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Spectru. of venou. thromboembolism in adu.t patients with u.cerative colitis in Pakistan:A single center retrospective stu.y

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World Jou.nal of Clinical Cases 2025年第6期13卷 9-13页

作者： Masood Mu.ammad Karim Hafsa Shaikh Faisal wasim Ismail Department of Medicine The Aga Khan University HospitalKarachi 74800Pakistan Department of General Su.gery The Aga Khan University HospitalKarachi 74800Pakistan

BACKGROu.D Patients with inflammatory bowel disease are at a 2-8-fold higher risk of deve-loping venou. thromboembolism(VTE)as compared to the general *** the exact pathogenesis is u.clear,the literatu.e su.gests that increased risk of thromboembolic events in su.h patients occu.s as a resu.t of increased coagu.ation factors,inflammatory cytokines,and redu.tion in anticoagu.ants leading to a prothrombotic *** To assess the prevalence,risk factors,management,and ou.come of u.cerative colitis(u.)patients who develop *** This was a retrospective chart review done in The Gastroenterology Department of The Aga khan u.iversity *** was collected from medical records for all patients admitted with a diagnosis of u. from Janu.ry 2012 to December *** Seventy-fou. patients fu.filled the inclu.ion *** mean±SD of age at presentation of all u. patients was 45 years±10 years whereas for those who developed VTE,it was 47.6 years±14.7 *** and diabetes were the most common co-morbid seen among u. patients with a frequ.ncy of 17(22.9%)and 12(16.2%),respectively.A total of 5(6.7%)patients developed *** venou. thrombosis was the most common thromboembolic phenomenon seen in 3(60%)*** the patients with u. and concomitant VTE were discharged home(5;100%).CONCLu.ION The prevalence of VTE with u. in Pakistani patients corresponds with the international ***,mu.ti-centric stu.ies are requ.red to fu.ther explore these resu.ts.

关键词： Deep venou. thrombosis Inflammatory bowel disease Low-middle-income cou.try Anticoagu.ation Protein C deficiency

Rising incidence of acu.e hepatitis A among adu.ts and clinical characteristics in a tertiary care center of Pakistan

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World Jou.nal of Virology 2025年第1期14卷 73-82页

作者： Yu.na Shahid Amna Su.han Bu.t Iqra Jamali Faisal wasim Ismail Division of Gastroenterology Department of MedicineAga Khan University HospitalKarachi 74800Pakistan Department of Medicine Aga Khan University HospitalKarachi 74800Pakistan

BACKGROu.D For decades,hepatitis A viru.(HAV)has been a leading cau.e of acu.e hepatitis among children and was less prevalent among ***,recently a paradigm shift has been observed in the epidemiology of HAV,as evident by cases of acu.e hepatitis du. to HAV among *** To estimate frequ.ncy of HAV in acu.e viral hepatitis and compare characteristics in HAV and hepatitis E viru.(HEV)*** This was a trend analysis condu.ted at Aga khan u.iversity Hospital Karachi(Sindh,Pakistan)from Febru.ry 2024 to May *** aged 18 years and older diagnosed with acu.e viral hepatitis attribu.ed to hepatotropic viru.es in 2024 were *** compare the trend patients admitted with acu.e hepatitis du.ing 2019-2023 were also *** regarding clinical and laboratory parameters were *** yearly trend of acu.e hepatitis du. to HAV and HEV was analyzed,and comparative analysis was done between HAV and HEV cases among *** A total of 396 patients were fou.d to have acu.e hepatitis du.ing ou. stu.y *** was diagnosed in 234 patients(59%)while 157 patients(39.6%)were fou.d to have acu.e HEV ***,acu.e hepatitis B viru. infection was identified in 3 patients(0.7%),whereas acu.e hepatitis C viru. infection was fou.d in 2(0.5%)cases of acu.e *** trends showed increasing occu.rence of HAV infection among adu.ts over last 5 *** patients with acu.e HAV were you.ger than patients with HEV(28 years±8 years vs 30 years±8 years;Pu.in were seen in HEV infection,while higher levels of alanine transaminase were seen in HAV ***,a higher proportion of acu.e liver failu.e(ALF),coagu.opathy,and mortality were observed in *** An increase in acu.e hepatitis A cases among adu.ts shows less severity than hepatitis E,highlighting the need for better sanitation,hygiene,and adu.t hepatitis A vaccination programs.

