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The role of pro-inflammatory components, carcinoma-associated fibroblasts, and tumorassociated macrophages in ovarian cancer progression and metastasis

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Journal of Cancer Metastasis and Treatment 2023年第1期9卷 385-398页

作者： Josiany Carlos de souza Roberto Silva Ribeiro Junior Tatiana Massariol Pimenta Bárbara da Silva Martins Leticia batista Azevedo Rangel Postgraduate Program in Biotechnology/RENORBIO Health Sciences CenterFederal University of Espirito SantoVitória 29047-105Brazil department of Pharmaceutical Sciences Health Sciences CenterFederal University of Espirito SantoVitória 29047-105Brazil Biochemistry Program Health Sciences CenterFederal University of Espirito SantoVitória 29047-105Brazil

Ovarian cancer(OC)is associated with poor outcomes and challenges scientists and *** is usually diagnosed in advanced stages when it is frequently aggressive,chemoresistant,and *** most prevalent form of OC is epithelial ovarian cancer(EOC),which displays significant heterogeneity,enhancing the difficulty in managing the *** factors have been associated with the disease’s development and progression,especially those related to the tumor microenvironment(TME).Here,we highlight components of the ovarian TME in the disease development process,including pro-inflammatory pathways activated by interleukins,cytokines and chemokines,cancer-associated fibroblasts,tumor-associated macrophages,and epithelial-mesenchymal *** compiled evidence identifying TME factors promoting the development,chemoresistance,and metastasis,including cytokines,chemokines,growth factors,and tumor-associated *** identify potential targets for treatment and improving *** targets block or alter pathways associated with OC(especially EOC)progression.

关键词： CAFs interleukins ovarian cancer TAMs tumor microenvironment

Preservation of platelet function in patients with cirrhosis and thrombocytopenia undergoing esophageal variceal ligation

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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 555-560页

作者： Evandro de Oliveira souza Elbio Antonio D’Amico Tania Rubia Flores da Rocha Caroline Marcondes Ferreira Juliana Medeiros batista Luiz Augusto CarneiroD’Albuquerque Flair Jose Carrilho Alberto Queiroz Farias Division of Gastroenterology and Hepatology University of Sao Paulo School of MedicineAv.Dr.Eneas Carvalho de Aguiar2559th flooroffice 9159Sao PauloSP 05403-000Brazil Hemostasis Laboratory Hematology ServiceUniversity of Sao Paulo School of MedicineAv.Dr.Eneas Carvalho de Aguiar2552nd floorSao PauloSP 05403-000Brazil

Background:Thrombocytopenia is a possible risk factor for bleeding after band ligation of esophageal ***,elevated von Willebrand factor(VWF)in cirrhosis improves platelet function and could decrease this *** objective was to assess platelet function in patients with cirrhosis undergoing esophageal variceal ligation(EVL).Methods:The assessment consisted of platelet count,antigen and activity of VWF and VWF-cleaving protease ADAMTS-13 activity,and a platelet adhesion and aggregation test simulating vascular flow in vivo(Impact-RR)prior to ***:Totally 111 patients were divided into three groups according to platelet count:(1)100×109/L(n=26,23.4%).No statistically significant difference was found in the aggregate size of platelets[group 1:41.0(31.8–67.3)μm 2;group 2:47.0(33.8–71.3)μm 2;and group 3:47.0(34.0–66.0)μm 2;P=0.60]and no significant correlation was found between aggregate size and platelet count(Spearman r=0.07;P=0.47).Surface coverage was 4.1%(2.8%–6.7%),8.5%(4.0%–10.0%),and 9.0%(7.1%–12.0%)(Pdemonstrated for platelet function ***:Platelet function is preserved even in the presence of thrombocytopenia,including in the patients with post-EVL bleeding.

关键词： Cirrhosis Hemostasis Thrombocytopenia Platelet aggregation Endoscopy Hemorrage

Blackberry jam fruit(Randia formosa(Jacq.)***):An Amazon superfruit with in vitro neuroprotective properties

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Food Bioscience 2022年第6期50卷 944-953页

作者： Giovanna Nascimento de Mello e Silva Edson Silvio batista Rodrigues Isaac Yves Lopes de Macêdo Henric Pietro Vicente Gil Hericles Mesquita Campos Paulo César Ghedini Lidya Cardozo da Silva Erica Aparecida batista Giovanna Lopes de Araújo Boniek Gontijo Vaz Tânia Aparecida Pinto de Castro Ferreira Renê Oliveira do Couto Eric de souza Gil LAFAM – Laboratory for Pharmaceutical and Environmental Analysis Faculdade de FarmáciaUniversidade Federal de GoiásGoiâniaGoiásBrazil DFar – Pharmacology department Instituto de Ciências BiológicasUniversidade Federal de GoiásGoiâniaGoiásBrazil LaCEM – Laboratory of Chromatography and Mass Spectometry Instituto de QuímicaUniversidade Federal de GoiásGoiâniaGoiásBrazil LANAL – Laboratory of Nutrition and Food Analysis Faculdade de NutriçãoUniversidade Federal de GoiásGoiâniaGoiásBrazil Universidade Federal de São João del-Rei (UFSJ) Campus Centro-Oeste Dona Lindu (CCO)DivinópolisMinas GeraisBrazil

