase Arabidopsis hydroperoxide lyase jasmonates oxylipin pathway rice

Black Holes in Role, Essence and Function

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Physics 2021年第6期12卷 744-760页

作者： wassim S. Daher Beirut Lebanon

This study endeavors to explain black holes through their role, essence and function. It utilizes a customized hypothetico-deductive methodology as a cognitive approach to construct and explain the model. The paper presents schematics as illustrations. Black holes are formed through a clash of Universal energy ripples, or through stellar collapse. Its micro level roles are to: recycle cosmological debris, stabilize the formation of galaxies, define the shape of galaxies, and stratify space around them. Their macro role is a subsystem in the preservation of the Universal balance, construct and shape. Black holes are made of two semi-cores of opposite spins. The cores are heterogeneous and made up of structures of dark matter particles. Surrounding the black hole are the process horizon, event horizon, and trap horizon. Primitive cores cannot survive;black holes which collapse to primitive cores decay and vanish. Black holes attract objects via energy fields, where energy tends to accumulate mass for more complex structure development in which more energy colonizes. Photons can either fall on the event horizon or directly cross to the process horizon depending on the black hole structure. This paper has transformed black holes from a set of scattered and vague ideas into structured objects of defined and necessary universal roles. The paper calls for empirical validation or falsification of its model, theoretical model, and hypothesis.

关键词： Dark Energy Dark Matter Energy Ripples Galaxies Processing Core

Cardiac differentiation is modulated by anti-apoptotic signals in murine embryonic stem cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2024年第5期16卷 551-559页

作者： Amani Yehya Joseph Azar Mohamad Al-Fares Helene Boeuf wassim Abou-Kheir Dana Zeineddine Ola Hadadeh Department of Anatomy Cell Biology and Physiological SciencesAmerican University of BeirutBeirut 1107-2020Lebanon Inserm BiotisU1026University BordeauxBordeaux F-33000France Rammal Rammal Lab Physio-Toxicity Environmental TeamFaculty of SciencesLebanese UniversityNabatieh 0000Lebanon

BACKGROUND Embryonic stem cells(ESCs)serve as a crucial ex vivo model,representing epiblast cells derived from the inner cell mass of blastocyst-stage *** exhibit a unique combination of self-renewal potency,unlimited proliferation,and *** latter is evident by the ability of the isolated cells to differ-entiate spontaneously into multiple cell lineages,representing the three primary embryonic germ *** regulatory networks guide ESCs,directing their self-renewal and lineage-specific ***,or programmed cell death,emerges as a key event involved in sculpting and forming various organs and structures ensuring proper embryonic ***-ever,the molecular mechanisms underlying the dynamic interplay between diffe-rentiation and apoptosis remain poorly *** To investigate the regulatory impact of apoptosis on the early differentiation of ESCs into cardiac cells,using mouse ESC(mESC)models-mESC-B-cell lym-phoma 2(BCL-2),mESC-PIM-2,and mESC-metallothionein-1(MET-1)-which overexpress the anti-apoptotic genes Bcl-2,Pim-2,and Met-1,*** mESC-T2(wild-type),mESC-BCL-2,mESC-PIM-2,and mESC-MET-1 have been used to assess the effect of potentiated apoptotic signals on cardiac *** hanging drop method was adopted to generate embryoid bodies(EBs)and induce terminal differentiation of *** size of the generated EBs was measured in each condition compared to the wild *** the functional level,the percentage of cardiac differentiation was measured by calculating the number of beating cardiomyocytes in the manipulated mESCs compared to the *** the molecular level,quantitative reverse transcription-polymerase chain reaction was used to assess the mRNA expression of three cardiac markers:Troponin T,GATA4,and ***,troponin T protein expression was evaluated through immunofluorescence and western blot *** Our findings showed that the upregulation of Bcl-

关键词： Mouse embryonic stem cells Self-renewal Apoptosis Cardiac differentiation B-cell lymphoma 2 PIM-2 Metallothionein-1