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Does diffusion tensor data reflect pathological changes in the spinal cord with chronic injury?

Neural Regeneration Research 2013年第36期8卷 3382-3390页

作者： Erjian Lin Houqing Long Guangsheng Li wanlong lei Department of Radiology the Eastern Hospital of the First Affiliated Hospital Sun Yat-sen University Department of Spinal Surgery Huangpu Branch First Affiliated Hospital of Sun Yat-sen University Department of Orthopedics Affiliated Hospital of Guangdong Medical College Department of Human Anatomy and Histoembryology Zhongshan School of Medicine Sun Yat-sen University

Magnetic resonance diffusion tensor imaging has been shown to quantitatively measure the early pathological changes in chronic cervical spondylotic myelopathy. In this study, a novel spongy poly- urethane material was implanted in the rat C^-s epidural space to establish a rat model of chronic cervical spondylotic myelopathy. Diffusion tensor data were used to predict pathological changes. Results revealed that the fractional anisotropy value gradually decreased at 4, 24, and 72 hours and 1 week after injury in rat spinal cord, showing a time-dependent manner. Average diffusion coeffi- cient increased at 72 hours and 1 week after implantation. Hematoxylin-eosin staining and Luxol-fast-blue staining exhibited that the number of neurons in the anterior horn of the spinal cord gray matter and the nerve fiber density of the white matter gradually reduced with prolonged com- pression time. Neuronal loss was most significant at 1 week after injury. Results verified that the fractional anisotropy value and average diffusion coefficient reflected the degree of pathological change in the site of compression in rat models at various time points after chronic spinal cord compression injury, which potentially has a reference value in the early diagnosis of chronic cervical spondylotic myelopathy.

关键词： neural regeneration magnetic resonance cervical spinal cord compression pathology diffusion tensor imaging cervical cord cervical myelopathy neurofilament grants-supported paper neuroregeneration

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Part of decortication ameliorates dopamine depletion-induced striatal neuron lesions in rats

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解剖学杂志 2021年第S1期44卷 144-145页

作者： Zhu Yaofeng Zheng Xuefeng wanlong lei Department of Anatomy Jishou UniversityJishou 416000China Department of Anatomy Zhongshan School of Medicine SunYat-sen University

The degeneration of dopaminergic neurons can lead to the hyperexcitability of striatal *** motor symptoms of Parkinson's disease(PD)are caused by striatal dopamine *** degeneration of dopaminergic neurons,the reduction of corticostriatal glutamate can reestablish the balance of striatal neurons which leads to relieve the PD pathology ***,the mechanisms that reduction of corticostriatal glutamate can relieve vulnerability of striatal neurons were *** the Golgi staining and electron microscopic analysis,we found that reduction of corticostriatal glutamate that used to decorticate decrease in the total length of dendrites and the density of dendritic spines of the striatal neurons in 6-hydroxydopamine(6-OHDA)lesion-induced PD rat ***,we found that reduction of corticostriatal glutamate recovered mitochondrial membrane potential.

关键词： dopamine cor degeneration

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Part of decortication ameliorates dopamine depletion-induced striatal neuron lesions in rats

Part of decortication ameliorates dopamine depletion-induced...

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中国解剖学会2021年年会

作者： Zhu Yaofeng Zheng Xuefeng wanlong lei Department of Anatomy Jishou University Department of Anatomy Zhongshan School of Medicine SunYat-sen University

The degeneration of dopaminergic neurons can lead to the hyperexcitability of striatal *** motor symptoms of Parkinson’s disease (PD) are caused by striatal dopamine *** degeneration of dopaminergic neurons,the reduction of corticostriatal glutamate can reestablish the balance of striatal neurons which leads to relieve the PD pathology process.

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Morphological characteristics of the striatal neural pathway by biotinylated dextran amine tracing in rats

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Neural Regeneration Research 2011年第25期6卷 1931-1936页

作者： Bingbing Liu Shuhua Mu Lisi Ouyang Yaxi Zhu Keyi Li Mali Zhan Zongwei Liu Yu Jia wanlong lei Department of Anesthesiology Guangdong Provincial Second People＇s Hospital Guangzhou 510317 Guangdong Province China Department of Anatomy Zhongshan School of Medicine Sun Yat-sen University Guangzhou 510080 Guangdong Province China

Using neural pathway tracing and immunohistochemical technique, the striato-direct pathway （BDA3 kDa injected into the rat lateral globus pallidus） and striato-indirect pathway （BDA3 kDa injected into the substantia nigra pars reticulata） neurons were specifically labeled, and then subjected to double-labeled immunohistochemistry for mu-OPIOID Receptor （specifically-labeled striatal patch compartment）, D1, and D2, respectively. The experimental findings showed that there are no statistically significant differences in the soma diameter and the number of primary dendrites between the striato-direct （substantia nigra pars reticularis） and indirect （globus pallidum externum） neurons labeled retrograde by BDA3 kDa. In addition, these two kinds of projection neurons revealed no obvious coexistence. This evidence indicates that as a highly sensitive neural pathway tracer, BDA could yield reliably and exquisitely detailed labeling of target neurons and synaptic structures. The variance of the morphologic structures and the localization of neurons were not statistically significant between the striato-substantia nigra pars reticularis and the globus pallidum externum projection neurons. Mesencephalic and thalamic neurons correlated with striatal neurons in morphology. Especially the latter which make typical excitatory synaptic contacts with striato-direct and -indirect neurons. Thus, this evidence suggests that thalamic neurons may extensively excite striatal neurons.

