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Chinese Journal of Chemistry 2024年第19期42卷 2346-2350页

作者： wanqing zuo Yu Cheng Zhizhen Zhu Lingling zuo Xiao Geng Zhifang Li Lei Wang Advanced Research Institute and School of Pharmaceutical Sciences Taizhou UniversityJaojiangZhejiang318000China College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of EducationHangzhou Normal UniversityHangzhouZhejiang 311121China

Comprehensive Summary Catalytic and green strategies for the synthesis of privileged scaffolds are synthetically *** now report a radical-polar crossover(RPC)-enabled three-component cyclization of bromodifluoroalkyls with enaminones and 6-aminouraciles via a visible-light-induced domino *** reaction exhibited a broad substrate scope(>40 examples)including complex molecules,which highlighted the utility of this strategy for the construction of a library of bioactive analogs.

关键词： Photocatalysis Heterocycles Radicals Bromodifluoroalkyls 6-Aminouraciles Enaminones

Switchable Multicomponent Cyclization Reactions to Access Fluoroalkylated Dihydropyrimidines and Pyrimidines under Solvent-Free Conditions

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Chinese Journal of Chemistry 2024年第12期42卷 1394-1398页

作者： wanqing zuo Zhizhen Zhu Yu Cheng Lingling zuo Xiao Geng Zhifang Li Lei Wang College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material TechnologyMinistryof EducationHangzhouNormal UniversityHangzhouZhejiang311121China Advanced Research Institute and School of Pharmaceutical Sciences Taizhou UniversityJiaojiangZhejiang 318000China state Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai200032China

Comprehensive Summary The development of switchable solvent-free multicomponent reactions to build high-value-added products is an important demand for organic ***,we detailed the successful implementation of a switchable strategy for the construction of diverse 4-fluoroalkyl-1,4-dihydropyrimidines and 4-fluoroalkyl-pyrimidines via a solvent/additive-free[3+2+1]annulation,starting from readily available enamines,trifluoroacetaldehyde hydrate or 1-ethoxy-2,2-difluoroethanol and amidines *** reaction conforms to the concept of green synthesis,and provides a new avenue to access valuable fluorinated heterocycles.

关键词： Fluorine chemistry Multicomponent reactions Environmental chemistry Heterocycles Enaminones Amidines

Synergy of Anodic Oxidation and Cathodic Reduction Leads to Electrochemical C—H Halogenation

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Chinese Journal of Chemistry 2019年第6期37卷 611-615页

作者： Zhilin Zhou Yong Yuan Yangmin Cao Jin Qiao Anjin Yao Jing Zhao wanqing zuo Wenjie Chen Aiwen Lei National Research Center for Carbohydrate Synthesis Jiangxi Normal UniversityNanchangJiangxi 330022China College of Chemistry and Molecular Sciences Institute for Advanced Studies (IAS)Wuhan UniversityWuhanHubei 430072China

We herein uncovered an electrochemical C—H halogenation protocol that synergistically combines anodic oxidation and cathodic reduction for C—X bond formation. The reaction was demonstrated under exogenous-oxidant-free conditions. Moreover, this is the first example of activating CBr4, CHBr3, and CCl3Br under electrochemical conditions.

关键词： anodic oxidation cathodic reduction electrochemistry C-H halogenation synthetic methods

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煤矸石的综合利用技术

环境与发展 2014年第4期26卷 122-123页

作者：左万庆奥尼斯付振娟内蒙古自治区环境科学研究院呼和浩特010010

针对矿区煤矸石大量存在的现状,分析了煤矸石的来源和种类;根据其组成和性质进行优化分类,给出了不同种类的煤矸石对应的综合利用技术;最后对煤矸石的综合利用技术的前景进行了展望。

关键词：煤矸石综合利用

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反渗透浓水回用乙炔发生工段的可行性分析

环境与发展 2015年第2期27卷 101-103页

作者：付振娟刘倩雯左万庆内蒙古自治区环境科学研究院呼和浩特010010

以内蒙古某13万t/a PVA企业为例,针对湿法乙炔发生工段用水特点,从水量、水质、电石渣对水泥品质的影响和经济效益等方面分析反渗透浓水回用湿法乙炔工段的可行性。

关键词：反渗透浓水乙炔发生回用可行性

National cancer incidence and mortality in China, 2012

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Chinese Journal of Cancer Research 2016年第1期28卷 1-11页

作者： wanqing Chen Rongshou Zheng Tingting zuo Hongmei Zeng Siwei Zhang Jie He Cancer Hospital Chinese Academy of Medical Sciences Peking Union Medical College & National Cancer Center Beijing 100021 China

