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Food Science and Human Wellness 2024年第1期13卷 349-359页

作者： Shuting Yin Qiangqiang Li Yuxiao Tao Enning Zhou Kun Wang wanwen chen Xiangxin Li Liming Wu Institute of Apicultural Research Chinese Academy of Agricultural SciencesBeijing 100093China Department of Animal Science McGill UniversityQuebec H9X 3V9Canada State Key Laboratory of Food Science and Technology School of Food Science and TechnologyJiangnan UniversityWuxi 214122China

Food allergy as a global health problem threatens food *** pollen(BP)is a typical food with allergenic potentials,although it performs various nutritional/pharmacological functions to *** this study,lactic acid bacteria(LAB)were used to ferment Brassica napus BP for alleviating its *** novel allergens(glutaredoxin,oleosin-B2,catalase and lipase)were identified with significant decreases in LAB-fermented BP(FBP)than natural BP by ***,metabolomics analysis showed significant increases of 28 characteristic oligopeptides and amino acids in FBP versus BP,indicating the degradation of LAB on ***,FBP showed alleviatory effects in BALB/c mice,which relieved pathological symptoms and lowered production of allergic *** high-throughput sequencing analysis showed that FBP could regulate gut microbiota and metabolism to strengthen immunity,which were closely correlated with the alleviation of allergic *** findings could contribute to the development and utilization of hypoallergenic BP products.

关键词： Alleviatory effects Lactic acid bacteria fermentation Bee pollen allergen Gut microbiota Host metabolism

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梨形环棱螺11个地理种群的几何形态学分析

中国农学通报 2024年第2期40卷 159-164页

作者：金武马学艳彭刚陈琬雯闻海波中国水产科学研究院淡水渔业研究中心/农业农村部稻渔综合种养生态重点实验室江苏无锡214081 南京农业大学无锡渔业学院江苏无锡214128 江苏省淡水水产研究所南京210017 中美淡水贝类种质资源保护及利用国际联合实验室江苏无锡214081

为了摸清国内梨形环棱螺的种质资源现状,提供下一步选择育种的优质种质资源材料。通过采集江苏、安徽、上海、山东、湖南、广西、江西、贵州、湖北、浙江、广东典型分布省份的249个野生样本,对不同群体的每个个体自壳顶开始顺时针设置2... 详细信息

为了摸清国内梨形环棱螺的种质资源现状,提供下一步选择育种的优质种质资源材料。通过采集江苏、安徽、上海、山东、湖南、广西、江西、贵州、湖北、浙江、广东典型分布省份的249个野生样本,对不同群体的每个个体自壳顶开始顺时针设置24个地标点,并在第11~12、12~13、13~14、14~15、15~11、15~16个地标点之间等距设置15个半地标点。基于地标点和半地标点设置结果进行普氏叠印,并删除超过上四分位的异常值。采用薄板样条曲线法进行缺失值检查,并利用主成分分析对形态学变异进行分析。对不同地理群体的普氏距离进行方差分析并根据不同群体之间的普氏距离进行聚类分析。梨形环棱螺11个地理种群外部形态的主要变异位置是壳顶及螺口上缘。不同地理种群形态特征变异的集中性较差,第1主成分和第2主成分不能显著区别区分不同的群体。11个群体大致可以划分为长江流域群体和长江以南群体两大类。不同群体的外形特征存在显著差异,这种外形差异可能与当地的生境有关。

关键词：梨形环棱螺地理种群几何形态地标半地标

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食品薄膜封窖在酱香型白酒生产中的应用研究

酿酒科技 2024年第6期 75-80页

作者：陈万文董帅杨刚仁钱磊吴渊贵州习酒股份有限公司贵州习水564500

酱香型白酒生产中的传统封窖方式不仅工作效率低下、末端处理成本较高,且因使用的窖泥为资源匮乏的本地紫红泥,大量使用不利于生态环境保护。为实现企业的可持续发展,通过使用食品薄膜替代部分窖泥,并优化封窖操作流程,以达到减少窖泥... 详细信息

