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Iron-nickel alloy particles with N-doped carbon “armor” as a highly selective and long-lasting catalyst for the synthesis of Nbenzylaniline molecules

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Nano Research 2024年第4期17卷 2308-2319页

作者： Gang Wang Longchao Sun wanyi Liu Haijuan Zhan Shuxian Bi College of Chemistry and Chemical Engineering Ningxia UniversityYinchuan 750021China

A scalable strategy for the convenient and rapid preparation of nitrogen-doped carbon-coated iron-based alloy catalysts was *** controlling the type and amount of metal salts in the precursor,various types of nitrogen-doped carbon-coated alloy catalysts can be prepared in a targeted ***_(2)Ni2@CN materials with small particle sizes and relatively homogeneous basic sites showed promising results in the N-alkylation reaction of benzyl alcohol with aniline(optimum yield:99%).It is worth noting that the catalyst can also be magnetically separated and recovered after the reaction,and its performance can be regenerated through simple ***,it was confirmed by kinetic experiments that the activation of C–H at the benzyl alcohol benzylic position is the rate-determining step(RDS).According to density flooding theory calculations,Fe_(2)Ni2@CN catalysts require less energy than other materials(Fe@CN and Ni@CN)for the RDS(dehydrogenation reaction)*** N-alkylation reactions are more easily carried out on Fe_(2)Ni2@CN catalysts,which may be the reason for the best catalytic activity of Fe-Ni alloy *** carbon-coated alloy materials will show great potential in more types of heterogeneous catalysis.

关键词： iron-nickel alloy catalyst N-alkylation reaction magnetic separation reaction path dehydrogenation reaction

Deep insight into the B-cell associated tertiary lymphoid structure and tumor immunotherapy

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Cancer Biology & Medicine 2024年第2期21卷 125-131页

作者： Jilong Yang Jin Xu Haotian Liu wanyi Xiao Gengpu Zhang Department of Bone and Soft Tissue Tumor Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Molecular Cancer EpidemiologyTianjin 300060China Department of Anaesthesiology Tianjin University Tianjin HospitalTianjin 300211China

Bod et al.1 recently published a study in Nature that garnered attention to B cell-associated anti-tumor immunity and immunotherapy of melanoma and other *** a promising supplemental immunotherapy to mainstream method... 详细信息

关键词： immunotherapy immunity

Environmental, social, and governance performance and corporate innovation novelty

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International Journal of Innovation Studies 2024年第2期8卷 109-131页

作者： wanyi Chen Yuchuan Xie Kang He SILC Business School Shanghai UniversityShanghai200444China School of Economics Huazhong University of Science and TechnologyWuhan430074China School of Business Shantou UniversityShantou515063China

Environmental,social,and governance(ESG)performance,along with the novelty of innovation,are significant factors in promoting sustainable development for *** study employs the Heckman two-stage model to examine the impact of ESG performance on innovation novelty using a dataset comprising A-share listed companies in the Shanghai and Shenzhen Stock Ex-changes from 2011 to *** results indicate that enhanced ESG performance significantly fosters innovation by expanding innovation resources and mitigating agency *** analysis reveals that this relationship is more pronounced under high economic policy uncer-tainty,a challenging information environment,elevated financing constraints,and in the context of digital *** study not only expands the research on the economic implications of ESG performance for enterprise innovation behavior but also places a distinct emphasis on innovation quality rather than ***,this study enriches the existing literature on the factors influencing innovation novelty and extends research into the link between envi-ronmental protection and firm innovation,particularly from the perspective of stakeholder ***,this study holds practical significance for governments aiming to enhance ESG evaluation systems and establish guiding policies that encourage novel innovations,ultimately contributing to sustainable and high-quality ***,this study provides guidance to enterprises by encouraging them to embrace green development,improve social responsibility,and elevate their governance standards to promote innovation quality.