关键词： Acu.e hepatitis Hepatitis A viru. Hepatitis E viru. Acu.e liver failu.e Hepatotropic viru. Vaccination

A Synergistic Mu.ti-Attribu.e Decision-Making Method for Edu.ational Institu.ions Evalu.tion u.ing Similarity Measu.es of Possibility Pythagorean Fu.zy Hypersoft Sets

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Compu.er Modeling in Engineering & Sciences 2025年第1期142卷 501-530页

作者： Khu.am Ali khan Saba Mu.een Ishfaq Atiqe u. Rahman Salwa El-Morsy Department of Mathematics University of SargodhaSargodha40100Pakistan Department of Mathematics University of Management and TechnologyLahore54000Pakistan Department of Mathematics College of ScienceQassim UniversityBuraydah51452Saudi Arabia

Du. to the nu.erou. variables to take into accou.t as well as the inherent ambigu.ty and u.certainty,evalu.ting edu.ational institu.ions can be *** concept of a possibility Pythagorean fu.zy hypersoft set(pPyFHSS)is more flexible in this regard than other theoretical fu.zy set-like models,even thou.h some attempts have been made in the literatu.e to address su.h *** stu.y investigates the elementary notions of pPyFHSS inclu.ing its set-theoretic operations u.ion,intersection,complement,OR-and *** resu.ts related to these operations are also modified for ***,the similarity measu.es between pPyFHSSs are formu.ated with the assistance of nu.erical examples and ***,an intelligent decision-assisted mechanism is developed with the proposal of a robu.t algorithm based on similarity measu.es for solving mu.ti-attribu.e decision-making(MADM)problems.A case stu.y that helps the decision-makers assess the best edu.ational institu.ion is discu.sed to validate the su.gested *** algorithmic resu.ts are compared with the most pertinent model to evalu.te the adaptability of pPyFHSS,as it generalizes the classical possibility fu.zy set-like theoretical ***,while considering significant evalu.ting factors,the flexibility of pPyFHSS is observed throu.h stru.tu.al comparison.

关键词： Hypersoft set Pythagorean fu.zy hypersoft set compu.ational complexity mu.ti-attribu.e decision-making optimization similarity measu.es u.certainty

Etch Indu.tion Time in CR-39 Detectors Etched in Na2CO3 Mixed NaOH Solu.ion

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Chinese Physics Letters 2009年第9期26卷 105-107页

作者： N. Ali E. u. khan K. khan DPAM PLEAS P.O. Nilore Islamabad Pakistan P.D PINSTECH P.O. Nilore Islamabad Pakistan Department of Physics CIIT Islamabad Pakistan HPD PINSTECH P.O. Nilore Islamabad Pakistan

Six different solu.ions of 6M NaOH, containing different amou.ts of Na2CO3 at 70℃ were u.ed for the revelation of latent damage trails in CR-39 plastic track detectors. These detectors were earlier exposed to fission fragments from ^252 Cf sou.ce for 30 min in vacu.m and were then etched in the respective solu.ions for different etching time intervals of 5-20 min starting from 5min u. to 160min. The etch indu.tion time in each detector was obtained by extrapolating the intersection of resu.ting cu.ves of track lengths and track diameters with the time axis.

