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水利学报 1990年第4期22卷 1-10页

作者：荷少苓 I.R.warren 水利水电科学研究院丹麦水力学研究院计算水力学中心

为了更合理地对明渠恒定或不恒定流数值计算中的涡粘扩散系数进行选取,作者在设计了消除各种不同波长短波分量的公式的基础上,找出了新的附加项形式,以代替通常在基本方程中所采用的所谓涡粘扩散项. 研究表明,新的附加项无论在物理含义... 详细信息

为了更合理地对明渠恒定或不恒定流数值计算中的涡粘扩散系数进行选取,作者在设计了消除各种不同波长短波分量的公式的基础上,找出了新的附加项形式,以代替通常在基本方程中所采用的所谓涡粘扩散项. 研究表明,新的附加项无论在物理含义及数值效应上都是合理的,而且在量值的选取上较之通常采用的方法更有依据,因而有较好的应用前景。

关键词：明渠平面二维涡粘扩散项恒定流

TDP-43 regulates cancer-associated microRNAs

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Protein & Cell 2018年第10期9卷 848-866页

作者： Xiaowei Chen Zhen Fan warren McGee Mengmeng Chen Ruirui Kong Pushuai Wen Tengfei Xiao Xiaomin Chen Jianghong Liu Li Zhu Runsheng Chen Jane Y. Wu CAS Key Laboratory of RNA Biology Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Research Network of Computational Biology RNCB Beijing 100101 China Core Facility for Protein Research institute of Biophysics Chinese Academy of Sciences Beijing 100101 China State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences Beijing 100101China Department of Neurology Center for Genetic Medicine Lurie Cancer Center Northwestern University Feinberg School ofMedicine Chicago IL 60611 USA Guangdong Geneway Decoding Bio-Tech Co. Ltd Foshan 528316 China

regulation of miRNA genes contributes to pathogenesis of a wide range of human diseases, including cancer. The TAR DNA binding protein 43 （TDP- 43）, a RNAJDNA binding protein associated with neu- rodegeneration, is involved in miRNA biogenesis. Here, we systematically examined miRNAs regulated by TDP- 43 using RNA-Seq coupled with an siRNA-mediated knockdown approach. TDP-43 knockdown affected the expression of a number of miRNAs. In addition, TDP-43 down-regulation led to alterations in the patterns of dif- ferent isoforms of miRNAs （isomiRs） and miRNA arm selection, suggesting a previously unknown role of TDP- 43 in miRNA processing. A number of TDP-43 associ- ated miRNAs, and their candidate target genes, are associated with human cancers. Our data reveal highly complex roles of TDP-43 in regulating different miRNAs and their target genes. Our results suggest that TDP-43 may promote migration of lung cancer cells by regulat- ing miR-423-3p. In contrast, TDP-43 increases miR-500a- 3p expression and binds to the mature miR-500a-3p sequence. Reduced expression of miR-500a-3p is associated with poor survival of lung cancer patients,suggesting that TDP-43 may have a suppressive role in cancer by regulating miR-500a-3p. Cancer-associated genes LIF and PAPPA are possible targets of miR-500a- 3p. Our work suggests that TDP-43-regulated miRNAs may play multifaceted roles in the pathogenesis of cancer.

关键词： TDP-43 miRNA cancer migration prognosis

Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ’long-haulers’?

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Chronic Diseases and Translational Medicine 2021年第1期7卷 14-26页

作者： Emily Wood Katherine H.Hall warren Tate Department of Biochemistry Health Sciences DivisionUniversity of OtagoDunedinNew Zealand Department of General Practice and Rural Health Otago Medical School-Dunedin CampusUniversity of OtagoDunedinNew Zealand

A significant number of SARS-CoV-2 (COVID-19) pandemic patients have developed chronic symptoms lasting weeks or months which are very similar to those described for myalgic encephalomyelitis/chronic fatigue syndrome. This study reviews the current literature and understanding of the role that mitochondria, oxidative stress and antioxidants may play in the understanding of the pathophysiology and treatment of chronic fatigue. It describes what is known about the dysfunctional pathways which can develop in mitochondria and their relationship to chronic fatigue. It also reviews what is known about oxidative stress and how this can be related to the pathophysiology of fatigue, as well as examining the potential for specific therapy directed at mitochondria for the treatment of chronic fatigue in the form of antioxidants. This study identifies areas which require urgent, further research in order to fully elucidate the clinical and therapeutic potential of these approaches.

