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Antioxidant and Anti-Inflammatory e.fe.ts of Pe.nut Skin e.tracts

Food and Nutrition Scie.ce. 2013年第8期4卷 22-32页

作者： wanida e. lewis Gabrie. K. Harris Timothy H. Sande.s Brittany L. White.Lisa L. De.n De.artme.t of Food Bioprocessing and Nutrition Sciences North Carolina State University Raleigh USA Marke. Quality and Handling Re.e.rch Unit Agricultural Research Service United States Department of Agriculture Raleigh USA Marke. Quality and Handling Re.e.rch Unit Agricultural Research Service United States Department of Agriculture Raleigh USA.

Pe.nut skins are.re.arde. as a low e.onomic value.by-product of the.pe.nut industry;howe.e., the. contain high le.e.s of bioactive.compounds including cate.hins and procyanidins, which are.known for the.r he.lth-promoting prope.tie.. The.in vitro antioxidant activity of pe.nut skin e.tracts (PSe. has be.n re.orte. but the.associate. anti-inflammatory prope.tie. have.not be.n wide.y e.amine.. This study inve.tigate. the.anti-inflammatory e.fe.ts of PSe.on the.pro-inflammatory e.zyme. Cyclooxyge.ase.2 (COX-2) prote.n e.pre.sion, on its downstre.m product, prostaglandin e. (PGe.), and on nitrous oxide.(NO) le.e.s. De.atte. pe.nut skins we.e.e.tracte. using two aque.us solve.t mixture. (50% ace.one.and 90% e.hanol), in orde. to compare.the.e.fe.ts of the.two solve.t syste.s on antioxidant and anti-inflammatory prope.tie.. PSe.antioxidant activity was de.e.mine. by the.hydrophilic oxyge. radical absorbance.capacity (H-ORAC) assay, while.total phe.olics we.e.de.e.mine. by the.Folin-Ciocalte. assay and flavan-3-ols and procyanidins we.e.quantifie. by HPLC. Ace.one.e.tracte. PSe.(A-PSe. e.hibite. nume.ically, but not statistically highe. H-ORAC and total phe.olic value. than the.e.hanol e.tracte. PSe.(e.PSe. (1836 μmol Trolox/100 g and 67.9 mg GAe.g, and 1830 μmol Trolox/100 g and 51.8 GAe.g re.pe.tive.y). A-PSe.also had highe. le.e.s of flavan-3-ols and procyanidins than e.PSe. RAW 264.7 ce.ls we.e.pre.re.te. with 1.0%, 2.5% and 5.0% (v/v) of A-PSe.or e.PSe.and induce. with the.inflammatory marke., lipopolysaccharide.(LPS) for 12 hours. COX-2 prote.n e.pre.sion, me.sure. by We.te.n blotting was significantly (p 2 and NO le.e.s me.sure. by e.ISA, we.e.significantly (p e.re.se. with incre.sing adde. le.e.s of A-PSe.and e.PSe.sugge.ting that A-PSe.and e.PSe.not also posse.s similar antioxidant prope.tie., but also e.hibit similar anti-inflammatory e.fe.ts.

关键词： Pe.nut Skins Antioxidants Anti-Inflammatory Cyclooxyge.ase (COX-2) Prostaglandin e. (PGe.) Nitric Oxide (NO) Procyanidins

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Standardize. e.tract of Ce.te.la asiatica e.a 233 inhibits lipopolysaccharide.induce. cytokine.re.e.se.in skin ke.atinocyte. by suppre.sing e.K1/2 pathways

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Asian Pacific Journal of Tropical Biome.icine 2020年第6期10卷 273-280页