We report on the bromatological profile,the preliminary phytochemical composition,the antioxidant capacity,and the in vitro neuroprotective effects of Blackberry Jam *** were the major macronutrients(20 g/100 g)in both pulp and seeds(36.5 g/100g),that also possess a low lipid content(0.1 g/100 g and 0.7 g/100,and 86 Kcal/100 g,respectively).Eleven compounds including a diterpenoid dimmer,a lactone,coumarins,sphingosines,and flavonoids have been identified for the first time in the pulp and seeds of *** by mass *** electrochemical index of the hydroalcoholic extract of the pulp(BJFp respectively)and an appreciable energy value(89 Kcal/100 g)was around 6.8μA/V and two reversible cathode peaks were observed up to 0.5 V,thus shedding light to its antioxidant capacity,which was also evidenced by the DPPH•and ABTS+radical scavenging assays(IC50 of 3.30±0.23μg/mL and 18.17±1.21μg/mL,respectively).The BJFp protected against oxidative stress in vitro by significantly decreasing both the lipid peroxidation and contents of carbonyl proteins in a dose-dependent manner in murine brain cells treated with ***,the BJFp increased the superoxide dismutase(EC50 of 11.99±0.35μg/mL)and catalase(EC50 of 69.53±0.43μg/mL)*** BJFp markedly decreased both the in vitro acetylcholinesterase(IC50 of 227.9±0.34μg/mL)and butyrylcholinesterase(IC50 of 8.77±0.40μg/mL)***,besides being a great source of energy,this Amazon superfruit may be promising for enhancing the treatment outcomes of ailments related to oxidative stress,which require further in vivo investigation.

关键词： Antioxidants Cholinesterase inhibitors Electrochemistry Functional foods Phenolic compounds

Antifungal activity and antidiarrheal activity via antimotility mechanisms of (-)-fenchone in experimental models

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World Journal of Gastroenterology 2020年第43期26卷 6795-6809页

作者： Michelle Liz de souza Pessoa Leiliane Macena Oliveira Silva Maria Elaine Cristina Araruna Catarina Alves de Lima Serafim Edvaldo Balbino Alves Junior Alessa Oliveira Silva Matheus Marley Bezerra Pessoa Hermes Diniz Neto Edeltrudes de Oliveira Lima Leonia Maria batista department of Pharmaceutical Sciences IPeFarMFederal University of ParaibaJoao Pessoa 58051-970ParaibaBrazil Health Sciences Center Federal University of ParaibaJoaoPessoa 58051-970ParaibaBrazil Postgraduate Program in Natural and Synthetic Bioactive Products Universidade Federal da ParaibaJoão Pessoa 58051-900Brazil

BACKGROUND(-)-Fenchone is a bicyclic monoterpene present in essential oils of plant species,such as Foeniculum vulgare and Peumus boldus,used to treatment of gastrointestinal *** studies report its anti-inflammatory,antioxidant,and antinociceptive *** To investigate antidiarrheal activity related to gastrointestinal motility,intestinal secretion and antimicrobial *** A castor oil-induced diarrhea model was used to evaluate antidiarrheal *** transit and gastric emptying protocols were used to assess a possible antimotility *** receptors,presynaptic α2-adrenergic and tissue adrenergic receptors,KATP channels,nitric oxide were investigated to uncover antimotility mechanisms of action and castor oil-induced enteropooling to elucidate antisecretory *** antimicrobial activity was evaluated in the minimum inhibitory concentration model,the fractional inhibitory concentration index using the(-)-fenchone association method with standard antifungal ***(-)-Fenchone(75,150 and 300 mg/kg)showed antidiarrheal activity,with a significant decrease in the evacuation *** activity is possibly related to a percentage of reduced intestinal transit(75,150 and 300 mg/kg).The antimotility effect of(-)-fenchone decreased in the presence of pilocarpine,yohimbine,propranolol,L-NG-nitroarginine methyl ester or *** the enteropooling model,no reduction in intestinal fluid weight was observed.(-)-Fenchone did not show antibacterial activity;on the other hand,inhibits the growth of strains of fungi with a minimum fungicide concentration of 32μg/***,when it was associated with amphotericin B,no synergism was *** The antidiarrheal effect of(-)-fenchone in this study involves antimotility effect and not involve antisecretory mechanisms.(-)-Fenchone presents antifungal activity;however,it did not show antibacterial activity.

