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Na^(+)/K^(+)-ATPase:ion pump,signal transducer,or cytoprotective protein,and novel biological functions

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Neural Regeneration Research 2024年第12期19卷 2684-2697页

作者： Songqiang Huang wanting Dong Xiaoqian lin Jinsong Bian Department of Pharmacology Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and DiseasesSchool of MedicineSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Department of Pharmacology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Na^(+)/K^(+)-ATPase is a transmembrane protein that has important roles in the maintenance of electrochemical gradients across cell membranes by transporting three Na^(+)out of and two K^(+)into ***,Na^(+)/K^(+)-ATPase participates in Ca^(2+)-signaling transduction and neurotransmitter release by coordinating the ion concentration gradient across the cell ***^(+)/K^(+)-ATPase works synergistically with multiple ion channels in the cell membrane to form a dynamic network of ion homeostatic regulation and affects cellular communication by regulating chemical signals and the ion balance among different types of *** re,it is not surprising that Na^(+)/K^(+)-ATPase dysfunction has emerged as a risk factor for a variety of neurological ***,published studies have so far only elucidated the important roles of Na^(+)/K^(+)-ATPase dysfunction in disease development,and we are lacking detailed mechanisms to clarify how Na^(+)/K^(+)-ATPase affects cell *** recent studies revealed that membrane loss of Na^(+)/K^(+)-ATPase is a key mechanism in many neurological disorders,particularly stroke and Parkinson's *** of plasma membrane Na^(+)/K^(+)-ATPase with an antibody is a novel strategy to treat these *** this reason,Na^(+)/K^(+)-ATPase acts not only as a simple ion pump but also as a sensor/regulator or cytoprotective protein,participating in signal transduction such as neuronal autophagy and apoptosis,and glial cell ***,the present review attempts to summarize the novel biological functions of Na^(+)/K^(+)-ATPase and Na^(+)/K^(+)-ATPase-related *** potential for novel strategies to treat Na^(+)/K^(+)-ATPase-related brain diseases will also be discussed.

关键词： antibody biological functions cellular communication electrochemical gradient ion balance ion channels Na^(+)/K^(+)-ATPase neurological diseases neurotransmitter release signal transduction

“1+1>2”:Highly efficient removal of organic pollutants by composite nanofibrous membrane based on the synergistic effect of adsorption and photocatalysis

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Journal of Materials Science & Technology 2022年第29期124卷 76-85页

作者： Yuanting Xu wanting lin Dandan Yuan Shifan Chen Fang Li Yanping Long Chao He Weifeng Zhao Changsheng Zhao College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China Department of Polymer Science and Engineering Zhejiang UniversityHangzhou 310027China Med-X Center for Materials Sichuan UniversityChengdu 610041China College of Chemical Engineering Sichuan UniversityChengdu 610065China

Adsorption and photocatalysis are regarded as two desirable technologies for wastewater remediation,but are still unsatisfactory in removal effect,eco-friendly regeneration and facile *** this study,we developed a composite nanofibrous membrane material with excellent removal performance for organic pollutants based on synergistic adsorption and photocatalysis.A novel boron-doped,nitrogen-deficient graphitic carbon nitride(B-C3N4)photocatalyst as well as an amphiphilic copolymer of methyl methacrylate and acrylic acid(p(MMA-AA))were synthesized respectively,and then used to modify polyethersulfone for the fabrication of composite nanofibrous membrane with improved hydrophilicity,negativelycharge property and enhanced visible light response ***,the synergistic effect of adsorption and photocatalytic degradation for organic pollutants were identified especially and resulted in an excellent removal efficiency even superior to the combination of adsorption and photocatalytic degradation,which could be called a“1+1>2”*** addition,the regeneration and reusability,the purification ability for multicomponent wastewater,and the photocatalytic mechanism,were investigated and discussed *** this work,we not only prepared the nanofibrous membrane with synergistic effect of adsorption and photocatalysis,but also provided a versatile approach to design dualfunctional support material to ensure the practical applications of powdery photocatalyst in wastewater treatment.