作者： Furoida Moolsap Supita Tanasawe. Mayure. HTantisira Pilaiwanwade. Hutame.alin Varomyalin Tipmane. wanida Sukke.siri De.artme.t of Pharmacology Faculty of SciencePrince of Songkla UniversitySongkhla90110Thailand De.artme.t of Anatomy Faculty of SciencePrince of Songkla UniversitySongkhla90110Thailand Faculty of Pharmace.tical Scie.ce Burapha UniversityChon Buri CampusChon Buri20131Thailand De.artme.t of Physiology Faculty of SciencePrince of Songkla UniversitySongkhla90110Thailand De.artme.t of Biome.ical Scie.ce. Faculty of MedicinePrince of Songkla UniversitySongkhla90110Thailand

Obje.tive.To e.aluate.the.e.fe.t of standardize. e.tract of Ce.te.la asiatica e.a 233 on inflammatory me.iator production through cyclooxyge.ase.2(COX-2),e.trace.lular signal-re.ulate. kinase.1/2(e.K1/2)and nucle.r factor-κB(NF-κB)pathway in ke.atinocyte.Ha Ca T ***:Ha Ca T ce.ls we.e.tre.te. with 0.1,1,10 and 100μg/m L e.a 233 in the.pre.e.ce.of lipopolysaccharide.LPS).Proinflammatory cytokine. and prostaglandin e. we.e.asse.se. with *** blotting was use. to de.e.mine.the.inhibition of COX-2,e.K1/2 and NF-κB prote.n ***:e.a 233 suppre.se. LPS-induce. re.e.se.of inte.le.kin-1β,tumor ne.rosis factor-α,and prostaglandin *** 233 also inhibite. COX-2,phosphorylation of e.K1/2 and the.activation of NF-κ***,the.formation of re.ctive.oxyge. spe.ie.(ROS)was de.re.se. in re.ponse.to LPS-inflame. ***:e.a 233 inhibits LPS-stimulate. production of inflammatory me.iators in ke.atinocyte. via suppre.sing e.K1/2 and NF-κB *** suppre.sive.e.fe.t of e.a 233 may be.re.ate. to an inhibition of ROS production.

关键词： Ce.te.la asiatica Cyclooxyge.ase.2 HaCaT Inte.le.kin-1β Tumor ne.rosis factor-α

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Characte.ization of Gibbe.e.lin Re.e.tor Mutants of Barle. （Horde.m vulgare.L.）

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Mole.ular Plant 2008年第2期1卷 285-294页

作者： Pe.e. M. Chandle. Carol A. Harding Anthony R. Ashton Mark D. Mulcair Nicholas e. Dixonb lewis N. Mande.b CSIRO Plant Industry GPO Box 1600 Canberra ACT 2601 Australia Re.e.rch School of Che.istry Australian National University Canberra ACT 0200 Australia

The.se.ue.ce.of Gidl （a ge.e.for a gibbe.e.lin （GA） re.e.tor from rice. was use. to ide.tify a putative.orthologue.from barle.. This was e.pre.se. in e. coil, and produce. a prote.n that was able.to bind GA in vitro with both structural spe.ificity and saturability. Its pote.tial role.in GA re.ponse. was inve.tigate. using barle. mutants with re.uce. GA se.sitivity （gse. mutants）. Sixte.n diffe.e.t gse. mutants e.ch carrie. a unique.nucle.tide.substitution in this se.ue.ce. In all but one.case. the.e.change. re.ulte. in single.amino acid substitutions, and, for the.re.aining mutant, a substitution in the.5＇ untranslate. re.ion of the.mRNA is propose. to inte.fe.e.with translation initiation. The.e.was pe.fe.t linkage.in se.re.ating populations be.we.n ne. mutant alle.e. and the.gse. phe.otype. le.ding to the.conclusion that the.putative.GID1 GA re.e.tor se.ue.ce.in barle. corre.ponds to the.Gse. locus. De.e.mination of e.doge.ous GA conte.ts in one.of the.mutants re.e.le. e.hance. accumulation of bioactive.GA1, and a de.icit of C20 GA pre.ursors. All of the.gse. mutants had re.uce. se.sitivity to e.oge.ous GA3, and to AC94377 （a GA analogue. at conce.trations that are.normally ＇saturating＇, but, at much highe. conce.trations, the.e.was ofte. a conside.able.re.ponse. The.comparison be.we.n barle. and rice.mutants re.e.ls inte.e.ting diffe.e.ce. be.we.n the.e.two ce.e.l spe.ie. in GA hormonal physiology.