关键词： ESG Innovation novelty Resource dependence theory Agency problem Innovation quality Sustainable development

Diet and physical activity influence the composition of gut microbiota,benefit on Alzheimer's disease

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Food Science and Human Wellness 2024年第2期13卷 541-555页

作者： Jinyue Zhou Min Tang wanyi Li Rui Fang Chunlan Tang Qinwen Wang 无 School of Public Health Health Science CenterNingbo UniversityNingbo 315211China Department of Neurology Ningbo Rehabilitation HospitalNingbo 3151000China Ningbo Institute of Life and Health Industry University of Chinese Academy of SciencesNingbo 315100China Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province Ningbo 315100China

Alzheimer's disease is a neurodegenerative disease with complex *** microbiota influences the gutbrain axis,which may affect pathways related to the pathogenesis of Alzheimer's ***,diet and physical activity are likely to affect the pathology of Alzheimer's disease as well as the gut *** demonstrates that it may be possible to prevent or halt the progression of Alzheimer's disease by regulating the gut microbiota using diet and physical activity ***,the present study reviews the association between these two interventions and gut microbiota in the human *** also summarizes how these two interventions benefit Alzheimer's ***,the primary limitations of these two interventions are discussed and promising strategies are proposed,which may be beneficial to further study and develop the intervening measure for the progression of Alzheimer's disease.

关键词： Alzheimer’s disease Gut microbiota Brain-gut axis Diet Physical activity

Weight change and all-cause and cause-specific mortality:A 25-year follow-up study

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Chinese Medical Journal 2024年第10期137卷 1169-1178页

作者： Huan Yang Jianbing Wang Xiaokun Wang wanyi Sun Chenyunhao Tong Jinhu Fan Youlin Qiao Christian *** Department of Cancer Epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Public Health Zhejiang University School of MedicineNational Clinical Research Center for Children’s HealthHangzhouZhejiang 310058China Metabolic Epidemiology Branch Division of Cancer Epidemiology and GeneticsNational Cancer InstituteRockvilleMD 20850USA

Background:Whether the dynamic weight change is an independent risk factor for mortality remains *** study aimed to examine the association between weight change and risk of all-cause and cause-specific mortality based on the Linxian Nutrition Intervention Trial(NIT)***:Body weight of 21,028 healthy residents of Linxian,Henan province,aged 40-69 years was measured two times from 1986 to *** events were prospectively collected up to *** maintenance group(weight changeause(HR_(All-cause)=1.14,95%CI:1.09-1.19,Pause,heart disease,and stroke mortality(all P_(

关键词： Weight change All-cause mortality Cancer Stroke Heart diseases Body mass index

Immunomodulatory potential of exopolysaccharides from Lactiplantibacillus plantarum YY-112

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Food Science and Human Wellness 2024年

作者： Mengfan Luo wanyi Zhou Wenyang Tao Jianrong Xing Jingrui Li Yuxing Guo Ying Yang Institute of Food Science Zhejiang Academy of Agricultural Sciences School of Food Science and Pharmaceutical Engineering Nanjing Normal University

In vitro simulated colonic fermentation studies have shown the prebiotic potential of exopolysaccharides from Lactiplantibacillus plantarum YY-112 (YEPS). Its immunomodulatory effects and related mechanisms were systematically investigated in this study. We observed that YEPS intervene in immune responses and improve intestinal microbial structure in normal mice， including significantly increasing the relative abundance of Enterorhabdus and norank＿f＿＿norank＿o＿＿Clostridia UCG-014 as well as decreasing that of unclassified＿c＿＿Bacilli (P < 0.05). In the immunocompromised mouse model， YEPS decreased IL-6 levels (P < 0.05) and protected the spleen by regulating lymphocyte levels. YEPS preserved the intestinal barrier by improving Mucin 2， Zonula occludens protein 1， and Occludin expression. Moreover， YEPS significantly reduced the relative abundance of Bacillus， unclassified＿c＿＿Bacilli， Lachnoclostridium， Eubacterium＿xylanophilum＿group， and Desulfovibrio (P < 0.05)， potentially enhancing mice immunity by improving the intestinal microbiota associated with immune function. In conclusion， YEPS can be used as a natural functional extract with prebiotic effects that may improve host immunity. This provided the basis for the application of YEPS as a novel potential food additive.

