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Journal of Pharmaceutical Analysis 2023年第6期13卷 625-639页

作者： Han Xiao Rong Zhao wangyang meng Yongde Liao Department of Thoracic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Thoracic Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China

In non-small cell lung cancer(NSCLC),the heterogeneity promotes drug resistance,and the restricted expression of programmed death-ligand 1(PD-L1)limits the immunotherapy *** on the mechanisms related to translation regulation and the association with PD-L1 of methyltransferaselike 3(METTL3),the novel small-molecule inhibitor STM2457 is assumed to be useful for the treatment of *** evaluated the efficacy of STM2457 in vivo and in vitro and confirmed the effects of its inhibition on disease ***,we explored the effect of STM2457 on METTL3 and revealed its effects on the inhibition of catalytic activity and upregulation of METTL3 protein ***,we described the genome-wide characteristics of multiple omics data acquired from RNA sequencing,ribosome profiling,and methylated RNA immunoprecipitation sequencing data under STM2457 treatment or METTL3 *** also constructed a model for the regulation of the translation of METTL3 and ***,we found PD-L1 upregulation by STM2457 in vivo and in *** conclusion,STM2457 is a potential novel suppressor based on its inhibitory effect on tumor progression and may be able to overcome the heterogeneity based on its impact on the ***,it can improve the immunotherapy outcomes based on PDL1 upregulation in NSCLC.

关键词： STM2457 METTL3 Translatomics Non-small cell lung cancer PD-L1

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作者混合共引网络对知识图谱绘制的改进研究

图书情报工作 2017年第3期61卷 118-124页

作者：黄文彬蒙汪阳步一北京大学信息管理系北京100871 美国印第安纳大学信息学与计算机学院印第安纳布鲁明顿47408

[目的/意义]作者共引网络分析(ACNA)是文献计量学中的重要分析方法,旨在通过寻找学术文献集合中作者之间的共引关系绘制出特定领域的知识图谱,进而指导科学研究。然而,ACNA的一个缺陷是其原始矩阵输入信息量过小。本文通过提出作者混合... 详细信息

[目的/意义]作者共引网络分析(ACNA)是文献计量学中的重要分析方法,旨在通过寻找学术文献集合中作者之间的共引关系绘制出特定领域的知识图谱,进而指导科学研究。然而,ACNA的一个缺陷是其原始矩阵输入信息量过小。本文通过提出作者混合共引网络(HACNA),绘制更为精确的科学知识图谱。[方法/过程]鉴于不同种类的学术网络能为绘制知识图谱提供不同维度的信息,提高知识图谱绘制的精确性,本文以合著网络和引用网络为例,结合其他种类的学术网络在ACNA基础上进行精确科学知识图谱的绘制。[结果/结论]实证研究结果显示,与ACNA相比,HACNA绘制出的知识图谱在聚类过程中能够使得同类作者更为聚拢、不同类作者更为分散,从而提高了聚类效果和可视化程度。同时,HACNA绘制出的知识图谱还能够挖掘出更多细节。

关键词：作者共引网络共引网络合著网络引文网络文献计量学

改良FOLFOX7方案联合复方苦参、艾迪注射液对进展期胃癌CA125、CEA、IL-6、TGFβ1和硫化氢水平的影响及用药安全性分析

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中华中医药学刊 2020年第7期38卷 208-211页

作者：孟祥云孟汪洋叶茜戴丽胡娟汪星辉李国辉合肥市第二人民医院药学部安徽合肥230000 华中科技大学同济医学院湖北武汉430030 中国医学科学院肿瘤医院药学部北京100200

目的探讨改良FOLFOX7方案联合复方苦参、艾迪注射液对进展期胃癌患者CA125、CEA、IL-6、TGFβ1和硫化氢水平的影响及用药安全性分析。方法将医院2016年6月—2018年6月收治的78例进展期胃癌患者纳入至本次研究,依照数字随机表法将其分为... 详细信息

目的探讨改良FOLFOX7方案联合复方苦参、艾迪注射液对进展期胃癌患者CA125、CEA、IL-6、TGFβ1和硫化氢水平的影响及用药安全性分析。方法将医院2016年6月—2018年6月收治的78例进展期胃癌患者纳入至本次研究,依照数字随机表法将其分为对照组与观察组各39例,对照组给予改良FOLFOX7方案治疗,观察组则行改良FOLFOX7方案联合复方苦参、艾迪注射液治疗,比较两组患者治疗前后血清免疫功能、血清CEA、CA125、白细胞介素-6(IL-6)、转化生长因子β1(TGFβ1)以及硫化氢水平,统计不良反应情况,观察治疗效果。结果对照组患者的血清免疫功能水平显著低于观察组,对比差异有统计学意义(P<0.05)。对照组患者的血清CEA、CA125水平明显高于观察组,对比差异有统计学意义(P<0.05)。对照组患者的IL-6和TGFβ1水平高于观察组,硫化氢水平低于观察组,对比差异有统计学意义(P<0.05)。对照组患者的不良反应发生率41.03%(16/39)高于观察组15.38%(6/39),对比差异有统计学意义(P<0.05)。对照组患者治疗的总有效率87.18%(34/39)低于观察组97.44%(38/39),对比差异有统计学意义(P<0.05)。结论在进展期胃癌患者接受治疗时,采用改良FOLFOX7方案联合复方苦参、艾迪注射液的临床治疗效果较好,值得在临床治疗中推广。