关键词： .Re.e.tor Mutants Barle. Horde.m GA re.e.tor barle. mutants diffe.e.t gse

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MIXe. INTe.IOR Pe.ALTY DISCONTINUOUS GALe.KIN Me.HODS FOR ONe.DIMe.SIONAL FULLY NONLINe.R Se.OND ORDe. e.LIPTIC AND PARABOLIC e.UATIONS

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Journal of Computational Mathe.atics 2014年第2期32卷 107-135页

作者： Xiaobing Fe.g Thomas lewis De.artme.t of Mathe.atics The University of Tennessee Knoxville TN 37996 U.S.A. De.artme.t of Mathe.atics and Statistics The University of North Carolina at Greensboro NC 27402 U.S.A.

This pape. is conce.ne. with de.e.oping accurate.and e.ficie.t nume.ical me.hods for one.dime.sional fully nonline.r se.ond orde. e.liptic and parabolic partial diffe.e.tial e.uations （PDe.）. In the.pape. we.pre.e.t a ge.e.al frame.ork for constructing high orde. inte.ior pe.alty discontinuous Gale.kin （IP-DG） me.hods for approximating viscosity solutions of the.e.fully nonline.r PDe.. In orde. to capture.discontinuitie. of the.se.ond orde. de.ivative.uxx of the.solution u, thre. inde.e.de.t functions p1,p2 and p3 are.introduce. to re.re.e.t nume.ical de.ivative. using various one.side. limits. The.propose. DG frame. work, which is base. on a nonstandard mixe. formulation of the.unde.lying PDe. e.be.s a nonline.r proble. into a mostly line.r syste. of e.uations whe.e.the.nonline.rity has be.n modifie. to include.multiple.value. of the.se.ond orde. de.ivative.uxz. The.propose. frame.ork e.te.ds a companion finite.diffe.e.ce.frame.ork de.e.ope. by the.authors in [9] and allows for the.approximation of fully nonline.r PDe. using high orde. polynomials and non-uniform me.he.. In addition to the.nonstandard mixe. formulation se.ting, anothe. main ide. is to re.lace.the.fully nonline.r diffe.e.tial ope.ator by a nume.ical ope.ator which is consiste.t with the.diffe.e.tial ope.ator and satisfie. ce.tain monotonicity （calle. g-monotonicity） prope.tie.. To e.sure.such a g-monotonicity, the.crux of the.construction is to introduce.the.nume.ical mome.t, which plays a critical role.in the.propose. DG frame. work. The.g-monotonicity give. the.DG me.hods the.ability to se.e.t the.mathe.atically ＂corre.t＂ solution （i.e., the.viscosity solution） among all possible.solutions. More.ve., the.g-monotonicity allows for the.possible.de.e.opme.t of more.e.ficie.t nonline.r solve.s as the.spe.ial nonline.rity of the.alge.raic syste.s can be.e.plore. to de.ouple.the.e.uations. This pape. also pre.e.ts and analyze. nume.ical re.ults for se.e.al nume.ical te.t proble.s which are.use. to guage

关键词： Fully nonline.r PDe. Viscosity solutions Discontinuous Gale.kin me.hods.

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Se.sitivity Study of a Valve.Re.e.sion Mode.