酱香型白酒生产中的传统封窖方式不仅工作效率低下、末端处理成本较高,且因使用的窖泥为资源匮乏的本地紫红泥,大量使用不利于生态环境保护。为实现企业的可持续发展,通过使用食品薄膜替代部分窖泥,并优化封窖操作流程,以达到减少窖泥使用量的同时提高工作效率和节约成本的目的。本文简述了食品薄膜封窖和窖泥封窖的操作流程差异,并对食品薄膜封窖在酱香型白酒生产中的应用进行试验研究,对食品薄膜和窖泥封窖两种方式的基酒产质量、出窖窖面糟醅理化指标、出窖窖面糟醅微生物指标、基酒骨架成分含量、相关食品安全指标、工作效率及成本等进行对比分析。结果表明,两种封窖方式的基酒质量、出窖窖面糟醅理化、出窖窖面糟醅微生物指标上无明显差异,基酒骨架成分含量相似度较高,相关食品安全指标均符合国家标准,食品薄膜封窖相较于窖泥封窖工作效率提高了41.67%、总成本相差不大、窖泥使用量减少66.67%。综合分析后判断出食品薄膜封窖在酱香型白酒生产中的应用具有可行性。

关键词：酱香型白酒食品薄膜封窖窖泥封窖

PD-1^(+)T细胞亚群比例与irAE患者的血清IFN-γ水平的相关性研究

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今日药学 2024年第3期34卷 209-213页

作者：陈婉文蔡俊滢何玉文曾军魏理广州医科大学附属第一医院药学部广东广州510120 广州医科大学药学院广东广州511436 广州医科大学基础医学院广东广州511436

目的分析使用免疫检查点抑制剂(ICI)治疗后出现免疫相关不良反应(irAE)的非小细胞肺癌(NSCLC)患者的外周血T淋巴细胞亚群水平及其与血清细胞因子的关系。方法前瞻性纳入2022年4~10月于某院就诊的非小细胞肺癌患者47例,其中根据有无发生i... 详细信息

目的分析使用免疫检查点抑制剂(ICI)治疗后出现免疫相关不良反应(irAE)的非小细胞肺癌(NSCLC)患者的外周血T淋巴细胞亚群水平及其与血清细胞因子的关系。方法前瞻性纳入2022年4~10月于某院就诊的非小细胞肺癌患者47例,其中根据有无发生irAE分为irAE组(n=12)和对照组(n=35),采用流式细胞术检测患者外周血淋巴细胞亚群的比例,比较两组间淋巴细胞亚群比例的差异性,Pearson相关性分析细胞因子与淋巴细胞亚群水平的相关性。结果与对照组相比,irAE组患者外周血TCR-αβ^(+)PD1^(+)CD4^(-)CD^(8-)T细胞水平升高,差异具有统计学意义(P=0.045),其他T淋巴细胞亚群无明显差异。Pearson相关性分析结果显示外周血TCR-αβ^(+)PD1^(+)CD4^(-)CD8^(-)T细胞与血清干扰素-γ(IFN-γ)呈正相关关系(r=0.448;P=0.019)。结论irAE患者外周血TCR-αβ^(+)PD1^(+)CD4^(-)CD8^(-)T细胞水平升高,并且与血清IFN-γ水平正相关,有可能参与irAE的发生。

关键词： T细胞免疫相关性不良反应非小细胞肺癌免疫检查点抑制剂

导向碳氢键活化与不饱和分子的电氧化环化反应

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有机化学 2022年第5期42卷 1286-1306页

作者：谢吴成陈浒黎韵越林洁玲陈婉雯石君君佛山科学技术学院环境与化学工程学院广东佛山524200

过渡金属催化导向碳氢键活化与不饱和分子的环化反应已成为合成复杂碳环和杂环化合物的高效途径,但反应中往往需要额外加入化学计量化学氧化剂来实现反应循环.电化学有机合成可利用电流代替昂贵、有毒的化学氧化剂,是一种环境友好的绿... 详细信息

过渡金属催化导向碳氢键活化与不饱和分子的环化反应已成为合成复杂碳环和杂环化合物的高效途径,但反应中往往需要额外加入化学计量化学氧化剂来实现反应循环.电化学有机合成可利用电流代替昂贵、有毒的化学氧化剂,是一种环境友好的绿色合成手段.近年来,电化学有机合成与过渡金属(如Pd、Ni、Co、Ru、Cu、Rh、Ir等)催化碳氢键活化的结合取得了显著的进展.重点介绍了过渡金属催化导向C—H活化与炔烃、烯烃、一氧化碳和异氰等不饱和分子的电氧化环化反应的最新进展,并对该领域未来发展方向进行了展望.