Background： Population-based cancer registration data in 2012 from all available cancer registries were collected by the National Central Cancer Registry （NCCR）. NCCR estimated the numbers of new cancer cases and cancer deaths in China with compiled cancer incidence and mortality rates. Methods： In 2015, there were 261 cancer registries submitted cancer incidence and deaths occurred in 2012. All the data were checked and evaluated based on the NCCR criteria of data quality. Qualified data from 193 registries were used for cancer statistics analysis as national estimation. The pooled data were stratified by area （urban/rural）, gender, age group [0, 1-4, 5-9, 10-14, ..., 85＋] and cancer type. New cancer cases and deaths were estimated using age-specific rates and corresponding national population in 2012. The Chinese census data in 2000 and Segi＇s population were applied for age-standardized rates. All the rates were expressed per 100,000 person-year. Results： Qualified 193 cancer registries （74 urban and 119 rural registries） covered 198,060,406 populations （100,450,109 in urban and 97,610,297 in rural areas）. The percentage of cases morphologically verified （NIV%） and death certificate-only cases （DCO%） were 69.13% and 2.38%, respectively, and the mortality to incidence rate ratio （M/I） was 0.62. A total of 3,586,200 new cancer cases and 2,186,600 cancer deaths were estimated in China in 2012. The incidence rate was 264.85/100,000 （289.30/100,000 in males, 239.15/100,000 in females）, the age-standardized incidence rates by Chinese standard population （ASIRC） and by world standard population （ASIRW） were 191.89/100,000 and 187.83/100,000 with the cumulative incidence rate （0-74 age years old） of 21.82%. The cancer incidence, ASIRC and ASIRW in urban areas were 277.17/100,000, 195.56/100,000 and 190.88/100,000 compared to 251.20/100,000, 187.10/100,000 and 183.91/100,000 in rural areas, respectively. The cancer mortality was 161.49/ 100,000 （ 198.99/100,000 in males,

关键词： Cancer registry incidence mortality epidemiology China

Epidemiology and trend analysis on malignant mesothelioma in China

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Chinese Journal of Cancer Research 2017年第4期29卷 361-368页

作者： Jun Zhao Tingting zuo Rongshou Zheng Siwei Zhang Hongmei Zeng Changfa Xia Zhixun Yang wanqing Chen National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China

Objective： Population-based cancer registration data were used to analyze the epidemiology and trend of malignant mesothelioma in China, and the result would provide basic data for its prevention and control. Methods： Malignant mesothelioma data in 2013 were retrieved from the database of National Cancer Registry. Malignant mesothelioma incidence and mortality were estimated using age-specific rate by urban/rural and gender according to the national population in 2013. Malignant mesothelioma data from 22 cancer registries were used for trend analysis during 2000-2013. Results： It is estimated that there were 2,041 new malignant mesothelioma cases and 1,659 malignant mesothelioma deaths occurred in 2013. The crude incidence rate in China were 1.50/106 （males 1.67/106, females 1.32/106）, age-standardized incidence rates by Chinese standard population （ASIRC） and by world standard population （ASIRW） were 1.03/106 and 1.02/106, respectively. The crude mortality rate in China was 1.22/106 （males 1.67/106, females 1.32/106）, age-standardized mortality rates by Chinese standard population （ASMRC） and by world standard population （ASMRW） were 0.83/106 and 0.81/106, respectively. There was an increasing trend of incidence rate for malignant mesothelioma in registration areas of China during 2000-2013 with annual percentage change （APC） of 2.5% [95% confidence interval （95% CI）： 0.6%--4.5%]. After age standardization, no significant differences were observed. No matter for crude mortality rates or age-standardized mortality rates, no significant differences were observed during 2000-2013. Conclusions： Malignant mesothelioma is the major occupational and environmental neoplasm associated with asbestos exposure. The increasing incidence trend suggests that more attention should be paid on this disease.

关键词： Malignant mesothelioma incidence mortality trend cancer registry

Cancer incidence and mortality in China in 2013：an analysis based on urbanization level

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Chinese Journal of Cancer Research 2017年第1期29卷 1-10页

作者： wanqing Chen Rongshou Zheng Siwei Zhang Hongmei Zeng Tingting zuo Changfa Xia Zhixun Yang Jie He National Central Cancer Registry National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China

Objective： To explore the cancer patterns in areas with different urbanization rates（URR） in China with data from 255 population-based cancer registries in 2013, collected by the National Central Cancer Registry（NCCR）.Methods： There were 347 cancer registries submitted cancer incidence and deaths occurred in 2013 to *** those data were checked and evaluated based on the NCCR criteria of data quality, and qualified data from 255 registries were used for this analysis. According to the proportion of non-agricultural population, we divided cities/counties into 3 levels： high level, with URR equal to 70% and higher; median level, with URR between 30%and 70%; and low level, with URR equal to 30% and less. Cancer incidences and mortalities were calculated,stratified by gender and age groups in different areas. The national population of Fifth Census in 2000 and Segi＇s population were applied for age-standardized ***： Qualified 255 cancer registries covered 226,494,490 populations. The percentage of cases morphologically verified（MV%） and death certificate-only cases（DCO%） were 68.04% and 1.74%, respectively,and the mortality to incidence rate ratio（M/I） was 0.62. A total of 644,487 new cancer cases and 399,275 cancer deaths from the 255 cancer registries were submitted to NCCR in 2013. The incidence rate was 284.55/100,000（314.06/100,000 in males, 254.19/100,000 in females）, and the age-standardized incidence rates by Chinese standard population（ASIRC） and by world standard population（ASIRW） were 190.10/100,000 and 186.24/100,000 with the cumulative incidence rate（0–74 age years old） of 21.60%. The cancer mortality was 176.28/100,000（219.03/100,000 in males, 132.30/100,000 in females）, and the age-standardized mortality rates by Chinese standard population（ASMRC） and by world standard population（ASMRW） were 110.91/100,000 and 109.92/100,000, and the cumulative mortality rate（0–74 age years old） was 12.43%. Low urbanization areas were high in crude cancer in

