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Clinical benefit of left atrial appendage closure in octogenarians

Journal of Geriatric Cardiology 2021年第11期18卷 886-896页

作者： Yamen Mohrez Steffen Gloekler Steffen Schnupp wasim allakkis Xiao-Xia Liu Monika Fuerholz Johannes Brachmann Stephan Windecker Stephan Achenbach Bernhard Meier Caroline Kleinecke Department of Cardiology Klinikum CoburgCoburgGermany Cardiovascular Department University Hospital of BernBernSwitzerland Department of Cardiology Klinikum HochrheinWaldshut-TiengenGermany Depart-ment of Cardiology Beijing Anzhen HospitalBeijingChina Department of Cardiology Friedrich-Alexander Uni-versity Erlangen-NuernbergErlangenGermany

OBJECTIVES Whether left atrial appendage closure(LAAC)in octogenarians yield similar net clinical benefit compared to younger patients,was the purpose of the present *** Two real-world LAAC registries,enrolling 744 consecutive Amplatzer and Watchman patients from 2009 to 2018,were retrospectively *** All events are reported per 100 *** hundred and sixty one octogenarians and 483 non-octogenarians with a mean follow-up of 1.7±1.3 and 2.3±1.6 years,and a total of 1,502 patient-years were *** had a higher risk for stroke(CHA2DS2-VASc score:5.2±1.2 vs.4.3±1.7,P<0.0001)and bleeding(HAS-BLED score:3.3±0.8 vs.3.1±1.1,P=0.001).The combined safety endpoint of major periprocedural complications and major bleeding events at follow-up was comparable(30/446,6.7%vs.47/1056,4.4%;hazard ratio[HR]=1.2;95%confidence interval[CI]:0.73−1.98;P=0.48)between the *** efficacy endpoint of all-cause stroke,systemic embolism,and cardiovascular/unexplained death occurred more often in octogenarians(61/446,13.7%vs.80/1056,7.6%;HR=7.0;95%CI:4.53−10.93;P<0.0001).Overall,octogenarians had a lower net clinical benefit,i.e.,the composite of all above mentioned hazards,from LAAC compared to younger patients(82/446,18.4%vs.116/1056,11.0%;HR=4.6;95%CI:3.11−7.0;P<0.0001).Compared to the anticipated stroke rate,the observed rate de-creased by 41%in octogenarians and 53%in *** observed bleeding rate was reduced by 10%octogenarians and 41%*** LAAC can be performed with similar safety in octogenarians as compared to younger *** the long-term,it both reduces stroke and bleeding events,although to a lesser extent than in non-octogenarians.

关键词： atrial closure younger

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Adipose-derived regenerative therapies for the treatment of knee osteoarthritis

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World Journal of Stem Cells 2024年第4期16卷 324-333页

作者： Ilias E Epanomeritakis wasim S Khan Division of Trauma and Orthopaedic Surgery Addenbrooke’s HospitalCambridge University Hospitals NHS Foundation TrustCambridge CB20QQUnited Kingdom Division of Trauma and Orthopaedic Surgery Department of SurgeryUniversity of CambridgeCambridge CB20QQUnited Kingdom

Knee osteoarthritis is a degenerative condition with a significant disease burden and no disease-modifying *** treatment ultimately requires joint *** capable of regenerating cartilage could significantly reduce financial and clinical *** regenerative potential of mesenchymal stromal cells(MSCs)has been extensively studied in the context of knee *** has yielded promising results in human studies,and is likely a product of immunomodulatory and chondroprotective biomolecules produced by MSCs in response to ***-derived MSCs(ASCs)are becoming increasingly popular owing to their relative ease of isolation and high proliferative *** vascular fraction(SVF)and micro-fragmented adipose tissue(MFAT)are produced by the enzymatic and mechanical disruption of adipose tissue,*** avoids expansion of isolated ASCs ex vivo and their composition of heterogeneous cell populations,including immune cells,may potentiate the reparative function of *** this editorial,we comment on a multicenter randomized trial regarding the efficacy of MFAT in treating knee *** discuss the study’s findings in the context of emerging evidence regarding adipose-derived regenerative *** underlying mechanism of action of ASCs is proposed while drawing important distinctions between the properties of isolated ASCs,SVF,and MFAT.