关键词： Composite nanofibrous membrane material Wastewater remediation Photocatalytic degradation Adsorption Synergistic effect

Boosting photocatalytic hydrogen evolution enabled by SiO_(2)-supporting chiral covalent organic frameworks with parallel stacking sequence

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Chinese Journal of Catalysis 2024年第9期64卷 87-97页

作者： Zheng lin wanting Xie Mengjing Zhu Changchun Wang Jia Guo State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China

Two-dimensional covalent organic frameworks(2D COFs)feature extendedπ-conjugation and ordered stacking sequence,showing great promise for high-performance *** atomic frameworks of 2D COFs facilitate the in-plane photogenerated charge transfer,but the precise ordered alignment is limited due to the non-covalentπ-stacking of COF layers,accordingly hindering out-of-plane transfer ***,we address a chiral induction method to construct a parallelly superimposed stacking chiral COF ultrathin shell on the support of SiO_(2) *** to the achiral COF analogues,the chiral COF shell with the parallel AA-stacking structure is more conducive to enhance the built-in electric field and accumulates photogenerated electrons for the rapid migration,thereby affording superior photocatalytic performance in hydrogen evolution from water *** the simplest ketoenamine-linked chiral COF as a shell of SiO_(2) particle,the resulting composite exhibits an impressive hydrogen evolution rate of 107.1 mmol g^(-1)h^(-1)along with the apparent quantum efficiency of 14.31%at 475 ***,the composite photocatalysts could be fabricated into a film device,displaying a remarkable photocatalytic performance of 178.0 mmol m^(-2)h^(-1)for hydrogen *** work underpins the surface engineering of organic photocatalysts and illustrates the significance of COF stacking structures in regulating electronic properties.

关键词： Covalent organic framework Photocatalysis Hydrogen generation Chiral induction Core-shell structure

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论民法典中土地经营权之性质

西安电子科技大学学报（社会科学版） 2021年第1期31卷 80-90页

作者：林婉婷中国政法大学法学院北京市102200

流转期限为五年以上的土地经营权是用益物权。从规范目的上来说,由于土地资源生产效率以及融资功能的需要,应当将土地经营权作为用益物权,由此方能达到放活土地经营权之目标。从规范适用体系上来说,土地经营权再流转以及抵押时的“承包... 详细信息

流转期限为五年以上的土地经营权是用益物权。从规范目的上来说,由于土地资源生产效率以及融资功能的需要,应当将土地经营权作为用益物权,由此方能达到放活土地经营权之目标。从规范适用体系上来说,土地经营权再流转以及抵押时的“承包人同意”要件并不足以否定其物权性质,该要件仅决定土地经营权伴生的地租债务是否随同移转,若未经承包人同意,则土地经营权依然能够转让至受让人,只是其上的农户地租仍然停留在原土地经营权人处。从权利结构上来说,对于双层用益物权质疑的回应是,承包经营权与用益物权性质之间存在着一定裂隙,反而一定程度地偏向了所有权,因此能够在其上再设立土地经营权这一用益物权。土地经营权的物权性质也不会导致集体土地所有权与承包经营权的虚化,前者的意义更在于维持政治上的所有制,并不要求权能的具体行使。

关键词：土地经营权三权分置用益物权民法典

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“公转铁”形势下铁路货运市场发展探讨

铁道货运 2019年第8期37卷 44-48页

作者：林婉婷中国铁路北京局集团有限公司北京货运中心

在国家大力推行“公转铁”的新形势下,现阶段铁路货运具有以大宗类货物为主、受政策导向明显、现代物流转型初见成效等特点,根据新形势对铁路货运市场的影响,针对现阶段铁路货运市场存在未完全融入多式联运交通网络、“最后一公里”问... 详细信息

在国家大力推行“公转铁”的新形势下,现阶段铁路货运具有以大宗类货物为主、受政策导向明显、现代物流转型初见成效等特点,根据新形势对铁路货运市场的影响,针对现阶段铁路货运市场存在未完全融入多式联运交通网络、“最后一公里”问题、产品市场适应性不强、信息透明化程度低等不足,提出完善基础设施建设、扩大集装化运输规模、强化组织协调机制、注重规则制度衔接等短期对策,以及建设现代化铁路物流基地、搭建信息共享平台、丰富运输产品开发、推出增值服务等中长期对策,以推动铁路货运市场快速健康发展。

关键词： "公转铁" 铁路货运市场运输特点基础设施建设信息共享平台运输产品

绘本阅读与“一日生活”活动的有机整合策略研究

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当代家庭教育 2022年第10期 38-40页

作者：林婉婷福建省宁德市柘荣县实验幼儿园

绘本是兼具绘画和文字的书籍,其主要内容是通过绘画及简单的辅助文字,来讲述一个个篇幅短小又富含哲理的故事。绘本读物图文并茂,绘画内容新颖有趣,符合幼儿的阅读兴趣,深受幼儿的喜爱,因此幼儿园较为注重绘本教学。一日活动指的是幼儿... 详细信息

