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石墨烯/柔性聚乳酸自传感复合材料结构3D打印与性能研究

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机械工程学报 2021年第7期57卷 215-223页

作者：田小永闫万权黄兰王清瑞李涤尘西安交通大学机械制造系统工程国家重点实验室西安710049

为了深入研究石墨烯复合材料压阻特性,解决压阻复合材料定量传感问题,实现自传感结构变形监测,通过球磨混合工艺和单螺杆挤出工艺制备了石墨烯/柔性聚乳酸复合丝材,采用材料挤出成形3D打印作为石墨烯/柔性聚乳酸自传感复合材料的结构成... 详细信息

为了深入研究石墨烯复合材料压阻特性,解决压阻复合材料定量传感问题,实现自传感结构变形监测,通过球磨混合工艺和单螺杆挤出工艺制备了石墨烯/柔性聚乳酸复合丝材,采用材料挤出成形3D打印作为石墨烯/柔性聚乳酸自传感复合材料的结构成型工艺,对导电高分子复合材料的压阻特性展开研究,探究了不同载荷条件对复合材料压阻特性的影响规律,为实现自传感结构变形监测提供了可靠的依据。最后搭建了基于Lab VIEW和实时数据采集模块的自传感结构变形重构实时监测系统,通过建立平面弯曲变形传感单元的计算模型,使用阵列传感单元实现了结构变形重构实时监测功能,其中重构形状误差低于3%。

关键词：石墨烯复合材料压阻特性 3D打印自传感变形重构

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中药三联用药法治疗胃炎临床研究

中医学报 2016年第3期31卷 436-438页

作者：颜万全开县人民医院重庆开县405400

目的:观察中药三联用药法治疗胃炎的临床疗效,并比较两组患者不良反应。方法:将96例患者随机分为对照组和治疗组,每组48例,对照组患者行西药三联用药法治疗,治疗组患者行中药三联用药法治疗。观察两组患者治疗后的临床疗效和不良反应情... 详细信息

目的:观察中药三联用药法治疗胃炎的临床疗效,并比较两组患者不良反应。方法:将96例患者随机分为对照组和治疗组,每组48例,对照组患者行西药三联用药法治疗,治疗组患者行中药三联用药法治疗。观察两组患者治疗后的临床疗效和不良反应情况。结果:治疗组患者治疗后有效率为95.83%,对照组患者治疗后有效率为79.17%,两组比较,差异有统计学意义(P<0.05);治疗后,两组患者复查肝肾功能和血常规,均为出现异常情况;治疗的过程中,治疗组患者没有出现不良反应,对照组患者有5例(占10.42%)出现轻度的腹泻,疗程结束后均好转。结论:中药三联用药法在胃炎疗效显著,并且本研究所用的加味四逆散的组方比较合理,疗效显著。

关键词：胃炎中药三联用药法加味四逆散

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Neural Regeneration Research 2025年第2期20卷 366-377页

作者： Samuel Abokyi Dennis yan-yin Tse School of Optometry The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Research Center for SHARP Vision The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Center for Eye and Vision Research Sha TinHong Kong Special Administrative RegionChina

Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecular underpinnings of their *** comprehensive review explores the mechanisms of retinal aging and investigates potential neuroprotective approaches,focusing on the activation of transcription factor *** meta-analyses have demonstrated promising outcomes of transcription factor EB-targeted strategies,such as exercise,calorie restriction,rapamycin,and metformin,in patients and animal models of these common retinal *** review critically assesses the role of transcription factor EB in retinal biology during aging,its neuroprotective effects,and its therapeutic potential for retinal *** impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and energy homeostasis in retinal neurons through the regulation of mitochondrial quality control and nutrient-sensing *** vascular endothelial cells,transcription factor EB controls important processes,including endothelial cell proliferation,endothelial tube formation,and nitric oxide levels,thereby influencing the inner blood-retinal barrier,angiogenesis,and retinal ***,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and *** retinal pigment epithelial cells,transcription factor EB modulates functions such as autophagy,lysosomal dynamics,and clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and regulating vascular endothelial growth factor A expression involved in *** cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and inflammation,ultimately offering pro

关键词： age-related macular degeneration anti-aging interventions autophagy calorie restriction diabetic retinopathy exercise glaucoma neuromodulation phagocytosis photoreceptor outer segment degradation retinal aging transcription factor EB

Autophagy-targeting modulation to promote peripheral nerve regeneration

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Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： yan Chen Hongxia Deng Nannan Zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu Zhang yanyu Zhang yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

Sonochemical synthesis and characterization of magnetic separable Fe_(3)O_(4)-TiO_(2)nanocomposites and their catalytic properties

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International Journal of Smart and Nano Materials 2010年第4期1卷 278-287页

作者： wanquan Jiang Xueping Zhang Xinglong Gong Fangfang yan Zhong Zhang Department of Chemistry University of Science and Technology of China(USTC)Hefei 230026PR China CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern MechanicsUSTCHefei 230027PR China National Center for Nanoscience and Technology Beijing 100080PR China