关键词： Knee osteoarthritis Mesenchymal stromal cells Adipose tissue Stromal vascular fraction Micro-fragmented adipose tissue Regeneration

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Robust design of sliding mode control for airship trajectory tracking with uncertainty and disturbance estimation

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Journal of Systems Engineering and Electronics 2024年第1期35卷 242-258页

作者： wasim Muhammad ALI Ahsan CHOUDHRY Mohammad Ahmad SHAIKH Inam Ul Hasan SALEEM Faisal Department of Aeronautics and Astronautics Engineering Institute of Space TechnologyIslamabad 44000Pakistan Department of Electrical Engineering University of Engineering and TechnologyTaxila 47080Pakistan Department of Measurements and Control Systems Silesian University of TechnologyGliwice 44-101Poland The Joint Doctoral School Silesian University of TechnologyGliwice 44-100Poland

The robotic airship can provide a promising aerostatic platform for many potential *** applications require a precise autonomous trajectory tracking control for *** has a nonlinear and uncertain *** is prone to wind disturbances that offer a challenge for a trajectory tracking control *** paper addresses the airship trajectory tracking problem having time varying reference path.A lumped parameter estimation approach under model uncertainties and wind disturbances is opted against distributed *** uses extended Kalman filter(EKF)for uncertainty and disturbance *** estimated parameters are used by sliding mode controller(SMC)for ultimate control of airship trajectory *** comprehensive algorithm,EKF based SMC(ESMC),is used as a robust solution to track airship *** proposed estimator provides the estimates of wind disturbances as well as model uncertainty due to the mass matrix variations and aerodynamic model *** stability and convergence of the proposed method are investigated using the Lyapunov stability *** simulation results show that the proposed method efficiently tracks the desired *** method solves the stability,convergence,and chattering problem of SMC under model uncertainties and wind disturbances.

关键词： airship chattering extended Kalman filter(EKF) model uncertainties estimation sliding mode controller(SMC)

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Understanding the Impact of H_(2) Diffusion Energy on the Formation Efficiency of H_(2) on the Interstellar Dust Grain Surface

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Research in Astronomy and Astrophysics 2024年第9期24卷 190-198页

作者： Xiaoying Guo wasim Iqbal Qiang Chang Xiao-Hu Li School of Physics and Optoeletronic Engineering Shandong University of TechnologyZibo 255000China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesUrumqi 830011China

We use microscopic Monte Carlo simulation techniques to investigate the impact of H_(2)diffusion energy on the recombination efficiency of H_(2)on interstellar dust grain surfaces under diffuse and translucent cloud *** constructed five models representing different possible conditions encountered by adsorbed H and H_(2)on interstellar dust *** implemented adsorption sites with multiple binding energies for surface species;the Encounter-Desorption mechanism was also *** study focused on silicate surfaces in diffuse clouds and water ice surfaces in translucent *** results show that the recombination efficiency of H_(2)on dust surfaces decreases as H_(2)diffusion energy *** interesting finding of this work is that considering different binding sites for H and H_(2)gives rise to multiple steady phases,during which the recombination efficiency remains constant with a change in H_(2)diffusion energy.

关键词： astrochemistry atomic processes ISM:molecules

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Impact of metal polluted sewage water on soil nematode assemblages in agricultural settings of Aligarh,India

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Soil Ecology Letters 2024年第1期6卷 61-75页

作者： Mohammed F.S.A.Ghanem Shahid Afzal Humira Nesar Zarrin Imran wasim Ahmad Nematode Biodiversity Research Lab Department of ZoologyAligarh Muslim UniversityAligarh 202002India

Sewage water in agriculture threatens human health and soil ecosystems through metal *** show promise as bioindicators of soil health due to their abundance and position in soil food ***-polluted water decreased abundance of certain nematode groups and Sigma Maturity *** pollution positively affected nematode groups with r-selected life *** water has been inappropriately used in agriculture,posing possible threats to human health and the soil ecosystems by its constituent pollutants,especially heavy *** evaluation of its influences on soil biomes needs to consider the response of soil *** soil organisms,nematodes are seen as the best promising candidates for bioindicators of soil *** in,we collected soil samples from fresh water irrigated field from three sites(S1,S2 and S3)and sewage water irrigated distance gradient(5 m-40 m),to assess the influence of metal(Cu,Zn,Cd,Mn,Pb)polluted water on various characteristics of nematode *** results indicated that the heavy metals decreased the abundance of C-p3 nematodes,herbivores,and predatory nematodes as well as sigma maturity index,whereas,C-p1,C-p2,bacterivore and fungivore nematodes abundance and diversity positively responded to the metal ***,nematode genera with r-selected life cycle were positively affected and those with K-selected life cycle were negatively affected by metal *** nematode community has potential to be used as indicator of pollution stress in agricultural soils to check soil health and sustainability.