关键词： neural pathway tracing rat striato immunoelectron microscopy direct pathway indirect pathway

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白介素-1βmRNA在缺血侧大脑半球不同区域表达的比较

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解剖学杂志 2000年第4期23卷 333-337页

作者：雷万龙刘勇袁群芳姚志彬中山医科大学解剖学教研室广州510089 西安医科大学解剖学教研室

目的 :比较缺血侧大脑半球尾壳核、视前区和顶叶皮质白介素 - 1β m RNA表达的差异 ,探讨脑不同区域对缺血敏感性的病理机制。方法 :运用原位杂交技术对 30只 SD大鼠进行了研究。结果 :缺血侧大脑半球尾壳核、视前区和顶叶皮质微血管内... 详细信息

目的 :比较缺血侧大脑半球尾壳核、视前区和顶叶皮质白介素 - 1β m RNA表达的差异 ,探讨脑不同区域对缺血敏感性的病理机制。方法 :运用原位杂交技术对 30只 SD大鼠进行了研究。结果 :缺血侧大脑半球尾壳核、视前区和顶叶皮质微血管内皮细胞和单核 /巨噬细胞显示白介素 - 1β m RNA的强杂交信号 ,尾壳核杂交信号较视前区和顶叶皮质出现早而强。顶叶皮质的白介素 - 1β m RNA阳性信号的高峰也明显迟于尾壳核。结论 :白介素 - 1β m RNA在尾壳核的早期以及高表达 ,提示白介素 - 1可能与尾壳核对脑缺血反应敏感有关。

关键词：尾壳核脑缺血原位杂交白细胞介素1β mRNA

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大鼠脑缺血区非特异性酯酶阳性细胞的分布和定量研究

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解剖学报 1999年第4期30卷 319-321,I008页

作者：雷万龙刘勇姚志彬袁群芳凌凤东中山医科大学解剖学教研室广州510089 西安医科大学解剖学教研室

目的　探查非特异性酯酶阳性细胞的变化和与脑缺血的病理联系。　方法　用酶组织化学方法对４０只ＳＤ大鼠脑局部缺血／再灌流损伤区非特异性酯酶阳性细胞的分布和数量进行了观查。　结果　脑缺血区非特异性酯酶阳性细胞的数量增加发生... 详细信息

目的　探查非特异性酯酶阳性细胞的变化和与脑缺血的病理联系。　方法　用酶组织化学方法对４０只ＳＤ大鼠脑局部缺血／再灌流损伤区非特异性酯酶阳性细胞的分布和数量进行了观查。　结果　脑缺血区非特异性酯酶阳性细胞的数量增加发生于脑缺血１ｈ再灌流２ｈ，随后逐渐增加，在脑缺血１ｈ再灌流１６ｈ达到高峰。阳性细胞的增加显示明显的时间依赖关系。阳性细胞主要位于小血管和微血管的壁内及其周围。在缺血侧基底节区非特异性酯酶阳性细胞比皮质缺血区多。　结论　非特异性酯酶阳性细胞对脑缺血刺激反应敏感，在缺血侧基底节区，其反应更为强烈，此因素可能是基底节区易发生中风的原因之一。

关键词：非特异性酯酶脑缺血酶组织化学阳性细胞

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大鼠局灶脑缺血区神经元轴突可塑性的实验研究

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中国康复 2000年第2期15卷 65-67,78页

作者：袁群芳雷万龙姚志彬中山医科大学人体解剖学教研室广州510089

为探查脑缺血后期神经元轴突在梗塞灶的出芽和再生情况，运用免疫组织化学技术对36只雄性SD大鼠进行了研究。结果：在脑缺血3d～7周，脑梗塞灶周围区NF200阳性神经元轴突的形态学改变不显著，但在梗塞灶中央区，神经元轴突排列紊乱，粗... 详细信息

为探查脑缺血后期神经元轴突在梗塞灶的出芽和再生情况，运用免疫组织化学技术对36只雄性SD大鼠进行了研究。结果：在脑缺血3d～7周，脑梗塞灶周围区NF200阳性神经元轴突的形态学改变不显著，但在梗塞灶中央区，神经元轴突排列紊乱，粗细不均和断裂，其数量显著减少；而在脑缺血2～6周，脑梗塞灶中央区神经元轴突的数量逐渐增加，其变化在脑缺血6周最显著，阳性纤维明显增粗、扭曲和染色加深，并从梗塞灶周围区向中央区延伸。提示：神经元轴突在脑缺血区出芽和再生发生于脑缺血后期，表明神经元对脑缺血发生形态学的可塑性改变。