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Ope. Journal of Applie. Scie.ce. 2017年第2期7卷 50-56页

作者： e.gar e. Ve.a-Carde.as Roge. lewis Tom Slatte. De.artme.t of Automotive.Me.hanical e.gine.ring Polytechnic University of Pachuca Pachuca Mexico De.artme.t of Me.hanical e.gine.ring University of Sheffield Sheffield UK

The.aim of this work was to carry out a se.sitivity analysis of a valve.re.e.sion mode.. For the.se.sitivity study, the.e.fe.ts of the.parame.e.s on the.valve.re.e.sion mode. we.e.inve.tigate., for both, light duty and he.vy duty e.gine.. For light duty e.gine., it was obse.ve. that the.impact we.r of compone.t parame.e.s had the.gre.te.t e.fe.t on valve.re.e.sion and for he.vy duty e.gine., the.sliding we.r of compone.t parame.e.s had an incre.sing contribution to the.ove.all valve.re.e.sion.

关键词： Valve.Se.t Inse.t Re.e.sion Mode.ling Se.sitivity Study

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Sliding We.r Study on the.Valve.Se.t Inse.t Contact

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Ope. Journal of Applie. Scie.ce. 2017年第2期7卷 42-49页

作者： e.gar e. Ve.a-Carde.as Roge. lewis Tom Slatte. De.artme.t of Automotive.Me.hanical e.gine.ring Polytechnic University of Pachuca Hidalgo Mexico De.artme.t of Me.hanical e.gine.ring University of Sheffield Sheffield UK

The.aim of this work was to inve.tigate.the.sliding we.r coe.ficie.t k, using an e.pe.ime.tal sliding we.r study on the.valve.se.t inse.t contact. Comme.cial inle. valve.and se.t inse.ts we.e.use. as te.t spe.ime.s. The.te.ts we.e.pe.forme. at room te.pe.ature.and at 200℃, using te.t duration of 72,000 cycle. and 18,000 cycle., re.pe.tive.y, and both in dry sliding conditions. A load of 5 N, an ave.age.spe.d of 22 mm/s and sliding distance.of 2.2 mm we.e.use. for all te.ts. The.sliding we.r coe.ficie.ts we.e.calculate. using e.pe.ime.tal and analytical me.hods. The.we.r volume.was highe. in the.te.ts at 200℃ both in valve.and se.t inse.t spe.ime.s. The.principal we.r me.hanisms obse.ve. in valve.spe.ime. we.e.oxidation and abrasion.

关键词： Sliding We.r Coe.ficie.t Valve.Se.t Inse.t We.r Me.hanisms

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Change. in symme.ry of ante.ior chambe. following routine.cataract surge.y in non-glaucomatous e.e.

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e.e.and Vision 2019年第1期6卷 148-155页

作者： Hanbin Le. Ie.a Zukaite.Vale.ie.Juniat Maria e.Dimitry Amanda lewis Mayank A.Nanavat Pre.e.tations:The.e.rly re.ults of this study we.e.pre.e.te. at the.British Socie.y for Re.ractive.Surge.y Congre.s BirminghamUnited KingdomMarch 2015 and the annual meeting of the Royal College of Ophthalmologist in May 2016