关键词： heavy metals sewage irigation agriculture nematodes bioindicators

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Airship aerodynamic model estimation using unscented Kalman filter

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Journal of Systems Engineering and Electronics 2020年第6期31卷 1318-1329页

作者： wasim Muhammad ALI Ahsan Department of Electrical Engineering University of Engineering and TechnologyTaxila 47080Pakistan

An airship model is made-up of aerostatic,aerodynamic,dynamic,and propulsive forces and *** others,the computation of aerodynamic forces and torques is ***,wind tunnel experimentation and potential flow theory are used for their ***,the limitations of these methods pose difficulties in their accurate *** this work,an online estimation scheme based on unscented Kalman filter(UKF)is proposed for their *** proposed method introduces six auxiliary states for the complete aerodynamic *** uses an extended model and provides an estimate of a complete state vector along with auxiliary *** proposed method uses the minimum auxiliary state variables for the approximation of the complete aerodynamic model that makes it computationally less *** estimation performance is evaluated by developing a nonlinear simulation environment for University of Engineering and Technology,Taxila(UETT)*** performance is vali􀅫dated by performing the error analysis based on estimation error and 2-σ uncertainty *** the same problem,the extended Kalman filter(EKF)is also implemented and its results are compared with *** simulation results show that UKF successfully estimates the forces and torques due to the aerodynamic model with small estimation error and the comparative analysis with EKF shows that UKF improves the estimation re􀅫sults and also it is more suitable for the under-consideration problem.

关键词： airship unscented Kalman filter(UKF) extend Kalman filter(EKF) state estimation aerodynamic model estimation

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Exploring Sulfur Chemistry in TMC-1 with NSRT

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Chinese Physics Letters 2024年第2期41卷 129-132页

作者： wasim Iqbal Xiaohu Li Juan Tuo Ryszard Szczerba Yanan Feng Zhenzhen Miao Jiangchao Yang Jixing Ge Gleb Fedoseev Donghui Quan Qiang Chang Chuan-Lu Yang Tao Yang Gao-Lei Hou Yong Zhang Xuan Fang Xia Zhang Fangfang Li Rong Ma Xiaomin Song Zhiping Kou Yuxuan Sun Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Xinjiang Key Laboratory of Radio Astrophysics Urumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Nicolaus Copernicus Astronomical Center Rabia´nska 887-100 Toru´nPoland Research Laboratory for Astrochemistry Ural Federal UniversityKuibysheva St.48620026 EkaterinburgRussia Astronomical Computing Research Center Zhejiang LaboratoryHangzhou 311100China School of Physics and Optoelectronic Engineering Shandong University of TechnologyZibo 255000China School of Physics and Optoelectronic Engineering Ludong UniversityYantai 264025China State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200062China MOE Key Laboratory for Non-Equilibrium Synthesis and Modulation of Condensed Matter School of PhysicsXi’an Jiaotong UniversityXi’an 710049China School of Physics and Astronomy Sun Yat-sen UniversityGuangzhou 510275China Laboratory for Space Research Faculty of ScienceThe University of Hong KongHong KongChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100012China

There have been several studies on sulfur depletion in dense cores like TMC-1(Taurus Molecular Cloud 1),employing updated reaction networks for sulfur species to explain the missing sulfur in the gas within dense *** of these studies used a C/O ratio of 0.7 or *** present NSRT(NanShan 26m Radio Telescope)observations of TMC-1 alongside results from time-dependent chemical simulations using an updated chemical *** findings highlight the impact of the C/O ratio on the gas-phase evolution of C2S and *** simulation results show that the C/O ratio is an important parameter,playing a fundamental role in determining the gas-phase abundances of sulfur species in dense cores.