关键词：脑缺血 NF200 神经元轴突可塑性

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Joint Probabilistic Scheduling and Resource Allocation for Wireless Networked Control Systems

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 258-260页

作者： Meng Zheng lei Zhang Wei Liang IEEE the State Key Laboratory of Robotics and the Key Laboratory of Networked Control Systems Shenyang Institute of Automation Chinese Academy of Sciences the University of Chinese Academy of Sciences

Dear Editor,This letter presents a joint probabilistic scheduling and resource allocation method(PSRA) for 5G-based wireless networked control systems(WNCSs). As a control-aware optimization method, PSRA minimizes the linear quadratic Gaussian(LQG) control cost of WNCSs by optimizing the activation probability of subsystems, the number of uplink repetitions, and the durations of uplink and downlink phases. Simulation results show that PSRA achieves smaller LQG control costs than existing works.

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Fluorinated poly(p-triphenylene isatin) anion exchange membranes based on hydrophilic hydroxyl side chain modulation for fuel cells

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Journal of Energy Chemistry 2025年第1期100卷 702-709页

作者： Yiman Gu Yanchao Zhang Zhanyu Li Yijia lei Baozeng Sun Xiaoyu Yu Zhe Wang College of Chemistry and Life Science Changchun University of Technology College of Chemical Engineering Changchun University of Technology School of Materials Science and Engineering Changchun University of Technology Key Laboratory of Advanced Functional Polymer Membrane Materials of Jilin Province

The development of alkaline fuel cells is moving forward at an accelerated pace,and the application of ether-free bonded polymers to anion exchange membranes （AEMs） has been widely ***,the question of the“trade-off”between AEM ionic conductivity and dimensional stability remains *** strategy of inducing microphase separation to improve the performance of AEM has attracted much attention recently,but the design of optimal molecular structures is still being ***,this work introduced different ratios of 3-bromo-1,1,1-trifluoroacetone （x=40,50,and 60） into the main chain of poly（p-terphenylene isatin）.Because fluorinated groups have excellent hydrophobicity,hydrophilic hydroxyl-containing side chains are introduced to jointly adjust the formation of phase separation *** results show that PTI-PTF50-NOH AEM with the appropriate fluorinated group ratio has the best ionic conductivity and alkali stability under the combined effect of *** has an ionic conductivity of 133.83 mS cm-1at 80°*** addition,the OH-conductivity remains at 89%of the initial value at 80°C and 3 M KOH for 1056 h of *** cell polarization curve based on PTI-PTF50-NOH shows a power density of 734.76 mW cm-2at a current density of 1807.7 mA cm-2.

关键词： Anion exchange membranes Poly(p-terphenylene isatin) Hydrophilic-hydrophobic phase separation Fluorinated group

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大鼠纹状体parvalbumin阳性中间神经元的超微结构

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解剖学杂志 2009年第6期32卷 785-789页

作者：欧阳丽斯穆淑花刘冰冰朱亚西李可一雷万龙中山大学中山医学院人体解剖学教研室广州510080

目的：研究纹状体parvalbumin（Parv）阳性中间神经元在神经通路上的突触连接。方法：利用免疫组织化学和神经示踪方法标记SD大鼠纹状体Parv及其相关神经元，光镜和电镜观察阳性神经元的结构和位置关系。结果：Parv阳性中间神经元中等... 详细信息

目的：研究纹状体parvalbumin（Parv）阳性中间神经元在神经通路上的突触连接。方法：利用免疫组织化学和神经示踪方法标记SD大鼠纹状体Parv及其相关神经元，光镜和电镜观察阳性神经元的结构和位置关系。结果：Parv阳性中间神经元中等大小，散在分布于纹状体，以背外侧居多。光镜免疫双标记显示Parv阳性中间神经元与皮质、丘脑和中脑黑质的传入轴突终末形成明显的形态位置上的邻近关系，其轴突终末则与纹状体不同类型投射神经元在光镜下也形成邻近关系。Parv阳性中间神经元的免疫电镜观察显示阳性产物主要游离于胞体、树突和轴突的胞质内。Parv阳性中间神经元的胞体和树突均接受大量的非对称型突触传入。Parv阳性轴突终末平均大小为（0．62±0．28）μm，可见其与纹状体神经元的树突、胞体和树突棘形成对称型突触，其中与树突形成的突触占69．64％，与胞体和树突棘形成的突触分别为26．78％和3．58％。结论：纹状体Parv阳性中间神经元形态学上与皮质、丘脑、黑质以及纹状体投射神经元形成突触连接，提示其可能在调节纹状体信息传入和输出过程中具有重要作用。

关键词：纹状体 parvalbumin 中间神经元投射神经元免疫组织化学免疫电镜

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