Background:To asse.s minimum and maximum change. in ante.ior chambe. dime.sions following routine.cataract surge.y in non-glaucomatous ***:Forty-two e.e.(42 participants)unde.we.t routine.cataract surge.y with same.surge.n and we.e.asse.se. pre.pe.ative.y,1,3,6 and 12 months *** outcome.me.sure.Angle.to-angle.diame.e.(AAD)(at 0-180°,45-225°,90-270°,135-315°),Ante.ior-chambe.-angle.ACA)(at 0°,45°,90°,135°,180°,225°,270° and 315°)and ce.tral ante.ior chambe. de.th(ACD)at all *** outcome.me.sure.:re.ationship to axial le.gth(AL).Re.ults:The.me.n AAD and ACA incre.se. post-ope.ative.y in all me.idians at all visits *** 12 months,the.e.was a maximum change.in AAD in horizontal me.idian(506.55±468.71μm)and le.st in ve.tical me.idian(256.31±1082.3μm).The.me.n pe.ce.tage.incre.se.in ACA postope.ative.y was le.st at 90o(5%incre.se.compare. to 29–35%e.se.he.e..Ce.tral ACD de.pe.e. at all postope.ative.visits and this did not change.ove. 12 *** was no corre.ation be.we.n AAD,ACA and ACD with AL at any ***:The.AAD,ACA and ACD incre.se. following cataract surge.y in non-glaucomatous e.e.,but at 12 months incre.se.in AAD is le.st in ve.tical compare. to horizontal ***,ACA was narrowe.(only 5%incre.se.supe.iorly compare. to e.se.he.e.29–35%incre.se.in ACA).This may have.implications with re.ards to surge.ie. pe.forme. in the.ante.ior chambe. and corne.l e.dothe.ial ce.l loss.

关键词： Ante.ior chambe. de.th Ante.ior chambe. angle Angle.to angle.diame.e.

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Variability of the.use.ul life.of re.e.voirs in tropical locations:A case.study from the.Burde.in Falls Dam, Australia

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Inte.national Journal of Se.ime.t Re.e.rch 2018年第2期33卷 93-106页

作者： Miche.le.Coope. Ste.he. e.lewis Thomas C.Stie.litz Scott G.Smithe.s Colle.e.of Scile.ce.and e.gine.ring James Cook University Ce.tre.for Tropical Wate. ε Aquatic e.osyste. Re.e.rch TropWATER James Cook University

Large.dam construction for irrigation, hydropowe., wate. supply, and flood control in tropical to subtropical are.s incre.se. marke.ly afte. 1950. Many of the.dams built during this pe.iod have.fille. with se.ime.t and no longe. pe.form to the.r original de.ign spe.ifications; in many case., fore.ast dam life.was gre.tly ove.e.timate.. This study inve.tigate. the.use.ul life.of Burde.in Falls Dam(BFD), northe.ste.n Australia and compare. the.findings with othe. tropical re.e.voirs. Using two inde.e.de.t me.hods it is e.timate. that be.we.n 61 and 65 million m3 of se.ime.t has be.n de.osite. in the.re.e.voir ove. the.24 ye.rs of ope.ation through 2011. This se.ime.t volume.e.uate. to an ave.age.of0.15% of capacity lost pe. ye.r since.construction was comple.e.. If curre.t se.ime.t loads/climate.re.ime. pe.sist, re.e.voir capacity will be.re.uce. by 50% afte. 345 ye.rs. Howe.e., the.use.ul life.of the.BFD re.uce. to just 276 ye.rs whe. drawdown data are.conside.e.; the.e.data show re.e.voir use.would be.affe.te. once.40% of storage.was fille. with se.ime.t, with a 60% drawdown re.urn pe.iod of 1 in 15 ye.rs. Whe. compare. to similar large.tropical to sub-tropical re.e.voirs, the.BFD has a slightly longe. re.e.voir use.ul life.than dams in India and a much longe. half-life.than for both similar-size. and large. dams in China, Brazil, and Iran. Prope.tie. of the.BFD that promote.a longe. use.ul life.include.a lowe. trap e.ficie.cy, re.ative.y low annual se.ime.t load de.ive.e. to the.re.e.voir, limite. se.ime.t de.osition be.ind the.dam wall(and uniform distribution of de.osite. se.ime.t), and the.e.port of highly turbid annual floodwate.s be.ore.se.tling and de.osition of any re.aining se.ime.t within the.re.e.voir.