关键词：改良FOLFOX7方案复方苦参注射液艾迪注射液进展期胃癌用药安全性

Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： Qian Yin Fan Wen Zhigang Tao Hai Pu Tianci Deng Yaoyao meng Qingbin meng Hongwen Jing Bo meng Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

Joint Probabilistic Scheduling and Resource Allocation for Wireless Networked Control Systems

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 258-260页

作者： meng Zheng Lei Zhang Wei Liang IEEE the State Key Laboratory of Robotics and the Key Laboratory of Networked Control Systems Shenyang Institute of Automation Chinese Academy of Sciences the University of Chinese Academy of Sciences

Dear Editor,This letter presents a joint probabilistic scheduling and resource allocation method(PSRA) for 5G-based wireless networked control systems(WNCSs). As a control-aware optimization method, PSRA minimizes the linear quadratic Gaussian(LQG) control cost of WNCSs by optimizing the activation probability of subsystems, the number of uplink repetitions, and the durations of uplink and downlink phases. Simulation results show that PSRA achieves smaller LQG control costs than existing works.

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The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan Jiao Lingyan meng Kang Du Xuezhi Li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein

A Novel Model for Describing Rail Weld Irregularities and Predicting Wheel-Rail Forces Using a Machine Learning Approach

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 555-577页

作者： Linlin Sun Zihui Wang Shukun Cui Ziquan Yan Weiping Hu Qingchun meng State Key Laboratory of High-Speed Railway Track System China Academy of Railway Sciences Corporation LimitedBeijing100081China Railway Engineering Research Institute China Academy of Railway Sciences Corporation LimitedBeijing100081China School of Aeronautic Science and Engineering Beihang UniversityBeijing100191China

Rail weld irregularities are one of the primary excitation sources for vehicle-track interaction dynamics in modern high-speed *** can cause significant wheel-rail dynamic interactions,leading to wheel-rail noise,component damage,and *** researchers have employed the vehicle-track interaction dynamic model to study the dynamic interactions between wheel and rail induced by rail weld geometry ***,the cosine wave model used to simulate rail weld irregularities mainly focuses on the maximum value and neglects the geometric *** this study,novel theoretical models were developed for three categories of rail weld irregularities,based on measurements of the high-speed railway from Beijing to *** vertical dynamic forces in the time and frequency domains were compared under different running *** forces generated by the rail weld irregularities that were measured and modeled,respectively,were compared to validate the accuracy of the proposed ***,based on the numerical study,the impact force due to rail weld irrregularity is modeled using an Artificial Neural Network(ANN),and the optimum combination of parameters for this model is *** results showed that the proposed model provided a more accurate wheel/rail dynamic evaluation caused by rail weld irregularities than that established in the *** ANN model used in this paper can effectively predict the impact force due to rail weld irrregularity while reducing the computation time.

关键词： Rail weld irregularity high-speed railway vehicle-track coupled dynamics wheel/rail dynamic vertical force artificial neural networks

Enhanced Photocatalytic Activity of ThienyI-Porphyrins-TiO2 for Degradation of 4-Nitrophenol

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Chinese Journal of Chemistry 2013年第2期31卷 230-236页

作者： wangyang Ma Jun Li Jingzhou Liu meng Feng Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry qf Education College of Chemistry and Material Science Northwest University Xi'an Shannxi 710069 China

5-Mono-（2-thienyl）-10,15,20-triphenyl porphyrin （H2MTP） and its Co（II）, Cu（II）, Zn（ll） metalloporphyrins （CoMTP, CuMTP, ZnMTP） were synthesized and characterized spectroscopically. The corresponding Co（ll）, Cu（ll）, Zn（II） metalloporphyrins-TiO2 photocatalysts were then prepared and characterized by means of scanning electron microscopy （SEM）, energy dispersive spectrometer （EDS）, UV-vis spectra and FT-IR. The photocatalytic activities of these photocatalysts were investigated by testing the photodegradation of 4-nitrophenol （4-NP） in aqueous solution under irradiation with high-pressure mercury lamp and metal halide lamp respectively. The results indicated that these metalloporphyrins greatly enhanced the photocatalytic efficiency of bare TiO2 in degradating the 4-NP, and CuMTP-TiO2 exhibited the highest photocatalytic activity of all photocatalysts. In addition, the first order rate constants of these photocatalytic reactions were calculated.

关键词： thienyl-appended porphyrin metalloporphyrin titanium dioxide photocatalytic degradation 4-nitrophenol

Shaanxi History Museum

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China Today 2025年第1期74卷 76-79页

作者： meng JIAXIN 不详

It is one of the must-visit history museums,known for its vast collection of historical artifacts,attracting around three million domestic and international visitors each *** Shaanxi History Museum(SHM),in the renowned historic city of Xi’an in Shaanxi Province,is often regarded as one of the museums most difficult to get a ticket to in *** day,approximately 12,000 free online tickets are made available and are fully booked within just a couple of *** vast collection of treasured relics and numerous national treasures leave visitors in awe.

关键词： History attracting visitors

Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing Li Zixuan He Weitai Chai meng Tian Huali Yu Xiaoxiao He Xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan