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The characteristics of driver lane-changing behaviour in congested road environments

Transportation Safety and Environment 2024年第3期6卷 96-110页

作者： wanqi wang Guozhu Cheng School of Traffic and Transportation Northeast Forestry UniversityHarbin 150040HeilongjiangChina

Lane-changing behaviour is one of the complex|driving *** lane-changing behaviour of drivers may exacerbate congestion,however driver behavioural characteristics are difficult to accurately acquire and quantify,and thus tend to be simplified or ignored in existing lane-changing *** this paper,the Bik-means clustering algorithm is used to analyse the urban road congestion state discrimination ***,simulated driving tests were conducted for different traffic congestion *** the force feedback system and infrared camera,the data of driver lane-changing behaviours at different traffic congestion levels are obtained separately,and the definitions of the start and end points of a vehicle changing lanes are ***,statistical analysis and discussion of key feature parameters including driver lane-changing behaviour data and visual data under different levels of traffic congestion were *** is found that the average lane-change intention times in each congestion state are 2 s,4 s,6 s and 7 s,while the turn-signal duration and the number of rear-view mirror observations have similar patterns of change to the data on lane-changing intention ***,drivers’pupil diameters become smaller during the lane-changing intention phase,and then relatively enlarge during lane-changing;the range of pupil variation is roughly 3.5 mm to 4 *** frequency of observing the vehicle in front of the target lane increased as the level of congestion increased,and the frequency of observation in the driver’s mirrors while changing lanes approximately doubled compared to driving straight ahead,and this ratio increased as the level of congestion increased.

关键词： road congestion lane-changing behaviour Bik-means clustering algorithm characterization study

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基于改进RandLA-Net的铁路桥梁点云构件级分割方法

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中国铁路 2024年第4期 42-48页

作者：吴承文王万齐卢文龙中国铁道科学研究院研究生部北京100081 中国铁道科学研究院集团有限公司电子计算技术研究所北京100081

随着无人机和激光扫描技术的快速发展,点云数据成为铁路桥梁施工进度管理的重要信息源。桥梁构件级结构的精细分割是施工进度监测和工期评估的关键步骤。为此,提出基于RandLA-Net改进的铁路桥梁点云构件级分割方法。首先,顾及自注意力机... 详细信息

随着无人机和激光扫描技术的快速发展,点云数据成为铁路桥梁施工进度管理的重要信息源。桥梁构件级结构的精细分割是施工进度监测和工期评估的关键步骤。为此,提出基于RandLA-Net改进的铁路桥梁点云构件级分割方法。首先,顾及自注意力机制,捕捉离散点之间的全局上下文语义关系,并嵌入位置编码块,增强点的位置特征;其次,根据输入特征动态调整权重或池化操作,改进注意力池化模块,使网络集中关注输入数据的特定区域,自适应地聚合来自相邻点的信息。结果表明,该方法在实际处理铁路桥梁点云数据集时,比RandLA-Net的平均交并比提升了2.4%,具有良好的分割性能。

关键词：三维点云深度学习语义分割铁路工程数据注意力机制点云数据

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基于知识图谱的铁路工程实体信息表达方法与应用

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铁道建筑 2024年第5期64卷 157-162页

作者：刘泽洋王万齐卢文龙中国铁道科学研究院研究生部北京100081 中国铁道科学研究院集团有限公司电子计算技术研究所北京100081

为解决铁路工程实体在多种标准下的铁路实体单元粒度不一致、语义异构性突出的问题,提出一种基于知识图谱的铁路工程实体信息表达方法并进行了应用场景研究。通过梳理铁路现有标准以及结构化和非结构化数据文档,从铁路桥梁与隧道工程出... 详细信息

为解决铁路工程实体在多种标准下的铁路实体单元粒度不一致、语义异构性突出的问题,提出一种基于知识图谱的铁路工程实体信息表达方法并进行了应用场景研究。通过梳理铁路现有标准以及结构化和非结构化数据文档,从铁路桥梁与隧道工程出发,定义了铁路工程实体的本体模型分类体系,并采用自上而下的方式逐步建立知识图谱本体,形成了铁路工程实体集成表达知识图谱的本体层。通过Aho-Corasick等算法建立编码的Jena推理规则库,将EBS(Engineering Breakdown Structure)、IFD(International Framework for Dictionaries)和工程量清单编码与知识图谱本体进行挂接,实现了铁路工程实体的编码映射。在此基础上,搭建Jena-Fuseki服务器与Bentley二次开发插件结合的架构体系,设计了多种功能模块,基于铁路工程实体知识图谱实现了信息抽取与应用。实现了在多源异质性的铁路工程信息模型背景下,基于知识图谱满足铁路工程实体的统一表达和精准映射与应用。