关键词：碳氢键活化电氧化环化不饱和分子

PD⁃1/PD⁃L1免疫检查点抑制剂相关性肺炎的影响因素研究

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药物不良反应杂志 2023年第4期25卷 204-210页

作者：蔡俊滢陈婉文何玉文广州医科大学药学院广州511436 广州医科大学附属第一医院药学部广州510120

目的探讨程序性细胞死亡1受体(PD⁃1)/程序性细胞死亡配体1(PD⁃L1)抑制剂致肺癌患者免疫检查点抑制剂相关性肺炎(CIP)的影响因素。方法收集2018年1月至2022年6月在广州医科大学附属第一医院接受PD⁃1/PD⁃L1抑制剂治疗肺癌患者的临床资料... 详细信息

目的探讨程序性细胞死亡1受体(PD⁃1)/程序性细胞死亡配体1(PD⁃L1)抑制剂致肺癌患者免疫检查点抑制剂相关性肺炎(CIP)的影响因素。方法收集2018年1月至2022年6月在广州医科大学附属第一医院接受PD⁃1/PD⁃L1抑制剂治疗肺癌患者的临床资料进行回顾性分析,将发生CIP者纳入CIP组,以1∶1比例筛选同期未发生任何免疫相关不良事件者纳入对照组。比较2组患者的临床特征,采用二元logistic回归法分析CIP发生的影响因素。效应量为风险比(OR)和95%置信区间(CI)。结果纳入分析的患者共246例(CIP组和对照组各123例),男性208例,女性38例;年龄(63±9)岁,范围32~86岁;非小细胞肺癌234例,小细胞肺癌12例。2组患者年龄、性别、呼吸系统疾病史、肿瘤组织学分型、TNM分期、使用的免疫检查点抑制剂类别等方面的差异均无统计学意义(均P>0.05)。与对照组相比,CIP组患者体重指数较低[(21.5±3.2)kg/m^(2)比(22.6±3.0)kg/m^(2),P=0.004],美国东部肿瘤协作组体力状况评分(ECOG⁃PS)≥2分者占比较高[39.0%(48/123)比22.0%(27/123),P=0.004],有放疗史者占比较高[25.2%(31/123)比13.8%(17/123),P=0.024],联合化疗/靶向治疗的患者占比较低[82.9%(102/123)%比97.6(120/123)%,P<0.001],免疫治疗前外周血白细胞介素1β和干扰素α水平较低[1.97(1.04,2.74)ng/L比2.40(1.75,4.03)ng/L,P=0.021;2.08(0.89,3.00)ng/L比2.76(1.97,3.94)ng/L,P=0.012],淋巴细胞计数较低[1.4(1.0,1.8)×10^(9)/L比1.5(1.2,2.1)×10^(9)/L,P=0.030],中性粒细胞与淋巴细胞比值较高[3.85(2.50,6.40)比3.11(2.25,4.61),P=0.006]。二元logistic回归分析结果显示,基线ECOG⁃PS≥2分(OR=3.400,95%CI:1.180~9.798,P=0.023)和PD⁃1/PD⁃L1抑制剂联合化疗/靶向治疗(OR=0.047,95%CI:0.005~0.454,P=0.008)是CIP发生的独立影响因素。结论治疗前患者ECOG⁃PS≥2分是CIP的影响因素,联用化疗/靶向治疗可能降低患者发生CIP的风险。

关键词：免疫检查点抑制剂程序性细胞死亡1受体肺炎危险因素 Logistic模型

Meridional deflection of global eddy propagation derived from tandem altimetry: Mechanism and implication

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Science China Earth Sciences 2024年第3期67卷 811-825页

作者： Ge chen Xiaoyan chen Frontiers Science Center for Deep Ocean Multispheres and Earth System School of Marine TechnologyOcean University of ChinaQindao 266100China Laboratory for Regional Oceanography and Numerical Modeling Laoshan LaboratoryQindao 266237China

A common view on meridional deflection of eddy propagation is poleward for cyclones and equatorward for anticyclones. This widely accepted polarity-sensitive pattern has been increasingly undermined given that it is systematically violated on both zonal and regional scales as recently reported. Here, we approach the problem by exploring these violations in terms of eddy effects of spatiotemporal geostrophy, thermal fading, and flow dragging, yielding the following main conclusions.(1) The polarity-dependent deflection discrepancy is a pseudo feature resulting from a biased fit to the normalized eddy tracks which are spatially asymmetric(though azimuthally symmetric) between the two signs;Instead, the primary pattern of eddy deflection appears to be geographically correlated and polarity independent.(2) Geostrophic adjustment plays a critical role in defining the meridional movement of an eddy. Specifically, a consistent poleward(equatorward) trajectory bending of spatially(temporally) ageostrophic eddies is observed irrespective of their polarity.(3) The mechanism of eddy deflection is also determined by its zonal propagation direction. Westward propagating eddies are substantially affected by thermal fading, while opposite ones by flow dragging. A realistic and comprehensive understanding of eddy deflection mechanisms serves as a significant contribution to the prediction of eddy trajectory, and the protection of ocean environment.