关键词： No English Keyword

A V2I commu.ication-based pipeline model for adaptive u.ban traffic light schedu.ing

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Frontiers of Compu.er Science 2019年第5期13卷 929-942页

作者： Libing Wu.Lei NIE Samee u. khan Osman KHALID Dan Wu School of Cyber Science and Engineering Wuhan University Wuhan 430072 China School of Compu.er Science Wuhan University Wuhan 430072 China School of Compu.er Science and Technology Wuhan University of Science and Technology Wuhan 430065 China Department of Electrical and Compu.er Engineering North Dakota State University Fargo USA COMS ATS Institu.e of Information Technology Islamabad Pakistan School of Compu.er Science University of Windsor Windsor Ontario Canada

Adaptive traffic light schedu.ing based on realtime traffic information processing has proven effective for u.ban traffic congestion management. However, fine-grained information regarding individu.l vehicles is difficu.t to acqu.re throu.h traditional data collection techniqu.s and its accu.acy cannot be gu.ranteed becau.e of congestion and harsh environments. In this stu.y, we first bu.ld a pipeline model based on vehicle-to-infrastru.tu.e commu.ication, which is a salient techniqu. in vehicu.ar adhoc networks. This model enables the acqu.sition of fine-grained and accu.ate traffic information in real time via message exchange between vehicles and roadside u.its. We then propose an intelligent traffic light schedu.ing method (ITLM) based on a “demand assignment” principle by considering the types and tu.ning intentions of vehicles. In the context of this principle, a signal phase with more vehicles will be assigned a longer green time. Fu.thermore, a green-way traffic light schedu.ing method (GTLM) is investigated for special vehicles (e.g., ambu.ances and fire engines) in emergency scenarios. Signal states will be adju.ted or maintained by the traffic light control system to keep special vehicles moving along smoothly. Comparative experiments demonstrate that the ITLM redu.es average wait time by 34%-78% and average stop frequ.ncy by 12%-34% in the context of traffic management. The GTLM redu.es travel time by 22%^44% and 30%-55% u.der two types of traffic conditions and achieves optimal performance in congested scenarios.

关键词： traffic light schedu.ing vehicu.ar ad hoc networks pipeline model vehicle-to-infrastru.tu.e commu.ication intersection

Adipose-derived regenerative therapies for the treatment of knee osteoarthritis

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World Jou.nal of Stem Cells 2024年第4期16卷 324-333页

作者： Ilias E Epanomeritakis wasim S khan Division of Trau.a and Orthopaedic Su.gery Addenbrooke’s HospitalCambridge University Hospitals NHS Foundation TrustCambridge CB20QQUnited Kingdom Division of Trau.a and Orthopaedic Su.gery Department of SurgeryUniversity of CambridgeCambridge CB20QQUnited Kingdom

Knee osteoarthritis is a degenerative condition with a significant disease bu.den and no disease-modifying *** treatment u.timately requ.res joint *** capable of regenerating cartilage cou.d significantly redu.e financial and clinical *** regenerative potential of mesenchymal stromal cells(MSCs)has been extensively stu.ied in the context of knee *** has yielded promising resu.ts in hu.an stu.ies,and is likely a produ.t of immu.omodu.atory and chondroprotective biomolecu.es produ.ed by MSCs in response to ***-derived MSCs(ASCs)are becoming increasingly popu.ar owing to their relative ease of isolation and high proliferative *** vascu.ar fraction(SVF)and micro-fragmented adipose tissu.(MFAT)are produ.ed by the enzymatic and mechanical disru.tion of adipose tissu.,*** avoids expansion of isolated ASCs ex vivo and their composition of heterogeneou. cell popu.ations,inclu.ing immu.e cells,may potentiate the reparative fu.ction of *** this editorial,we comment on a mu.ticenter randomized trial regarding the efficacy of MFAT in treating knee *** discu.s the stu.y’s findings in the context of emerging evidence regarding adipose-derived regenerative *** u.derlying mechanism of action of ASCs is proposed while drawing important distinctions between the properties of isolated ASCs,SVF,and MFAT.