关键词： Cancer incidence mortality epidemiology urbanization China

The influence of stage at diagnosis and molecular subtype on breast cancer patient survival: a *** *** study

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Chinese Journal of Cancer 2017年第11期36卷 647-656页

作者： Tingting zuo Hongmei Zeng Huichao Li Shuo Liu Lei Yang Changfa Xia Rongshou Zheng Fei Ma Lifang Liu Ning Wang Lixue Xuan wanqing Chen National Office for Cancer Prevention and Control & National Central Cancer Registry National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 P. R.China Key Laboratory of Carcinogenesis and Translation Research (Ministry of Education/Beijing) Beijing Office for Cancer Prevention and Control Peking University Cancer Hospital & Institute Beijing 100142 P. R. China Department of Medical Oncology National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 P. R. China Department of Statistics The European Organization for Research and Treatment of Cancer (EORTC) 111200 Brussels Belgium Department of Breast Surgery National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 P. R. China

Background: Stage at diagnosis and molecular subtype are important clinical factors associated with breast cancer patient survival. However, subgroup survival data from a large study sample are limited in *** estimate the survival differences among patients with different stages and various subtypes of breast cancer, we conducted a hospital-based multi-center study on breast cancer in Beijing, ***: All resident patients diagnosed with primary, invasive breast cancer between January 1,2006 and December 31,2010 from four selected hospitals in Beijing were included and followed up until December 31,2015. Hospitalbased data of stage at diagnosis, hormone receptor status, and selected clinical characteristics, including body mass index(BMI), menopausal status, histological grade, and histological type, were collected from the medical records of the study subjects. Overall survival(OS) and cancer-specific survival(CSS) were estimated. Cox proportional hazards models were employed to evaluate the associations of stage at diagnosis and molecular subtype with patient ***: The 5-year OS and CSS rates for all patients were 89.4% and 90.3%. Survival varied by stage and molecular subtype. The 5-year OS rates for patients with stage I, Ⅱ, Ⅲ, and IV diseases were 96.5%, 91.6%, 74.8%, and 40.7%,respectively, and the corresponding estimates of 5-year CSS rates were 97.1%, 92.6%, 75.6%, and 42.7%, *** 5-year OS rates for patients with luminal A, luminal B, HER2, and triple-negative subtypes of breast cancer were92.6%, 88.4%, 83.6%, and 82.9%, respectively, and the corresponding estimates of 5-year CSS rates were 93.2%, 89.1 %,85.4%, and 83.5%, respectively. Multivariate analysis showed that stage at diagnosis and molecular subtype were important prognostic factors for breast ***: Survival of breast cancer patients varied significantly by stage and molecular subtype. Cancer screening is encouraged for the early detection and earl

关键词： Breast cancer Stage Molecular subtype Survival China

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中国乳腺癌全人群生存率分析研究进展

中国肿瘤临床 2016年第14期43卷 639-642页

作者：左婷婷陈万青中国医学科学院北京协和医学院肿瘤医院国家癌症中心全国肿瘤防治研究办公室北京市100021

乳腺癌是女性最常见的恶性肿瘤之一,在我国乃至全球乳腺癌居女性恶性肿瘤发病率首位,严重影响女性的健康。人群为基础的癌症生存分析能够反映某一国家或地区癌症预防、诊断、治疗的整体水平,为有针对性地制定卫生政策提供基础数据支持... 详细信息

乳腺癌是女性最常见的恶性肿瘤之一,在我国乃至全球乳腺癌居女性恶性肿瘤发病率首位,严重影响女性的健康。人群为基础的癌症生存分析能够反映某一国家或地区癌症预防、诊断、治疗的整体水平,为有针对性地制定卫生政策提供基础数据支持。在世界范围内由于人种、社会经济文化、基础医疗保健、诊疗水平等多方面存在差异,不同国家或地区乳腺癌生存率差距较大。乳腺癌生存率与肿瘤分期、受体状态、治疗方式等密切相关,通过深入比较相关因素与乳腺癌生存率的关系,为预测乳腺癌预后、提高临床诊疗水平提供帮助。本文着重概述国内外乳腺癌生存现状,并针对目前我国癌症监测工作提供相关参考建议。

关键词：乳腺肿瘤人群为基础生存分析癌症监测