关键词： sulfur Sulfur depletion

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Hepatitis D: Scenario in the Asia-Pacifi c region

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World Journal of Gastroenterology 2010年第5期16卷 554-562页

作者： Zaigham Abbas wasim Jafri Sajjad Raza Department of Hepatogastroenterology Sindh Institute of Urology and Transplantation Karachi 74200 Sindh Pakistan Department of Medicine The Aga Khan University Hospital Karachi 74800 Pakistan Dow Medical College Karachi 74200 Pakistan

Hepatitis D virus (HDV) infection is present worldwide and affects all age groups. Around 18 million people are estimated to be infected with HDV. An important trend in HDV infection is global decline. HDV prevalence has decreased significantly in Europe since the 1970s and 1980s when it was f irst reported. The Asia-Pacif ic region now seems to be where HDV is a major health concern. There is a lack of available data from most of the countries from this region; hence, the true status of HDV cannot be determined. In South Asia, most of the countries have conditions that are favorable for the spread of hepatitis B and other related infections. Countries like Pakistan and Iran have shown an increase in HDV prevalence over a period of time. Other countries and region like China, Turkey, Australia, Japan, India and Taiwan, some of which had very high HDV prevalence in the past, have shown a decline in the incidence, but high prevalence persists in some. Intravenous drug abusers, homosexual men and women, prostitutes, and people on hemodialysis are the groups with very high HDV prevalence.

关键词： Hepatitis D Asia-Pacif ic region Prevalence Epidemiology

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Extent, reasons and consequences of off-labeled and unlicensed drug prescription in hospitalized children: a narrative review

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World Journal of Pediatrics 2021年第4期17卷 341-354页

作者： wasim Shuib Xin-Yin Wu Fang Xiao Xiangya School of Public Health Central South UniversityChangsha410078China

Background Off-label and unlicensed prescriptions pose a severe safety concern among the pediatric *** aimed to summarize the up-to-date evidence on the extent,reasons,and consequences of off-label and unlicensed drugs in hospitalized pediatric *** We systematically searched PubMed,EMBASE,SCOPUS,Web of Science and Google Scholar between 1990 and 2020 in which the last search was conducted on 12 February *** included studies with the following inclusion criteria:(1)observational studies in design;(2)target population was hospitalized pediatric patients whether admitted in the intensive care unit or in the general ward;(3)study reporting the prevalence of off-label,unlicensed prescriptions or both;and(4)published in *** A total of 47 studies were eligible for *** proportion of off-label and unlicensed prescriptions ranged from 7.4%to 99.5%and 0.1%to 74.4%,*** most frequent category of off-label prescriptions was prescription outside the age range,with the most commonly reported reason for off-label prescriptions being the lack of information specifically for pediatrics on the drug information *** consequences of off-label and unlicensed prescriptions ranged from minor and bearable skin reactions to debilitating renal failure,risking *** Off-label and unlicensed prescriptions are extensive and require progressively meditative ***,the pediatric population is currently a“therapeutic orphan”.Unless adequate pediatric clinical trials and licensed drugs become available,off-label and unlicensed drug prescription should not entirely be banned but rather promoted in an organized manner.

关键词： Licensed medicines Off-label prescribing Pediatrics Unlicensed prescribing

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Validity and cost comparison of ^(14)carbon urea breath test for diagnosis of H Pylori in dyspeptic patients

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World Journal of Gastroenterology 2007年第6期13卷 925-929页

作者： Shahid Rasool Shahab Abid wasim Jafri Section of Gastroenterology Department of Medicine The Aga Khan University Hospital Karachi Pakistan.

AIM： To validate and compare the cost of microdose ^14C urea breath test （UBT） with histology and rapid urease test for the diagnosis of H Py/ori. METHODS： Ninety-four consecutive patients with dyspeptic symptoms undergoing gastroscopy were enrolled. Gastric biopsies were taken for histology and rapid urease test. UBT was performed after gastroscopy by microdose ^14 urea capsules. Sensitivity, specificity and accuracy of UBT were calculated and compared with histology and rapid urease test. Cost comparison of these tests was also performed. RESULTS： H pylori was diagnosed by histology and rapid urease test in 66 （70%） and 61 （65%） patients, while ^14C UBT detected infection in 63 （67%）. Accuracy of UBT was 93% in comparison with histology while its positive and negative predictive values were 97% and 84%, respectively. Comparison of ^14C UBT with rapid urease test gives an accuracy of 96%, with positive and negative predictive values of 95% and 97%, respectively. These results were highly reproducible with a Kappa test （P value 〈 0.001）. Cost of histology or rapid urease test with gastroscopy was 110 USD or 95 USD respectively while the cost of UBT was 15 USD.CONCLUSION： Microdose ^14C UBT was comparable to histology and rapid urease test. ^14C UBT is an economical, self sufficient and suitable test to diagnose active Hpylori infection in less developed countries.

关键词： H pylori Microdose ^14C urea breath test Diagnosis Reliable Economical

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