A novel sonochemical method is described for the preparation of Fe_(3)O_(4)–TiO_(2)photocatalysts in which nanocrystalline titanium dioxide particles are directly coated onto a magnetic *** Fe_(3)O_(4)nanoparticles were partially embedded in TiO_(2)***_(2)nanocrystallites were obtained by hydrolysis and condensation of titanium tetraisopropyl in the presence of ethanol and water under high-intensity ultrasound *** method is attractive since it eliminated the high-temperature heat treatment required in the conventional sol–gel method,which is important in transforming amorphous titanium dioxide into a photoactive crystalline *** comparison to other methods,the developed method is simple,mild,green and *** magnetization hysteresis loop for Fe_(3)O_(4)–TiO_(2)nanocomposites indicates that the hybrid catalyst shows superparamagnetic characteristics at room *** activity studies confirmed that the as-prepared nanocomposites have high photocatalytic ability toward the photodegradation of RhB ***,the photodecomposition rate decreases only slightly after six cycles of the photocatalysis ***,these Fe_(3)O_(4)–TiO_(2)nanocomposites can be served as an effective and conveniently recyclable photocatalyst.

关键词： sonochemical synthesis recyclable photocatalyst TiO_(2)nanocomposite rhodamine B degradation

Neuronal regulated cell death in aging-related neurodegenerative diseases:key pathways and therapeutic potentials

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Neural Regeneration Research 2025年第8期20卷 2245-2263页

作者： Run Song Shiyi Yin Jiannan Wu Junqiang yan Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Neuromolecular Biology Laboratory The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Regulated cell death(such as apoptosis,necroptosis,pyroptosis,autophagy,cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathways and molecular effectors,and has been proven to be an important regulatory mechanism for regulating neuronal aging and ***,excessive activation of regulated cell death may lead to the progression of aging-related *** review summarizes recent advances in the understanding of seven forms of regulated cell death in age-related ***,the newly identified ferroptosis and cuproptosis have been implicated in the risk of cognitive impairment and neurodegenerative *** forms of cell death exacerbate disease progression by promoting inflammation,oxidative stress,and pathological protein *** review also provides an overview of key signaling pathways and crosstalk mechanisms among these regulated cell death forms,with a focus on ferroptosis,cuproptosis,and *** instance,FDX1 directly induces cuproptosis by regulating copper ion valency and dihydrolipoamide S-acetyltransferase aggregation,while copper mediates glutathione peroxidase 4 degradation,enhancing ferroptosis ***,inhibiting the Xc-transport system to prevent ferroptosis can increase disulfide formation and shift the NADP^(+)/NADPH ratio,transitioning ferroptosis to *** insights help to uncover the potential connections among these novel regulated cell death forms and differentiate them from traditional regulated cell death *** conclusion,identifying key targets and their crosstalk points among various regulated cell death pathways may aid in developing specific biomarkers to reverse the aging clock and treat age-related neurodegenerative conditions.

关键词： apoptosis autophagy cuproptosis disulfidptosis ferroptosis necroptosis neurodegenerative disease neurological aging diseases PANoptosis pyroptosis

Development and prospect of near-infrared spectroscopy-assisted schizophrenia diagnosis based on bibliometrics

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World Journal of Psychiatry 2025年第1期15卷 7-11页

作者： yan Zhang Hao-Yu Xing Juan yan Administration Office Lishui Second People’s HospitalLishui 323060Zhejiang ProvinceChina Department of Medical Engineering The Affiliated Mental Health Center&Hangzhou Seventh People's HospitalZhejiang University School of MedicineHangzhou 310013Zhejiang ProvinceChina Quality Control Office The Affiliated Mental Health Center&Hangzhou Seventh People's HospitalZhejiang University School of MedicineHangzhou 310013Zhejiang ProvinceChina

In this editorial,we comment on the recent article by Fei et al exploring the field of near-infrared spectroscopy(NIRS)research in schizophrenia from a bibliometrics *** recent years,NIRS has shown unique advantages in the auxiliary diagnosis of schizophrenia,and the introduction of bibliometrics has provided a macro perspective for research in this *** the opportunities brought about by these technological developments,remaining challenges require multidi-sciplinary approach to devise a reliable and accurate diagnosis system for ***,NIRS-assisted technology is expected to contribute to the division of methods for early intervention and treatment of schizophrenia.

关键词： Bibliometrics Schizophrenia Near-infrared spectroscopy Diagnostic technique Data analysis

Curcumin in gastric cancer treatment:A commentary on mechanistic insights and future directions

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 265-267页

作者： Xin-Yue Wei Wen-Bo Cao Sai-Jun Mo Zhi-yan Sun Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medical Science Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Special Service No.988 Hospital of the Joint Service Support Force of PLAZhengzhou 450042Henan ProvinceChina

The study by yang et al presents a comprehensive investigation into the thera-peutic potential of curcumin for gastric cancer(GC).Using network pharma-cology,the researchers identified 48 curcumin-related genes,31 of which overlap with GC *** genes,including ESR1,EGFR,CYP3A4,MAPK14,CYP1A2,and CYP2B6,are linked to poor survival in GC *** docking con-firmed strong binding affinity of curcumin to these *** vitro experiments demonstrated that curcumin effectively inhibits the growth and proliferation of BGC-823,suggesting its therapeutic potential in GC through multiple targets and pathways.

关键词： Curcumin Gastric cancer Network pharmacology Mechanism of action In vitro experiments