关键词： Mesoscale eddies Eddy propagation Eddy meridional deflection Satellite observation Geostrophic adjustment

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A refined representation method of the particle size distribution curve based on grading entropy

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Particuology 2024年第5期88卷 302-311页

作者： Xing Li Qun chen Zhaozhao Liu cheng Zhou chen Wang chen chen State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China

The particle size distribution(PSD)curve is an important expression of the basic properties of the *** characteristic parameters such as median particle size D_(50),effective particle size D_(10),and some combinations of characteristic parameters can only represent some points of the PSD curve,failing to represent all information of the PSD *** this paper,a fraction characteristic parameter F that could reflect the fraction size variation of the PSD curve was introduced based on grading *** a new presentation method of the A-B-F three parameters was proposed for a refined representation of the PSD *** was found that the newly constructed model not only better represents the differences in the width of PSD curves but also has a higher sensitivity than the A-B two-parameter model proposed by Lő*** PSD curves with similar distributions,the new presentation method has a higher degree of discrimination than that of the D_(50)-C_(u)-C_(c) three-parameter or the four-parameter combination G_(c) proposed by ***,the application of this new method in describing the spatial nonuniformity distribution of depositions and predicting the soil hydraulic conductivity was *** research results can provide a reference for the refined representation of PSD curves.

关键词： Grading entropy Particle size distribution curve Refined representation

Track correlation algorithm based on CNN-LSTM for swarm targets

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Journal of Systems Engineering and Electronics 2024年第2期35卷 417-429页

作者： chen Jinyang WANG Xuhua chen Xian Research Institute for National Defense Engineering Academy of Military SciencesLuoyang 471023China Information Engineering University Zhengzhou 450001China School of Computer Science and Technology Xidian UniversityXi’an 710071China

The rapid development of unmanned aerial vehicle(UAV) swarm, a new type of aerial threat target, has brought great pressure to the air defense early warning system. At present, most of the track correlation algorithms only use part of the target location, speed, and other information for *** this paper, the artificial neural network method is used to establish the corresponding intelligent track correlation model and method according to the characteristics of swarm ***, a route correlation method based on convolutional neural networks (CNN) and long short-term memory (LSTM)Neural network is designed. In this model, the CNN is used to extract the formation characteristics of UAV swarm and the spatial position characteristics of single UAV track in the formation,while the LSTM is used to extract the time characteristics of UAV swarm. Experimental results show that compared with the traditional algorithms, the algorithm based on CNN-LSTM neural network can make full use of multiple feature information of the target, and has better robustness and accuracy for swarm targets.

关键词： track correlation correlation accuracy rate swarm target convolutional neural network(CNN) long short-term memory(LSTM)neural network

Aerial target threat assessment based on gated recurrent unit and self-attention mechanism

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Journal of Systems Engineering and Electronics 2024年第2期35卷 361-373页

作者： chen chen QUAN Wei SHAO Zhuang School of Automation Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Intelligent Control and Decision of Complex Systems Beijing 100081China

Aerial threat assessment is a crucial link in modern air combat, whose result counts a great deal for commanders to make decisions. With the consideration that the existing threat assessment methods have difficulties in dealing with high dimensional time series target data, a threat assessment method based on self-attention mechanism and gated recurrent unit(SAGRU) is proposed. Firstly, a threat feature system including air combat situations and capability features is established. Moreover, a data augmentation process based on fractional Fourier transform(FRFT) is applied to extract more valuable information from time series situation features. Furthermore, aiming to capture key characteristics of battlefield evolution, a bidirectional GRU and SA mechanisms are designed for enhanced ***, after the concatenation of the processed air combat situation and capability features, the target threat level will be predicted by fully connected neural layers and the softmax classifier. Finally, in order to validate this model, an air combat dataset generated by a combat simulation system is introduced for model training and testing. The comparison experiments show the proposed model has structural rationality and can perform threat assessment faster and more accurately than the other existing models based on deep learning.

关键词： target threat assessment gated recurrent unit(GRU) self-attention(SA) fractional Fourier transform(FRFT)