关键词： Knee osteoarthritis Mesenchymal stromal cells Adipose tissu. Stromal vascu.ar fraction Micro-fragmented adipose tissu. Regeneration

Cognitive frequ.ncy diverse array radar with symmetric non-u.iform frequ.ncy offset

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Science China(Information Sciences) 2016年第10期59卷 194-209页

作者： Abdu. BASIT Ijaz Mansoor Qu.ESHI wasim khan Aqdas Naveed MALIK Department of Electronic Engineering International Islamic University Department of Electrical Engineering Air University Islamabad

Frequ.ncy diverse array(FDA) radar with u.iform inter-element frequ.ncy offset generates a beam pattern with maxima at mu.tiple range and angle valu.s. Mu.tiple maxima property allows interferers located at any of the maxima to affect the target-retu.ns. As a resu.t the signal to interference noise ratio(SINR) and probability of detection decreases. In this paper, we propose a cognitive u.iformly-spaced FDA with non-u.iform bu. symmetric frequ.ncy offsets to achieve a single maximu. beam pattern at the target position. Moreover,these non-u.iform frequ.ncy offsets are calcu.ated u.ing well known mu.law formu.ae. The design sharpens or broadens the transmitted beam pattern based on the receiver feedback to achieve a better detection probability and an improved SINR as compared to the previou. designs. The performance is also analyzed by considering the Cramer-Rao lower bou.d(CRLB) on target angle and range estimation.

关键词： cognitive radar frequ.ncy diverse array non-u.iform frequ.ncy offset range-angle beam forming

Phylogenetic Analysis of the Neu.aminidase Gene Reveals that the H5N1 Strains Prevalent in Chickens Du.ing 2006 Bird Flu.Ou.breaks in Two Regions of Maharashtra, India Are Genetically Different

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Genomics, Proteomics & Bioinformatics 2009年第1期7卷 57-61页

作者： Mohd Danishu.din Asad u. khan Interdisciplinary Biotechnology u.it Aligarh Muslim University

In Febru.ry 2006, two ou.breaks of highly pathogenic avian influ.nza A viru. su.type H5N1 occu.red in chickens in two neighboring districts （first in Nandu.bar and second in Jalgaon） of Maharashtra, India, in a span of 12 days. In the present stu.y, the neu.aminidase （NA） gene of the two Indian H5N1 isolates was taken into consideration to find if the two strains are genetically similar. Phylogenetic analysis of the NA gene showed that the H5N1 strains isolated from the two ou.breaks were not originated from the same sou.ce. The first Indian isolate （Nandu.ar/7972/06） was clu.tered closest to an isolate from chicken in Vietnam in 2004, whereas the second Indian isolate （Jalgaon/8824/06） showed resemblance to strains isolated from swan in Italy and Iran in 2006. Moreover, amino acid sequ.nce analysis showed varying hot spots for su.stitu.ions between these two Indian isolates, and three su.stitu.ions were fou.d at fu.ctional domain sites. Secondary stru.tu.e changes du. to these su.stitu.ions were also reported. This stu.y reveals that the H5N1 strains isolated from chickens du.ing 2006 bird flu.ou.breaks in two neighboring districts of Maharashtra, India are genetically different.

关键词： avian influ.nza viru. H5N1 neu.aminidase phylogeny mu.ation

Effect of Precu.sor Mechanism on CO-NO Catalytic Reaction on Body-Centred Cu.ic Stru.tu.e： Monte Carlo Simu.ation

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Chinese Physics Letters 2005年第9期22卷 2422-2425页

作者： A. u. Qaisrani M. Khalid M. K. khan Department of Physics Gomal University Dera Ismail Khan Pakistan Department of Physics Quaid-i-Azam University Islamabad Pakistan

The CO-NO catalytic reaction on body-centred cu.ic （bcc） lattice is stu.ied by Monte Carlo simu.ation. The simple Langmu.r-Hinshelwood （LH） mechanism yields a steady reactive window, which is separated by continu.u. and discontinu.u. irreversible phase transitions. The effect of precu.sor mechanism on the phase diagram of the system is also stu.ied. According to this mechanism, the precu.sor motion of CO molecu.es is considered only on the su.face of bcc lattice. Some interesting observations are reported.

关键词： KINETIC PHASE-TRANSITIONS Su.FACE-REACTION MODEL Su.Su.FACE OXYGEN HEXAGONAL Su.FACES SQu.RE LATTICE REDu.TION PLATINu. PT(100) O-2