关键词：知识图谱铁路工程编码映射知识推理二次开发

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模数一体化平台赋能下的智能高铁2.0关键技术展望

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中国铁路 2024年第7期 1-6页

作者：王同军王万齐李平卢文龙中国国家铁路集团有限公司北京100844 中国铁道科学研究院集团有限公司电子计算技术研究所北京100081 中国铁道科学研究院集团有限公司科技和信息化部(总工室) 北京100081

依托京张高铁重大工程,中国铁路融合应用多项数智化技术形成智能高铁1.0成套技术,并推广应用到多条新建线路。随着建造、装备、运营等领域智能化应用的不断深入,对模型、数据一体化共享和分析的需求日益迫切。分析模数一体化的内涵及关... 详细信息

依托京张高铁重大工程,中国铁路融合应用多项数智化技术形成智能高铁1.0成套技术,并推广应用到多条新建线路。随着建造、装备、运营等领域智能化应用的不断深入,对模型、数据一体化共享和分析的需求日益迫切。分析模数一体化的内涵及关键,提出由模数汇聚层、模数存储层、模数管理层、模数计算层、模数聚合层等构成的模数一体化平台总体架构,并展望工程智能勘察及生成式设计、全专业智能施工、铁路工程数字孪生、CR450智能动车组、新一代铁路专用移动通信(5G-R)、多源信息感知、传输与融合分析的运营安全防护、基于位移的全行程智能服务(MaaS+)、区域路网的智能综合调度、动车组轮轨一体化智能维修等领跑型关键技术和多项创新型关键技术,可为数字铁路建设、智能高铁2.0科技攻关提供指导和借鉴。

关键词：智能高铁2.0 模数一体化平台数智化数字铁路

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氨氮、镉胁迫下对虾Hippo通路对肠道恢复的响应

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水产科学 2024年第4期43卷 622-629页

作者：廖国威虞娇萍王莞淇范兰芬华南农业大学海洋学院海洋生物资源保护与利用粤港澳高校联合实验室广东广州510642 华南农业大学农业绿色发展研究中心广东广州510642

为探明在氨氮和镉分别胁迫下凡纳滨对虾Hippo信号通路对肠道损伤恢复的响应,在(3.99±0.50)g对虾胁迫阶段(0、24、48 h),以及恢复阶段的3、6、12、24、48 h检测Hippo信号通路中部分基因在肠道组织中的表达情况,同时进行肠道组织学观察... 详细信息

为探明在氨氮和镉分别胁迫下凡纳滨对虾Hippo信号通路对肠道损伤恢复的响应,在(3.99±0.50)g对虾胁迫阶段(0、24、48 h),以及恢复阶段的3、6、12、24、48 h检测Hippo信号通路中部分基因在肠道组织中的表达情况,同时进行肠道组织学观察。结果显示:在氨氮胁迫48 h后恢复阶段,与对照组相比,Wts、Yki、TEAD基因表达量在恢复阶段的6 h极显著升高(P<0.01);TEAD基因表达量在恢复阶段的12 h显著升高(P<0.05);Hpo基因表达量除在恢复阶段的3 h无显著差异外,其余阶段均极显著降低(P<0.01);Wts基因表达量在恢复阶段的3 h和恢复阶段的24 h极显著降低(P<0.01)且在恢复阶段的12 h和48 h显著降低(P<0.05)。在镉胁迫后,与对照组相比,Wts基因表达量在胁迫后24 h和48 h均极显著降低(P<0.01);Hpo和Wts基因表达量除Hpo基因表达量在恢复阶段的6 h和Wts基因表达量在恢复阶段的48 h无显著差异外,其余时间均极显著降低(P<0.01);Yki基因表达量在恢复阶段的6、12 h和24 h均极显著升高(P<0.01);TEAD基因表达量在恢复阶段的6 h极显著升高(P<0.01)。同时,肠道组织学分析显示,对虾肠道分别在氨氮胁迫后的48 h和镉胁迫后24 h肠绒毛完全脱落,在恢复阶段的24 h肠绒毛有明显的恢复生长迹象。试验结果表明,Hippo信号通路参与凡纳滨对虾氨氮和镉单因素胁迫下肠绒毛恢复与再生过程的调控。

关键词：凡纳滨对虾氨氮胁迫镉胁迫 Hippo信号通路肠组织损伤

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高速铁路智能建造标准体系研究

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中国铁路 2024年第7期 21-29页

作者：王万齐郭芳贺晓玲卢文龙张晨李子龙中国铁道科学研究院集团有限公司电子计算技术研究所北京100081

随着数字化与智能化技术的发展,铁路工程建设领域的智能化水平也在不断提升。建立统一的高速铁路智能建造标准体系,成为进一步提升智能建造水平的关键因素。聚焦智能高速铁路下的智能建造板块,分析国内外工程建设标准制定情况和智能建... 详细信息