关键词： (-)-Fenchone Monoterpenes Diarrhea Motility Antifungal

Prevalence of congenital cytomegalovirus infection in preterm,small for gestational age and low birth weight newborns:characteristics and cytokines profile

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World Journal of Pediatrics 2022年第7期18卷 498-504页

作者： Janaina Fortes Lino Llian Martins Oliveira Diniz debora Marques de Miranda Daniela Valadao Freitas Rosa Nathalia Gualberto souza e Silva Eduardo de souza Nicolau Larissa Goncalves Rezende Lais Silva Carvalho Marianna Fischer de Paula Lopes Luisa Petri Correa Gabriela Mafra de Oliveira Flavia Miranda da Silva Alves Lorena batista Pascoal Erika Lima Dolabella Teixeira da Costal Leni Marcia Anchieta Roberta Maia de Castro Romaneli Odete Valadares Maternity Hospital Belo HorizonteBrazil Pediatrics department.Faculy of Medice of Federal University of Minas Gerais Belo Horizonte.Brazil Molecular Laboratory of the INCT-MM.Faculy of Medicine.Federal University of Minas Gerais-UFMG.Belo Horizonte Brazil Faculty of Medicine.Federal University of Minas Gerais-UFMG Belo Horizonte.Brazil Risoleta Tolentino.Neves University Hospital's Maternity Belo HorizonteBrazil Sofia Feldman Maternity Hospital Belo HorizonteBrazil Hospital das Clinicas Maternity-Federal University of Minas Gerais.Belo Horizonte Brazil Pediatrics department of Federal University of Minas Gerais School Medicine.Minas Gerais.Av Professor Alfredo Balena 190.Belo Horizonte 30130-100Brazil

Cytomegalovirus is the most frequent agent of congenital viral infections,affecting approximately 0.2%-2.4%of live births in different countries[1-7].Universal screening for congenital cytomegalovirus infection in newborns is not a standard practice considering cost-benefit issues and viabil-ity of diagnostic ***,most newborns are asympto-matic and there is no effective treatment for this population[2-5].

关键词： weight birth characteristics

Chemical composition of Rosmarinus officinalis essential oil and antioxidant action against gastric damage induced by absolute ethanol in the rat

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Asian Pacific Journal of Tropical Biomedicine 2016年第8期6卷 677-681页

作者： Christiane Takayama Felipe Meira de-Faria Ana Cristina Alves de Almeida Ricardo Jose Dunder Luis Paulo Manzo Eduardo Augusto Rabelo Socca Leonia Maria batista Marcos Jose Salvador Alba Regina Monteiro souza-Brito Anderson Luiz-Ferreira Functional and Structural Biology department Biology Institute Campinas State University Pharmacology department Faculty of Medical Sciences Campinas State University department of Pharmaceutical Sciences Federal University of Paraiba Plant Physiology department Biology Institute Campinas State University Federal University of Goias Institute of Biotechnology Nucleus of Biological Sciences Regional Catalao

Objective: To evaluate the antioxidant activity of the essential oil obtained from Rosmarinus officinalis(R. officinalis) in ethanol-induced gastric ulcer model in ***: The antioxidant properties of the essential oil obtained from R. officinalis were evaluated against gastric injury induced by absolute ethanol. Gastric tissues were prepared to enzymatic assays. The levels of glutathione, lipid peroxides, and the activities of glutathione peroxidase, superoxide dismutase and myeloperoxidase were ***: Ethanol produced severe hemorrhagic lesions in the stomach with ulcerative lesion of(140.2 ± 37.2) mm2. In animals pretreated with essential oil of R. officinalis(50 mg/kg, p.o.), a significant inhibition of mucosal injury of(21.2 ± 7.1) mm2(84%inhibition) was observed. The essential oil of R. officinalis protected the gastric mucosa probably by modulating the activities of the enzymes(superoxide dismutase and glutathione peroxidase) and increasing or maintaining the levels of glutathione. In addition,lipid peroxides levels were reduced. The essential oil of R. officinalis was analyzed by gas chromatography–mass spectrometer and the main constituents were cineole(28.5%),camphor(27.7%) and alpha-pinene(21.3%).Conclusions: We suggest that the monoterpenes present in the essential oil obtained from R. officinalis may be among the active principles responsible for the antioxidant activity shown by essential oil of R. officinalis.