关键词： Chronic fatigue syndrome Mitochondria Oxidative stress Antioxidants SARS-CoV-2

Bacterial vaginosis:a synthesis of the literature on etiology,prevalence,risk factors,and relationship with chlamydia and gonorrhea infections

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Journal of Medical Colleges of PLA(China) 2016年第2期31卷 93-103页

作者： Christian T.Bautista Eyako Wurapa warren B.Sateren Sara Morris Bruce Hollingsworth Jose L.Sanchez Division of Health Research Lancaster University Lancaster UK. Walter Reed Army Institute of Research Maryland USA Armed Forces Health Surveillance Center and Cherokee Nation Technology Solutions Maryland USA

Bacterial vaginosis(BV) is a common vaginal disorder in women of reproductive age. Since the initial work of Leopoldo in 1953 and Gardner and Dukes in 1955, researchers have not been able to identify the causative etiologic agent of BV. There is increasing evidence, however, that BV occurs when Lactobacillus spp., the predominant species in healthy vaginal flora, are replaced by anaerobic bacteria, such as Gardenella vaginalis, Mobiluncus curtisii, M. mulieris, other anaerobic bacteria and/or Mycoplasma hominis. Worldwide, it estimated that 20%–30% of women of reproductive age attending sexually transmitted infection(STI) clinics suffer from BV, and that its prevalence can be as high as 50%–60% in high-risk populations(e.g., those who practice commercial sex work(CSW). Epidemiological data show that women are more likely to report BV if they: 1) have had a higher number of lifetime sexual partners; 2) are unmarried; 3) have engaged in their first intercourse at a younger age; 4) have engaged in CSW, and 5) practice regular douching. In the past decade, several studies have provided evidence on the contribution of sexual activity to BV. However, it is difficult to state that BV is a STI without being able to identify the etiologic agent. BV has also emerged as a public health problem due to its association with other STIs, including: human immunodeficiency virus(HIV), herpes simplex virus type 2(HSV-2), Chlamydia trachomatis(CT) and Neisseria gonorrhoeae(NG). The most recent evidence on the association between BV and CT/NG infection comes from two secondary analyses of cohort data conducted among women attending STI clinics. Based on these studies, women with BV had a 1.8 and 1.9-fold increased risk for NG and CT infection, respectively. Taken together, BV is likely a risk factor or at least an important contributor to subsequent NG or CT infection in high-risk women. Additional research is required to determine whether this association is also present in other low-r

关键词： Bacterial vaginosis Chlamydia Gonorrhea Military Epidemiology STI

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沉淀是金印度风格

Sequence and structure of naturally-occurring tRNA transcripts and site-directed variants are significant barriers to forming oligomers beyond dimers

丛书名：建筑与设计图书馆

2002年

作者： ALEXANDRABONFANTE-warren 冯晓慧翻译

本书介绍了印度风格建筑的外部设计、装饰，以及与众不同的细部设计，展现了印度风格住宅结构的精华和魅力。

ISBN: (纸本)7543314479

本书介绍了印度风格建筑的外部设计、装饰，以及与众不同的细部设计，展现了印度风格住宅结构的精华和魅力。

关键词：建筑艺术印度

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Advances in Bioscience and Biotechnology 2013年第5期4卷 1-16页

作者： Harold S. Bernhardt warren P. Tate Department of Biochemistry University of Otago Dunedin New Zealand

Dimers of tRNAs can form through quasi self-complementary anticodon-anticodon interactions, for example at neutral pH in yeast tRNAAsp(GUC) and at pH4.5 inEscherichia coli tRNAGly(GCC) through a partially protonated interaction. The requirements for tRNA oligomerization, and the factors that prevented higher orders of structures forming were examined with unmodified wild-type and variant E. coli tRNAsGly(GCC). Non-denaturing agarose gel electrophoresis was used as a rapid screening method. A number of tRNAGly(GCC) variants with nucleotide substitutions in the loop regions formed dimers, but surprisingly there was no evidence that distinct higher oligomers formed in any of the variants tested. The dimer interfaces of two of the variants were delineated by competitive inhibition with complementary DNA oligonucleotides. Components of an oligomerization facilitating buffer, containing monovalent, divalent and multivalent cations (magnesium and sodium ions and spermine), were tested separately and in combination, to optimize oligomerization and its detection using agarose gel electrophoresis. A rationale for the requirement for magnesium for dimerization is suggested from its role in RNA loop-loop interactions. Sequence specific variant tRNAs that can rapidly form heterodimers with damaging infectious RNA are potential therapeutic agents against viral mechanisms by acting as base pairing inhibitors.