随着数字化与智能化技术的发展,铁路工程建设领域的智能化水平也在不断提升。建立统一的高速铁路智能建造标准体系,成为进一步提升智能建造水平的关键因素。聚焦智能高速铁路下的智能建造板块,分析国内外工程建设标准制定情况和智能建造技术应用与标准制定现状,探讨高速铁路智能建造标准体系编制需求,对高速铁路智能建造标准体系开展结构分析,提出高速铁路智能建造标准体系架构并进一步明确标准体系框架及各部分的制定内容,可为铁路智能建造标准制修订提供指导。

关键词：智能高铁工程建设智能建造标准体系

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Developmental and epileptic encephalopathy 44 due to compound heterozygous variants in the UBA5 gene:a case report

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Acta Epileptologica 2023年第4期6卷 264-271页

作者： Suli Zhang Shuangzhu Lin wanqi wang Yuru Gan Cui wang Bangtao Li Qiming Pang Department of Neuroscience Hainan Women and Children’s Medical CenterHaikou570100China Diagnosis and Treatment Center for Children First Affiliated HospitaltoChangchun University of Chinese MedicineChangchun130021China Changchun University of Chinese Medicine Changchun University of Chinese Medicine Graduate SchoolChangchun130000China

Background Developmental and epileptic encephalopathy(DEE)is a group of rare inherited disorders characterized by intellectual disability,delayed development,epileptic seizures,and other related ***44 is caused by mutations in the UBA5 gene,which encodes a ubiquitin-like protein involved in protein degradation and cell ***,there is limited information on the genotype–phenotype correlation of DEE44,and its clinical features remain to be fully *** presentation We report a 12-month-old infant who presented with epileptic spastic seizures beginning at 4 months of age,accompanied by overall developmental delay,short stature,microcephaly,inability to hold his head upright,chasing vision,and high muscle tone in the *** findings showed compound heterozygous mutations of the UBA5 gene:NM_024818 c.562C>T(p.R188X)from the mother and NM_024818 c.214C>T(p.R72C)from the *** This case report expands the clinical spectrum of DEE44 and highlights the importance of considering DEE44 in the differential diagnosis of developmental delay and epilepsy,even in the absence of classical symptoms suggestive of the *** hope that this case report will advance the understanding of DEE44 and improve the expertise of clinicians and early diagnose of this disease.

关键词： Infantile spasms Epilepsy Developmental and epileptic encephalopathy UBA5 gene

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ABCA1 is associated with the development of acquired chemotherapy resistance and predicts poor ovarian cancer outcome

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Cancer Drug Resistance 2021年第2期4卷 485-502页

作者： wanqi wang Noor A Lokman Tannith M Noye Anne M Macpherson Martin K Oehler Carmela Ricciardelli Adelaide Medical School Robinson Research InstituteUniversity of AdelaideAdelaideSA 5000Australia Department of Gynaecological Oncology Royal Adelaide HospitalAdelaideSA 5000Australia.

Aim:This study investigated the ATP binding cassette(ABC)transporter(ABCA1,ABCB1,ABCB3,ABCC2 and ABCG2)expression in high grade serous ovarian cancer(HGSOC)tissues,cell lines and primary cells to determine their potential relationship with acquired chemotherapy resistance and patient ***:ABC transporter mRNA and protein expression(ABCA1,ABCB1,ABCB3,ABCC2 and ABCG2)was assessed in publicly available datasets and in a tissue microarray(TMA)cohort of HGSOC at diagnosis,*** transporter mRNA expression was also assessed in chemosensitive ovarian cancer cell lines(OVCAR-5 and CaOV3)versus matching cell lines with acquired carboplatin resistance and in primary HGSOC cells from patients with chemosensitive disease at diagnosis(n=10)as well as patients with acquired chemotherapy resistance at relapse(n=6).The effects of the ABCA1 inhibitor apabetalone in carboplatin-sensitive and-resistant cell lines were also ***:High ABCA1 mRNA and protein expression was found to be significantly associated with poor patient ***1 mRNA and protein levels were significantly increased in ovarian cancer cell lines(OVCAR-5 CBPR and CaOV3 CBPR)with acquired carboplatin ***1 mRNA was significantly increased in primary HGSOC cells obtained from patients with acquired chemotherapy *** treatment reduced ABCA1 protein expression and increased the sensitivity of both parental and carboplatin-resistant ovarian cancer cells to ***: These results suggest that inhibiting ABCA1 transporter may be useful in overcoming acquired chemotherapy resistance and improving outcome for patients with HGSOC.