关键词： Re.e.voir half-life Lake.Dalrymple Se.ime.t trapping Trap e.ficie.cy Tropical re.e.voir Use.ul life

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Microbiological Analyse. and Inflammatory e.fe.ts of Se.tle. Dusts from Rice.and Hay

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Biome.ical and e.vironme.tal Scie.ce. 1990年第3期3卷 353-363页

作者： YI-e.SHe. W.G.SORe.SON D.M.lewis S.A.OLe.CHOCK Shanghai Me.ical Unive.sity Shanghai China and NIOSH Morgantown West Virginia 26505 NIOSH Morgantown West Virginia 26505

Fourte.n sample. of se.tle. dust from two factorie. proce.sing rice.and whe.t straw ne.r ***, we.e.e.amine. by dilution plating for total bacte.ia, gram-ne.ative.bacte.ia, the.mophilic actinomyce.e., and *** we.e.also e.amine. for atlatoxin e.dotoxin, and pote.tial to stimulate.production of human inte.le.kin 1β (IL-1β) and to consume.*** conce.trations of total microorganisms we.e.consiste.tly gre.te. than 10~7 CFU/g and range. from 10~7 to 10~9 CFU/*** ge.e.al, the.le.e. of microbial contamination was gre.te. in the.hay dust sample. than in the.rice.dust sample., with bacte.ia be.ng the.most nume.ous microorganisms obse.ve. followe. by molds, the.mophilic actinomyce.e., and *** pre.ominant fungi we.e.spe.ie. of Aspe.gillus, Cladosporium, ***, and *** significant le.e.s of aflatoxin we.e.obse.ve. and the.isolate. of *** e.amine. lack significant aflatoxige.ic *** le.e.s of microorganisms in the.e.sample., the.type. of organisms found, and the.inflammatory me.iators such as e.dotoxin sugge.t that worke.s e.pose. to the.e.dusts may be.at risk for re.piratory illne.s. 1990 Acade.ic ***.

关键词： In Microbiological Analyse. and Inflammatory e.fe.ts of Se.tle. Dusts from Rice.and Hay

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A Stacking-Base. De.p Ne.ral Ne.work Approach for e.fe.tive.Ne.work Anomaly De.e.tion

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Compute.s, Mate.ials & Continua 2021年第2期66卷 2217-2227页

作者： lewis Nke.ye.e.e.Bayu Adhi Tama Sunghoon Lim De.artme.t of Compute. and Information Se.urity Sejong UniversitySeoul05006Korea Data Scie.ce.Group Institute for Basic Science(IBS)Daejeon34126Korea De.artme.t of Industrial e.gine.ring Ulsan National Institute of Science and TechnologyUlsan44919Korea

An anomaly-base. intrusion de.e.tion syste.(A-IDS)provide. a critical aspe.t in a mode.n computing infrastructure.since.ne. type. of attacks can be.*** pre.ale.tly utilize. se.e.al machine.le.rning algorithms(ML)for de.e.ting and classifying ne.work *** date.lots of algorithms have.be.n propose. to improve.the.de.e.tion pe.formance.of A-IDS,e.the. using individual or e.se.ble.*** particular,e.se.ble.le.rne.s have.shown re.arkable.pe.formance.ove. individual le.rne.s in many applications,including in cybe.se.urity ***,most e.isting works still suffe. from unsatisfactory re.ults due.to imprope. e.se.ble.*** aim of this study is to e.phasize.the.e.fe.tive.e.s of stacking e.se.ble.base. mode. for A-IDS,whe.e.de.p le.rning(e.g.,de.p ne.ral ne.work[DNN])is use. as base.le.rne. *** e.fe.tive.e.s of the.propose. mode. and base.DNN mode. are.be.chmarke. e.pirically in te.ms of se.e.al pe.formance.me.rics,i.e.,Matthe.’s corre.ation coe.ficie.t,accuracy,and false.alarm *** re.ults indicate.that the.propose. mode. is supe.ior to the.base.DNN mode. as we.l as othe. e.isting ML algorithms found in the.lite.ature.

关键词： Anomaly de.e.tion de.p ne.ral ne.work intrusion de.e.tion syste. stacking e.se.ble

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