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Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies

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Acta Pharmaceutica Sinica B 2024年第2期14卷 533-578页

作者： Xiaopeng Peng Zhihao Hu Limei Zeng Meizhu Zhang Congcong Xu Benyan Lu Chengpeng Tao Weiming Chen Wen Hou Kui Cheng Huichang Bi wanyi Pan Jianjun Chen College of Pharmacy Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of EducationGannan Medical UniversityGanzhou 314000China College of Basic Medicine Gannan Medical UniversityGanzhou 314000China Guangdong Provincial Key Laboratory of New Drug Screening NMPA Key Laboratory for Research and Evaluation of Drug MetabolismSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China

Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators(e.g., inhibitors). However, epigenetic inhibitors have faced multiple challenges,including limited clinical efficacy, toxicities, lack of subtype selectivity, and drug resistance. As a result,the design of new epigenetic modulators(e.g., degraders) such as PROTACs, molecular glue, and hydrophobic tagging(Hy T) degraders has garnered significant attention from both academia and pharmaceutical industry, and numerous epigenetic degraders have been discovered in the past decade. In this review,we aim to provide an in-depth illustration of new degrading strategies(2017-2023) targeting epigenetic proteins for cancer therapy, focusing on the rational design, pharmacodynamics, pharmacokinetics, clinical status, and crystal structure information of these degraders. Importantly, we also provide deep insights into the potential challenges and corresponding remedies of this approach to drug design and development. Overall, we hope this review will offer a better mechanistic understanding and serve as a useful guide for the development of emerging epigenetic-targeting degraders.

关键词： Epigenetic Degrader PROTAC Molecularglue Hydrophobic tagging

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数字普惠金融、公共服务供给与城乡协调发展

华东经济管理 2024年第8期38卷 106-117页

作者：张婉嫕成都大学旅游与文化产业学院四川成都610106

文章基于2010—2022年中国30个省域面板数据,构建城乡协调发展水平综合评价指标体系,以层次分析法以及变异系数法测度中国城乡协调发展水平,并实证研判数字普惠金融对中国城乡协调发展的影响效应、传导机制。研究发现:数字普惠金融对中... 详细信息

文章基于2010—2022年中国30个省域面板数据,构建城乡协调发展水平综合评价指标体系,以层次分析法以及变异系数法测度中国城乡协调发展水平,并实证研判数字普惠金融对中国城乡协调发展的影响效应、传导机制。研究发现:数字普惠金融对中国城乡协调发展存在显著积极影响,且该影响具有空间溢出效应;深入探究可知,公共服务供给是数字普惠金融释放城乡协调发展红利的关键传导机制,数字普惠金融对城乡协调发展的助推作用存在区域异质性;通过门槛检验结果可知,数字普惠金融对城乡协调发展的影响效应具有非线性特征。研究成果可为发挥数字普惠金融对城乡协调发展的作用提供理论和现实借鉴。

关键词：数字普惠金融公共服务供给城乡协调发展人力资本空间溢出效应

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数字金融发展、经济双循环与农民农村共同富裕

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征信 2024年第5期42卷 73-81页

作者：张婉嫕成都大学旅游与文化产业学院四川成都610106

以2011—2022年中国265个地级及以上城市数据为基础,借助计量模型深入探究数字金融发展对农民农村共同富裕的影响,并考察经济双循环的机制作用。基准回归结果显示,数字金融发展能够显著促进农民农村共同富裕。机制检验结果表明,数字金... 详细信息

以2011—2022年中国265个地级及以上城市数据为基础,借助计量模型深入探究数字金融发展对农民农村共同富裕的影响,并考察经济双循环的机制作用。基准回归结果显示,数字金融发展能够显著促进农民农村共同富裕。机制检验结果表明,数字金融发展可通过经济双循环间接促进农民农村共同富裕。异质性分析结果证明,数字金融发展对农民农村共同富裕的促进作用在高城镇化水平地区更为显著。鉴于此,提出持续推动数字金融供给侧结构性改革、积极发挥经济内循环与外循环赋能效应、因地制宜助力数字金融发展等相关建议,以期为推进农民农村共同富裕提供借鉴。

关键词：农民农村共同富裕数字金融发展经济内循环经济外循环

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