关键词： HGSOC chemotherapy resistance ABC transporter ABCA1 ABCB1 TAP2 ABCB3 ABCC2 ABCG2 apabetalone

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Gene characterization and phylogenetic analysis of four mitochondrial genomes in Caenogastropoda

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Acta Oceanologica Sinica 2024年第2期43卷 137-150页

作者： Jiangyong Qu wanqi Yang Xindong Teng Li Xu Dachuan Zhang Zhikai Xing Shuang wang Xiumei Liu Lijun wang Xumin wang College of Life Science Yantai UniversityYantai 264005China Qingdao International Travel Healthcare Center Qingdao 266071China Qingdao Dagang Customs Qingdao 266071China

Caenogastropoda is a highly diverse group,containing~60%of all existing *** in this subclass predominantly inhabit marine environments and have a high ecological and economic *** to the increase in relevant phylogenetic studies,our understanding of between species relatedness in Caenogastropoda has ***,the biodiversity,taxonomic status,and phylogenetic relationships of this group remain *** the present study,we performed next-generation sequencing of four complete mitochondrial genomes from three families(Buccinidae,Columbellidae,and Cypraeidae)and the four mitogenomes were classical circular structures,with a length of 16177 bp in Volutharpa ampullacea,16244 bp in Mitrella albuginosa,16926bp in Mauritia arabica asiatica and 15422 bp in Erronea *** composition analysis indicated that whole sequences were biased toward A and *** compared them with 171 complete mitochondrial genomes of *** phylogenetic relationship of Caenogastropoda derived from Maximum Likelihood(ML)and Bayesian Inference(BI)trees constructed based on CDS sequences was consistent with the results of traditional morphological analysis,with all three families showing close *** study supported Caenogastropoda at the molecular level as a separate clade of *** to our divergence time estimations,Caenogastropoda was formed during the middle Triassic period(~247.2–237 Ma).Our novel mitochondrial genomes provide evidence for the speciation of Caenogastropoda in addition to elucidating the mitochondrial genomic evolution of this subclass.

关键词： mitochondrial genome phylogenetic analysis Caenogastropoda

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Exploring the molecular mechanisms and potential therapeutic strategies of ferroptosis in ovarian cancer

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BIOCELL 2024年第3期48卷 379-386页

作者： LISHA MA wanqi SHAO WEILI ZHU Department of Gynecology Jiaxing University Master Degree Cultivation BaseZhejiang Chinese Medical UniversityJiaxingChina Department of Gynecology Jiaxing University Affiliated Women and Children’s HospitalJiaxingChina

The morbidity rate of ovarian cancer,a malignant tumour in gynaecological tumours,is rising,and it is considered to be the most lethal *** majority of patients are typically diagnosed during the advanced stages of the illness due to the elusive characteristics of ovarian cancer and an absence of highly sensitive and speciﬁc diagnostic *** excision of the lesions,along with chemotherapy,is the conventional treatment for ovarian cancer;however,resistance to platinum-based chemotherapeutic drugs and molecular targeted therapies frequently *** the survival rate and prognosis of patients with end-stage or recurring ovarian cancer requires the identiﬁcation of new therapeutic targets due to the absence of efﬁcient medications,and this has emerged as a highly demanding *** have demonstrated that ferroptosis effectively hinders the proliferation of ovarian cancer and induces the demise of malignant *** is composed of the cystine/glutamate antiporter system(the system Xc-)and glutathione peroxidase 4(GPX4).Solute carrier family 7 member 11(SLC7A11)and solute carrier family 3 member 2(SLC3A2)play crucial roles in the regulation of ferroptosis by facilitating the uptake of cystine into cells and the efﬂux of glutamate out of cells,*** cells,GPX4 is the exclusive enzyme employed for reducing liposomal peroxide through glutathione peroxidase *** occurrence of ferroptosis in ovarian cancer is strongly associated with three main pathways,namely,the GPX4-glutathione(GSH)protective pathway,the ferroptosis suppressor protein 1(FSP1)-coenzyme Q10(CoQ10)protective pathway,and the guanosine 5'-triphosphate cyclohydrolase I(GCH1)protective *** ovarian cancer cells,the postsynaptic density-95,discs-large,zona occludens 1(PDZ)-binding motif-angiopoietin-like 4-nicotinamide adenine dinucleotide phosphate oxidases 2(TAZ-ANGPTL4-NOX2)pathway can be regulated by Yes-associated protein(YAP)/TAZ,a downstream

关键词： Ovarian cancer Ferroptosis Therapy

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