绘本是兼具绘画和文字的书籍,其主要内容是通过绘画及简单的辅助文字,来讲述一个个篇幅短小又富含哲理的故事。绘本读物图文并茂,绘画内容新颖有趣,符合幼儿的阅读兴趣,深受幼儿的喜爱,因此幼儿园较为注重绘本教学。一日活动指的是幼儿在幼儿园一天之内要完成的目标或任务,将绘本阅读融入一日活动中去,能够提升教学效果。本文要探讨的主要内容是如何实现绘本阅读与“一日生活”活动的有机结合。

关键词：绘本阅读 “一日生活” 有机整合

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眼科专科护士资格认证及培训的研究进展

护理学杂志 2019年第8期34卷 111-113页

作者：刘乔容林婉婷洪欢华中科技大学同济医学院附属协和医院眼科湖北武汉430000

随着医疗护理行业的改革发展及大众健康需求的逐渐提升,护理人员的职责及角色分工不断细化完善,各专业专科护士的发展及培养已成为护理行业进步的必然。本研究对眼科专科护士资格认证及培训的相关研究进行综述,以期为我国眼科专科护士... 详细信息

随着医疗护理行业的改革发展及大众健康需求的逐渐提升,护理人员的职责及角色分工不断细化完善,各专业专科护士的发展及培养已成为护理行业进步的必然。本研究对眼科专科护士资格认证及培训的相关研究进行综述,以期为我国眼科专科护士的发展及培训提供依据。

关键词：眼科专科护士资格认证培训综述文献

粪菌移植治疗儿童肠道外疾病的研究进展和临床应用前景

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生命的化学 2023年第2期43卷 221-226页

作者：林婉婷刘坚南方医科大学第二临床医学院广州510515 深圳市宝安区人民医院儿科深圳518101

肠道微生物群影响着人体的生理状况和营养吸收代谢。粪菌移植(fecal microbiota transplantation,FMT)是将健康人粪便中的功能菌群移植到患者体内,重塑肠内菌群结构进而调节人类肠道微生物群,成为新兴的治疗手段。本文回顾了近年来粪菌... 详细信息

肠道微生物群影响着人体的生理状况和营养吸收代谢。粪菌移植(fecal microbiota transplantation,FMT)是将健康人粪便中的功能菌群移植到患者体内,重塑肠内菌群结构进而调节人类肠道微生物群,成为新兴的治疗手段。本文回顾了近年来粪菌移植对儿童代谢性疾病、过敏性疾病与孤独症谱系障碍等肠道外疾病的运用与进展,表明粪菌移植治疗安全有效改变了肠道病理生理,有望成为治疗多种儿科疾病的技术。现就FMT在儿童肠道外疾病的应用现状及前景进行探讨。

关键词：粪菌移植儿童青少年临床应用

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维生素A棕榈酸酯传递体处方及工艺优化

中国医药工业杂志 2014年第8期45卷 744-749页

作者：陈文荣龙晓英陈宝林婉婷王一帆广东药学院中药学院广东广州510006 中山大学药学院广东广州510006

以粒径、ζ电位为考察指标,采用单因素法考察剪切速度、乙醇溶液滴加速度及高压均质次数等工艺因素,以及磷脂种类、表面活性剂、电解质及投药量等处方因素对维生素A棕榈酸酯(1)传递体的影响,并初步评价了传递体的稳定性。所得最佳处方... 详细信息

以粒径、ζ电位为考察指标,采用单因素法考察剪切速度、乙醇溶液滴加速度及高压均质次数等工艺因素,以及磷脂种类、表面活性剂、电解质及投药量等处方因素对维生素A棕榈酸酯(1)传递体的影响,并初步评价了传递体的稳定性。所得最佳处方与工艺为:取大豆磷脂1 g、Tween-80 0.2 g和1 0.2 g,溶于无水乙醇0.5 ml中;另取苯氧乙醇0.5 g溶于水约100 ml中。水相保持13 000 r/min的剪切速度,以2 ml/min速度滴加乙醇溶液,得初级传递体,然后在1 500 bar压力下均质1次得纳米传递体。优化后产品的平均粒径为(100.8±16.5)nm,ζ电位为(-43.7±1.1)mV,包封率为(96.2±1.2)%,但该传递体在4℃贮存6个月粒径和药物含量下降,ζ电位绝对值增大。

关键词：维生素A棕榈酸酯传递体制备优化