关键词： Rosmarinus officinalis L. Antioxidant activity Gastric ulcer Antioxidant enzymes

determination of Essential (Ca, Fe, I, K, Mo) and Toxic Elements (Hg, Pb) in Brazilian Rice Grains and Estimation of Reference Daily Intake

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Food and Nutrition Sciences 2012年第1期3卷 129-134页

作者： Bruno Lemos batista Letícia Ramos Nacano Rodolfo de Freitas Vanessa Cristina de Oliveira-souza Fernando Barbosa 不详

The levels of Hg and Pb (toxic elements) and Ca, Fe, I, K, Mo (essential elements) were measured in 44 Brazilian rice samples divided among white polished (W), parboiled white (PW) and parboiled brown (PB). Rice grains were ana- lyzed by inductively coupled plasma mass spectrometry (ICP-MS). Concentrations of toxic elements varied from 0.3 to 13.4 and 0.4 to 14.5 ng?g–1 for Hg and Pb, respectively. The values for essential elements were in the same range of those for rice produced in other countries. In general parboiled samples presented higher levels of all elements in study compared to white samples. The Estimated Daily Intake through rice consumption was 0.44 μg for Pb, 0.22 μg for Hg, 0.65 μg for I, 39.5 μg for Mo, 0.43 mg for Fe, 4.1 mg for Ca and 88.9 mg for K. Our findings demonstrated that rice can contribute significantly to the RDIs of molybdenum and potassium, but it can not be considered an important source of I, Fe and Ca. Moreover, the estimated

关键词： Rice Trace Metals ICP-MS Daily Intake

Anti-inflammatory intestinal activity of Combretum duarteanum Cambess. in trinitrobenzene sulfonic acid colitis model

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World Journal of Gastroenterology 2017年第8期23卷 1353-1366页

作者： Gedson Rodrigues de Morais Lima Flavia Danniele Frota MachadoLarissa Lucena Périco Felipe Meira de Faria Anderson Luiz-Ferreira Alba Regina Monteiro souza Brito Cláudia Helena Pellizzon Clélia Akiko Hiruma-Lima Josean Fechine Tavares JoséMaria Barbosa Filho LeOnia Maria batista departamento de Ciências Farmacêuticas Centro de Ciências da SaúdeLaboratório de Farmacologia do Trato GastrintestinalUniversidade Federal da Paraíba(UFPB)Cidade Universitária departamento de Fisiologia Instituto de BiociênciasUniversidade Estadual Paulista departamento de Biologia Estrutural e Funcional Instituto de BiologiaUniversidade Estadual de Campinas(UNICAMP departamento de Ciencias Biológicas Instituto de BiotecnologiaUniversidade Federal de Goiás departamento de Morfologia Instituto de BiociênciasUniversidade Estadual Paulista

To evaluate the anti-inflammatory intestinal effect of the ethanolic extract (EtOHE) and hexane phase (HexP) obtained from the leaves of Combretum duarteanum (Cd).METHODSInflammatory bowel disease was induced using trinitrobenzenesulfonic acid in acute and relapsed ulcerative colitis in rat models. Damage scores, and biochemical, histological and immunohistochemical parameters were *** Cd-EtOHE and Cd-HexP caused significant reductions in macroscopic lesion scores and ulcerative lesion areas. The vegetable samples inhibited myeloperoxidase increase, as well as pro-inflammatory cytokines TNF-α and IL-1β. Anti-inflammatory cytokine IL-10 also increased in animals treated with the tested plant samples. The anti-inflammatory intestinal effect is related to decreased expression of cyclooxygenase-2, proliferating cell nuclear antigen, and an increase in superoxide *** data indicate anti-inflammatory intestinal activity. The effects may also involve participation of the antioxidant system and principal cytokines relating to inflammatory bowel disease.

关键词： Combretum duarteanum Medicinal plants Combretaceae Inflammatory bowel disease Anti-inflammatory intestinal activity

device design for SAE 1020 Steel Tool Storage Applied to Automotive Industry

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Management Studies 2019年第6期7卷 588-600页

作者： Marcílio Antunes Leite Filho Rosinei batista Ribeiro Adriano JoséSorbile de souza JoséWilson de Jesus Silva Wellington de Oliveira University Center Teresa D’ávila-UNIFATEA LorenaBrazil

Wood pallets are the most commonly used resources in tool storage in the press industry,where components are modeled for automotive *** aim of this work was to develop AISI 1020 carbon steel metal rack for storing the set of cutting,drilling,and folding *** collaborating company is a manufacturer of automotive components for buses,trucks,and pickup *** is located in the municipality of Cruzeiro,S?o Paulo and Metropolitan Sub-region of Vale do Paraíba and Litoral Norte *** used in the execution of this project was the microstructural characterization of AISI 1020 by techniques of metallography,hardness,modeling and mechanical simulation,development of metal rack design by technical details in 2D via AutoCad?for prototype,or in 3D by means of virtual modeling Cliever Lab(Pro)?to create a *** production and operations management the average time of handling of forklifts was analyzed using the timer in the current logistic process in the forklift,crane,tool,and pallet *** result obtained so far by means of development of metal rack was the reduction of environmental liabilities,greater storage safety and reduction in time of tool movement.

关键词： rack design design and material selection product design 3D prototyping