关键词： Transfer RNA TRNA Dimerization Oligomerization Kissing-Loop Interaction

Deepwater Horizon Oil Spill as a Case Study for Interdisciplinary Cooperation within Developmental Biology, Environmental Sciences and Physiology

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World Journal of Engineering and Technology 2015年第4期3卷 7-23页

作者： warren Burggren Benjamin Dubansky Aaron Roberts Matthew Alloy Developmental Integrative Research Group Department of Biological Sciences University of North Texas Denton TX USA

The Deepwater Horizon Oil Spill in the USA’s Gulf of Mexico created a high degree of exposure of marine organisms to toxic polyaromatic hydrocarbons (PAHs) present in crude oil. To determine the ecological and physiological effects of crude oil on the Gulf of Mexico ecosystem, the Gulf of Mexico Research Initiative created several research consortia to address overreaching questions concerning the biological impacts of the ecology of the Gulf of Mexico that would otherwise be beyond the capabilities of an individual investigator or a small group. One of these consortia, highlighted in this article, is the RECOVER Consortium, which brings together physiologists, developmental biologists, toxicologists and other life scientists to focus on the multifaceted physiological effects of PAHs, especially as they pertain to cardiovascular and metabolic physiology of economically important fish species. Using the Recover Consortium’s interdisciplinary approach to revealing the biological impacts of the Deepwater Horizon Oil Spill as a case study, we make the argument for interdisciplinary teams that bring together scientists with different specialties as an efficient way—and perhaps the only way—to unravel highly complex biological effects of marine oil spills.

关键词： Deepwater Horizon Oil Spill Gulf of Mexico Interdisciplinarity Research Consortium

The Anti-Tumor Effect of a High Caloric Diet in the PyMT Mouse Breast Cancer Model Is Initiated by an Increase in Metabolic Rate

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Journal of Cancer Therapy 2012年第5期3卷 718-730页

作者： Linda C. Enns warren C. Ladiges Department of Comparative Medicine University of Washington Seattle USA

Obesity is associated with an increased risk of mortality from certain types of cancer, including cancer of the breast. Because obesity is associated with multiple risk factors, however, the exact reasons remain unclear. The objective of this study was to determine which of the risk factors associated with obesity are related to enhanced tumor development. The MMTV-PyMT mouse model develops mammary tumors which share numerous characteristics with those of humans. We challenged these mice with a high fat/high carbohydrate, high caloric (HC) diet, and looked for relationships between enhanced primary tumor development and adiposity, various aspects of glucose homeostasis, and metabolic factors. The HC diet enhanced tumor progression in PyMT mice. While mice on the HC diet also developed increased adiposity, hyperglycemia and hyperinsulinemia, none of these risk factors was found to be associated with the observed increases in tumor growth. Rather, we found that while overall, tumor growth was enhanced in HC diet-fed mice compared to those maintained on a regular diet, it was attenuated in individuals by an HC diet-induced increase in metabolic rate and decrease in respiratory exchange ratio. Tumor size in HC diet-fed mice was directly related to p38 phosphorylation and Bcl-2 inhibition, and the degree of vascularization of these tumors was closely and indirectly related to the rate of mouse oxygen consumption. The data suggest that an increase in metabolic rate and oxygen consumption, induced by the introduction of a high caloric diet, has a protective effect against tumor growth by increasing the activity levels of the tumor suppressor p38 and decreasing the activity of the antiapoptoic protein Bcl-2, as well as by reducing hypoxia-induced tumor vascularization.

关键词： Obesity Breast Cancer Metabolism Oxygen ROS p38 Hypoxia

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三氯化铁浸取闪锌矿的数学模型

成都科技大学学报 1984年第4期 163-164页

作者：金作美 G.W.warren

本文在加拿大25届冶金学术会议上宣读在我们以前的工作中指出;闪锌矿在三氯化铁溶液中的溶出可以描述为局部化学的表面反应控制模型;得出了活化能为58.4仟焦耳/克分子;求出在铁离子浓度低的条件下,列[Fe3+]的反应级数为0.5;在铁离子浓... 详细信息

本文在加拿大25届冶金学术会议上宣读在我们以前的工作中指出;闪锌矿在三氯化铁溶液中的溶出可以描述为局部化学的表面反应控制模型;得出了活化能为58.4仟焦耳/克分子;求出在铁离子浓度低的条件下,列[Fe3+]的反应级数为0.5;在铁离子浓度较高时,反应级数为零级反应。在本文

关键词：三价铁离子反应级数数学模型试验模型闪锌矿硫化矿物